Spider Bites (Spider Bite)

07/01/2017 - "The most useful treatment for spider bite is anti-venom administration. "
03/01/2005 - "Antivenom is scarce; capture of the offending spider appears to be most helpful in the diagnosis and proper treatment of spider bites."
01/01/2016 - "A better knowledge of the burden and risk factors associated with severity due to spider bites would lead to improved management with a reduction of sequelae usually seen for this neglected health problem, and would ensure proper use of antivenoms in remote localities in the Brazilian Amazon. "
01/01/2019 - "The Efficacy of Antivenin Latrodectus (Black Widow) Equine Immune F(ab')2 Versus Placebo in the Treatment of Latrodectism: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial."
08/01/2006 - "The efficacy of antivenom in loxoscelism treatment."

10/01/2022 - "After suspicion of cutaneous loxoscelism based on the clinical record and corticosteroid administration, the patient presented a favorable evolution. "
06/15/1984 - "[Early treatment of loxoscelism with corticosteroids]."
04/01/1990 - "Using systemic corticosteroids may be helpful in treating the much rarer systemic loxoscelism, which has minimal skin changes but produces massive hemolysis. "
01/01/2018 - "From these, 11.8% corresponded to viscerocutaneous loxoscelism, successfully managed with supportive measures, systemic corticosteroids and antihistamines. "
10/01/2023 - "Rare Loxoscelism-Associated IgG Coombs-Positive Hemolytic Anemia Treated Successfully With Systemic Corticosteroids."

06/15/2016 - "Considering that alterations in the microcirculatory network are involved in the pathogenesis of different diseases, including the inflammatory process, the aim of this study was to investigate the action of venoms of males and females of Loxosceles intermedia and Loxosceles laeta on the microcirculatory network and examine the systemic production of inflammatory mediators in a murine model of loxoscelism. "
12/28/2022 - "Results demonstrate the potential of using mutated recombinant PLDs in total or partial replacement of Loxosceles venoms in animal immunizations to produce anti-Loxosceles sera for treatments of Loxoscelism."
09/01/2022 - "Although the venom is rarely fatal, the recent spider bites raise questions about the influence of higher air temperatures on their possibly increased toxicity. "
12/01/2020 - "similis venom, which may be valuable biotechnological and immunological tools against loxoscelism."
12/01/2020 - "Loxoscelism is a recognized public health problem in Brazil, but the venom from Loxosceles similis, which is widespread in Brazil due to its adaptability to the urban environment, remains poorly characterized. "

12/15/2015 - "The results bring out new insights on brown spider venom toxins for study, diagnosis and treatment of loxoscelism and putative biotechnological applications concerning immune conserved features in the toxins."
01/01/2021 - "SMases D are considered the toxins that cause the main pathological effects of the Loxosceles venom, that is, those responsible for the development of loxoscelism. "
11/22/2019 - "TCTP from Loxosceles Intermedia (Brown Spider) Venom Contributes to the Allergic and Inflammatory Response of Cutaneous Loxoscelism."
01/01/2018 - "Loxoscelism is a severe human envenomation caused by Loxosceles spider venom. "
01/01/2015 - "Loxosceles venom variation and loxoscelism in the Mediterranean Basin and the Canary Islands."

06/01/2014 - "Verified spider bites in Oregon (USA) with the intent to assess hobo spider venom toxicity."
06/01/2014 - "The objective of the present review is to provide insights into the brown spider venoms and loxoscelism based on recent results. "
09/22/2023 - "This minireview describes a simple method for detection of this activity that will be useful for studies of its occurrence in spider venoms and other biological samples, perhaps including lesions from suspected spider bites and infections."
03/01/2012 - "Although wolf spider venom has been implicated in necrotic arachnidism without acceptably documented verification, limited, prospectively collected data demonstrate a lack of cutaneous necrosis. "
01/01/2020 - "The diagnosis of latrodectism is purely clinical, combined with the patient's history of spider bite, as no analytical assays exist to detect widow spider venom. "

06/01/2007 - "Common ground?: Tetracyclines, matrix metalloproteinases, pustular dermatoses, and loxoscelism."
01/01/2017 - "These results indicate that MMPs may play an important role in Loxosceles venom-induced kidney injury and that tetracycline administration may be useful in the treatment of human systemic loxoscelism."
01/01/2016 - "In previous studies, we have demonstrated that increased expression/secretion of matrix metalloproteinases 2 and 9, induced by Loxosceles intermedia venom Class 2 SMases D (the main toxin in the spider venom), contribute to the development of cutaneous loxoscelism. "

08/01/2023 - "Although no specific treatment exists in Sri Lanka for spider bites, calcium supplements can be beneficial for Sri Lankan ornamental tarantula (Poecilotheria fasciata) bites."
01/01/2017 - "The management of mild to moderate latrodectism is primarily supportive while severe cases have variously been treated with intravenous calcium, muscle relaxants, widow-spider antivenom and analgesic opioids. "
01/01/1993 - "To study the effects of loxosceles laeta venom on red blood cells and the possible factors involved in hemolysis during arachnidism, in vitro models were designed to measure the role of loxosceles venom, calcium, complement and antibodies in the mechanism of red blood cell destruction. "

06/01/2014 - "[A possible gold standard for the diagnosis of loxoscelism and a solution for research]."
12/01/2014 - "In a multicenter randomized placebo-controlled trial of redback spider antivenom for latrodectism, 224 patients (>7 years) with a redback spider bite and severe pain, with or without systemic effects, were randomized to receive normal saline solution (placebo) or antivenom after receiving standardized analgesia. "

01/01/2001 - "While this study is limited by the optimized premixing of antigen with antibody, it generates the hypothesis that redback antivenom would be effective in the treatment of latrodectism in humans caused by the two clinically relevant species of North American widow spiders."
12/01/2021 - "These results indicate a great potential for mutated recombinant PLDs to be employed as antigens in developing protective vaccines for Loxoscelism."

11/01/1990 - "[The treatment of cutaneous loxoscelism with dapsone]."
01/01/1985 - "Recent reports have suggested the use of dapsone for brown spider bites. "
11/01/2000 - "Dapsone should be used only in adult patients who experience necrotic arachnidism and who have been screened for glucose-6-phosphate dehydrogenase deficiency. "
01/01/1985 - "Methemoglobinemia from dapsone therapy for a suspected brown spider bite."
01/01/2018 - "Most cases of cutaneous loxoscelism presented excellent response and rapid resolution of the disease after combined therapy with systemic corticosteroids, antibiotics and dapsone, suggesting that the use of these therapies could stop the progression of cutaneous necrosis and prevent complications associated with loxoscelism."

12/01/2022 - "Systemic loxoscelism, which occurs in 1 in 5 cases and is the most frequent in children, can be fatal, so the study of effective therapy is of great relevance. "
05/01/2022 - "Therapy of loxoscelism is directed at limiting the dermatonecrosis at the site of the envenomation and in cases of systemic illness supportive care is recommended. "
01/01/2021 - "In addition, these recombinant toxins may be useful to develop a rational therapy for loxoscelism. "
01/01/2016 - "Loxosceles spider bites often lead to serious envenomings and no definite therapy has yet been established. "
12/15/2010 - "Loxoscelism: From basic research to the proposal of new therapies."

12/01/2010 - "Loxoscelism and negative pressure wound therapy (vacuum-assisted closure): an experimental study."
11/01/2009 - "Loxoscelism and negative pressure wound therapy (vacuum-assisted closure): a clinical case series."
03/01/2007 - "Although not much is known regarding the application of negative pressure wound therapy (NPWT) to spider bites, this therapy has considerable literature support for its efficacy, cost-effectiveness and ease of use in chronic, difficult-to-heal wounds. "

09/01/2001 - "These findings must be considered in order to improve loxoscelism immunotherapy."
05/01/2005 - "gaucho venom is an important step towards understanding the physiopathology of the envenomation, leading to improvements in the immunotherapy of loxoscelism."
01/01/2018 - "To the best of our knowledge, no study has evaluated the presence of antibodies against Loxosceles venom in loxoscelism patients without treatment with antivenom immunotherapy. "

10/01/2011 - "Although most cases in adults are secondary to drug use and intracavernosal injections, blood dyscrasias and hypercoagulable states, vasculitis, penile metastases, neurological conditions, spider bites, carbon monoxide poisoning, and total parenteral nutrition may also result in priapism. "
07/01/1979 - "[A preliminary study of treatment of experimental systemic (cutaneous-visceral) loxoscelism in the rabbit with injectable methyl prednisolone (author's transl)]."

12/01/2014 - "The addition of antivenom to standardized analgesia in patients with latrodectism did not significantly improve pain or systemic effects."
12/01/2014 - "We aimed to investigate whether antivenom resulted in resolution of pain and systemic effects in patients with latrodectism who received standardized analgesia. "
01/01/2017 - "Antivenom with opioid analgesia is often the major treatment reported for latrodectism however; recent high quality evidence has cast doubt on the clinical effectiveness of this combination and suggests that other treatments need to be investigated."
12/01/2014 - "In a multicenter randomized placebo-controlled trial of redback spider antivenom for latrodectism, 224 patients (>7 years) with a redback spider bite and severe pain, with or without systemic effects, were randomized to receive normal saline solution (placebo) or antivenom after receiving standardized analgesia. "