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Arachidonate 5-Lipoxygenase (5 Lipoxygenase)

An enzyme that catalyzes the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-HPETE) which is rapidly converted by a peroxidase to 5-hydroxy-6,8,11,14-eicosatetraenoate (5-HETE). The 5-hydroperoxides are preferentially formed in leukocytes.
Also Known As:
5 Lipoxygenase; Arachidonate 5 Lipoxygenase; Arachidonic Acid 5-Lipoxygenase; LTA4 Synthase; Leukotriene A Synthase; Leukotriene A4 Synthase; Leukotriene A4 Synthetase; 5-Lipoxygenase, Arachidonate; 5-Lipoxygenase, Arachidonic Acid; Arachidonic Acid 5 Lipoxygenase; Synthase, LTA4; Synthase, Leukotriene A; Synthase, Leukotriene A4; Synthetase, Leukotriene A4; 5-Lipoxygenase; Arachidonate:oxygen 5-oxidoreductase
Networked: 1101 relevant articles (44 outcomes, 151 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Werz, Oliver: 17 articles (08/2015 - 08/2005)
2. Sautebin, Lidia: 14 articles (09/2014 - 06/2003)
3. Rossi, Antonietta: 11 articles (09/2014 - 06/2003)
4. Cuzzocrea, Salvatore: 11 articles (01/2007 - 06/2003)
5. Praticò, Domenico: 10 articles (11/2015 - 04/2008)
6. Ghosh, Jagadananda: 9 articles (02/2015 - 01/2002)
7. Steinhilber, Dieter: 9 articles (01/2015 - 08/2005)
8. Allayee, Hooman: 9 articles (08/2012 - 07/2002)
9. Wei, Er-Qing: 9 articles (01/2012 - 04/2006)
10. Funk, Colin D: 9 articles (05/2010 - 07/2002)

Related Diseases

1. Inflammation
2. Asthma (Bronchial Asthma)
3. Colitis
4. Ulcerative Colitis
5. Psoriasis (Pustulosis Palmaris et Plantaris)

Related Drugs and Biologics

1. zileuton (Zyflo)
2. Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
3. Arachidonic Acid (Vitamin F)
4. Leukotriene B4
5. Cyclooxygenase 2 (Cyclooxygenase-2)
6. licofelone
7. Leukotriene Antagonists (Leukotriene Receptor Antagonists)
8. 2,3,5- trimethyl- 6- (12- hydroxy- 5,10- dodecadiynyl)- 1,4- benzoquinone
9. Indomethacin (Indometacin)
10. Naproxen (Naprosyn)

Related Therapies and Procedures

1. Oral Administration
2. Homologous Transplantation (Allograft)
3. Chemoprevention
4. Drug Therapy (Chemotherapy)
5. Tourniquets