Arachidonate Lipoxygenases

Enzymes catalyzing the oxidation of arachidonic acid to hydroperoxyarachidonates. These products are then rapidly converted by a peroxidase to hydroxyeicosatetraenoic acids. The positional specificity of the enzyme reaction varies from tissue to tissue. The final lipoxygenase pathway leads to the leukotrienes. EC 1.13.11.- .

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Networked: 16 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cai, Chang: 1 article (01/2022)
2.	Jin, Minli: 1 article (01/2022)
3.	Li, Chengye: 1 article (01/2022)
4.	Li, Xi: 1 article (01/2022)
5.	Lou, Lejing: 1 article (01/2022)
6.	Luo, Yacan: 1 article (01/2022)
7.	Yang, Song: 1 article (01/2022)
8.	Zhou, Meixi: 1 article (01/2022)
9.	DU, Jie: 1 article (08/2021)
10.	Han, Ying-Chun: 1 article (08/2021)

Related Diseases

1.	Vascular Calcification 08/25/2021 - "This study aims to explore the effects of arachidonic acid lipoxygenase metabolism in vascular calcification. " 08/25/2021 - "These results suggest that the metabolism of arachidonic acid lipoxygenase is activated in calcified aorta, and the Alox15/12-HETE signaling pathway may play a protective role in vascular calcification."
2.	Pleurisy (Pleuritis) 02/01/1989 - "5. This study suggests that Paf-acether-induced pleurisy in the rat may be mediated by lipoxygenase arachidonic acid metabolites and that pleurisy induced by zymosan, but not by carrageenin, is largely dependent upon Paf-acether."
3.	Neoplasms (Cancer) 08/01/1997 - "Arachidonate lipoxygenases (LOX) and their products play an important role in mediating growth factor-supported tumor cell proliferation and growth. " 01/01/2023 - "Arachidonate lipoxygenases 5 is a novel prognostic biomarker and correlates with high tumor immune infiltration in low-grade glioma." 01/01/1989 - "These results suggest that arachidonic acid/lipoxygenase, protein kinase C and calcium-calmodulin systems play essential roles in the mechanism of tumor promotion by TPA."
4.	Carcinogenesis 01/01/2020 - "Arachidonate lipoxygenases (ALOX) have been implicated in playing a critical role in tumorigenesis, development, and metastasis. "
5.	Intracranial Vasospasm 10/01/1997 - "Ebselen, a seleno-organic compound which inhibits arachidonic acid lipoxygenase activity and exerts glutathione peroxidase-like activity, ameliorated delayed cerebral vasospasm in a canine two-hemorrhage model. "

Related Drugs and Biologics

1.	Zymosan
2.	Platelet Activating Factor
3.	Carrageenan
4.	Dinoprostone (PGE2)
5.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
6.	Acids
7.	Intercellular Signaling Peptides and Proteins (Growth Factors)
8.	Leukotriene Antagonists (Leukotriene Receptor Antagonists)
9.	Anti-Allergic Agents (Antiallergic Agents)
10.	Cholinergic Antagonists (Anticholinergics)