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Arabinofuranosyluracil (Ara U)

A pyrimidine nucleoside formed in the body by the deamination of CYTARABINE.
Also Known As:
Ara U; 1-beta-D-Arabinofuranosyl Uracil; NSC 68928; 1 beta D Arabinofuranosyl Uracil; Arabinofuranoside, Uracil; Arabinoside, Uracil; Uracil, 1-beta-D-Arabinofuranosyl; Ara-U; Arabinosyluracil; Arauridine; Sponguridine; Uracil Arabinofuranoside; Uracil Arabinoside; 2,4(1H,3H)-Pyrimidinedione, 1-beta-D-arabinofuranosyl-
Networked: 32 relevant articles (3 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Wang, Hsin-Ell: 2 articles (11/2013 - 10/2011)
2. Lin, Wuu-Jyh: 2 articles (11/2013 - 10/2011)
3. Wu, Chun-Yi: 2 articles (11/2013 - 10/2011)
4. Chang, Wei-Ting: 2 articles (11/2013 - 10/2011)
5. Chan, Pei-Chia: 2 articles (11/2013 - 10/2011)
6. Li, Zibo: 2 articles (09/2012 - 07/2011)
7. Alauddin, Mian: 2 articles (10/2011 - 07/2009)
8. Liao, Chuanrong: 1 article (11/2013)
9. Fu, Guoqiang: 1 article (11/2013)
10. Hu, Shuhua: 1 article (11/2013)

Related Diseases

1. Sarcoma (Soft Tissue Sarcoma)
2. Neoplasms (Cancer)
01/01/1987 - "We investigated whether ara-U or THU pretreatments can protect ara-C from excessive deamination in tumor- (L1210) bearing mice. "
09/01/2012 - "We therefore evaluated the biodistribution and effect of androgen on tumor uptake of the cellular proliferation imaging marker [(18)F]-2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil ((18)F-FMAU) in xenograft mouse models of human prostate cancer. "
02/01/2001 - "Accordingly, the presence of the Q125N mutation in HSV-1 TK gene-transfected tumor cells was found to result in a multilog decrease in the cytostatic activity of those pyrimidine nucleoside analogs that in their monophosphate form do not have marked affinity for thymidylate synthase [i.e., 1-beta-D-arabinofuranosylthymine and (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil]."
05/01/2000 - "Pharmacokinetics of the thymidine analog 2'-fluoro-5-[(14)C]-methyl-1-beta-D-arabinofuranosyluracil ([(14)C]FMAU) in rat prostate tumor cells."
11/01/2000 - "To investigate the factors influencing the bystander effect--a key element in the efficacy of suicide gene therapy against cancer--we compared the effect triggered by four extremely efficient gene/prodrug combinations, i.e., VZVtk/BVDU, the thymidine kinase of Varicella zoster virus associated with (E)-5-(2-bromovinyl)-2'-deoxyuridine; VZVtk/BVaraU, the same enzyme associated with (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil; HSVtk/BVDU, the association of the Herpes simplex virus thymidine kinase with BVDU; and the classical HSVtk/GCV (ganciclovir) paradigm. "
3. Renal Insufficiency (Renal Failure)
4. Lymphoma (Lymphomas)
5. Chronic Kidney Failure (Chronic Renal Failure)

Related Drugs and Biologics

1. Cytarabine (Cytosar-U)
2. 2'-fluoro-5-methylarabinosyluracil (Clevudine)
3. vinorelbine (Navelbine)
4. Thymidine Kinase
5. Deoxyuridine
6. Ganciclovir (Cytovene)
7. Thymidine
8. 2'-fluoro-5-ethylarabinosyluracil (FEAU)
9. ara-UTP
10. triphosphoric acid (triphosphate)

Related Therapies and Procedures

1. Renal Dialysis (Hemodialysis)
2. Heterologous Transplantation (Xenotransplantation)
3. Intravenous Infusions
4. Combination Drug Therapy (Combination Chemotherapy)
5. Aftercare (After-Treatment)