|5.||Abdominal Pain (Pain, Abdominal)
|1.||St Peter, Shawn D: 34 articles (08/2015 - 05/2006)|
|2.||Ostlie, Daniel J: 21 articles (06/2013 - 05/2006)|
|3.||Holcomb, George W: 19 articles (08/2015 - 05/2006)|
|4.||Sharp, Susan W: 16 articles (08/2015 - 06/2008)|
|5.||Lee, Steven L: 13 articles (01/2013 - 04/2003)|
|6.||Andersson, Roland E: 12 articles (01/2016 - 10/2002)|
|7.||Snyder, Charles L: 11 articles (10/2012 - 05/2006)|
|8.||Chen, Ray-Jade: 9 articles (07/2015 - 02/2003)|
|9.||Nguyen, Ninh T: 9 articles (10/2014 - 12/2004)|
|10.||Mason, Rodney J: 9 articles (04/2013 - 09/2005)|
|1.||Anti-Bacterial Agents (Antibiotics)IBA
10/01/2010 - "Acute appendicitis can be treated successfully with conservative (antibiotics) treatment with a short hospital stay. "
06/01/2006 - "Acute non-perforated appendicitis can be treated successfully with antibiotics. "
05/01/2011 - "For patients surgically treated for acute appendicitis, a change of perioperative antibiotics to those effective for ESBL+organisms is not needed at present only on the basis of ESBL prevalence rates. "
01/01/2011 - "Although surgical intervention is the mainstay of treatment, conservative management with antibiotics is an option if the diagnosis of appendicitis is equivocal. "
02/01/2010 - "With the emergence of antibiotic resistant-bacteria, the traditional choice of broad spectrum antibiotics may not be effective in complicated appendicitis. "
|2.||Metronidazole (Metric)FDA LinkGeneric
08/01/1980 - "It is suggested that an antibiotic which is effective against both aerobic and anaerobic organisms might have an advantage over metronidazole in appendicitis."
01/01/2011 - "Single dose of oral metronidazole prior to operation can provide a sufficient prophylaxis for nonperforated appendicitis; so, it can be substitute the parental route of antibiotic administration."
10/01/1995 - "It is concluded that a single preoperative dose of metronidazole significantly decreases the rate of postoperative infectious complications in children with appendicitis. "
11/06/1993 - "They had been operated elsewhere on suspicion of appendicitis and had been treated with metronidazole, which had failed to eliminate the amoebae. "
01/01/1991 - "The authors observations with prophylactic administration of metronidazole manufactured by the Gedeon Richter Company, Hungary (trade mark Klion) in children with phlegmonous appendicitis are reported. "
01/01/2006 - "Laboratory tests of the white cell count, neutrophil count and C-reactive protein are more effective in supporting a clinical diagnosis of acute appendicitis in patients with typical clinical features than in excluding the diagnosis."
07/01/2011 - "Is C-reactive protein helpful for early diagnosis of acute appendicitis?"
07/01/2011 - "Simple investigations like white cell count (WCC) and C-reactive protein (CRP) may help to improve the accuracy of diagnosis in paediatric appendicitis. "
02/01/2015 - "The aims of this study were to present the effect of in-hospital delay on the risk of perforation in appendicitis and to assess the utility of C-reactive protein (CRP) measurement in detecting the patients with complicated appendicitis. "
05/01/2014 - "The aim of the study was to evaluate whether C-reactive protein (CRP) level on admission could aid the diagnostic accuracy of Alvarado score in acute appendicitis. "
|4.||Gentamicins (Gentamicin)FDA LinkGeneric
07/01/2005 - "The purpose of this study was to determine the influence of weight with gentamicin assay error on the Bayesian and nonlinear least squares regression analysis in 12 Korean appendicitis patients. "
05/01/2005 - "The purpose of this study was to determine the influence of weight with gentamicin assay error on the Bayesian and nonlinear least squares regression analysis in 12 Korean appendicitis patients. "
07/01/2005 - "The influence of weight with assay error on gentamicin pharmacokinetics using the Bayesian and nonlinear least square regression analysis in appendicitis patients."
05/01/2005 - "The influence of assay error weight on gentamicin pharmacokinetics using the Bayesian and nonlinear least square regression analysis in appendicitis patients."
03/01/1987 - "Comparison of four methods for predicting serum gentamicin concentrations in surgical patients with perforated or gangrenous appendicitis."
|5.||Cefoxitin (Cefoxitin Sodium)FDA LinkGeneric
01/01/1994 - "The purpose of this investigation was to examine the safety and efficacy of cefoxitin in preoperative prophylaxis of acute nonperforated, appendicitis. "
10/01/1990 - "The data from this study indicate that cefoxitin was effective and generally well tolerated in the management of gangrenous and/or perforated appendicitis. "
01/01/1986 - "This study was undertaken to assess the efficacy and safety of a 3-day course of treatment with Mefoxitin (cefoxitin sodium, MSD) in patients with perforated or ruptured appendicitis. "
01/01/1994 - "During twelve consecutive months, a single i.v. dose of cefoxitin was administered to 151 patients suffering from nonperforated appendicitis. "
01/01/1987 - "To assess the value of the third day temperature in predicting intraperitoneal infectious complications we studied 235 consecutive patients treated with a 3-day course of cefoxitin after surgery for perforated appendicitis. "
|6.||Morphine (MS Contin)FDA LinkGeneric
09/01/2008 - "A study was undertaken to assess the analgesic effect of morphine in patients with acute appendicitis. "
01/01/2015 - "The primary objective was to compare the influence of IV morphine on the ability of surgical residents to diagnose appendicitis. "
03/01/2012 - "Common conditions such as appendicitis and fracture were leading diagnoses associated with morphine use."
03/01/2012 - "On logistic mixed-effects modeling for patients with appendicitis and for patients with fractures, there was hospital variation in morphine use after controlling for variables in the model. "
03/01/2012 - "The 2 diagnoses most frequently associated with morphine use were appendicitis (14.4%) and fracture (11.1%). "
|7.||Clindamycin (Cleocin)FDA LinkGeneric
04/01/1993 - "Prospective randomized study of two different doses of clindamycin admixed with gentamicin in the management of perforated appendicitis."
05/01/1996 - "We compared patients with advanced appendicitis (gangrenous or perforated) treated with 1,000 mg MP every eight hours with those given the combination of tobramycin 5 mg/kg/day at eight hour intervals and clindamycin 900 mg every eight hours. "
04/01/1994 - "102 (20 drop-outs) patients with appendicitis were given Ornidazole (40 patients) or Clindamycin (42 patients). "
04/01/1993 - "One hundred twenty-six patients with gangrenous (n = 34) or perforated appendicitis (n = 91) were randomized (2:1) to receive gentamicin admixed with clindamycin 900 mg IVPB every 8 hours (Group I n = 80) or gentamicin IVPB q8h plus clindamycin 600 mg IVPB every 6 hours (Group II n = 46). "
01/01/1991 - "This combination was compared with gentamicin and clindamycin in 99 consecutive patients with complicated appendicitis. "
08/01/2010 - "However, CRP is superior to bilirubin for anticipation of perforation in acute appendicitis."
01/01/2011 - "It is concluded that assessment of preoperative total bilirubin is useful for the differential diagnosis of perforated versus acute suppurative appendicitis, whereas WBC assessment is effective for diagnosing the presence versus absence of appendicitis. "
11/01/2013 - "Recent studies show that a high level of serum bilirubin could emerge as a prognostic marker for gangrenous or perforated stages of acute appendicitis. "
08/01/2013 - " aim of this study was to determine and compare pre-operative total and direct bilirubin levels incases of simple and perforated acute appendicitis in order to improve the clinical decision making. "
01/01/2013 - "Medline, Embase, and Cochrane databases were searched for studies evaluating elevated bilirubin in the diagnosis of perforated appendicitis. "
12/20/1986 - "The effectiveness of piperacillin was investigated in 30 children operated upon for peritonitis: 13 had acute appendicitis with puriform peritoneal reaction, or a recently perforated appendix; 5 had generalized peritonitis of appendicular origin, and 13 had intraperitoneal abscess. "
11/01/2013 - "Our clinical pathway now recommends piperacillin-tazobactam as the most effective empiric therapy for advanced appendicitis in children. "
02/01/1994 - "Prophylactic cefoxitin or piperacillin were each therefore similarly effective in minimizing the rate of wound infections in patients with non-perforated appendicitis."
08/01/2015 - "Piperacillin-tazobactam is used frequently in pediatric patients with complicated appendicitis and other intra-abdominal infections. "
06/01/2006 - "The incidence of intraperitoneal abscess in the group of patients who underwent surgery for severe acute appendicitis was lower when they were treated with piperacillin-tazobactam. "
03/01/2008 - "Moreover, the use of MPR in addition to conventional CT may provide improved visualization of the normal appendix and thereby enhance confidence in excluding appendicitis and diagnosing diseases that mimic appendicitis. "
01/01/2003 - "We conclude that in equivocal cases of acute appendicitis, imaging studies performed by skilled operators can improve the accuracy of diagnosis, saving patients unnecessary surgery, and identifying other conditions that mimic appendicitis."
01/01/2015 - "Ileal perforation due to fish bone is a rare condition that can mimic common conditions like appendicitis. "
01/01/2014 - "This infestation is usually harmless, but can mimic appendicitis. "
05/01/2013 - "To date, there is no literature evidence that herniation pit (HP) may mimic acute appendicitis. "
07/01/2008 - "Despite its increasing popularity, laparoscopic appendectomy does not put an unanimous end to the answer to the best treatment for appendicitis. "
01/01/1996 - "In a clear situs the laparoscopic appendectomy with the RODER-loop with manual stump-sinking is recommended; in cases with a difficult preparation or advanced appendicitis the application of the Endo-GIA is a safe technique with the best results."
05/01/1995 - "Laparoscopic appendectomy is presently at the efficacy stage of development, because most of the data on feasibility and safety originate from centers with special interest in endoscopic surgery: it is not yet the gold standard for acute appendicitis. "
12/01/2002 - "The implementation of an imaging protocol using US and CT resulted in a marked decrease in the perforation and negative appendectomy rates in children with suspected appendicitis."
04/01/2013 - "Because of lack of good evidence supporting laparoscopic approach for complicated appendicitis, we carried out this study to evaluate efficacy of laparoscopic appendectomy (LA) in management of patients with complicated appendicitis. "
10/01/1991 - "The combined approach of clinical evaluation and routine ultrasonography markedly improved the diagnostic accuracy (sensitivity 85.9%, specificity 96.4%, accuracy 94%) and substantially reduced the negative laparotomy rate (7.9%) in patients with suspected acute appendicitis. "
07/06/2000 - "In experienced hands, US has significantly improved the diagnostic accuracy in suspected appendicitis, while halving the negative laparotomy rate to 8-15%. "
09/01/1989 - "Routine use of ultrasonography has significantly improved the diagnostic accuracy in patients with suspected appendicitis and has reduced the negative laparotomy rate from 22.9% to 13.2%."
06/01/2004 - "The principal advantages of CT are its operator independency with resultant higher diagnostic accuracy, enhanced delineation of disease extent in perforated appendicitis, and improved patient outcomes including decreased negative laparotomy and perforation rates."
04/01/2004 - "The principal advantages of CT include its operator independency, with resultant higher diagnostic accuracy, enhanced delineation of disease extent in perforated appendicitis, and improved patient outcomes including decreased negative laparotomy and perforation rates."
|3.||Length of Stay
12/01/2012 - "This study suggests that in young men with suspected appendicitis, the use of an abdominal CT scan is associated with improved immediate postoperative complications, lower readmission rates with observed higher length of stay, and increased cost of care."
01/01/2012 - "The secondary outcome measures were efficacy of treatment, length of stay, and incidence of complicated appendicitis and readmissions. "
12/01/2013 - "The objective of our study was to examine whether the rate of complicated appendicitis and the hospital length of stay (LOS) increased during the transition to an ultrasound-first paradigm for the imaging evaluation of acute appendicitis. "
10/01/2013 - "This study aimed to determine the test characteristics of a pathway for pediatric appendicitis and its effects on emergency department (ED) length of stay, imaging, and admissions. "
04/01/2011 - "The study populations were no different in terms of age, weight, operative time, blood loss, length of stay, or proportion of acute versus perforated appendicitis. "
|4.||Drug Therapy (Chemotherapy)
08/01/1997 - "There is no gold standard for antimicrobial chemotherapy in perforated appendicitis. "
06/01/2013 - "Due to its non-specific clinical presentation, NEC is often misdiagnosed as appendicitis; however, it can advance rapidly and carries a very poor prognosis, despite chemotherapy. "
01/01/2013 - "In the setting of AML, prior cases described the development of appendicitis with active chemotherapy. "
08/01/2012 - "Univariate analysis revealed that presence of symptoms of acute appendicitis, curative resection, histological grade, histological subtype, preoperative CEA level, systematic chemotherapy, and stage were all significant factors affecting the survival. "
06/01/2008 - "The management of acute appendicitis in the febrile neutropenic patient after intensive chemotherapy is controversial. "
01/01/2014 - "Although mesh repairs in the presence of appendicitis have been reported, the safest approach remains a primary suture repair."
08/01/2007 - "The diaphragmatic defect was repaired using non-absorbable sutures and an appendicectomy was then performed for purulent appendicitis. "
01/01/2004 - "The proposed complex of surgical measures in patients with destructive forms of acute appendicitis complicated by the inflammatory-necrotic phenomena in the blind gut wall was shown to prevent the development of dangerous postoperative complications, incompetence of the sutures included."
04/17/1982 - "Removable subcuticular skin suture in acute appendicitis: a prospective comparable clinical trial."
03/20/1982 - "Removable subcuticular skin suture in acute appendicitis: a prospective comparative clinical trial."