|1.||Havekes, Louis M: 45 articles (11/2015 - 09/2002)|
|2.||Alzheimer's Disease Neuroimaging Initiative: 40 articles (04/2015 - 01/2009)|
|3.||Holtzman, David M: 35 articles (11/2015 - 04/2002)|
|4.||Blennow, Kaj: 34 articles (11/2015 - 04/2003)|
|5.||Scheltens, Philip: 32 articles (09/2015 - 03/2002)|
|6.||Petersen, Ronald C: 29 articles (12/2015 - 07/2003)|
|7.||Weber, Christian: 29 articles (10/2015 - 11/2003)|
|8.||Reiman, Eric M: 29 articles (04/2015 - 06/2002)|
|9.||Caselli, Richard J: 28 articles (10/2014 - 06/2002)|
|10.||Vitek, Michael P: 27 articles (07/2014 - 06/2002)|
01/01/2006 - "There was an important strain-dependence of the effect, with no protection against atherosclerosis in apoE(-/-) mice."
01/01/2012 - "Uncoupling of eNOS occurs in apoE(-/-) atherosclerosis but does not negate the enzyme's strong protective effects."
08/01/2008 - "TxA(2) receptor antagonism alone also afforded a significant reduction in atherosclerosis in apoE-deficient mice. "
05/01/2000 - "This notion has been further supported by a recent finding that administration of ET receptor antagonists resulted in a significant reduction of atherosclerosis in apoE-KO mice."
05/01/2000 - "We anticipate that pharmacological approaches to increase apoE synthesis and/or secretion by macrophages might be beneficial for the treatment of atherosclerosis."
|2.||Alzheimer Disease (Alzheimer's Disease)
07/01/2004 - "Thus, Apoe seems to be important in the degradation and clearance of deposited Abeta species by astrocytes, a process that may be impaired in Alzheimer disease."
06/01/2004 - "Risk and protective effects of the APOE gene towards Alzheimer's disease in the Kungsholmen project: variation by age and sex."
01/01/2005 - "[ApoE genotype and efficacy of neurotrophic and cholinergic therapy in Alzheimer's disease]."
06/01/2015 - "Functional magnetic resonance imaging (MRI) studies have shown that APOE ε2- and ε4-carriers have similar patterns of blood-oxygenation-level-dependent (BOLD) activation suggesting that we need to look beyond the BOLD signal to link APOE's effect on the brain to Alzheimer's disease (AD)-risk. "
01/01/2015 - "The genome-wide association study was performed via a meta-analysis of two non-overlapping discovery sample sets to identify genetic variants other than APOE ε4 predictive of the CSF biomarker level (Aβ1-42, t-Tau, p-Tau181P, t-Tau:Aβ1-42 ratio, and p-Tau181P:Aβ1-42 ratio) in patients enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI) study. "
|3.||Atherosclerotic Plaque (Atheroma)
01/01/2015 - "We found that TXL treatment significantly reduced serum lipid levels and atherosclerotic plaque formation of apoE-deficient mice, and improved endothelial cell function as evidenced by increased expression of CD31 and eNOS. "
12/01/2012 - "Mice transplanted with miR-33(-/-)Apoe(-/-) bone marrow showed a significant reduction in lipid content in atherosclerotic plaque compared with mice transplanted with miR-33(+/+)Apoe(-/-) bone marrow, without an elevation of HDL-C. "
06/15/2012 - "A significant reduction in T-lymphocytes and macrophages was noted in the atheromas of the ApoE(-/-)/Kit(W-sh/W-sh) mice. "
05/01/2006 - "A significant reduction of the atherosclerotic plaque in the aortic sinus and arch with the decrease in smooth muscle cell-positive area was observed in MMP-2(-/-):apoE(-/-) mice compared with that of MMP-2(+/+):apoE(-/-) mice. "
08/01/2015 - "The aim of this study was to characterize effects of low carbohydrate, high protein diet (LCHP) on atherosclerotic plaque development in brachiocephalic artery (BCA) in apoE/LDLR-/- mice and to elucidate mechanisms of proatherogenic effects of LCHP diet. "
07/01/2006 - "In this study, we improved the nonisotopic PCR-SSCP method for determining APOE genotypes in 42 cases of AD patients, 40 cases of non-AD dementia patients, and 49 cases of age-matched controls. "
08/01/2012 - "The APOE genotyping may be helpful in diagnosing AD especially in patients presenting with atypical features or early age of onset of dementia."
03/30/2011 - "Addition of APO-E genotype and a number of baseline clinical covariates improved the dementia prediction utility of the latent classes; application of class-specific penalization improved precision while retaining that prediction utility. "
11/15/2015 - "The presence of the APOE*E4 allele predicted future depression in this Swedish population study, even after excluding depressed individuals who later developed dementia, suggesting that the APOE*E4 allele could potentially identify people at high risk for clinically significant depression."
11/15/2015 - "Among subjects without depression at study entry and without dementia or significant cognitive decline during the subsequent 9 years, APOE*E4 was prospectively associated with more severe depressive symptoms (b = 1.56, p = .007), incident minor depression (odds ratio = 1.99 [confidence interval = 1.11-3.55], p = .020), and any depression (odds ratio = 1.75 [confidence interval = 1.01-3.03], p = .048). "
08/01/2013 - "But the ratio of CD206+ M2 macrophages was significantly improved, when compared with the ApoE(-/-) hyperlipidemia group (P < 0.05). "
02/19/2002 - "These results indicate that the apoE peptidomimetic encapsulated in DepoFoam has potential as an alternative therapeutic treatment of hyperlipidemia."
05/01/1995 - "In these studies, we demonstrated the usefulness of STZ-induced diabetes in mice as an animal model for diabetic hyperlipidemia and demonstrated that endogenous induction of apoE in transgenic mice improved diabetic hyperlipidemia."
01/01/2006 - "To study the relationship between the polymorphism of ApoE gene and TCM syndrome type of primary hyperlipemia. "
01/01/2006 - "[Study on the relationship between polymorphism of ApoE gene and TCM syndrome type of primary hyperlipemia]."
|5.||Amyloid (Amyloid Fibrils)
|6.||Apolipoproteins E (ApoE)
|9.||LDL Receptors (LDL Receptor)
|10.||Apolipoprotein A-I (Apolipoprotein A1)
|2.||Transplantation (Transplant Recipients)
|4.||Bone Marrow Transplantation (Transplantation, Bone Marrow)