Aortic Valve Stenosis (Aortic Stenosis)

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1619 relevant articles (60 outcomes, 179 trials/studies) found for this Disease

Description: A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.

Also Known As:

Aortic Stenosis; Aortic Valve Stenoses; Stenoses, Aortic; Stenoses, Aortic Valve; Stenosis, Aortic; Stenosis, Aortic Valve; Valve Stenoses, Aortic; Valve Stenosis, Aortic

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 18443

Heart Diseases: 12330

Heart Valve Diseases: 640

Aortic Valve Stenosis: 1619

Supravalvular Aortic Stenosis: 101

Subvalvular Aortic Stenosis: 19

Ventricular Outflow Obstruction: 74

Aortic Valve Stenosis: 1619

Supravalvular Aortic Stenosis: 101

Subvalvular Aortic Stenosis: 19

Related Diseases

1.	Aortic Valve Insufficiency (Aortic Regurgitation)
2.	Hypertrophy
3.	Heart Failure
4.	Mitral Valve Insufficiency (Mitral Regurgitation)
5.	Left Ventricular Dysfunction
201 Diseases and 641 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	Stewart, Ralph A H: 5 articles (08/2008 - 11/2003)
2.	Matter, Gregory John: 5 articles (12/2007 - 08/2007)
3.	Ko, Jong Mi: 5 articles (12/2007 - 08/2007)
4.	Henry, Albert Carl: 5 articles (12/2007 - 08/2007)
5.	Hamman, Baron Lloyd: 5 articles (12/2007 - 08/2007)
6.	Hebeler, Robert Frederick: 5 articles (12/2007 - 08/2007)
7.	Filardo, Giovanni: 5 articles (12/2007 - 08/2007)
8.	Roberts, William Clifford: 5 articles (12/2007 - 08/2007)
9.	Satta, Jari: 5 articles (09/2007 - 01/2002)
10.	Soini, Ylermi: 5 articles (09/2007 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Aortic Valve Stenosis:

1.	Dobutamine FDA LinkGeneric 04/01/2008 - "We conclude that patients with severe aortic stenosis and a contractile reserve of <20% improvement in stroke volume on dobutamine stress testing have a very poor prognosis of only 10-20% at two years" 11/01/2001 - "More precise recommendations can be made according to an improved characterization of the patients from fast to slow evolution, according to age, type of aortic stenosis, degree of calcification, changes in transaortic gradients over time, tolerance to exercise test and response of aortic valve area to dobutamine" 07/22/2003 - "BACKGROUND: The prognostic value of dobutamine stress hemodynamic data in the setting of low-gradient aortic stenosis has been addressed in small, single-center studies" 01/01/2003 - "OBJECTIVES: This study was designed to assess which hemodynamic index best accounts for clinical severity of aortic stenosis (AS) and to analyze the value of low-dose dobutamine testing" 01/01/2002 - "THE AIMS: The aim of the study was to assess the safety of dobutamine echocardiography (DE) in patients with aortic stenosis and left ventricular ejection fraction < or = 45%" Get all the results and reference details, order at left...
2.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 10/01/2005 - "Are angiotensin converting enzyme inhibitors beneficial in patients with aortic stenosis?" 10/01/2005 - "Effects of angiotensin converting enzyme inhibitors in hypertensive patients with aortic valve stenosis: a drug withdrawal study." 10/01/2001 - "Further studies are merited to assess the possible role of ACE inhibitors in aortic stenosis both before and after valve replacement" 06/01/2006 - "Emerging medical treatments for aortic stenosis: statins, angiotensin converting enzyme inhibitors, or both?" 03/01/2006 - "The left ventricle in aortic stenosis: evidence for the use of ACE inhibitors." Get all the results and reference details, order at left...
3.	Nitroprusside (Sodium Nitroprusside)FDA LinkGeneric 02/01/1986 - "Increasing LV pressure by aortic stenosis now resulted in a stimulus-dependent decrease in heart rate that was significantly greater than that in the nitroprusside group" 09/01/1988 - "To study this relation, the vasodilator nitroprusside was administered to eight patients with aortic stenosis and normal systolic function" 05/01/2003 - "METHODS: We determined the response to intravenous nitroprusside in 25 patients with severe aortic stenosis and left ventricular systolic dysfunction" 12/15/1992 - "Hemodynamic effects of nitroprusside on valvular aortic stenosis." 02/01/1992 - "Hemodynamic effects of nitroprusside on valvular aortic stenosis." Get all the results and reference details, order at left...
4.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 11/01/2004 - "BACKGROUND AND AIM OF THE STUDY: There are many possible determinants of left ventricular (LV) mass, including the angiotensin-converting enzyme (ACE) genotype, which have rarely been compared in aortic stenosis (AS)" 04/01/2005 - "OBJECTIVE: To assess the role of the AT1 receptor blocker and the angiotensin-converting enzyme inhibitor in cardiac remodeling induced by aortic stenosis in rats" 04/01/2004 - "BACKGROUND: Angiotensin-converting enzyme (ACE) inhibitor use is presumed to be contraindicated in patients with aortic stenosis (AS)" 04/01/2003 - "Does angiotensin-converting enzyme inhibition improve the energetic status of cardiac and skeletal muscles in heart failure induced by aortic stenosis in rats?" 09/01/2002 - "Influence of insertion-deletion polymorphism of the angiotensin converting enzyme gene on left ventricular hypertrophy in patients with aortic stenosis--differences in men and women]" Get all the results and reference details, order at left...
5.	OxygenIBA 09/01/1988 - "We speculate that the clinical improvement, which often occurs in these patients after valvuloplasty despite persistence of hemodynamically "critical" aortic stenosis, is in part attributable to immediate improvement in the myocardial oxygen supply:demand ratio." 10/01/2003 - "The infarct was caused solely by the severe aortic stenosis and resulted from the extreme disparity between myocardial oxygen supply and demand." 05/01/1994 - "Oxygen delivery and uptake relationships in patients with aortic stenosis." 09/01/1988 - "Second, aortic stenosis itself may cause an imbalance between oxygen supply and demand during hemodynamic stress by decreasing aortic pressure (decreasing coronary perfusion or oxygen supply) and increasing left ventricular pressure (increasing oxygen demand)" 03/01/1987 - "Aortic stenosis itself did not alter oxygen extraction, although partial occlusion similarly increased extraction for all groups in the ischemic zone" Get all the results and reference details, order at left...
6.	von Willebrand FactorIBA 02/01/2006 - "The goal of the present study was to determine the effect of aortic valve replacement on von Willebrand factor levels in patients with aortic stenosis" 02/01/2006 - "CONCLUSIONS: In conclusion, valve replacement can result in increases in von Willebrand factor in patients with aortic valve stenosis." 02/01/2006 - "METHODS: von Willebrand factor levels were assessed by using immunoblotting electrophoresis techniques before and 1 month after surgery in 29 consecutive patients with severe aortic valve stenosis" 08/01/2005 - "Functional von Willebrand Factor assays are not predictive for the absence of highest-molecular weight von Willebrand Factor multimers in patients with aortic-valve stenosis." 09/12/2000 - "Proteolysis of von Willebrand factor and shear stress-induced platelet aggregation in patients with aortic valve stenosis." Get all the results and reference details, order at left...
7.	Lipoproteins (Lipoprotein)IBA 06/01/2008 - "These positive results justify the further testing of high-density lipoprotein (HDL)-based therapies in patients with valvular aortic stenosis" 09/01/2008 - "Low-density lipoprotein and aortic stenosis." 09/01/2008 - "Association between circulating oxidised low-density lipoprotein and fibrocalcific remodelling of the aortic valve in aortic stenosis." 04/01/1996 - "These results are consistent with the hypothesis that lipoprotein accumulation in the aortic valve contributes to pathogenesis of aortic stenosis." 09/01/2007 - "Aortic valve stenosis is a complex inflammatory process, akin to arterial atherosclerosis, involving lymphocytic infiltrates, macrophages, foam cells, endothelial activation and dysfunction, increased cellularity and extracellular matrix deposition, and lipoprotein accumulation" Get all the results and reference details, order at left...
8.	Nitroglycerin (Dynamite)FDA LinkGeneric 06/15/1995 - "In study A, a curvilinear dose-response relation with maximal vasodilation after 90 micrograms intracoronary nitroglycerin was found in both control subjects and patients with aortic stenosis" 06/15/1995 - "The dose-response relation of intracoronary nitroglycerin was assessed in 14 patients (7 control subjects and 7 patients with aortic stenosis [study A]) using quantitative coronary angiography" 06/15/1995 - "Vasodilator capacity was reduced in those with aortic stenosis, although sensitivity to nitroglycerin was similar in both groups" 12/01/1979 - "Mechanism of nitroglycerin effect in valvular aortic stenosis." 08/01/1965 - "THE EFFECT OF NITROGLYCERIN ON LEFT VENTRICULAR WALL TENSION IN FIXED ORIFICE AORTIC STENOSIS." Get all the results and reference details, order at left...
9.	Dihydrotachysterol (AT 10)IBA 03/01/2007 - "Her claudication then improved, although follow-up CT angiography at 10 months revealed mild recurrent aortic stenosis." 01/01/2005 - "Simple repairs (blunt valvotomy, commissurotomy, or commissurotomy with leaflet thinning) directed at congenital aortic stenosis resulted in 86% +/- 5% freedom from reintervention at 10 years" 07/01/1987 - "To determine whether a low preoperative left ventricular (LV) ejection fraction (EF) returns to normal late after aortic valve replacement for aortic stenosis, 42 patients with critical aortic stenosis (valve area 0.7 cm2 or less), LV systolic dysfunction (EF 0.45 or less), angiographically normal coronary arteries, and no other significant valvular disease were studied at 10 to 84 months (mean 41 +/- 21) postoperatively" 07/01/2007 - "CONCLUSIONS: This study showed no negative effects of prosthesis-patient mismatch on survival at 10 years after aortic valve replacement for aortic stenosis" 01/01/1986 - "The actuarial survival was 72% at 5 years and 63% at 10 years: long term survival was lower in aortic incompetence (25% at 10 years) compared with aortic stenosis (68%) and mixed aortic valve disease (78%)" Get all the results and reference details, order at left...
10.	OxidoreductasesIBA 08/01/1978 - "To study the effect of abdominal aorta clamping and revascularization and appraise the efficacy of the drug gordox during surgical intervention, the values of the kinin system, acid-base balance, acid metabolites, and the total activity of lactic dehydrogenase and its isoenzymatic spectrum were determined in 24 patients with aortic stenosis of atherosclerotic origin" 10/30/2001 - "We sought to determine whether therapy with hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) might slow the progression of aortic stenosis" 10/30/2001 - "Effect of hydroxymethylglutaryl coenzyme a reductase inhibitors on the progression of calcific aortic stenosis." 03/01/2003 - "Although hydroxymethyl glutaryl co-enzyme A reductase inhibitor (statin) treatment therapy has been shown to delay the rate of progression of valvular aortic stenosis, the salutary mechanism of the statin may be cholesterol-lowering and/or anti-inflammatory" 11/20/2002 - "Association of cholesterol levels, hydroxymethylglutaryl coenzyme-A reductase inhibitor treatment, and progression of aortic stenosis in the community." Get all the results and reference details, order at left...
424 Drugs and Important Bio-Agents and 821 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Balloon Dilatation 06/01/1998 - "Newer interventions, such as balloon valvuloplasty, should be carefully evaluated for long-term results and should be compared more appropriately to current surgical results to determine the best treatment modality for the neonate and infant with critical aortic stenosis." 08/01/1991 - "Percutaneous balloon valvuloplasty has proven to be acutely effective in the treatment of congenital valvar aortic stenosis; however, the intermediate- and long-term effectiveness of the procedure remain to be documented" 12/01/1989 - "The results indicate that balloon valvuloplasty can be offered to very elderly patients with severe aortic stenosis and can produce improvement in hemodynamic and clinical status." 07/01/1995 - "Hospital stay was significantly shorter in group 1. It is concluded that balloon dilatation for valvar aortic stenosis is effective and safe for the entire paediatric population" 04/01/1991 - "Since March 1989, when improved catheter technology became available, all five neonates presenting with critical aortic stenosis were treated successfully by balloon valvuloplasty" Get all the results and reference details, order at left...
2.	Prostheses and Implants (Prosthesis) 01/01/1986 - "Over the years the Starr Edwards prosthesis has demonstrated a high durability and improved survival in patients with severe aortic stenosis or insufficiency" 11/01/2007 - "Due to improvement in surgical techniques and better prosthesis, aortic valve surgery can now be offered at low risk to a selected group of asymptomatic patients with severe aortic stenosis" 06/01/2008 - "The aim of this study was to evaluate midterm echocardiographic results and changes in quality of life after aortic valve replacement with 17-mm St. Jude Medical Regent mechanical prostheses in patients with aortic valve stenosis" 07/01/2007 - "The aim of this study was to evaluate the effect of prosthesis-patient mismatch on survival and the extent of left ventricular mass regression after aortic valve replacement for aortic stenosis" 02/20/2007 - "OBJECTIVES: This prospective-randomized study investigated the effect of aortic valve design and patient-prosthesis mismatch (PPM) on coronary flow reserve (CFR) after mechanical or biological aortic valve replacement (AVR) in patients with aortic stenosis (AS)" Get all the results and reference details, order at left...
3.	Surgical Instruments (Clip) 04/01/2002 - "OBJECTIVE: Aortic stenosis leads to the derangement of cardiac function and contraction mode because of chronic pressure overload that is relieved after surgical valve replacement" 08/01/2001 - "Percutaneous aortic valvuloplasty produces acute hemodynamic and clinical improvement in patients with aortic stenosis who are poor candidates for surgical valve replacement" 04/01/2002 - "The purpose of this study was to determine the changes in left ventricular systolic rotation and contraction using MR tagging in patients with aortic stenosis before and after surgical valve replacement compared with age-matched healthy volunteers" 01/01/2008 - "Calcific aortic valve stenosis is the most common indication for surgical valve replacement" 05/01/2007 - "Calcific aortic stenosis in the elderly is the number one cause of surgical valve replacement in the US and Europe" Get all the results and reference details, order at left...
4.	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 03/01/2003 - "This study compared the outcomes of combined coronary artery bypass grafting (CABG)/aortic valve replacement (AVR) and CABG alone in patients with moderate aortic stenosis and determined the possible indications for AVR at the time of CABG" 03/01/2002 - "BACKGROUND AND AIMS OF THE STUDY: Manual decalcification of the aortic valve was performed systematically in a prospective series of patients with asymptomatic moderate aortic stenosis (AS) undergoing coronary artery bypass grafting (CABG)" 12/01/2008 - "BACKGROUND: The question whether the aortic valve in patients with mild aortic stenosis undergoing coronary artery bypass grafting (CABG) should be replaced or left alone is still controversial" 06/01/2007 - "METHODS: All patients undergoing aortic valve replacement (AVR) for aortic stenosis from 1995 through 2000 in the southeast region of Sweden (n = 398) were compared with a cohort, matched for age and sex, undergoing coronary artery bypass grafting (CABG [n = 398])" 07/01/2006 - "Aortic valve replacement for aortic stenosis after previous coronary artery bypass grafting: could early reoperation be prevented?" Get all the results and reference details, order at left...
5.	Transplants (Transplant) 09/01/1990 - "We describe a technique performed on a 14-year-old patient with normal aortic annulus and severe diffuse supravalvar aortic stenosis in which the replacement of ascending aorta and proximal aortic arch with a tubular prosthetic graft completely relieved the obstruction as confirmed by cardiac catheterization." 05/01/2008 - "Thoraco-abdominal bypass graft was performed in 2 patients who had abdominal aortic stenosis" 10/01/2007 - "Total arterial grafting with a left internal thoracic-radial artery T-graft can be performed in selected patients with aortic valve stenosis requiring simultaneous aortic valve replacement." 10/01/2007 - "The safety of total arterial revascularization with a left internal thoracic artery-radial artery T-graft was evaluated in patients with at least two-vessel coronary artery disease and aortic valve stenosis requiring concomitant aortic valve replacement" 03/01/2007 - "The number of stenosed vessels, the number of bypass grafts, incomplete revascularization, and the presence of aortic stenosis or aortic insufficiency did not predict mortality" Get all the results and reference details, order at left...
111 Therapies and Procedures and 874 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

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