Aortic Valve Insufficiency (Aortic Regurgitation)

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699 relevant articles (30 outcomes, 43 trials/studies) found for this Disease

Description: Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root).

Also Known As:

Aortic Regurgitation; Insufficiency, Aortic Valve; Regurgitation, Aortic Valve; Incompetence, Aortic; Incompetence, Aortic Valve; Regurgitation, Aortic; Aortic Incompetence; Aortic Valve Incompetence

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 18443

Heart Diseases: 12330

Heart Valve Diseases: 640

Aortic Valve Insufficiency: 699

Related Diseases

1.	Aortic Valve Stenosis (Aortic Stenosis)
2.	Heart Failure
3.	Mitral Valve Stenosis (Mitral Stenosis)
4.	Endocarditis
5.	Mitral Valve Insufficiency (Mitral Regurgitation)
139 Diseases and 329 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	Matter, Gregory John: 5 articles (12/2007 - 08/2007)
2.	Hebeler, Robert Frederick: 5 articles (12/2007 - 08/2007)
3.	Henry, Albert Carl: 5 articles (12/2007 - 08/2007)
4.	Ko, Jong Mi: 5 articles (12/2007 - 08/2007)
5.	Roberts, William Clifford: 5 articles (12/2007 - 08/2007)
6.	Filardo, Giovanni: 5 articles (12/2007 - 08/2007)
7.	Hamman, Baron Lloyd: 5 articles (12/2007 - 08/2007)
8.	Cheung, Edson Hoi-Kam: 4 articles (12/2007 - 10/2007)
9.	Hamm, Christian: 1 article (07/2008)
10.	Elsaesser, Albrecht: 1 article (07/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Aortic Valve Insufficiency:

1.	Nitroprusside (Sodium Nitroprusside)FDA LinkGeneric 04/01/1982 - "In patients with aortic regurgitation, vasodilator therapy was effective in increasing forward output only in 2 patients who had an initially elevated end-diastolic pressure which was reduced only to levels slightly above normal with nitroprusside" 07/01/1979 - "Although nitroprusside improved cardiac function in both groups, only the patients with aortic regurgitation achieved normal pulmonary artery pressure (17 torr) and pulmonary vascular resistance (2.1 units) as a result of unloading" 11/04/1976 - "Afterload reduction therapy with nitroprusside in severe aortic regurgitation: improved cardiac performance and reduced regurgitant volume." 11/01/1980 - "After load reduction therapy with nitroprusside in chronic severe aortic regurgitation" 05/01/1980 - "Intravenous administration of the vasodilator sodium nitroprusside has beneficial haemodynamic effects in subjects with severe aortic regurgitation while acute digitalisation can produce unwanted effects associated with an increase in systemic vascular resistance" Get all the results and reference details, order at left...
2.	Nifedipine (Adalat)FDA LinkGeneric 09/01/2001 - "Left ventricular outflow tract obstruction unmasked by nifedipine: a therapeutic pitfall in the management of chronic aortic regurgitation." 11/01/1984 - "In aortic regurgitation, the acute administration of nifedipine improved cardiac performance and reduced regurgitation at rest and during exercise as a result of afterload reduction and increased heart rate" 01/01/1993 - "This study, therefore, shows the beneficial acute hemodynamic effect induced by nifedipine in asymptomatic patients affected by chronic aortic regurgitation and shows that Doppler-echocardiography is a useful instrument for the evaluation of hemodynamic changes immediately after the administration of drugs." 08/01/1990 - "To evaluate the effects of 12 months of therapy with nifedipine, a randomized, double-blind, placebo-controlled trial was performed in 72 asymptomatic patients with severe aortic regurgitation" 09/01/2001 - "This case report illustrates the aggravation of a clinically silent left ventricular outflow tract obstruction by maintenance use of nifedipine in a patient with chronic severe aortic regurgitation, and demonstrates a potential limitation of vasodilator therapy in the management of this patient population" Get all the results and reference details, order at left...
3.	Nitroglycerin (Dynamite)FDA LinkGeneric 02/01/1984 - "Resting end-systolic meridional and circumferential stress were increased in patients with aortic regurgitation (113.9 +/- 29 and 260 +/- 50.7 X 10(3) dynes/cm2) compared with those in normal subjects (85.6 +/- 15.4 and 214.1 +/- 28.4 X 10(3) dynes/cm2) (both p less than .01) and remained significantly greater after nitroglycerin" 10/01/1991 - "DESIGN--The values of arterial compliance and total peripheral resistance were assessed during aortic regurgitation at different regurgitant orifice areas in eight pigs before and after a bolus of glyceryl trinitrate" 10/01/1991 - "Haemodynamic effects of arterial compliance, total peripheral resistance, and glyceryl trinitrate on regurgitant volume in aortic regurgitation." 03/15/1989 - "Hemodynamic effects of nitroglycerin in an experimental model of acute aortic regurgitation." 02/01/1984 - "Ejection fraction in patients with aortic regurgitation and normal subjects were similar at rest (55 +/- 10% vs 59 +/- 6%) and were unchanged by nitroglycerin" Get all the results and reference details, order at left...
4.	Hydralazine (Apresoline)FDA LinkGeneric 04/01/1990 - "Beneficial long-term effects of hydralazine in aortic regurgitation." 05/01/1986 - "Effects of six-month afterload reduction therapy with hydralazine in chronic aortic regurgitation." 08/01/1983 - "Hydralazine also produces beneficial hemodynamic effects in patients with mitral and aortic regurgitation and in some patients with large ventricular septal effect with reduced systemic output" 05/01/1983 - "Oral hydralazine reduces left ventricular internal diameters, improves left ventricular performance, presumably at a lower level of oxygen consumption, and improves exercise capacity in patients with modest mitral or aortic incompetence." 05/01/1983 - "Twenty-two patients with mild or moderate mitral or aortic incompetence were randomly assigned to treatment with either hydralazine (mean 127 mg/day, range 37-225) or placebo" Get all the results and reference details, order at left...
5.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 03/01/2004 - "The efficacy of angiotensin-converting enzyme inhibitors (ACEIs) in the treatment of chronic aortic regurgitation (AR) is not well established and remains controversial" 12/01/1997 - "Long-term treatment with ACE-inhibitors improves left ventricular function in patients with aortic regurgitation" 01/01/2006 - "ACE inhibitors induce a small increase in left ventricular ejection fraction, left ventricular fractional shortening, and systemic blood flow in children with left ventricular dysfunction, mitral regurgitation, and aortic regurgitation" 02/01/1996 - "Long-term treatment with angiotensin-converting enzyme (ACE) inhibitors has beneficial effects in patients with chronic aortic regurgitation by reducing left ventricular volumes and regurgitant fraction" 11/01/1996 - "In studies of long-term vasodilator therapy in patients with chronic aortic regurgitation, a reduction in left ventricular volumes and regurgitant fraction, with or without an increase in ejection fraction, has been observed during treatment with hydralazine, nifedipine and ACE inhibitors" Get all the results and reference details, order at left...
6.	Digoxin (Digitek)FDA LinkGeneric 06/01/1989 - "These data suggest that digoxin improved left ventricular performance and may be of benefit in the treatment of patients with chronic aortic regurgitation." 05/01/1980 - "This study compares the haemodynamic effects of the vasodilator prazosin and digoxin in eight patients with isolated severe aortic regurgitation" 09/15/1994 - "To assess whether vasodilator therapy reduces or delays the need for valve replacement, we randomly assigned 143 asymptomatic patients with isolated, severe aortic regurgitation and normal left ventricular systolic function to receive either nifedipine (20 mg twice daily, 69 patients) or digoxin (0.25 mg daily, 74 patients)" 06/01/1989 - "Effect of digoxin and vasodilators on left ventricular function in aortic regurgitation." 05/01/1980 - "Comparison of vasodilator drug prazosin with digoxin in aortic regurgitation." Get all the results and reference details, order at left...
7.	Taurine FDA Link 04/01/1987 - "In rabbits with aortic regurgitation a bolus injection of taurine improved cardiac performance" 08/01/1984 - "Cardiac function (max dP/dt) was significantly decreased in rabbits with aortic regurgitation, whereas in taurine-treated rabbits, cardiac function was maintained the same as control" 08/01/1984 - "Nine rabbits were treated daily with taurine (100 mg/kg) after producing aortic regurgitation" 08/01/1984 - "The present study was designed to see whether oral treatment with taurine could improve the status of congestive heart failure induced by aortic regurgitation" 12/01/1986 - "To examine the effect of daily treatment with taurine on improving the status of congestive heart failure (CHF), we used rabbits with artificially induced aortic regurgitation" Get all the results and reference details, order at left...
8.	Enalapril FDA LinkGeneric 02/01/1996 - "Velocity-encoded cine magnetic resonance imaging was used in 9 patients with moderate to severe aortic regurgitation (regurgitant fraction 49% +/- 17%) to measure regurgitant fraction, regurgitant volume, and forward stroke volume at baseline and 3 months after therapy with enalapril (mean dose 29 +/- 13 mg)" 10/01/1994 - "These findings suggest that early unloading enalapril therapy has the potential to favorably influence the natural history of chronic aortic regurgitation." 10/01/1994 - "Because the renin-angiotensin system may be activated in chronic aortic regurgitation, early enalapril therapy might be beneficial" 10/01/1994 - "This study attempted to evaluate the long-term efficacy of enalapril versus hydralazine therapy on left ventricular volume, mass and function as well as on the renin-angiotensin system in chronic asymptomatic aortic regurgitation" 10/01/1994 - "Between 1990 and 1993, 76 asymptomatic nonrheumatic patients with mild to severe chronic aortic regurgitation were enrolled in a randomized, double-blind trial comparing enalapril with hydralazine" Get all the results and reference details, order at left...
9.	Perindopril FDA Link 09/01/2002 - "Twenty male Sprague-Dawley rats, in which aortic regurgitation was produced, were divided into untreated and perindopril-treated (5 mg x kg(-1) x d(-1)) rats" 09/01/2002 - "We investigated the effects of the ACE inhibitor perindopril on cardiac performance, myocardial energy efficiency, and uncoupling protein expression in an aortic regurgitation rat model" 11/01/2000 - "Effects of perindopril on left ventricular remodeling and aortic regurgitation in rats assessed by echocardiography." 09/01/2002 - "In the chronic stage of aortic regurgitation, perindopril improved cardiac performance and myocardial energy efficiency, in which the suppression of uncoupling protein-2 may play an important role." 11/01/2000 - "This study investigated the effect of the angiotensin-converting enzyme (ACE) inhibitor perindopril on left ventricular (LV) remodeling and cardiac function in rats with aortic regurgitation (AR)" Get all the results and reference details, order at left...
10.	Captopril (Capoten)FDA LinkGeneric 09/01/1997 - "OBJECTIVES: To verify the efficacy of long-term captopril therapy to reduce left ventricular mass and dimensions in patients with severe chronic aortic regurgitation" 04/01/1998 - "Beneficial effects of 1-year captopril therapy in children with chronic aortic regurgitation who have no symptoms." 09/01/1997 - "CONCLUSIONS: These results suggest that captopril has a favourable effect on left ventricular mass, dimensions and load conditions, and could favourably influence the natural history of chronic aortic regurgitation" 03/01/1994 - "Six month pilot study of captopril for mildly symptomatic, severe isolated mitral and isolated aortic regurgitation." 05/01/1986 - "In 16 patients with chronic aortic regurgitation, we studied the acute hormonal and hemodynamic effects of 12.5 to 25 mg captopril; in 12 patients the changes after a 4 to 8 week treatment period (mean 6.3 +/- 2 weeks; doses: 3 times 12.5 to 3 times 25 mg/day) were investigated" Get all the results and reference details, order at left...
204 Drugs and Important Bio-Agents and 330 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Sutures (Suture) 08/01/1981 - "We think this surgical technique is superior to closure of these openings by primary sutures only, which can result in stretching and distortion of the aortic ring and leaflets leading to postoperative residual aortic regurgitation." 11/01/2006 - "this technique, the possibility of aortic regurgitation caused by stretching and distortion of the aortic ring and leaflets by primary suture closure of tunnel is eliminated" 10/01/1980 - "In one patient, simply cutting the overhanging suture eliminated the aortic regurgitation" 09/01/2007 - "Capnocytophaga haemolytica was isolated in blood cultures and the repeated echocardiograms showed growth of vegetations and disruption of the proximal prosthetic valve suture line with progressive aortic regurgitation" 02/01/1996 - "Aortic regurgitation was due to a perforation at the base of the right coronary cusp, probably caused during the initial VSD patch closure, and it was repaired by suture" Get all the results and reference details, order at left...
2.	Transplants (Transplant) 03/01/1998 - "Although currently some surgeons prefer to resuspend rather than replace the aortic valve, composite valve graft replacement for aortic root dilatation and aortic valve insufficiency has steadily improved patient outcome" 10/01/2000 - "The objective of this study was to create native aortic valve insufficiency in recipient rats to provide for a functional abdominal aortic valve graft implant" 01/01/2007 - "METHODS AND RESULTS: From January 1993 to December 2003, 100 patients (87 men), aged >65 years (mean 51 (SD 10.4 years), presenting with isolated aortic root dilatation with or without aortic valve insufficiency, undergoing elective root replacement using a mechanical valve graft were reviewed" 09/01/2004 - "Aortography revealed no aortic regurgitation and good patency of bypass graft." 12/01/2003 - "OBJECTIVE: To clarify the merits of various surgical approaches, we studied the outcome after composite valve graft versus separate valve and graft replacement versus conservative valve treatment with replacement of the ascending aorta in patients with acute type A aortic dissection complicated by aortic regurgitation" Get all the results and reference details, order at left...
3.	Prostheses and Implants (Prosthesis) 08/01/1982 - "Our study comprised 302 consecutive patients seen between 1962 and 1971 who underwent mitral (MVR) (132 patients) or aortic valve replacement (AVR) (170 patients) with a Starr-Edwards prosthesis because of advanced mitral or aortic incompetence" 11/01/2007 - "Subvalvular pannus overgrowth on the inflow aspect of the prosthesis impeded normal closure of one leaflet causing severe aortic regurgitation, which occurred intermittently" 11/01/2007 - "Cyclic intermittent aortic regurgitation of a mechanical bileaflet aortic valve prosthesis: diagnosis and clinical implications." 08/01/2007 - "METHODS: Of ten patients with longstanding aortic regurgitation and ventricular dilatation subjected to aortic valve replacement using mechanical valve prostheses, five were in addition subjected to application of the Cardiac Support Device (Acorn)" 08/01/2007 - "The echocardiogram showed a severe aortic regurgitation and a mitral valve prosthesis well functioning" Get all the results and reference details, order at left...
4.	Homologous Transplantation (Allograft) 11/01/1992 - "Following germ-free confirmation, aortic allograft valves were implanted in 5 patients having aortic regurgitation with good results" 07/01/1968 - "A study of aortic regurgitation in aortic-valve homografts." 07/01/2007 - "Herein is presented the case of a male adult with rapid deterioration of the aortic valve homograft wall, without loss of the valve leaflets, resulting in severe aortic regurgitation" 04/01/2007 - "A 77-year-old lady underwent re-operation for homograft aortic regurgitation and mitral valve replacement" 08/01/2005 - "Six patients required reoperation and prosthetic or homograft replacement for aortic valve incompetence" Get all the results and reference details, order at left...
5.	Bioprosthesis 09/04/1992 - "Despite this the cardiac status deteriorated, the aortic regurgitation reaching grade IV. The valve was replaced with a bioprosthesis and the patient quickly improved postoperatively" 11/01/2003 - "BACKGROUND AND AIM OF THE STUDY: Aortic root dilation at the sinotubular junction (STJ) results in aortic regurgitation associated with normal valves and with a complete subcoronary stentless aortic bioprosthesis" 11/01/2007 - "Percutaneous aortic valve replacement for severe aortic regurgitation in degenerated bioprosthesis: the first valve in valve procedure using the Corevalve Revalving system." 01/01/2004 - "Durability and prevalence of aortic regurgitation nine years after aortic valve replacement with the Toronto SPV stentless bioprosthesis." 12/01/2002 - "However, despite excellent long-term hemodynamics, patients with stentless bioprostheses need to be evaluated with echocardiography at regular intervals to discover the rare cases of progressive aortic regurgitation." Get all the results and reference details, order at left...
61 Therapies and Procedures and 397 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

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