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Aortic Rupture

The tearing or bursting of the wall along any portion of the AORTA, such as thoracic or abdominal. It may result from the rupture of an aneurysm or it may be due to TRAUMA.
Also Known As:
Ruptured Aortic Aneurysm; Aneurysm, Ruptured Aortic; Aneurysms, Ruptured Aortic; Aortic Aneurysms, Ruptured; Aortic Ruptures; Rupture, Aortic; Ruptured Aortic Aneurysms; Ruptures, Aortic; Aortic Aneurysm, Ruptured
Networked: 362 relevant articles (5 outcomes, 15 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Myocardial Infarction
2. Hypertension (High Blood Pressure)
3. Hemorrhage
4. Ischemia
5. Hypotension (Low Blood Pressure)

Experts

1. Daugherty, Alan: 7 articles (05/2015 - 08/2005)
2. Nienaber, Christoph A: 7 articles (06/2013 - 06/2002)
3. Eggebrecht, Holger: 6 articles (06/2013 - 06/2002)
4. Erbel, Raimund: 6 articles (06/2013 - 06/2002)
5. Chiesa, Roberto: 4 articles (10/2014 - 03/2012)
6. Rousseau, Hervé: 4 articles (06/2013 - 06/2003)
7. Howatt, Deborah A: 4 articles (01/2013 - 08/2006)
8. Cassis, Lisa A: 4 articles (01/2013 - 08/2005)
9. Baumgart, Dietrich: 4 articles (02/2006 - 06/2002)
10. Herold, Ulf: 4 articles (02/2006 - 09/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Aortic Rupture:
1. glucuronyl glucosamine glycan sulfate (Vessel)IBA
2. Vitamin EFDA LinkGeneric
3. Nitroprusside (Sodium Nitroprusside)FDA LinkGeneric
4. Antihypertensive Agents (Antihypertensives)IBA
5. tranilast (N 5')IBA
6. Polyethylene Terephthalates (Polyethylene Terephthalate)IBA
7. CollagenIBA
07/01/2013 - "Echocardiography and histological analysis evidenced that early deaths were caused by thoracic aortic ruptures preceded by dissections and associated with low aortic collagen fibrils content. "
05/29/2007 - "Through thick and thin collagen fibrils, stress, and aortic rupture: another piece in the jigsaw."
01/01/2015 - "The findings of this study suggest that a connective tissue disorder affecting elastin or collagen in the aortic media is potentially the underlying cause of aortic rupture in Friesian horses. "
03/19/1966 - "The osteolathyrogen, gamma-glutamyl-beta-aminopropionitrile, in sweet pea (Lathyrus odoratus) seeds induces skeletal deformities and aortic rupture, probably by interfering with normal maturation of collagen fibres. "
07/01/1972 - "1. The influence of feeding 2 levels of sotalol on the incidence of beta-aminopropionitrile (BAPN)-induced aortic ruptures of immature turkeys was determined.2. Four of 22 turkeys fed 0.12% sotalol and 0.07% BAPN died of aortic ruptures, but 6 of 21 turkeys fed only BAPN died of the syndrome.3. Blood pressure, heart rate, aortic tensile strength, and aortic structure as seen by light- and electron-microscope were similar in turkeys fed BAPN alone or both BAPN and 0.12% sotalol concurrently.4. In a second experiment, 13 of 24 turkeys fed 0.7% BAPN alone died of aortic ruptures, but only 2 of 24 turkeys fed BAPN and 0.2% sotalol concurrently died of the disease.5. Aortic tensile strength was lower, heart rate was faster, alterations of aortic elastic fibres as seen by light- and electron-microscope were more severe, and aortic salt soluble collagen with a higher amino acid content was increased in turkeys fed only BAPN, as compared to turkeys fed both BAPN and 0.2% sotalol."
8. Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
9. ElastinIBA
10. Natriuretic PeptidesIBA

Therapies and Procedures

1. Angioplasty (Angioplasty, Transluminal)
2. Thoracotomy
3. Chest Tubes (Chest Tube)
09/01/1997 - "In 42 patients (41%) the additional TCT findings resulted in a change of therapy: chest tube placement, chest tube correction of pneumothoraces or large hemothoraces (n = 31), change in mode of ventilation and respiratory care (n = 14), influence on the management of fracture stabilization (n = 12), laparotomy in cases of diaphragmatic lacerations (n = 2), bronchoscopy for atelectasis (n = 2), exclusion of aortic rupture (n = 2), endotracheal intubation (n = 1), and pericardiocentesis (n = 1). "
01/01/1997 - "In 42 patients (41%) the additional TCT findings resulted in a change of therapy: chest tube placement or chest tube correction of pneumothoraces or large hemothoraces (n = 31), change in mode of ventilation and respiratory care (n = 14), influence on the management of fracture stabilization (n = 12), laparotomy in cases of diaphragmatic lacerations (n = 2), bronchoscopy for atelectasis (n = 2), exclusion of aortic rupture (n = 2), endotracheal intubation (n = 1), pericardiocentesis (n = 1). "
08/01/1987 - "The following occurred with significantly greater frequency in patients with thoracic aortic rupture than in those without: history of significant hypotension (mean arterial pressure less than 80 mm Hg) (p less than 0.04); the presence of upper extremity hypertension, bilateral lower extremity pulse pulse deficits, or an initial chest tube output greater than 750 ml of blood (p less than 0.05); and greater incidence of myocardial contusions, intra-abdominal injuries, and pelvic fractures compared with patients without thoracic aortic rupture (p less than 0.05). "
4. Stents
5. Transplants (Transplant)