Aortic Diseases

06/19/2023 - "The advent of 4D flow magnetic resonance imaging has allowed for the calculation of new biomarkers for the study of aortic diseases, such as wall shear stress. "
01/01/2021 - "Several serum biomarkers have been investigated for their potential as diagnostic tools in aortic disease; however, no study has investigated the association between serum biomarkers and outcomes after aortic surgery. "
10/01/2023 - "Reply to letter to the editor: "Novel biomarkers associated with thoracic aortic disease"."
06/01/2023 - "As thoracic aortic disease (TAD) is generally asymptomatic, biomarkers are needed to provide insight into early progression. "
06/01/2023 - "Circulating biomarkers associated with aortic diameter in male and female patients with thoracic aortic disease: a cross-sectional study."

08/21/2012 - "By establishing a link between S100A12 expression and apoptosis of aortic smooth muscle cells, this study identifies novel S100A12 signaling pathways and indicates that S100A12 may be a useful molecular marker and possible target for treatment for human aortic diseases."
01/01/2017 - "Our findings suggested that reduction of S100A12 protects HVSMCs against H2O2-induced injury, and may be useful as a treatment for aortic disease."
01/01/2017 - "The aim of the present study was to investigate the protective effects of S100A12 reduction on hydrogen peroxide (H2O2)-induced human vascular smooth muscle cells (HVSMCs) injury and evaluate the relevance of S100A12 and aortic disease. "
12/01/2017 - "Increased levels of S100A12 and activated matrix metalloproteinase 2/9 (MMP-2/9) produced by human aortic smooth muscle cells (HASMCs) have recently implicated in the development of thoracic aortic disease. "

04/01/2019 - "This article reviews the pathogenesis of thoracic aortic diseases, the molecular mechanism of FQ-associated collagen toxicity, and the possible contribution of FQs to aortic diseases."
10/12/2023 - "Type IV and V collagens are also integral components of arterial walls, and whereas collagenopathies including AS are implicated in aortic disease, the incidence of aortic aneurysm in AS is unknown probably because of underreporting. "
06/01/2001 - "This study demonstrates the integral role of type I collagen in the biomechanical and functional properties of the aorta and may help to elucidate the role of collagen in the development of aneurysmal aortic disease or dissection."
01/01/2016 - "These data suggest that a missense mutation in LOX is associated with aortic disease in humans, likely through insufficient cross-linking of elastin and collagen in the aortic wall. "
03/21/2014 - "Alteration of the quantity and/or arrangement of the main load-bearing components of this micro-architecture--the elastin and collagen fibers--leads to mechanical, and hence functional, changes associated with aortic disease and aging. "

07/01/1999 - "Optimized single-dose breath-hold gadolinium-enhanced 3D MR angiography is superior to double-dose non-breath-hold 3D MR angiography for evaluation of thoracic aortic disease."
07/01/1999 - "The purpose of this study was to compare single-dose (0.1 mmol/kg) breath-hold gadolinium-enhanced three-dimensional (3D) MR angiography and double-dose (0.2 mmol/kg) non-breath-hold 3D MR angiography for evaluation of thoracic aortic disease. "
01/01/2010 - "Non-gadolinium-enhanced 3-dimensional magnetic resonance angiography for the evaluation of thoracic aortic disease: a preliminary experience."
04/01/2006 - "Gadolinium (Gd)-enhanced three-dimensional breath-hold magnetic resonance cardiac-synchronized angiography was performed in 13 patients suspected or known to have thoracic aortic disease. "
11/01/1999 - "We investigated the diagnostic accuracy of gadolinium-enhanced 3D MRA in the assessment of thoracic aortic diseases. "

10/01/1999 - "This differential expression of IL-6 may help explain the pathogenesis of these 2 distinct aortic diseases."
01/01/2023 - "Inclusion of interleukin-6 improved the performance of postoperative acute lung injury prediction for patients undergoing surgery for thoracic aortic disease."
01/01/2023 - "We studied acute lung injury (ALI) in thoracic aortic disease (TAD) patients and investigated the predictive effect of interleukin-6 (IL-6) in acute lung injury after thoracic aortic disease. "
10/01/1999 - "Differential expression of prostaglandin E2 and interleukin-6 in occlusive and aneurysmal aortic disease."
10/01/1999 - "The purpose of this study was to analyze the inflammatory cytokines interleukin-6 (IL-6) and prostaglandin E2 (PGE2) in aortic disease and compare AAA with AIOD, as well as to compare both with normal aorta. "

06/01/2001 - "This study demonstrates the integral role of type I collagen in the biomechanical and functional properties of the aorta and may help to elucidate the role of collagen in the development of aneurysmal aortic disease or dissection."

01/01/2017 - "The aim of the present study was to investigate the protective effects of S100A12 reduction on hydrogen peroxide (H2O2)-induced human vascular smooth muscle cells (HVSMCs) injury and evaluate the relevance of S100A12 and aortic disease. "

01/01/2021 - "Regarding other inflammasomes, more preclinical research is needed to investigate their role in the pathophysiology of aortic disease. "
01/01/2021 - "This review will thus focus on inflammasome activities in vascular cells of different chronic and acute aortic diseases and discuss their role in development and progression. "
01/01/2021 - "The participation of innate immunity and inflammasome activation in different cell types is common in aortic diseases. "
01/01/2021 - "Inflammasomes in the Pathophysiology of Aortic Disease."
01/01/2021 - "In conclusion, inflammasome targeted therapies, more precisely targeting the NLRP3 inflammasome, have shown promising results in rodent models and deserve further investigation in preclinical research to potentially translate them into clinical research for the treatment of human patients with aortic disease. "

01/25/2023 - "Aortic diseases with chronic consumption coagulopathy may lead to disseminated intravascular coagulation (DIC) and cause fatal bleeding. "
10/01/2020 - "Patients with unexplained bleeding diathesis with DIC should include aortic disease as one of the differential diagnoses. "
10/15/2020 - "We collected data on patient characteristics and underlying disorders of DIC including sepsis, solid cancer, leukemia, trauma, obstetric diseases, aortic diseases, pancreatitis, and miscellaneous diseases. "
10/15/2020 - "leukemia, trauma, obstetric diseases, or aortic diseases); organ failure type (sepsis or pancreatitis); and asymptomatic type of DIC (solid cancer). "
01/25/2023 - "Although the use of antifibrinolytic agents in DIC is generally not recommended due to enhanced fibrin deposition risking thrombotic symptoms, the efficacy of TXA has been reported in several cases of DIC with aortic diseases. "

12/01/2018 - "Hemodynamic analysis may be helpful to evaluate the therapeutic effects of other aortic diseases."
01/01/2022 - "Our findings suggest that the therapeutic effects of AT1R antagonisms in preclinical models of aortic disease depend on both regional and systemic factors and suggest that combinatorial approaches targeting both processes may prove beneficial for aneurysm mitigation."

11/01/2021 - "Thoracic endovascular aortic repair (TEVAR) has developed to be the most effective treatment for aortic diseases. "
07/01/2007 - "The early and mid-term results of endovascular stent-grafting for the treatment of chronic and acute thoracic aortic diseases showed a good outcome and low rate of complications. "
01/01/2022 - "Endovascular abdominal aortic repair (EVAR) and thoracic endovascular aortic repair (TEVAR) have become the first-line treatment for aortic diseases, but current evidence is uncertain regarding whether a percutaneous approach has better outcomes than cutdown access, especially for patient-centered outcomes (PCOs). "
01/01/2011 - "Since its introduction more than a decade ago, thoracic endovascular aortic repair (TEVAR) has shown promising results for patients with various thoracic aortic diseases. "
01/01/2020 - "Endovascular aneurysm repair (EVAR) is a popular and effective treatment for descending aortic disease. "

05/01/2010 - "Although the long-term durability of stent grafts is still a concern, stent-graft treatment is already the best option in a large number of patients with descending thoracic aortic diseases who are poor candidates for surgical repair, or in an acute setting. "
01/01/2005 - "However, short-term morbidity and mortality rates from endovascular treatment compare favorably with those from surgery, and stent-graft placement is proving to be a safe, minimally invasive, and effective treatment for thoracic aortic diseases and is already the best option in many affected patients who are poor surgical candidates."
08/01/2010 - "The purpose of this study was to establish the safety and efficacy of antegrade delivery techniques of aortic stent grafting for the treatment of high-risk, complex thoracic aortic disease. "
02/01/2013 - "Endovascular treatment of the obstructive aortic disease using self-expanding stents was safe and effective, with high technical success and long-term patency. "
01/01/2013 - "Endovascular stent-graft is a feasible and safe treatment for aortic diseases, with high procedural success and low incidences of post-procedural complications and short-term mortality. "

01/01/2019 - "Innovations in endovascular therapy for aortic disease have improved surgical outcomes, even in high-risk patients with LC."
06/01/2007 - "With advances in molecular technology, the molecular diagnosis and treatment of aortic diseases will begin to expand at a rapid rate and provide unique, improved therapies."
01/01/2020 - "We propose that iPSC-derived aortic disease models could guide future clinical trials via "clinical-trials-in-a-dish", thus paving the way for new and improved therapies for patients."
02/01/2022 - "This study preliminary demonstrates the feasibility of shear-activated targeted nanoparticle drug delivery in the treatment of aortic diseases and provides a theoretical basis for developing the drug delivery system and novel therapy."
10/01/2016 - "The following types of studies with long-term follow-up would be required: 1) a prospective cohort study comparing the incidence of aortic diseases in OSA patients with that in non-OSA subjects and 2) a randomized controlled trial determining whether CPAP therapy for OSA reduces the incidence of aortic diseases."

12/01/2017 - "Endovascular repair has revolutionised the emergency treatment of thoracic aortic disease. "
06/01/2003 - "endoluminal repair of thoracic aortic disease requiring urgent/emergency treatment has encouraging results with low morbidity and mortality rates compared with open surgery. "
01/01/2008 - "To investigate the long-term outcome and efficacy of emergency treatment of acute aortic diseases with endovascular stent-grafts. "
05/01/2002 - "To investigate the safety and efficacy of emergency treatment of acute aortic diseases with endovascular stent grafts. "
08/01/2002 - "The aim of this study was to evaluate the feasibility, safety, and effectiveness of endovascular stent-graft placement for the emergency treatment of acute descending thoracic aortic disease. "

11/01/2020 - "The Conformable GORE TAG Thoracic Endoprosthesis and GORE TAG Thoracic Endoprosthesis thoracic endografts provide an effective treatment for ruptured thoracic aortic diseases. "
08/01/2020 - "For the current study, all patients were treated only with the Conformable GORE® TAG® Thoracic Endoprosthesis and GORE® TAG® Thoracic Endoprosthesis devices for any kind of thoracic aortic disease. "
09/01/2018 - "Six 3D printed real scale prototypes were built representing different aortic diseases, taken from real patients, to simulate the correction of the disease with endoprosthesis deployment. "
08/01/2018 - "Early evaluation of precise deployment with the new low-profile Zenith Alpha Thoracic Endoprosthesis in thoracic aortic disease."
01/01/2018 - "Orthotopic branched endovascular aortic arch repair using the Bolton Relay Plus double-branch endoprosthesis is a safe and feasible technique enriching the armamentarium to treat patients with thoracic aortic disease who cannot undergo classical surgery. "