Aortic Coarctation

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541 relevant articles (21 outcomes, 43 trials/studies) found for this Disease

Description: A birth defect characterized by the narrowing of the AORTA that can be of varying degree and at any point from the transverse arch to the iliac bifurcation. Aortic coarctation causes arterial HYPERTENSION before the point of narrowing and arterial HYPOTENSION beyond the narrowed portion.

Also Known As:

Aortic Coarctations; Coarctation, Aortic; Coarctations, Aortic

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 18443

Heart Diseases: 12330

Congenital Heart Defects: 685

Aortic Coarctation: 541

Cardiovascular Abnormalities: 167

Congenital Heart Defects: 685

Aortic Coarctation: 541

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 420

Congenital Abnormalities: 9307

Cardiovascular Abnormalities: 167

Congenital Heart Defects: 685

Aortic Coarctation: 541

Related Diseases

1.	Pathologic Constriction (Stenosis)
2.	Aortic Aneurysm (Aneurysm, Aortic)
3.	Cardiomyopathies (Cardiomyopathy)
4.	Hypertension (High Blood Pressure)
5.	Aneurysm (Aneurysms)
97 Diseases and 220 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	Peters, Bjoern: 4 articles (10/2008 - 10/2004)
2.	Ewert, Peter: 4 articles (10/2008 - 10/2004)
3.	Berger, Felix: 3 articles (10/2008 - 04/2006)
4.	Nagdyman, Nicole: 3 articles (10/2008 - 10/2004)
5.	Miera, Oliver: 2 articles (10/2008 - 01/2008)
6.	Kühne, Titus: 2 articles (10/2008 - 01/2008)
7.	Bryan, Alan J: 2 articles (06/2008 - 09/2005)
8.	Galal, M O: 2 articles (05/2007 - 09/2003)
9.	Zubrzycka, Maria: 2 articles (04/2006 - 02/2004)
10.	Qureshi, Shakeel A: 2 articles (04/2006 - 02/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Aortic Coarctation:

1.	Coenzyme A (CoA)IBA 01/01/1997 - "The objective of this study was to assess the reliability of spiral CT angiography (CTA) and 3D reconstruction in patients with aortic coarctation (CoA)" 10/01/2006 - "The results of the surgical repair of aortic coarctation (CoA) are excellent" 03/01/2005 - "AIMS: Increased cardiovascular morbidity is manifested a long time after the repair of aortic coarctation (CoA)" 02/08/2005 - "BACKGROUND: MRI is increasingly used for anatomic assessment of aortic coarctation (CoA), but its ability to predict the transcatheter pressure gradient, considered the reference standard for hemodynamic severity, has not been studied in detail" 08/01/1999 - "The spectral Doppler pattern at the site of an aortic coarctation (CoA) generally displays increased maximal velocity (Vmax) during systole with a slow velocity decay, resulting in the characteristic "sawtooth" pattern" Get all the results and reference details, order at left...
2.	ReninIBA 10/01/2000 - "In the aortic coarctation model, inactive renin comprised 68 % of TRC in the right kidney and no or very little prorenin was found in the left kidney" 04/01/1993 - "We conclude that reduction of perfusion pressure after abdominal aortic coarctation acutely enhances renin gene expression and downregulates AT1 receptor gene expression.(ABSTRACT TRUNCATED AT 250 WORDS)" 10/01/1987 - "Peripheral renin activity was measured at operation, just before the correction of aortic coarctation, 1/2, 1 h, 1, 3, 7 days, 2 and 6 months after the correction operation" 09/01/1982 - "We studied plasma renin activity (PRA) in eight children before and after surgical correction of aortic coarctation" 12/01/1976 - "Aortic coarctation produced severe hypertension (MAP greater than 150 mmHg) and plasma renin activity values (radioimmunoassay) at least 10 times normal within 2-6 days after surgery" Get all the results and reference details, order at left...
3.	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/01/1998 - "These results suggest that shear stress induced nitric oxide release in lower aortic segments from aortic coarctation-induced hypertensive rats." 07/01/1998 - "The effect of aortic coarctation on nitric oxide production by the vascular endothelium]" 09/01/2001 - "Enhanced nitric oxide inactivation in aortic coarctation-induced hypertension." 08/01/2006 - "Despite high-frequency oscillatory ventilation plus nitric oxide and uneventful repair of the hernia, the infant died after 6 days of uncontrolled pulmonary hypertension and severe aortic coarctation that developed postnatally." 01/01/2007 - "One infant after repair of ventricular septal defect and aortic coarctation had pulmonary hypertension non-responsive to nitric oxide, another infant and 3.5 year child following palliative surgery for congenital heart disease with univentricular physiology were treated with inhaled nitric oxide and had severe systemic desaturations associated with endotracheal suctioning" Get all the results and reference details, order at left...
4.	Angiotensin IIIBA 12/01/1976 - "These results suggest that angiotensin II is in part responsible for the elevation in blood pressure following aortic coarctation in rats" 05/01/1986 - "The present study was designed: (a) to examine the contribution of the renin-angiotensin system (RAS) to elevated regional vascular resistance during the onset of aortic coarctation hypertension, and (b) to determine the role of angiotensin II (Ang II)-neural interactions during the maintenance of high arterial pressure (AP)" 08/01/1991 - "These data suggest that a prostanoid-mediated and endothelium-dependent mechanism of vasoconstriction contributes to the constrictor effect of angiotensin II in aortic rings of rats in the early phase of aortic coarctation-induced hypertension." 03/01/1989 - "Exaggerated renal thromboxane and prostaglandin release by angiotensin II in suprarenal aortic coarctation hypertension." 07/01/1996 - "In the present study we evaluated the nitric oxide contribution of the regulation of angiotensin II-induced vasoconstriction in normotensive rats and aortic coarctation-induced hypertensive rats" Get all the results and reference details, order at left...
5.	Messenger RNA (mRNA)IBA 07/30/2004 - "No changes in GAL mRNA expression were observed in petrosal and nodose ganglia following aortic coarctation" 03/01/1987 - "In response to aortic coarctation, there was a rapid induction of the beta-MHC mRNA followed by the appearance of comparable levels of the beta-MHC protein in parallel to an increase in the left ventricular weight" 07/01/2006 - "Time course analysis, showed an increase in TH mRNA expression in the NTS 7 days after aortic coarctation when compared to 2 h and 3 days groups, as well as an increase in LC 3 days and 7 days following coarctation hypertension in comparison with the 2 h group" 04/01/2004 - "In this study we have employed in situ hybridization to analyze changes in mRNA expression of NPY receptor subtypes Y1 and Y2 in the nucleus tractus solitarii (NTS), paraventricular nucleus of the hypothalamus (PVN) and petrosal and nodose ganglions 2 h, 3 and 7 days after aortic coarctation induced hypertension" 03/01/1996 - "Increased ventricular workload, produced by aortic coarctation for 5 days, resulted in ventricular hypertrophy (heart/body weight, 4.05 +/- 0.19 vs. 3.42 +/- 0.16 mg/g; P < 0.02) and a 3.4-fold increase in betaMHC messenger RNA content" Get all the results and reference details, order at left...
6.	Atrial Natriuretic Factor (ANF)IBA 12/01/1997 - "Our recent partial cloning of the ovine BNP gene has enabled us to study changes in cardiac tissue concentration, together with tissue and circulating molecular forms of ANP and BNP, in response to cardiac overload induced by rapid ventricular pacing (n = 7) and aortic coarctation (n = 6)" 10/01/1989 - "To study the occurrence of atrial natriuretic peptide (ANP) in overloaded ventricles, suprarenal aortic coarctation was performed on adult rats (n = 60) to induce overloaded left ventricle" 11/01/1996 - "In conclusion, suprarenal aortic coarctation leads to progressive hypertension resulting in LVH, progressive increases in plasma ANP and BNP and, in most cases, death from heart failure." 09/01/2007 - "EXPERIMENTAL APPROACH: To address this question, the foetal gene programme, of which atrial natriuretic peptide (ANP), the beta-isoform of myosin heavy chain (beta-MHC), and the alpha-skeletal muscle isoform of actin (skACT) are classical members, was induced by thoracic aortic coarctation (TAC) in C57BL/6 mice, or by phenylephrine, a selective alpha(1)-adrenoceptor agonist, in cultured rat neonatal cardiomyocytes" 07/01/1997 - "To dissociate humoral effects from the effects of mechanical loading on cardiac hypertrophic responses, we examined expression of ANP and BNP at both mRNA and protein levels and proportions of myosin isoforms in transplanted cervical hearts that were mechanically unloaded under conditions with or without hypertension by aortic coarctation" Get all the results and reference details, order at left...
7.	CalciumIBA 11/01/1988 - "Direct correlation between calcium content and blood pressure: a study of aortic coarctation in rats." 10/01/1997 - "Rings of thoracic aortae taken from rats made hypertensive by aortic coarctation express a calcium-dependent basal tone" 11/01/1988 - "On the distal, low pressure side of the aortic coarctation, calcium was reduced significantly" 08/01/1990 - "This study examined the calcium dependency of contractions in arteries from rats made hypertensive by aortic coarctation and in rats with genetic hypertensive (stroke-prone spontaneously hypertensive rats)" 10/01/1997 - "Contribution of constrictor prostanoids to the calcium-dependent basal tone in the aorta from rats with aortic coarctation-induced hypertension: relationship to nitric oxide." Get all the results and reference details, order at left...
8.	Insulin-Like Growth Factor I (IGF-1)IBA 02/01/1993 - "The purpose of this study was to characterize IGF I gene expression in a model of aortic coarctation hypertension in the rat" 12/01/1994 - "Recently, we have demonstrated that interrenal aortic coarctation in the rat increases IGF-I mRNA levels in the thoracic aorta, consistent with a role for this mitogen in hypertensive vascular remodeling" 12/01/1994 - "To obtain insights into the regulation of IGF-I and more specifically to study potential changes in IGF binding proteins in high-renin hypertension, we studied male Sprague-Dawley rats that had undergone abdominal aortic coarctation" Get all the results and reference details, order at left...
9.	salicylhydroxamic acid (SHAM)IBA 05/01/2005 - "Twenty-four hours after the operation, osmotic minipumps were surgically implanted subcutaneously in the rats, which were randomly divided into 3 groups, including a sham-operation group (n=15) receiving infusion with normal saline, a suprarenal aortic coarctation group (n=12), and a suprarenal aortic coarctation group (n=14) with Ang-(1-7) treatment at the dose of 25 mug x kg(-1) x h(-1)" 11/01/2001 - "Anesthetized Wistar rats were used 7 days after aortic coarctation or sham operation" 11/01/2000 - "Bolus injection of AA (1, 2, 4, and 8 microg) increased perfusion pressure in a dose-dependent manner by 20 +/- 4, 28 +/- 5, 38 +/- 6, and 44 +/- 7 mm Hg in sham-operated rats and 30 +/- 3, 55 +/- 5, 78 +/- 5, and 113 +/- 8 mm Hg in rats with aortic coarctation" 07/01/1999 - "Bolus injection of Ang II (9, 18, 36, 72 ng) increased perfusion pressure in a dose-dependent manner by 16.5+/-4, 23.5+/-4, 35.5+/-7, and 42.5+/-7 mm Hg in sham-operated rats and 50+/-6, 72+/-10, 92+/-6, and 120+/-6 mm Hg in rats with aortic coarctation" 04/01/1998 - "In both groups, aortic coarctation caused a significant increase in pressure (25% and 28%, respectively) and a depression of the aortic nerve activity/pressure relationship when compared with sham-operated coarcted animals" Get all the results and reference details, order at left...
10.	tranilast (N 5')IBA 06/01/2007 - "Aortic arch anatomy showed: localized aortic coarctation (n=10) and coarctation with hypoplastic aortic arch (n=6) and interrupted aortic arch (n=5)" 03/01/2005 - "Three groups of patients (n = 12) were identified: infants with isolated muscular VSDs (n = 2), neonates with aortic coarctation and muscular VSDs (n = 3) or patients with muscular VSDs and other complex cardiac lesions (n = 2), and patients with muscular VSDs and pulmonary artery bands (n = 5)" 08/01/1989 - "Systolic pressure difference across the recoarctation site decreased from 37 +/- 16 to 14 +/- 11 mm Hg and coarctation/aortic diameter ratio increased from 0.45 +/- 0.14 to 0.85 +/- 0.16 immediately after balloon dilation regardless of the nature of the previous operation (subclavian flap [n = 12], resection with end to end anastomosis [n = 21], patch angioplasty [n = 4] or multiple operations [n = 5])" 11/01/1993 - "Cardiovascular and thoracic interventions included balloon angioplasty of aortic coarctation (10 patients, 2 of whom later required surgical repair), permanent pacemaker placement (n = 4), extracorporeal membrane oxygenation (n = 4), right pulmonary artery banding (n = 1), retransplantation (n = 2), repair of pulmonary venous obstruction (three patients, one of whom underwent two more reoperations), thrombectomy of the abdominal aorta (n = 1), delayed sternotomy closure (n = 10), plication of the diaphragm (n = 5), tracheostomy (n = 2), and repair of lung herniation (n = 1)" 05/01/2000 - "Defects included aortic coarctation (n = 6), ventricular septal defect (n = 5), tetralogy of Fallot (n = 2), transposition of great arteries (n = 2), truncus arteriosus (n = 2), total anomalous pulmonary venous return (n = 1), double outlet right ventricle (n = 1), and pulmonary atresia with intact ventricular septum (n = 1)" Get all the results and reference details, order at left...
181 Drugs and Important Bio-Agents and 239 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Balloon Angioplasty (Angioplasty, Transluminal) 03/15/1999 - "Based on our experience and recent reports, balloon angioplasty is safe and effective in most children older than 7 months and should be considered a viable alternative to operation for discrete aortic coarctation" 03/01/1992 - "Our experience suggests that balloon angioplasty of native aortic coarctation in adolescents and young adults is safe and highly effective with sustained improvement on intermediate-term follow-up." 02/01/1996 - "On the basis of these data, it is concluded that balloon angioplasty is safe and effective in the treatment of native aortic coarctation; significant incidence of recoarctation is seen in neonates and infants; repeat balloon angioplasty for recoarctation is feasible and effective; and the time has come to consider balloon angioplasty as a therapeutic procedure of choice for the treatment of native aortic coarctation." 03/01/1995 - "Balloon angioplasty of native aortic coarctation is effective in infants and older children" 11/01/2002 - "Recent data and studies have showed that percutaneous balloon angioplasty is a safe and effective treatment for aortic coarctation" Get all the results and reference details, order at left...
2.	Stents 07/01/2008 - "CONCLUSION: Covered stent implantation for treatment of aortic coarctation is safe and highly effective in selected patients" 10/01/2008 - "Feasibility and efficacy of stent redilatation in aortic coarctation." 10/01/2006 - "CONCLUSIONS: There were few patients in the study, but we think that we must predilate the lesion before to release a stent in critical aortic coarctation." 08/01/2008 - "METHODS: Sixty covered CP stents were implanted in patients with aortic coarctation or recoarctation between January 2004 and October 2007" 07/01/2008 - "OBJECTIVES: We describe our complete experience with covered stent implantation for aortic coarctation including short- to medium-term outcomes" Get all the results and reference details, order at left...
3.	Balloon Dilatation 01/01/2006 - "Balloon dilation of native aortic coarctation has been employed safely and effectively in selected patients and with good results during follow-up" 01/01/2002 - "CONCLUSIONS: Balloon dilation is an effective and safe alternative to treat aortic coarctation" 11/01/2005 - "BACKGROUND: The efficacy of balloon dilatation as primary treatment for neonatal aortic coarctation remains controversial" 09/01/1986 - "After balloon dilatation of aortic coarctation the systolic pressure in the descending aorta rose from 86.4 (17.7) to 107.8 (20) mm Hg and the peak systolic pressure difference across the coarctation fell from 44.1 (19.1) to 8.5 (8.5) mm Hg. The diameter of the angiographically measured coarcted segment increased, the Doppler estimate of the pressure difference across the coarctation decreased, and the femoral pulses improved" 06/01/1999 - "Table 3 illustrates the immediate and late results of balloon dilatation of aortic coarctation in 3 different studies" Get all the results and reference details, order at left...
4.	Angioplasty (Angioplasties) 11/01/2007 - "A 29-year-old patient with aortic coarctation was admitted for angioplasty, which was performed successfully" 06/01/2007 - "In order to determine the frequency, spectrum, and outcome of injury to the aortic wall caused by angioplasty or stenting of aortic coarctation, the nomenclature of mural injury in these patients must be adapted to the conditions of transcatheter therapy" 10/01/2006 - "Angioplasty and stenting in treatment of critical aortic coarctation]" 03/21/2006 - "A review was performed to compare the results of endovascular therapy (stenting and angioplasty) with surgical techniques to repair adult aortic coarctation" 02/01/2006 - "Afterwards the patient underwent angioplasty in order to correct aortic coarctation" Get all the results and reference details, order at left...
5.	Extracorporeal Membrane Oxygenation (ECMO) 06/01/1998 - "Depending on its anatomic location and severity, an aortic coarctation associated with life-threatening CDH may limit the physiological efficacy of venoarterial ECMO" 06/01/1998 - "The authors present two cases of aortic coarctation associated with CDH requiring ECMO that illustrate the management challenges of these coincident diagnosis" 12/01/1994 - "The authors encountered a peculiar problem caused by a single carotid artery in a post-ECMO patient during the surgical correction of aortic coarctation with hypoplastic distal aortic arch" 12/01/1994 - "Surgical repair of an aortic coarctation in a patient after treatment with extracorporeal membrane oxygenation." 01/01/2008 - "After surgical repair of an aortic coarctation a term infant presented with severe pulmonary hypertension and cyanosis unresponsive to treatment including extracorporeal membrane oxygenation" Get all the results and reference details, order at left...
52 Therapies and Procedures and 335 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

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on Aortic Coarctation

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