Imperforate Anus

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108 relevant articles (0 outcomes, 9 trials/studies) found for this Disease

Description: A congenital abnormality characterized by the persistence of the anal membrane, resulting in a thin membrane covering the normal ANAL CANAL. Imperforation is not always complete and is treated by surgery in infancy. This defect is often associated with NEURAL TUBE DEFECTS; MENTAL RETARDATION; and DOWN SYNDROME.

Also Known As:

Anus, Imperforate; Anal Atresias; Atresias, Anal; Anal Atresia; Atresia, Anal

Disease Context: Research Results

Digestive System Diseases: 29

Digestive System Abnormalities

Imperforate Anus: 108

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 421

Congenital Abnormalities: 9330

Digestive System Abnormalities

Imperforate Anus: 108

Related Diseases

1.	Hirschsprung Disease (Hirschsprung's Disease)
2.	Constipation
3.	Fistula
4.	Syndrome
5.	Hypospadias

Experts

1.	Bonnot, O: 2 articles (11/2003 - 08/2001)
2.	Robert, E: 2 articles (11/2003 - 08/2001)
3.	Oshio, Takehito: 1 article (01/2008)
4.	Novotny, Nathan M: 1 article (12/2007)
5.	Rescorla, Frederick J: 1 article (12/2007)
6.	Shelley, Anita A: 1 article (12/2007)
7.	Mattix, Kelly D: 1 article (12/2007)
8.	Tobias, Joseph D: 1 article (12/2007)
9.	Zhengwei, Yuan: 1 article (03/2005)
10.	Weilin, Wang: 1 article (03/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Imperforate Anus:

1.	Lorazepam (Ativan)FDA LinkGeneric 11/01/2003 - "Six cases of anal atresia were found among all newborns exposed to BZD in utero, and five of them were exposed to lorazepam, representing a hypothesis to be tested in further" 11/01/2003 - "Step 4: similarly, the lorazepam/anal atresia finding was upheld when the analysis was restricted to the 262 malformed infants exposed to BZDs in utero" 11/01/2003 - "Step 2: further defining drug exposure as a specific BZD, and all others unexposed, a significant association was seen between lorazepam and anal atresia" 11/01/2003 - "Is there a risk for anal atresia with lorazepam?]" 08/01/2001 - "Maternal exposure to lorazepam and anal atresia in newborns: results from a hypothesis-generating study of benzodiazepines and malformations." Order ALL the reference details at left...
2.	Complement System Proteins (Complement)IBA 08/01/1991 - "Therefore, early urodynamic study is recommended for all patients with an imperforate anus and it should complement neonatal uroradiographic evaluation" 02/26/1986 - "Physical therapy for better control of defecation is an effective complement to surgery of anal atresia]" Order ALL the reference details at left...
3.	tranilast (N 5')IBA 04/01/1999 - "RESULTS: Causes of fistulas included Crohn's disease (n = 3), previous rectal surgery (n = 5), anal atresia (n = 1), and sphincter repair (n = 1)" 01/01/2006 - "The purpose of this study is to report our 4-year experience with the cecostomy procedure in 31 children with functional constipation (n = 9), Hirschsprung's disease (n = 2), imperforate anus (n = 5), spinal abnormalities (n = 8), and imperforate anus in combination with tethered spinal cord (n = 7)" Order ALL the reference details at left...
4.	SynaptophysinIBA 12/01/2005 - "The purpose of this study was to describe synaptophysin (SY) immunoreactivity in colonic specimens from patients with Hirschsprung's disease (HD), chronic constipation (CC), or anal atresia (AA)" Order ALL the reference details at left...
5.	Polyurethanes (Polyurethane)IBA 06/01/2000 - "38 totally or partially incontinent patients following imperforate anus repair (age 6-15 years) tested a new polyurethane (PU) anal plug against another, widely used anal plug (PVA) in a randomized crossover trial" 06/01/2000 - "A new polyurethane anal plug in the treatment of incontinence after anal atresia repair." Order ALL the reference details at left...
6.	BenzodiazepinesIBA 08/01/2001 - "Maternal exposure to lorazepam and anal atresia in newborns: results from a hypothesis-generating study of benzodiazepines and malformations." Order ALL the reference details at left...
7.	glutamyl- glycyl- valyl- tyrosyl- valyl- histidyl- prolyl- valineIBA 02/01/2008 - "PURPOSE: The aim of this study was to evaluate the relevance of anal endosonography (AES) during Georgeson laparoscopy-assisted anorectoplasty (GLA) for high/intermediate type imperforate anus (HIIA) using a continence evaluation questionnaire (CEQ) and postoperative AES (post-AES)" Order ALL the reference details at left...
8.	Triad FDA Link 02/01/1990 - "Two male neonates (46XY karyotype) were born with a triad of penile agenesis associated with imperforate anus and complete absence of the median raphe" 03/01/1989 - "Ectopic vas deferens, imperforate anus and hypospadias: a new triad." 01/01/1982 - "The triad of caudal regression-imperforate anus, spinal anomalies, and genitourinary tract anomalies-was present in 19 (53%) of the 36 cases, much more than any other combination of major system abnormalities such as the VATER of VACTEL syndromes." Order ALL the reference details at left...
9.	Valproic Acid (Valproate, Semisodium)FDA LinkGeneric 05/15/2008 - "These included patients with chromosomal abnormalities (25, 29.0%); non-chromosomal syndromes including Beckwith-Wiedemann syndrome, Goltz syndrome, Marshall-Smith syndrome, Meckel-Gruber syndrome, Oto-palato-digital type II syndrome, CHARGE syndrome, and fetal valproate syndrome; malformation sequences, including ectopia cordis, body stalk anomaly, exstrophy of bladder, exstrophy of cloaca, and OEIS (Omphalocele, Exstrophy of bladder, Imperforate anus, Spinal defect); malformation complexes including Pentalogy of Cantrell, and non-syndromic multiple congenital anomalies (MCA) (26, 30.2%)" 06/01/2007 - "This article provides a comprehensive review of omphalocele-related disorders: otopalatodigital syndrome type II; Melnick-Needles syndrome; Rieger syndrome; neural tube defects; Meckel syndrome; Shprintzen-Goldberg omphalocele syndrome; lethal omphalocele-cleft palate syndrome; cerebro-costo-mandibular syndrome; fetal valproate syndrome; Marshall-Smith syndrome; fibrochondrogenesis; hydrolethalus syndrome; Fryns syndrome; omphalocele, diaphragmatic defects, radial anomalies and various internal malformations; diaphragmatic defects, limb deficiencies and ossification defects of skull; Donnai-Barrow syndrome; CHARGE syndrome; Goltz syndrome; Carpenter syndrome; Toriello-Carey syndrome; familial omphalocele; Cornelia de Lange syndrome; C syndrome; Elejalde syndrome; Malpuech syndrome; cervical ribs, Sprengel anomaly, anal atresia and urethral obstruction; hydrocephalus with associated malformations; Kennerknecht syndrome; lymphedema, atrial septal defect and facial changes; and craniosynostosismental retardation syndrome of Lin and Gettig" Order ALL the reference details at left...
10.	Growth Hormone (Somatotropin)IBA 07/01/2004 - "Stratton and Parker [1989] described a 17-month-old boy with the previously unreported combination of growth hormone (GH) deficiency, Wormian bones, mild developmental delay, brachycamptodactyly, heart defects, kidney hypoplasia, imperforate anus, bilateral cryptorchidism, and facial anomalies" 02/01/1989 - "We report on a 17-month-old boy with Wormian bones, short stature, growth hormone deficiency, developmental delay, brachycamptodactyly, dextrocardia, cryptorchidism, midshaft hypospadias, hypoplastic left kidney, and imperforate anus" Order ALL the reference details at left...

Therapies and Procedures

1.	Biofeedback (Psychology) (Biofeedback) 03/01/2005 - "BACKGROUND: The aim of this study was to design an individualized biofeedback program based on the underlying dysfunctions and to assess the short-term and long-term clinical and quality-of-life outcomes for patients with imperforate anus" 03/17/2004 - "The aim of this study was to design a individualized biofeedback program based on the underlying dysfunctions and to assess the short-term and long-term clinical and quality of life outcomes for patients with imperforate anus" 03/01/2005 - "Long-term outcomes of individualized biofeedback training based on the underlying dysfunction for patients with imperforate anus." 03/17/2004 - "CONCLUSION: The causes of postoperative fecal dysfunction in patients with imperforate anus are multifactorial, and the individualized biofeedback is more suitable for improvement of the clinical outcome and the quality of life, and it maintain good clinical outcome and quality of life at short-term and long-term follow-up." 03/17/2004 - "Long-term outcomes of individualized biofeedback training based on the underlying dysfunction for patients with imperforate anus]" Order ALL the reference details at left...
2.	Colostomy 06/01/2008 - "RESULTS: The operative time was 144 minutes in the HD patients (including concomitant laparoscopic biopsies and a leveling colostomy) and 40 minutes in the imperforate anus patient" 01/01/2008 - "A colostomy was performed on a 2-day-old male infant at the proximal sigmoid colon, because the finding of an invertgram revealed an intermediate type of imperforate anus" 11/01/2007 - "Recently, a minimally invasive approach to the repair of high imperforate anus has been described in infants after colostomy" 11/01/2007 - "PURPOSE: The standard approach to males with high imperforate anus has been a staged procedure starting with a descending colostomy, then posterior sagittal anorectoplasty with colostomy closure after 3 months" 03/01/2007 - "A colostomy for the imperforate anus had been performed 36 hours after his birth and was planned for subsequent posterior sagittal anorectalplasty to reestablish continuity" Order ALL the reference details at left...
3.	Cecostomy 03/01/2002 - "Therapeutic cecostomy tubes in infants with imperforate anus and caudal agenesis." 01/01/2006 - "The purpose of this study is to report our 4-year experience with the cecostomy procedure in 31 children with functional constipation (n = 9), Hirschsprung's disease (n = 2), imperforate anus (n = 5), spinal abnormalities (n = 8), and imperforate anus in combination with tethered spinal cord (n = 7)" Order ALL the reference details at left...
4.	Enema (Enemas) 10/01/1993 - "A teenage boy with repaired high imperforate anus relied on daily enemas for social continence" 04/01/1996 - "Materials and Methods: Since December 1992, 18 antegrade colonic enema procedures were performed in 12 female and 6 male patients 5 to 31 years old of whom 14 had spina bifida, 2 had imperforate anus and 2 had spinal cord injury" 12/01/2007 - "Malone antegrade continence enema (MACE) for fecal incontinence in imperforate anus improves quality of life." 07/01/1958 - "Unlike Hirschsprung's disease, symptoms do not appear at birth, encopresis is common, and the barium enema shows no narrow distal segment.2. Mental retardation and cerebral defect.3. Corrected imperforate anus-on the basis of stenosis, imperfect innervation or poor habit training.4. Cretinism-with severe constipation and intestinal dilatation perhaps the presenting symptoms" Order ALL the reference details at left...
5.	Transplants (Transplant) 11/01/1985 - "Based on these clinical, manometric, and histologic results, smooth-muscle transposition (tunnel graft) can be recommended to improve continence in infants as a non-time-consuming modification of the well-established Rehbein-Romualdi-Kiesewetter pull-through procedure in the high imperforate anus" 01/01/1979 - "Incontinence after repair of imperforate anus : treatment by a free muscle transplant (author's transl)]" 03/01/1976 - "Following several unsuccessful postnatal attempts at anoplasty to correct anal atresia with a rectovaginal fistula, the patient, 20 years later, underwent an anorectal sphincteric construction using a gracilis-muscle transplant" Order ALL the reference details at left...

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