Antitussive Agents (Antitussives)

Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally.

Also Known As:

Antitussives; Antitussive Drugs; Cough Suppressants; Agent, Antitussive; Agents, Antitussive; Drug, Antitussive; Drugs, Antitussive; Suppressant, Cough; Suppressants, Cough; Antitussive; Antitussive Agent; Antitussive Drug; Cough Suppressant

Networked: 905 relevant articles (83 outcomes, 130 trials/studies)

Relationship Network

Drug Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Therapeutic Uses: 47080
    - Respiratory System Agents: 148
      - Antitussive Agents: 905
    - Central Nervous System Agents: 51
      - Antitussive Agents: 905

Experts

1.	Dicpinigaitis, Peter V: 18 articles (01/2022 - 06/2002)
2.	Birring, Surinder S: 11 articles (01/2020 - 04/2009)
3.	Takahama, Kazuo: 11 articles (01/2019 - 06/2006)
4.	Bolser, Donald C: 10 articles (01/2021 - 01/2002)
5.	Lanata, Luigi: 10 articles (01/2019 - 10/2011)
6.	Canning, Brendan J: 9 articles (01/2022 - 01/2008)
7.	Shirasaki, Tetsuya: 9 articles (01/2019 - 07/2007)
8.	Zanasi, Alessandro: 9 articles (01/2019 - 04/2002)
9.	Chung, K F: 9 articles (06/2011 - 01/2002)
10.	Chung, Kian Fan: 8 articles (08/2020 - 01/2008)

Related Diseases

1.	Cough 04/01/1977 - "The antitussive effect appears clinically useful for the treatment of cough, but further studies are indicated to define optimal dosage schedules." 06/01/2006 - "Like other over the counter antitussives, SO did not result in marked improvement in cough symptoms." 01/24/2022 - "NRG-NSps improved the antitussive effect significantly compared with the original NRG, the cough frequency was decreased from 22 to 15 times, and the cough incubation period was prolonged from 85.3 to 121.6 s. " 10/01/2012 - "Unfortunately, therapeutic options for acute cough in children are severely limited due to the absence of drugs shown to be effective antitussives with an acceptable safety profile. " 09/01/1992 - "The device may be useful in the study into the efficacy of new antitussive drugs and the assessment of cough clearance. "
2.	Chronic Cough 06/01/2008 - "[Lower airway nervous system as a putative target of antitussive drugs effective for treatment of chronic cough]." 12/01/2023 - "Improved understanding of CANVAS may lead to an enhanced grasp of the pathophysiology of chronic cough, and new approaches to antitussive treatments." 01/01/2023 - "Antitussive efficacy of the current treatment protocol for refractory chronic cough: our real-world experience in a retrospective cohort study." 01/01/2020 - "P2X3-Receptor Antagonists as Potential Antitussives: Summary of Current Clinical Trials in Chronic Cough." 11/09/2023 - "This retrospective observational cohort study considered chronic cough patients aged 18 years and older who were consistently prescribed antitussive agents for more than 2 months between 1 January 2017 and 30 June 2019. "
3.	Cough-Variant Asthma 09/01/2019 - "This study aimed to detect an effective therapeutic approach for cough variant asthma (CVA) through evaluating the relaxant effect of these two bioactive herbal monomers as antitussive and antiasthmatic on rat tracheal smooth muscle. " 02/10/2016 - "Suhuang antitussive capsule (Suhuang), a traditional Chinese medication, is found effective in treating chronic cough and cough variant asthma (CVA). " 10/10/2022 - "Whether cysteinyl-leukotriene receptor antagonists (LTRAs) have a similar antitussive effect to inhaled corticosteroids and long-acting β2-agonist (ICS/LABA), and that LTRA plus ICS/LABA is superior to LTRAs alone or ICS/LABA alone in treating cough variant asthma (CVA) remain unclear. " 05/10/2023 - "β-Hydroxybutyric acid upregulated by Suhuang antitussive capsule ameliorates cough variant asthma through GSK3β/AMPK-Nrf2 signal axis." 10/01/2019 - "Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma."
4.	Respiratory Tract Infections (Respiratory Tract Infection) 12/01/2015 - "Antitussive effect of a fixed combination of Justicia adhatoda, Echinacea purpurea and Eleutherococcus senticosus extracts in patients with acute upper respiratory tract infection: A comparative, randomized, double-blind, placebo-controlled study." 06/01/2001 - "A significant proportion of patients reported upper respiratory tract infection or the use of antitussive medication prior to attacks." 06/01/2001 - "Seventeen (23.6%) patients were noted to have an upper respiratory tract infection before the attack, and 25 (34.7%) patients had taken antitussive agents. " 09/01/1989 - "Sometimes, antitussives can be a valid adjuvant to respiratory tract infections treatment. " 02/01/1965 - "[CLINICAL EVALUATION OF AN ANTITUSSIVE DRUG IN CHILDREN WITH RESPIRATORY TRACT INFECTIONS]."
5.	Inflammation (Inflammations) 01/01/2023 - "The mechanism of antitussive activity may be associated with reducing airway inflammation. " 05/10/2020 - "Eriobotrya japonica leaves has a very long history of medicinal use as an anti-inflammatory and antitussive agent for bronchial inflammation. " 10/28/2018 - "carnosus are widely used in Portugal for the treatment of inflammatory-related conditions, such as inflammation of the respiratory tract, being the later also used as an antitussive. " 01/01/2018 - "The results demonstrated that Kangzhi syrup exerted a considerable antitussive effect in CVA animal model, which depended on its marked impact on the anti-anaphylactic inflammation. " 07/28/2006 - "Other factors that may be very important in the action of central antitussive drugs in humans include the role of sensations produced by a tussigenic stimulus as well as plasticity of central pathways in response to airway inflammation. "

Related Drugs and Biologics

1.	Dextromethorphan (Racemethorphan)
2.	Codeine (Codeine Phosphate)
3.	Antitussive Agents (Antitussives)
4.	Expectorants (Mucolytics)
5.	Opioid Analgesics (Opioids)
6.	Capsules (Microcapsules)
7.	Guaifenesin
8.	Anti-Bacterial Agents (Antibiotics)
9.	Citric Acid (Citrate)
10.	dipropizine (dropropizine)

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Kampo Medicine (Kampo)
4.	Nutritional Support (Artificial Feeding)
5.	Traditional Medicine (Folk Remedies)