Antisickling Agents

02/01/2001 - "In spite of the full understanding of the pathology, physiology, and the molecular nature of the disease, and the development of large number of antisickling agents, a cure for sickle cell anemia still is unavailable. "
07/12/2023 - "These results reveal the potential role for both red and white flower extracts as possible antisickling agents in sickle cell anemia management."
02/01/2001 - "Sickle cell anemia and antisickling agents then and now."
09/01/1982 - "The lack of effective therapy of sickle cell anemia has prompted investigation of a large number of antisickling agents. "
01/01/2023 - "X-ray crystallography and structure-based drug discovery have played a major role in the discovery of antisickling agents that target hemoglobin (Hb) for the treatment of sickle cell disease (SCD). "

01/01/2020 - "These include the isolation, structure determination, and biological mechanism of action of many natural products including the triterpenoid pristimerin; the diterpenoid ginkgolides; insect and crustacean molting hormones; phytoalexins; the toxic red tide principle brevetoxin; the vanadium tunicate pigments; philanthotoxin from killer wasps; antisickling agents; mitomycin DNA adducts; insect antifeedants; a mitotic hormone, the small molecule fish attractants from the sea anemone; new isolation and purification technologies; molecular chemistry of vision; age-related macular degeneration; and the development of the exciton circular dichroism (CD) chirality method for microscale determination of absolute configuration of natural products and chirality of other chiral molecules and supramolecular assembly."

05/01/1984 - "New approaches to treatment - including induced hyponatremia, membrane-active antisickling agents, and gene manipulation - are described."