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alpha-2-Antiplasmin (alpha 2 Antiplasmin)

A member of the serpin superfamily found in plasma that inhibits the lysis of fibrin clots which are induced by plasminogen activator. It is a glycoprotein, molecular weight approximately 70,000 that migrates in the alpha 2 region in immunoelectrophoresis. It is the principal plasmin inactivator in blood, rapidly forming a very stable complex with plasmin.
Also Known As:
alpha 2 Antiplasmin; Serpin F2; alpha(2)-Plasmin Inhibitor; alpha-2 Antiplasmin; alpha 2 Plasmin Inhibitor; alpha 2-Plasmin Inhibitor
Networked: 155 relevant articles (3 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Visseren, Frank L J: 3 articles (10/2014 - 10/2013)
2. de Kleijn, Dominique P V: 3 articles (10/2014 - 10/2013)
3. Pasterkamp, Gerard: 3 articles (10/2014 - 10/2013)
4. Uiterwaal, Cuno S P M: 3 articles (10/2014 - 10/2013)
5. Uitte de Willige, Shirley: 2 articles (01/2015 - 06/2011)
6. Schoneveld, Arjan H: 2 articles (10/2014 - 10/2013)
7. Philippou, Helen: 2 articles (09/2014 - 06/2011)
8. Kanhai, Danny A: 2 articles (01/2014 - 10/2013)
9. SMART Study Group: 2 articles (01/2014 - 10/2013)
10. van der Graaf, Yolanda: 2 articles (01/2014 - 10/2013)

Related Diseases

1. Toxemia
2. Hemorrhage
3. Ganglion Cysts (Ganglion)
4. Sepsis (Septicemia)
06/01/1997 - "To investigate prospectively whether plasma levels of plasminogen or the ratio of plasminogen to alpha-2-antiplasmin have a prognostic value for survival from sepsis and to study the variation of other hemostatic parameters during septicemia. "
05/01/1991 - "Increased plasminogen activator inhibitor-1 (PAI-1) antigen levels in plasma from patients with septicemia decreased the ratio of the plasma clot lysis rate induced by an anti-alpha 2-plasmin inhibitor monoclonal antibody to the tissue-type plasminogen activator (t-PA) concentration. "
01/01/1992 - "To estimate the degree of coagulopathy in abdominal sepsis, we measured the plasma levels of prothrombin fragment 1 + 2 (F1 + 2), thrombin-antithrombin III complex (TAT) and plasmin-alpha 2-plasmin inhibitor complex (PIC) by the enzyme-linked immunosorbent assay in 38 patients with disseminated intravascular coagulation (DIC). "
01/15/1990 - "Patients defined as having fulminant septicemia (n = 13) with high (greater than 700 ng/L) levels of endotoxin (LPS) in plasma and severe coagulopathy, had significantly lower functional levels of plasminogen (P less than 0.05) and alpha-2-antiplasmin (P less than 0.01) and higher antigen levels of plasminogen activator inhibitor 1 (PAI-1) (P less than 0.01), and fibrin degradation products (FDP) (P less than 0.01), but not of PAI-2 (P greater than 0.1) as compared with less severely ill patients (meningitis and meningococcemia) (n = 25). "
02/01/2000 - "Standard coagulation data and molecular markers of coagulation activation and fibrinolytic activity (soluble thrombomodulin, protein C, free protein S, thrombin/antithrombin III complex, plasmin-alpha 2-antiplasmin complex, tissue plasminogen activator, platelet factor 4, beta-thromboglobulin were measured from arterial blood samples on the day of admission to the intensive care unit (trauma/neurosurgery patients) or on the day of diagnosis of sepsis (baseline value) and serially during the next 5 days. "
5. Nephrotic Syndrome (Syndrome, Nephrotic)

Related Drugs and Biologics

1. Fibrinolysin
2. Dacarbazine (DIC)
3. Antifibrinolytic Agents (Antifibrinolytics)
4. fibrin fragment D (D-dimer)
5. formycin diphosphate (FDP)
6. antithrombin III-protease complex
7. Antithrombin III
8. Plasminogen
9. Protein C
10. Thrombin

Related Therapies and Procedures

1. Intravitreal Injections
2. Ligation
3. Thrombolytic Therapy
4. Drug Therapy (Chemotherapy)
5. Transplants (Transplant)