Histocompatibility Antigens Class II

Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Also Known As:
Class II Antigen; Class II Histocompatibility Antigens; Class II Major Histocompatibility Antigens; I-A Antigen; I-A-Antigen; IA Antigen; Antigen, Class II; Antigen, I-A; Antigen, IA; Antigens, Class II; Antigens, Ia; Antigens, Ia-Like; Antigens, Immune-Associated; Antigens, Immune-Response-Associated; I A Antigen; Ia Like Antigens; Immune Associated Antigens; Immune Response Associated Antigens; Antigens, Immune Response; Class II Antigens; Ia Antigens; Ia-Like Antigens; Immune Response Antigens; Immune-Associated Antigens; Immune-Response-Associated Antigens
Networked: 1508 relevant articles (19 outcomes, 111 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Ferrone, Soldano: 5 articles (03/2015 - 12/2005)
2. Haque, Azizul: 5 articles (07/2014 - 02/2008)
3. Krishnakumar, Subramanian: 5 articles (03/2004 - 08/2003)
4. Abhyankar, Dhiraj: 5 articles (03/2004 - 08/2003)
5. Biswas, Jyotirmay: 5 articles (03/2004 - 08/2003)
6. van Luijn, Marvin M: 4 articles (06/2015 - 03/2010)
7. Amria, Shereen: 3 articles (07/2014 - 02/2008)
8. van de Loosdrecht, Arjan A: 3 articles (04/2011 - 03/2010)
9. Chamuleau, Martine E D: 3 articles (04/2011 - 03/2010)
10. Ossenkoppele, Gert J: 3 articles (04/2011 - 03/2010)

Related Diseases

1. Infection
12/14/2005 - "Human leukocyte antigen class II DQB1*0301, DRB1*1101 alleles and spontaneous clearance of hepatitis C virus infection: a meta-analysis."
08/01/1998 - "Protection against ascending infection of the genital tract by Chlamydia trachomatis is associated with recruitment of major histocompatibility complex class II antigen-presenting cells into uterine tissue."
06/30/1997 - "Finally, increased expression of both, class I and class II major histocompatibility antigens was also observed in MVV-infected PAM on days 5 and 7, whereas SCPC only demonstrated upregulation of MHC class I. These results, indicative of an alteration of some cell functions in MVV-infected cells, may help to understand interactions between MVV-infected cells and bacteria in simultaneous infections and may provide clues to the possible in vivo interactions of both pathogens."
01/01/1989 - "Kinetic studies indicated that MHC class II antigen expression continues to increase three days after infection. "
12/01/1986 - "Since several reviews on the immunologic aspects in the OS model have been published in recent years we have in this communication attempted to discuss the - mostly still rudimentary - findings concerning the target organ itself, including morphological changes before the beginning of infiltration, the analysis of Tg, the altered thyroid function before onset of SAT, the results of cross-breeding studies of OS and inbred normal chickens in respect to the susceptibility of the offspring for the transfer of SAT, the possible role of a virus infection and the aberrant expression of MHC class II antigens on TEC. "
2. Neoplasms (Cancer)
3. Melanoma (Melanoma, Malignant)
4. Leukemia
5. Inflammation

Related Drugs and Biologics

1. Antigens
2. HLA-DR Antigens (HLA-DR)
3. HLA-DQ Antigens (HLA-DQ)
4. DNA (Deoxyribonucleic Acid)
5. Isoantigens (Alloantigen)
6. I-antigen
7. Proteins (Proteins, Gene)
8. HLA-DP Antigens (HLA-DP)
9. HLA-DR8
10. N-Acetylneuraminic Acid (Sialic Acid)

Related Therapies and Procedures

1. Immunotherapy
2. Homologous Transplantation (Allograft)
3. Ligation
4. Transplants (Transplant)
5. Transplantation (Transplant Recipients)