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Non-Steroidal Anti-Inflammatory Agents (NSAIDs)

Anti-inflammatory agents that are not steroids. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They are used primarily in the treatment of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. Certain NSAIDs also may inhibit lipoxygenase enzymes or TYPE C PHOSPHOLIPASES or may modulate T-cell function. (AMA Drug Evaluations Annual, 1994, p 1814-5)
Also Known As:
NSAIDs; Anti-Inflammatory Agents, Non-Steroidal; Anti Inflammatory Agents, Nonsteroidal; Antiinflammatory Agents, Non Steroidal; Antiinflammatory Agents, Nonsteroidal; Antirheumatic Agents, Non-Steroidal; Nonsteroidal Anti-Inflammatory Agents; Agents, Aspirin-Like; Agents, Non-Steroidal Anti-Inflammatory; Agents, Non-Steroidal Anti-Rheumatic; Agents, Non-Steroidal Antirheumatic; Agents, Nonsteroidal Anti-Inflammatory; Agents, Nonsteroidal Antiinflammatory; Analgesics, Anti Inflammatory; Anti Inflammatory Agents, Non Steroidal; Anti Rheumatic Agents, Non Steroidal; Anti-Inflammatory Agents, Nonsteroidal; Anti-Inflammatory Analgesics; Antirheumatic Agents, Non Steroidal; Aspirin Like Agents; Non Steroidal Anti Inflammatory Agents; Non-Steroidal Anti-Rheumatic Agents; Non-Steroidal Antirheumatic Agents; Nonsteroidal Anti Inflammatory Agents; Nonsteroidal Antiinflammatory Agents; Analgesics, Anti-Inflammatory; Anti-Rheumatic Agents, Non-Steroidal; Aspirin-Like Agents
Networked: 8202 relevant articles (752 outcomes, 1294 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Lanas, Angel: 30 articles (07/2015 - 02/2003)
2. Rigas, Basil: 20 articles (05/2015 - 01/2002)
3. Potter, John D: 19 articles (04/2015 - 05/2004)
4. Hawkey, C J: 19 articles (04/2007 - 02/2000)
5. Lanas, A: 18 articles (05/2015 - 02/2000)
6. Moore, R Andrew: 16 articles (01/2015 - 05/2004)
7. Derry, Sheena: 16 articles (01/2015 - 05/2004)
8. Friis, Søren: 15 articles (09/2015 - 02/2003)
9. Slattery, Martha L: 15 articles (03/2015 - 01/2004)
10. Moore, Nicholas: 15 articles (01/2015 - 01/2003)

Related Diseases

1. Pain (Aches)
2. Inflammation
3. Osteoarthritis
4. Neoplasms (Cancer)
5. Rheumatoid Arthritis

Related Drugs and Biologics

1. Aspirin (Acetylsalicylic Acid)
2. Acetaminophen (Paracetamol)
3. Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)
4. Opioid Analgesics (Opioids)
5. Analgesics (Analgesic Drugs)
6. celecoxib (Celebrex)
7. Ibuprofen (Motrin)
8. Adrenal Cortex Hormones (Corticosteroids)
9. Naproxen (Naprosyn)
10. Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)

Related Therapies and Procedures

1. Chemoprevention
2. Injections
3. Analgesia
4. Drug Therapy (Chemotherapy)
5. Aftercare (After-Treatment)