|3.||Pulmonary Hypertension (Ayerza Syndrome)
|1.||Semenza, Gregg L: 132 articles (01/2016 - 01/2002)|
|2.||Harris, Adrian L: 131 articles (12/2015 - 02/2002)|
|3.||Ratcliffe, Peter J: 92 articles (12/2015 - 01/2002)|
|4.||Johnson, Randall S: 86 articles (01/2016 - 03/2002)|
|5.||Prabhakar, Nanduri R: 74 articles (09/2015 - 01/2002)|
|6.||Giaccia, Amato J: 74 articles (06/2015 - 01/2002)|
|7.||Simon, M Celeste: 71 articles (07/2015 - 04/2002)|
|8.||Schofield, Christopher J: 69 articles (08/2015 - 06/2002)|
|9.||Harris, A L: 68 articles (10/2015 - 01/2000)|
|10.||Gassmann, Max: 66 articles (12/2015 - 01/2002)|
07/01/2014 - "Most elk became hypoxemic regardless of BAM dosage, but hypoxemia tended to be most severe in the high-BAM group; regardless of BAM dosage, oxygen supplementation improved the percentage of oxygen saturation and stabilized the vital rates. "
01/01/2013 - "After cold acclimation, susceptibility to hypoxia was not significantly different between the groups, while HCVR significantly increased in Groups 1 and 3, HVR significantly increased in Group 3 and HCVR, HVR did not change in Group 2. Short-term cold exposures caused an increase in functional reserves and improved oxygen supply of tissues in Group 1. Cold exposure hypoxia has caused energy loss in Group 3. Group 2 showed the most appropriate energy conservation reaction mode to cold exposures. "
11/01/2009 - "We found that (1) in contrast to oxygen partial pressure in blood (P(a)O(2)), the baseline value of P(t)O(2) in summer euthermic AGS is significantly higher than in rats; (2) both P(t)O(2) and P(a)O(2) are dramatically reduced by inspired 8% O(2) in AGS and rats, but AGS have a greater capacity in P(t)O(2) to cope with environmental hypoxia; (3) metabolic rate before, during, and after hypoxic exposure is consistently lower in AGS than in rats; (4) the respiratory responding patterns to hypoxia in the two species differ in that f(R) decreases in AGS but increases in rats. "
09/13/2004 - "Acute hypoxia reduced the median oxygen partial pressure (pO(2)) dramatically (1 vs 10 mmHg in controls), whereas in chronically hypoxic tumours the pO(2) was significantly improved (median pO(2)=4 mmHg), however not reaching the control level. "
07/04/1977 - "Portacaval transposition and end-to-side shunt led to a striking oxygen deficit of the liver tissue with no incidence of compensation by the hepatic artery; Oxygen supply was improved considerably by a side-to-side shunt and tissue hypoxia could be prevented by a mesenterico-caval shunt and splenocaval shunt. "
|2.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/17/2006 - "Levels of VEGF and of hypoxia-inducible factor 1alpha, elevated in the human MECs under hypoxia, were dramatically reduced or even suppressed in the presence of the ITPP-loaded RBCs. "
09/20/2012 - "In addition, to explore whether VEGF secreted by HIF-1α-AA-modified BMSCs plays an important role in preventing hypoxia-induced apoptosis and the possible mechanism involved, exogenous VEGF were applied and the similar protective effects on PC12 cells were observed in vitro. "
04/01/2011 - "On the one hand, neoangiogenesis driven by VEGF, if intact, ameliorates hypoxia, on the other, VEGF is a potent pro-inflammatory mediator and neoangiogenesis, if defective because interference by other pathologies exaggerates injury. "
07/01/2010 - "The mechanism seems to involve in inhibiting hypoxia-mediated activation of p-ERK1/2, it leads to a marked decrease in hypoxia-induced HIF-1alpha protein accumulation and VEGF secretion. "
06/01/2010 - "Combination treatment resulted in a marked inhibition of HIF-1 alpha expression levels in hypoxic cells and caused a significant reduction in the expression of activated phosphorylated AKT, ERK1/2, p-BAD and VEGF in both normoxia and hypoxia with greater levels of inhibition in hypoxia. "
|3.||Adenosine Triphosphate (ATP)IBA
01/01/2011 - "We then confirmed the presence of autophagy under hypoxic conditions and demonstrated that the inhibition of this catabolic process dramatically reduced the ATP levels in hypoxic cells and stimulated hypoxia-induced cell death. "
12/01/1985 - "Decreasing the extracellular Ca to 2.5 microM decreased LDH release significantly during anoxia, suggesting that plasma membrane damage during anoxia may be associated with increased intracellular free Ca. Addition of Mg-adenosine triphosphate during anoxia dramatically improved recovery of all the measured parameters after the anoxic period."
03/01/2006 - "Anoxia triggered a marked decrease of metabolic activity (measured by microcalorimetry) and of ATP levels in both species. "
01/20/1992 - "This enhancement should provide more ATP for energy-requiring ion transport processes, and lead (1) to a delayed onset of complete depolarization of CA1 pyramidal cells during anoxia (anoxic depolarization) and (2) to greater ion transport activity following anoxia. "
11/01/1990 - "Acute hypoxia, which leads to a decrease in cellular ATP levels, was responsible for a marked decrease in myocardial performance, while R1 increased (+66 +/- 8%, P less than 0.05) and R2 decreased (-14 +/- 1%, P less than 0.05). "
|4.||Glucose (Dextrose)FDA LinkGeneric
06/01/1983 - "After perfusion with glucose-free Tyrode solution for longer periods (greater than 2 hr), hypoxia and CN- caused a greater decrease in developed tension and a marked decrease in the magnitude of the Ca transient. "
01/01/2015 - "Thus, a short-time exposure to moderate hypobaric hypoxia may be beneficial for people with impaired glucose tolerance. "
10/01/1990 - "These findings indicate that enhanced utilization of exogenous glucose improved cardiac function during hypoxia without increasing total glycolytic flux or tissue high-energy phosphate levels, suggesting a novel cardioprotective mechanism."
11/01/1984 - "During hypoxia with glucose present, tension fell less rapidly than during hypoxia without glucose despite a significantly greater fall in pHo in the former case. "
06/01/1987 - "At higher glucose concentrations (22 mM), both 18-mo-old WKY and SHR demonstrated improved tolerance to hypoxia; moreover, the differences between strains were no longer evident. "
01/01/2012 - "These patients have a characteristic lung function profile, with unexpected subnormal dynamic and static lung volumes, contrasting with a significant reduction of carbon monoxide transfer (DL(co)) and exercise hypoxemia. "
12/01/2010 - "These patients have a characteristic lung function profile, with dynamic and static lung volumes apparently normal or minimally altered, contrasting with a significant reduction of carbon monoxide transfer (DLco) and exercise hypoxemia. "
07/01/2004 - "Inheritance patterns showed potentiation effects of hypoxia on HCVS (i.e., CO(2) potentiation) unique to the B6C3F1/J offspring of B6 and C3 progenitors; i.e., the change in Ve from 3 to 8% CO(2) was significantly greater (P < 0.01) with hypoxia relative to normoxia in F1 mice. "
01/01/2002 - "The duration of the phrenic burst, the interval between bursts and the burst amplitude were not significantly different following equilibration with 21-6%O(2) at 5% CO(2) or with 0-9% CO(2) at 6% O(2), with the exception that the burst amplitude was significantly greater in hypercapnic-hypoxia (9% CO(2) at 6% O(2)). "
09/01/1999 - "After exposure to 6 h of hypoxia, endothelial cells co-incubated with platelets showed significantly greater neutrophil adherence (63.1 +/- 4.0%) and migration (78.2 +/- 6.7%) than endothelial cells alone (adhesion: 44.2 +/- 2.8%, migration: 57.9 +/- 4.9%). "
|6.||Nitric Oxide (Nitrogen Monoxide)FDA Link
01/01/2003 - "A less marked decrease in this vascular reaction in patients with AH who live in high-altitude areas may be due to additional production and/or release of nitric oxide in order to increase the vasodilator reserve in moderate hypoxia. "
12/01/2006 - "Inhaled nitric oxide does not appear to be cost effective when treating hypoxemia in medical patients with high-risk scores and irreversible disease."
05/01/2001 - "As severe hypoxemia, we immediately started inhaled nitric oxide (iNO) that improved significantly pulmonary gas exchange. "
01/01/2012 - "In the current study, we investigated whether early IPC could upregulate hypoxia inducible transcription factor-1α (HIF-1α) expression and could reduce endoplasmic reticulum (ER) stress after renal I/R and whether pharmacological inhibition of nitric oxide (NO) production would abolish these protective effects. "
05/01/2007 - "[Nitric oxide is involved in the protective effects of short-term adaptaion to hypoxia in the course of stress-induced disorders in Krushinsky-Molodkina rats]."
|7.||Messenger RNA (mRNA)IBA
08/06/2010 - "In hearts of both fetuses and adult offspring, hypoxia-induced methylation of SP1 sites was significantly greater in males than in females, and decreased PKCepsilon mRNA was seen only in males. "
08/01/2010 - "Knockdown of mutant BRAF(V600E) or both the wild type and the BRAF(V600E) by RNA interference induced a significant reduction of hypoxia-inducible factor-1alpha expression at mRNA and protein levels. "
10/15/1999 - "A significant reduction in the messenger RNA (mRNA) level of these genes was observed in response to hypoxia. "
06/01/2009 - "To gain mechanistic insight into the cardio-protective effects of apelin/APJ, cultured cardiomyocytes were treated with apelin (30 pmol/L), and those under hypoxia/re-oxygenation showed H/R-induced apoptosis and up-regulated apelin/APJ mRNA expression by 6-fold and 7-fold, respectively (both p<0.01). "
01/01/2015 - "MgIG reduced hypoxia-reoxygenation injury of liver cells, indicating that it improved hepatic cell activity, inhibited lipid peroxidation and inflammatory reactions, and decreased nuclear factor-kB mRNA expression. "
10/01/2002 - "This study indicates that following systemic hypoxia, adenosine levels in the NTS increase to a significantly greater extent than in the VLM. "
06/01/2010 - "CFA was significantly improved after adenosine treatment during hypothermic hypoxia compared to control (80.7+/-17.4% vs 40.5+/-10.7%, p<0.001). "
12/01/1995 - "Acute fetal hypoxemia in six fetuses to an arterial PO2 of 8.8 +/- 0.8 mmHg and an arterial O2 content (CaO2) of 1.7 +/- 0.2 ml/dl was not associated with significant change in coronary perfusion pressure; yet left ventricular myocardial flow increased to 1,020 +/- 198 ml.min-1 x 100 g-1, a value significantly greater than that seen with adenosine (P < 0.05). "
12/01/1994 - "This leads to improved high energy phosphate concentrations during hypoxia and a reduction in adenosine formation."
02/01/1990 - "As with hypoxia, adenosine decreased the incidence of rapid eye movements by 55% and the incidence of breathing by 77% without significantly affecting the incidence of low-voltage electrocortical activity. "
06/01/2005 - "However, it is important that these findings be extended into contractile models of hypoxia/reoxygenation injury to further test the notion that pmKATP channel activation affords protection against contractile dysfunction and calcium overload. "
04/18/2003 - "The SM-induced reduction of changes in contraction and intracellular calcium induced by anoxia/reoxygenation indicates that SM may be beneficial for cardiac tissue in recovery of mechanical function and intracellular calcium homeostasis."
01/01/2013 - "This study explores the biological functions of ERK pathway in cardiomyocytes hypoxia/reoxygenation injury and clarifies the mechanisms by which F2 ameliorates cardiomyocytes hypoxia/reoxygenation injury through the extracellular-calcium-dependent and -independent ERK1/2-related pathways. "
05/01/2004 - "Protection against hypoxia-induced blood-brain barrier disruption: changes in intracellular calcium."
01/01/1998 - "Reductions of extracellular calcium concentration from 1.6 to 0.8 mM eliminated all age-dependent differences in relaxation responses to hypoxia. "
|10.||Lactic AcidFDA LinkGeneric
03/01/1990 - "These data suggest that, with time, neurons in vitro adapt to severe hypoxia and that alterations in pH, lactate, and bicarbonate by themselves are probably not neurotoxic since the most acidotic cultures exhibited improved survival."
05/01/2009 - "The finding that visual stimulation leads to significantly greater visual cortex lactate responses in panic patients is not predicted by the hypoxia model. "
03/01/1996 - "Whether this would be beneficial in patients with elevated lactate levels, indicating tissue hypoxia, remains to be determined. "
01/01/2010 - "Respiratory quotient and lactate at the anaerobic threshold as well as body composition improved more in the hypoxia group. "
04/01/2013 - "To identify the presence of a hypercoagulable state in sick newborns, the behavior of SFMC with special reference to those of other coagulation tests, and the relationships with other parameters of blood coagulation as well as lactate, which is considered to be the gold standard for assessing tissue hypoxia, were studied. "
01/01/2008 - "The modelling performed in this project has shown that the postulated radiobiological differences between acute and chronic hypoxia have some important clinical implications which may help to understand the mechanism behind the current success rates of radiotherapy. "
02/01/2007 - "The findings of this study suggest that intermittent hypoxia might influence the efficacy of radiotherapy by more strongly affecting the growth and survival of vascular endothelial cells. "
12/15/2006 - "By contrast, prolonged hypoxia failed to exert protective effects and even seemed deleterious when combined with radiotherapy. "
09/01/2012 - "Not only does the presence of hypoxia compromise the efficacy of locally-directed therapies, such as radiotherapy, but the proteomic and genomic changes activated by hypoxia can promote malignant progression and systemic dissemination. "
01/01/2012 - "A predictive 15-gene hypoxia classifier could identify patients associated with improved outcome after combining radiotherapy with hypoxic modification and underlines the relevance of such therapy. "
|2.||Drug Therapy (Chemotherapy)
02/01/2013 - "Hypoxia imaging is an important field in radiopharmaceutical research since hypoxic cells are very resistant to radiation treatment and diffusional limitations restrict the efficacy of chemotherapy. "
04/01/2005 - "Hypoxia-mediated cancer gene therapy strategies may represent a promising mean to significantly improve the efficacy of standard radiation therapy and chemotherapy approaches."
06/01/2001 - "These factors pose considerable challenges for the development of a successful hypoxia-directed gene therapy, but once this has been achieved, this type of therapy in combination with traditional radiation and chemotherapy should provide an improved clinical outcome for patients with these diseases."
04/01/2001 - "Hypoxia is known to directly or indirectly (e.g., via cell cycle effects) affect the therapeutic efficacy of sparsely ionizing radiation and some forms of chemotherapy. "
01/01/2012 - "We aimed to test the role of HBx and acute hypoxia in the efficacy of chemotherapy. "
|3.||Positive-Pressure Respiration (PEEP)
11/01/2003 - "The use of PEEP improved oxygenation such that one-half of patients after 6 h, and most after 24 h did not fulfill AECC hypoxemia criteria of ARDS. "
01/01/1975 - "Group III had least hypoxia which rapidly and markedly improved with PEEP. "
09/01/2013 - "Supportive therapies like surfactant replacement therapy and prone positioning can be beneficial in patients with ARDS in whom severe hypoxemia persists despite high levels of positive end-expiratory pressure (PEEP) and plateau pressures."
10/20/2009 - "High PEEP may help to prevent life-threatening hypoxemia in selected patients."
06/01/2003 - "Their age, sex, APACHE II score, PaO2/FiO2, Qs/Qt, use of artificial ventilation and its duration, level of PEEP, and the extent of relief from hypoxemia showed no significant differences between two groups (P>0.05). "
|4.||Artificial Respiration (Mechanical Ventilation)
05/01/2013 - "After 19 days of unsuccessful attempts to reverse the hypoxemia using conventional mechanical ventilation and HFOV, the patient responded dramatically to APRV, with rapid improvement in her PaO2 and sharp decline in her OI. "
06/01/2010 - "Although these interventions have been linked to physiologic improvement, including relief from severe hypoxemia, and some are associated with outcome benefits, such as shorter duration of mechanical ventilation, demonstration of survival benefit has been rare in clinical trials. "
05/15/2005 - "Hypoxia was relieved by BiPAP (Bi-level Positive Airway Pressure) or mechanical ventilation if necessary. "
02/01/2004 - "Hypoxia was improved gradually and on ICU day 7, she was weaned from mechanical ventilation, and extubated. "
01/01/1987 - "A second child, transplanted in remission of null-cell ALL, developed severe hypoxia and hypercarbia on day +11 but recovered fully following prolonged mechanical ventilation. "
09/01/2009 - "Post-resuscitation administration of NAC improved cardiac function and reduced oxidative stress in newborn pigs with hypoxia-reoxygenation insult. "
01/01/2009 - "Using a swine model of neonatal hypoxia-reoxygenation, we examined whether administration of NAC after resuscitation improved intestinal perfusion and reduced intestinal damage. "
09/01/2012 - "The aim of this study is to describe and evaluate an experimental model of neonatal normocapnic hypoxia and resuscitation. "
11/01/2011 - "With magnetic resonance imaging (MRI) and ultrasonography (US), this study aimed to quantify microvascular perfusion changes due to hypoxia and resuscitation, by comparing contrast-enhanced ultrasound (CEUS) to dynamic susceptibility contrast-enhanced (DSC)-MRI and diffusion-weighted MRI. "
09/20/2011 - "The present study focused on the serotonergic regulation of neonatal hypoxia and its resuscitation methods. "