Anodontia (Hypodontia)

Congenital absence of the teeth. It may involve all (total anodontia) or only some of the teeth (partial anodontia, hypodontia), or six or more of the teeth (oligodontia) and both the deciduous and the permanent dentition, or only teeth of the permanent dentition.

Also Known As:

Hypodontia; Hypodontia Oligodontia 1; Tooth Agenesis, Familial; Tooth Agenesis, Selective, 1; Agenesis, Familial Dental; Agenesis, Familial Tooth; Anodontia, Partial; Anodontia, Total; Familial Dental Ageneses; Familial Tooth Ageneses; Oligodontia 1, Hypodontia; Oligodontias; Partial Anodontias; Total Anodontias; Dental Agenesis, Familial; Familial Dental Agenesis; Familial Tooth Agenesis; Oligodontia; Partial Anodontia; Total Anodontia

Networked: 374 relevant articles (4 outcomes, 39 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Malocclusion (Crossbite)
2.	Anodontia (Hypodontia)
3.	Cleft Palate (Palate, Cleft)
4.	Ectodermal Dysplasia (Aplasia Cutis Congenita)
5.	Neoplasms (Cancer)

Experts

1.	Bernard, Geneviève: 6 articles (01/2021 - 11/2013)
2.	Bergendal, Birgitta: 6 articles (01/2019 - 05/2008)
3.	Raghoebar, Gerry M: 5 articles (09/2020 - 05/2005)
4.	Vissink, Arjan: 5 articles (09/2020 - 05/2005)
5.	Han, Dong: 4 articles (11/2020 - 07/2011)
6.	Bian, Zhuan: 4 articles (01/2016 - 01/2013)
7.	Zhu, Junxia: 3 articles (05/2022 - 05/2012)
8.	Stanford, Clark: 3 articles (11/2021 - 07/2013)
9.	Feng, Hailan: 3 articles (11/2020 - 07/2011)
10.	Anweigi, Lamyia: 3 articles (07/2020 - 08/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Anodontia:

1.	Dental Implants (Dental Implant)IBA 03/01/2016 - "This study evaluated the behavior over 36 months of AstraTech Osseospeed TX 3.0 S dental implants placed into narrow one-tooth defect edentulous ridges as a result of hypodontia. " 04/01/2015 - "Dental implant treatment in maturing adolescents with extensive oligodontia before is supported by the data of the present study. " 10/15/2019 - "Over a period of 15 years (2000-2015), a total of 43 patients were diagnosed with hypodontia and 165 dental implants were inserted. " 10/15/2019 - "In this retrospective study, we evaluated the functional and aesthetic results after dental implants in hypodontia patients, corroborated by Albrektsson implant success criteria. " 10/15/2019 - "Oral Rehabilitation of Hypodontia Patients Using an Endosseous Dental Implant: Functional and Aesthetic Results."
2.	Proteins (Proteins, Gene)FDA Link 01/01/2011 - "In addition, this study reveals the role of desmosomes in the development of teeth and suggests that other genes encoding proteins of the desmosome could be involved in oligo/hypodontia." 04/01/2009 - "Therefore, the identified 11-nucleotide deletion may decrease the expression level of the MSX1 protein, but the link with oligodontia needs further study." 01/01/2016 - "Based on a computerized protein structure analysis, we suggest that the change p.Arg289His in EDA impairs protein stabilization and thus might possibly be involved in the development of oligodontia concomitant with a mild ED phenotype." 03/01/2015 - "Axis inhibition protein 2 polymorphisms may be a risk factor for families with isolated oligodontia." 10/01/2012 - "A significant difference was observed, between subjects with non-syndromic hypodontia and controls, in the allele and genotype frequencies of two markers [rs929387 of GLI family zinc finger 3 (GLI3) and rs11001553 of Dickkopf-related protein 1 (DKK1)]. "
3.	Melanocyte-Stimulating Hormones (MSH)IBA 11/01/2016 - "In this study, we enrolled 16 individuals affected by tooth agenesis, prevalently hypodontia, and we carried out direct Sanger sequencing of paired box 9 (PAX9) and Msh homeobox 1 (MSX1) genes in 9 subjects. " 11/28/2014 - "We conducted a comprehensive meta-analysis of 4 case-control studies to explore the association between polymorphisms of Msh homeobox 1 (MSX1) and transforming growth factor-β1 (TGF-β1) genes and hypodontia. " 09/01/2014 - "Msh homeobox 1 (MSX1) was the first gene identified as causing non-syndromic oligodontia. " 01/01/2019 - "Study of rs12532, rs8670 Polymorphism of Msh Homeobox 1 (MSX1), rs61754301, rs4904155 Polymorphism of Paired Box Gene 9 (PAX9), and rs2240308 Polymorphism of Axis Inhibitor Protein 2 (AXIN2) Genes in Nonsyndromic Hypodontia." 03/01/2015 - "The objective of the present study was to search for Msh homeobox 1 (MSX1), paired box gene 9 (PAX9), ectodysplasin‑A (EDA) and axis inhibition protein 2 (AXIN2) variants in a family with isolated oligodontia and analyse the pathogenesis of mutations that result in oligodontia phenotypes. "
4.	DNA (Deoxyribonucleic Acid)IBA 12/01/2013 - "An additional 465 DNA samples (93 cases with hypodontia and 372 controls without family history for tooth agenesis or oral clefts) from Brazil were also available for this study. " 01/01/2005 - "In this study, the association between these DNA polymorphisms and hypodontia has been investigated. " 07/01/2023 - "We identified a novel frameshift variant of PAX9 (c.491-510delGCCCT-ATCACGGCGGCGGCC, p.P165Qfs*145) outside the DNA-binding domain causing an autosomal-dominant nonsyndromic oligodontia in a Chinese family. " 08/01/2021 - "These results indicated that OPN3 was involved in non-syndromic oligodontia, which has made an anchoring point for clinical application including DNA diagnostics." 10/01/2015 - "Our results identify LRP6 variants as contributing to the etiology of non-syndromic autosomal-dominant oligodontia and suggest that this gene is a candidate for screening in DNA diagnostics. "
5.	NucleotidesIBA 01/01/2018 - "In this study, a novel frameshift mutation, the twenty-nucleotide deletion (c.128_147del20, p.Met43Serfsx125), in exon1 of MSX1 was detected in a Chinese family causing autosomal dominant nonsyndromic oligodontia. " 11/01/2013 - "Given the crucial role of the Wnt signalling pathway during tooth development, the purpose of this study was to determine whether nucleotide variants of genes encoding components of this signalling pathway might be associated with hypodontia and oligodontia in the Polish population. " 09/01/2013 - "DNA sequencing of the MSX1 gene revealed two mutations in the two patients with oligodontia: a heterozygotic silent mutation, c.348C>T (P.Gly116=), in exon 1 and a homozygotic deletion of 11 nucleotides (c.469+56delins GCCGGGTGGGG) in the intron. "
6.	Interferon Regulatory FactorsIBA 12/01/2009 - "Studies of palatine rugae and interferon regulatory factor 6 variations in a group of families with sporadic hypodontia." 04/01/2008 - "The aim of this study was to characterize Swedish families with non-syndromic cleft lip and/or palate (NSCL/P) for mutations or other sequence variants in the interferon regulatory factor 6 (IRF6) gene, as well as to describe their cleft phenotypes and hypodontia. "
7.	EctodysplasinsIBA 12/01/2010 - "Recent studies in a few families showed that mutations in the ectodysplasin A (EDA) gene result in X-linked nonsyndromic hypodontia. " 01/01/2021 - "Functional Analysis of Ectodysplasin-A Mutations in X-Linked Nonsyndromic Hypodontia and Possible Involvement of X-Chromosome Inactivation." 01/01/2019 - "Genetic variations in genes known to be associated with EDs that affect only one derivative of the ectoderm (attenuated phenotype) will be grouped as non-syndromic traits of the causative gene (e.g., non-syndromic hypodontia or missing teeth associated with pathogenic variants of EDA "ectodysplasin"). " 04/01/2014 - "Oligodontia and curly hair occur with ectodysplasin-a mutations." 12/01/2010 - "A novel missense mutation in the ectodysplasin-A (EDA) gene underlies X-linked recessive nonsyndromic hypodontia."
8.	TitaniumIBA 01/01/2006 - "Multipurpose titanium miniplates were placed on the lateral nasal wall of the maxilla as anchorage for face mask protraction in an 11-year-old girl presenting with severe maxillary hypoplasia and hypodontia. " 06/01/2005 - "Skeletal Class III oligodontia patient treated with titanium screw anchorage and orthognathic surgery." 06/01/2005 - "This article reports the successful treatment of a patient, aged 15 years 8 months, with a Class III malocclusion and oligodontia; a titanium screw was used for absolute anchorage during treatment. " 08/01/2011 - "On examination she presented with hypodontia, shortened roots, and the mandibular anteriors had a titanium trauma splint fixed to reduce the mobility. " 11/01/2002 - "The purposes of this study were to: 1) create baseline cephalometric norms for male children with ED; 2) assess craniofacial growth and development in hypohidrotic ED male children with severe hypodontia, compared with non-ED children with class I dental relationships; 3) compare the craniofacial morphology of titanium dental implant-treated ED males with non-implant-treated ED males; and 4) correlate the severity of hypodontia to craniofacial dysmorphology. "
9.	PAX9 Transcription FactorIBA 03/01/2011 - "Previous studies have indicated that mutations in the homeobox gene MSX1, paired domain transcription factor PAX9, and EDA are associated with non-syndromic oligodontia. " 09/01/2011 - "Mutations in the transcription factor PAX9 which plays a critical role in the switching of odontogenic potential from the epithelium to the mesenchyme during tooth development cause autosomal dominant non-syndromic hypodontia primarily affecting molars. " 07/01/2000 - "A frameshift mutation recently identified within the paired domain of the transcription factor, PAX9, has been linked to a unique form of oligodontia in a single, multigenerational family (Stockton et al., 2000). "
10.	Transcription Factors (Transcription Factor)IBA 12/01/2002 - "Coupling these new clinical findings with results from recent molecular studies, we suggest that transcription factors such as MSX1 and PAX9, which have been associated with agenesis of molars, might be involved in the genetic control of Mn.I2.C transposition and PDC, tooth malpositions connected here with the specific expression of posterior-field (M3) hypodontia." 08/01/2013 - "To investigate the mutation in transcription factor paired box gene PAX9 in a mongolian family with non-syndromic oligodontia. " 01/01/2009 - "At present, the list of genes involved in human non-syndromic hypodontia includes not only those encoding a signaling molecule (TGFA) and transcription factors (MSX1 and PAX9) that play critical roles during early craniofacial development, but also genes coding for a protein involved in canonical Wnt signaling (AXIN2), and a transmembrane receptor of fibroblast growth factors (FGFR1). "

Therapies and Procedures

1.	Overlay Denture 05/01/2016 - "This case report identifies a new way to utilize CAD CAM technology to produce an improved overdenture for the oligodontia patient. " 05/01/2016 - "A Digital Approach to Improved Overdentures for the Adolescent Oligodontia Patient." 05/01/2016 - "CAD-CAM manufacture of monolithic overdentures is a viable approach to completing high value esthetic management of the adolescent oligodontia patient. " 05/01/2016 - "The use of overdentures for treatment of oligodontia in adolescent patients using conventional techniques has described limitations. " 09/01/2014 - "Implant-retained overdentures for young children with severe oligodontia: a series of four cases."
2.	Partial Denture (Partial Dentures) 07/01/2003 - "This report describes the management of a 20-year-old man with hypodontia who wanted an improvement in his appearance and in his existing upper partial denture. " 01/01/2013 - "Aesthetic rehabilitation of oligodontia in primary dentition with adhesive partial denture." 01/01/2019 - "The treatment plan was agreed on a multidisciplinary hypodontia clinic and involved an upper sectional fixed orthodontic appliance to close a 7-mm midline diastema aiding subsequent partial denture provision. " 03/13/2023 - "Hypodontia and oligodontia were commonly managed by using either a partial denture or overdenture. "
3.	Osteotomy 04/01/2013 - "This paper presents the Sandwich Osteotomy Technique (interpositional rhBMP-2 and bone subtitute grafting) in a young female with congenital oligodontia. " 10/01/2022 - "Thus, posterior mandibular segmental split osteotomy can be considered an effective treatment for skeletal Class III malocclusion with posterior hypodontia."
4.	Implant-Supported Dental Prosthesis 11/01/2009 - "Rehabilitation with implant supported dental prostheses is a good treatment for oligodontia. "
5.	Orthodontics 03/01/2017 - "All patients with nonsyndromic oligodontia who had been treated at the study center (Department of Orthodontics, University of Giessen, Germany) over the period 1986-2013 were contacted. " 01/01/2001 - "Fifty-two patients met inclusion criteria into the comparison study in which the prevalence of hypodontia was compared with a group of patients from the Department of Orthodontics at Harvard School of Dental Medicine. " 10/01/2023 - "Severity of hypodontia varies and some cases can be managed by orthodontics alone. " 10/01/2023 - "This article aims to give an overview of the part orthodontics plays in the management of hypodontia cases. " 10/01/2023 - " Hypodontia patients referred to UDHM are triaged by consultants in orthodontics or restorative dentistry, and if MDT planning is required, they are booked onto the MHC. "