Anisomycin

05/29/2007 - "Anisomycin protects cortical neurons from prolonged hypoxia with differential regulation of p38 and ERK."
03/01/2007 - "Compared to wild-type cells, Atf-2(-/-) mouse embryonic fibroblasts (MEFs) were more resistant to hypoxia- and anisomycin-induced apoptosis but remained equally susceptible to other stresses, including UV. "
05/29/1992 - "Anisomycin and cycloheximide (100 micrograms/ml) offered, respectively, a 97 +/- 4% and 26 +/- 13% protection against anoxia-induced neuronal death."
09/01/2015 - "Anisomycin had no significant effect on Kv1.5 channel expression under hypoxia, but the expression of Kv1.5 was still significantly lower than the normal oxygen group. "
06/01/2007 - "It was also shown that the amount of Akt protein slightly decreased by either hypoxia or anisomycin treatment. "

01/01/2023 - "As a p38 agonist, anisomycin counteracted the effect of BMSCs-exo on HDF's viability, oxidative stress, and inflammation. "
01/01/2022 - "Treated cells with JNK specific activator anisomycin, the inflammation and apoptosis inhibited by Andr were counteracted. "
11/01/2020 - "Furthermore, Anisomycin treatment could enhance inflammation and inhibit angiogenesis. "
11/01/2021 - "These results suggest that anisomycin prevented acute inflammation by inhibiting NF-κB-related inflammatory gene expression and could be a potential therapeutic candidate for sepsis. "
08/26/2023 - "Anisomycin (a p38 MAPK activator) enhanced OA chondrocytes inflammation, promoted cell apoptosis, and reduced cell viability; however, this was reversed by SNHG7 overexpression. "

10/01/1989 - "It has recently been suggested that intraperitoneal (IP) injection of anisomycin (ANI) in the chick produces amnesia for a one-trial passive avoidance task in a state-dependent manner. "
01/01/2022 - "No post-retrieval amnesia by anisomycin and no altered GluA2 expression by reactivation was observed, suggesting that the memories did not undergo destabilization. "
05/28/2009 - "Interestingly, rats treated with anisomycin 6 and 12 h post-retrieval exhibited amnesia for the running skill. "
05/28/2009 - "Similarly, PSI impaired the post-retrieval reconsolidation of the rotarod-running skill: well-trained rats treated with anisomycin 0 h but not 0.5, 2 and 4 h after the task performance exhibited amnesia for the running skill later on. "
04/01/2009 - "Applying this paradigm, we demonstrate here that infusing anisomycin into the dorsal hippocampus induces amnesia by impairing memory storage, not retrieval."

07/15/2009 - "A low dose of anisomycin was also remarkably effective in treating established mammary tumor in the mice. "
10/01/2021 - "Recent studies emphasize anisomycin as a promising anti-cancer drug candidate. "
06/01/2013 - "The aim of this study was to explore the potential of anisomycin to treat tumors in vivo and its mechanism(s) of action. "
12/01/2021 - "Using AML xenograft mouse models, anisomycin exhibited inhibitory effect on tumor growth throughout the whole duration without causing toxicity in mice. "
09/01/2021 - "Recently, the potent anti-tumor effects of anisomycin have received much attention. "

06/01/2022 - "Subsequently, we employed LPS to induce alveolar type ii epithelial cells and observed that Ov-GPR43 infection markedly reduced the expression levels of inflammatory factors and apoptosis levels, while exposure of cells to anisomycin was also effective in blunting the effects of Ov-GPR43 on these processes. "
01/01/2023 - "Similar to the effect of CVB3 infection, EEF1A1 transcription was increased in response to anisomycin treatment. "
12/01/1991 - "Two of the three UL36-38 IE transcripts were largely unaffected by anisomycin and were expressed abundantly throughout infection, but a third, multiply spliced UL36-38 IE transcript was abundant only during infection in the presence of anisomycin. "
01/01/2023 - "Here we observed that anisomycin showed potent inhibition on CVB type 3 (CVB3) infection with negligible cytotoxicity when applied at the early stage of virus infection. "
04/01/1983 - "These studies have been extended in the present report, which shows that early viral proteins can be detected in Ad5 dl312- and Ad5 hr-1-infected HeLa cells which have been treated for several hours with anisomycin either shortly after infection or before infection. "