Angiotensinogen

An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver in response to lowered blood pressure and secreted into blood circulation. Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME) yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN SYSTEM.

Also Known As:

Proangiotensin; Renin Substrate Tetradecapeptide; Serpin A8; Renin Substrate; Tetradecapeptide, Renin Substrate; Hypertensinogen; Renin-Substrate; SERPINA8; Angiotensinogen (protein renin substrate)

Networked: 1828 relevant articles (18 outcomes, 318 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Serpins: 906
    - Angiotensinogen: 1828
  - Protein Precursors: 37
    - Angiotensinogen: 1828
- Peptides: 82426
  - Serpins: 906
    - Angiotensinogen: 1828
  - Oligopeptides: 519
    - Angiotensins: 6068
      - Angiotensinogen: 1828
        H 142: 3
        H 189: 2
        human AGT protein: 1
        human angiotensin-(1-12): 1
        angiotensinogen (1-14)
        angiotensinogen (6-13)
        mouse Agt protein
        rat Agt protein
        rat proangiotensin-12

Experts

1.	Kobori, Hiroyuki: 57 articles (01/2021 - 03/2001)
2.	Navar, L Gabriel: 26 articles (01/2021 - 03/2001)
3.	Nishiyama, Akira: 23 articles (01/2021 - 01/2003)
4.	Ohashi, Naro: 22 articles (07/2021 - 05/2007)
5.	Urushihara, Maki: 21 articles (01/2020 - 08/2008)
6.	Satou, Ryousuke: 16 articles (01/2020 - 06/2007)
7.	Ingelfinger, Julie R: 14 articles (01/2021 - 12/2002)
8.	Sigmund, Curt D: 14 articles (12/2017 - 02/2002)
9.	Katsurada, Akemi: 13 articles (01/2020 - 06/2007)
10.	Bader, Michael: 12 articles (01/2020 - 02/2002)

Related Diseases

1.	Hypertension (High Blood Pressure) 06/01/1997 - "Covariate analysis revealed an independent relationship between the M235T genotype and systolic, diastolic, and mean ambulatory BP. Ambulatory monitoring improved the analytic power of our study and allowed detection of a clear and consistent relationship between angiotensinogen polymorphism and hypertension with a relatively small sample size." 01/01/2021 - "The study aim was to analyse the frequency of polymorphic variants of angiotensinogen gene polymorphism (AGT 704T>C, rs699) in essential arterial hypertension (EAH) patients. " 01/01/2013 - "Recent studies using experimental animal models have documented the involvement of angiotensinogen in the intrarenal renin-angiotensin system activation and development of hypertension. " 04/01/2012 - "Previous studies on the effects of angiotensinogen (AGT) gene polymorphisms and chronic exposure to occupational noise on the risk of hypertension have mainly been cross-sectional or prevalent case-control studies, where temporality constitutes problems. " 08/01/2011 - "The main aim of this study was to investigate the possible influence of angiotensinogen M268T polymorphisms on hypertension in two endogamous caste populations of South India. "
2.	Essential Hypertension 12/01/2015 - "The aim of this study was to investigate the contribution of the polymorphisms localized in the angiotensinogen (AGT) gene, a main component of the renin-angiotensin-aldosterone system, in inducing the susceptibility to essential hypertension (EH) among isolated populations (Yi and Hani minorities) with low prevalence rate from the remote region of Yunnan in China. " 10/21/2015 - "The A-20C polymorphism in the angiotensinogen (AGT) gene has been associated with increased risk of essential hypertension in several studies; however, these studies gave inconsistent results. " 05/25/2015 - "Numerous studies have evaluated the association between the angiotensinogen (AGT) G-217A gene polymorphism and essential hypertension risk. " 04/01/2012 - "The aim of this study was to analyze the relationship between angiotensinogen gene polymorphisms and haplotypes with plasma angiotensinogen levels and the risk of essential hypertension in the Mexican population. " 05/01/2005 - "2. The renin-angiotensin system plays an important role in the regulation of blood pressure and previous studies have suggested that angiotensinogen (AGT) gene locus is linked with human essential hypertension. "
3.	Fibrosis (Cirrhosis) 10/01/2022 - "Hepatic and proximal tubule angiotensinogen play distinct roles in kidney dysfunction, glomerular and tubular injury, and fibrosis progression." 01/01/2020 - "There were no histological signs of fibrosis and pathology in the cardiac sections of either genotype post-SCI. Gene expression of Agtr1a showed a trend for up-regulation at 2 months post-SCI; angiotensinogen was up-regulated at 2 month post-SCI in both genotypes. " 11/01/2006 - "[Expression of angiotensinogen during development and spontaneous reversal of hepatic fibrosis]." 04/01/2000 - "A statistically significant relationship was seen between inheritance of high TGF-beta1- and angiotensinogen (AT)-producing genotypes and the development of progressive hepatic fibrosis. " 01/01/1999 - "Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice."
4.	Pre-Eclampsia (Preeclampsia) 03/01/2022 - "This study evaluated urinary angiotensinogen in preeclampsia. " 10/01/2021 - "A study of the association between angiotensinogen (AGT) gene polymorphism (M235T) and preeclampsia in Thai pregnant women." 11/01/2019 - "The aim of this study is to investigate the relationships between the polymorphisms of angiotensinogen (AGT) gene and preeclampsia. " 11/01/2019 - "Association study of M235T and A-6G polymorphisms in angiotensinogen gene with risk of developing preeclampsia in Iranian population." 01/01/2008 - "Genetic analysis of the angiotensinogen gene in pre-eclampsia: study of german women and review of the literature."
5.	Diabetic Nephropathies (Diabetic Nephropathy) 01/01/2019 - "Although the angiotensinogen ( AGT) gene T174M polymorphism has been implicated in the pathogenesis of diabetic nephropathy (DN), study results have been inconsistent. " 08/01/2018 - "The aim of the present study was to clarify the potential relationship of angiotensinogen (AGT) M235T polymorphism and diabetic nephropathy (DN) risk. " 08/01/2014 - "In this study, the authors investigated the determinants of urinary angiotensinogen and its associations with staging of diabetic nephropathy. " 01/01/2019 - "Association between angiotensinogen T174M polymorphism and the risk of diabetic nephropathy: A meta-analysis." 01/01/2019 - "The intrarenal renin-angiotensin system, in particular augmentation of angiotensinogen (AGT) in proximal tubular cells (PTC), plays a crucial role in the development of diabetic nephropathy. "

Related Drugs and Biologics

1.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
2.	Renin
3.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
4.	Angiotensin II
5.	Messenger RNA (mRNA)
6.	Enzymes
7.	Angiotensin Receptors (Angiotensin II Receptor)
8.	Angiotensins
9.	Biomarkers (Surrogate Marker)
10.	Interleukin-6 (Interleukin 6)

Related Therapies and Procedures

1.	Therapeutics
2.	Kidney Transplantation
3.	Stents
4.	Ligation
5.	Endurance Training