Angiotensin I

A decapeptide that is cleaved from precursor angiotensinogen by RENIN. Angiotensin I has limited biological activity. It is converted to angiotensin II, a potent vasoconstrictor, after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME.
Also Known As:
I, Angiotensin
Networked: 371 relevant articles (11 outcomes, 34 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Irigoyen, Maria Claudia: 3 articles (12/2012 - 01/2010)
2. Hong, Fang: 3 articles (04/2011 - 06/2008)
3. Campbell, Duncan J: 3 articles (02/2009 - 10/2004)
4. Dominiczak, Anna F: 2 articles (12/2014 - 02/2004)
5. Graham, Delyth: 2 articles (12/2014 - 02/2004)
6. Borchers, Christoph H: 2 articles (01/2013 - 10/2010)
7. Holmes, Daniel T: 2 articles (01/2013 - 10/2010)
8. Machado, Ubiratan Fabres: 2 articles (12/2012 - 11/2011)
9. Schaan, Beatriz D'Agord: 2 articles (12/2012 - 11/2011)
10. Furuta, Takahisa: 2 articles (03/2012 - 09/2007)

Related Diseases

1. Hypertension (High Blood Pressure)
2. Heart Failure
3. Hypertrophy
4. Myocardial Infarction
03/01/2010 - "Optimal pharmacological treatment to improve LV function was considered as: (i) angiotensin-blocking agent (ACE-I/ARB) in patients with LVEF <or=40%; (ii) ACE-I/ARB and beta-blocker in patients with LVEF <or=40% + heart failure symptoms or previous myocardial infarction; and (iii) a diuretic in patients with symptomatic heart failure, regardless of LVEF. "
11/01/1998 - "In addition, most importantly, we found no interaction between angiotensin II type 1 receptor A1166C gene variation and angiotensin I-converting Insertion/Deletion polymorphism, either in connection with the risk of coronary artery disease or myocardial infarction. "
01/01/1989 - "1. The effects of heart failure due to chronic myocardial infarction on the responsiveness to injected angiotensin I and ACE inhibition by intravenous cilazapril (1 mg kg-1) were evaluated. "
04/01/1994 - "To determine whether cardiac unloading by inhibition of angiotensin I (AI) to AII conversion by captopril or blockade of the AII receptor (AT1) by losartan was more effective in prevention of the detrimental hemodynamic consequences of myocardial infarction (MI), inhibition of metabolic production of AII by captopril was compared with blockade of AT1 with losartan in Sprague-Dawley rats with large MI. "
05/01/1977 - "Plasma renin activity (PRA) stimulated by upright posture was measured, in 300 men aged 45-64 years, by a radio-immunoassay of angiotensin I. The subjucts examined were divided into six groups, comparable in mean age, each containing 50 subjects: group 1, normotensives without manifest atherosclerosis; group 2, normotensives with angina pectoris definite; group 3, normotensives with a history of a transmural myocardial infarction; groups 4 to 6, patients with benign essential hypertension, without manifest atherosclerosis in group 4, with angina pectoris in group 5 and with a history of myocardial infarction in group 6. Significant differences in mean PRA were found between corresponding groups of hypertensives and normotensives, the values in hypertensives being lower. "
5. Renal Artery Obstruction (Renal Artery Stenosis)
11/01/1990 - "Intrarenal de novo production of angiotensin I in subjects with renal artery stenosis."
02/01/1993 - "To study regional metabolism and production of angiotensin II, we measured steady-state plasma levels of 125I-angiotensin I and II and endogenous angiotensin I and II in the aorta and the antecubital, femoral, renal, and hepatic veins during systemic infusion of 125I-angiotensin I or II. Extraction of arterially delivered angiotensin II ranged from 30-50% in the limbs to 80-100% in the renal and hepatomesenteric vascular beds both in essential hypertension (n = 13) and in unilateral renal artery stenosis (n = 7). "
05/01/1985 - "In 15 of the 16 patients found to have renal artery stenosis at angiography and cured by either revascularization or nephrectomy, Captopril stimulated both plasma renin activity and plasma angiotensin I to a far greater extent than in the majority of the 53 classified as essential hypertensives. "
11/01/1990 - "To estimate the renal extraction and de novo production of angiotensin I and to assess the contribution of blood-borne renin to renal angiotensin I production, the aortic and renal venous plasma levels of renin and intact [125I]angiotensin I and endogenous angiotensin I during continuous systemic intravenous infusion of monoiodinated [125I]angiotensin I were measured in subjects with unilateral renal artery stenosis (n = 8) who were treated with captopril (50 mg b.i.d.). "
09/22/1972 - "The elevated blood pressure induced by the renal artery stenosis can be prevented by prior treatment with the nonapeptide Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro, which blocks conversion of angiotensin I to angiotensin II. Further, the nonapeptide can restore systemic pressure to normnal in the early phase of renovascular hypertension. "

Related Drugs and Biologics

1. Angiotensin II
2. Renin
3. Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
4. Captopril (Capoten)
5. Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
6. Norepinephrine (Noradrenaline)
7. Losartan (Cozaar)
8. aliskiren
9. Vaccines
10. Insulin (Novolin)

Related Therapies and Procedures

1. Nephrectomy
2. Denervation
3. Intravenous Infusions
4. Surgical Instruments (Clip)
5. Oral Administration