Angiolymphoid Hyperplasia with Eosinophilia

Solitary or multiple benign cutaneous nodules comprised of immature and mature vascular structures intermingled with endothelial cells and a varied infiltrate of eosinophils, histiocytes, lymphocytes, and mast cells.

Also Known As:

Networked: 100 relevant articles (11 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hutchinson's Melanotic Freckle (Lentigo Maligna)
2.	Pruritus (Itching)
3.	Neoplasms (Cancer)
4.	Melanosis (Freckles)
5.	Granuloma

Experts

1.	Janowska, Agata: 2 articles (08/2021 - 04/2017)
2.	Oranges, Teresa: 2 articles (08/2021 - 04/2017)
3.	Panduri, Salvatore: 2 articles (08/2021 - 04/2017)
4.	Romanelli, Marco: 2 articles (08/2021 - 04/2017)
5.	Khurana, Ananta: 1 article (11/2022)
6.	Savitha, B: 1 article (11/2022)
7.	Barzilai, A: 1 article (03/2022)
8.	Galili, E: 1 article (03/2022)
9.	Hodak, E: 1 article (03/2022)
10.	Lapidoth, M: 1 article (03/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Angiolymphoid Hyperplasia with Eosinophilia:

1.	Tacrolimus (Prograf)FDA LinkGeneric 01/01/2017 - "Complete remission of angiolymphoid hyperplasia with eosinophilia using topical tacrolimus." 05/01/2015 - "[Treatment of angiolymphoid hyperplasia with eosinophilia (ALHE) using topical tacrolimus: Two cases]." 02/01/2010 - "Angiolymphoid hyperplasia with eosinophilia successfully treated with tacrolimus ointment." 04/01/2006 - "A case of angiolymphoid hyperplasia with eosinophilia successfully treated with tacrolimus ointment." 08/01/2016 - "Successful management of angiolymphoid hyperplasia with eosinophilia in a split-face trial of topical tacrolimus and timolol solution."
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 04/01/2017 - "Retroauricular angiolymphoid hyperplasia with eosinophilia: sustained long-term remission following treatment with corticosteroids." 11/20/2023 - "Treatment of Vulvar Angiolymphoid Hyperplasia with Eosinophilia with Topical Corticosteroids." 02/01/1980 - "Papular lesions of pseudopyogenic granuloma were examined before and during treatment with systemic corticosteroid using both light and electron microscopy. " 02/01/1980 - "Pseudopyogenic granuloma: effects of corticosteroid on newly-formed vessels." 08/01/2021 - "Unusual presentation of angiolymphoid hyperplasia with eosinophilia treated with intralesional and topic corticosteroid combination therapy."
3.	Propranolol (Inderal)FDA LinkGeneric 10/01/2014 - "Propranolol: a novel treatment for angiolymphoid hyperplasia with eosinophilia." 01/01/2021 - "Successful treatment of angiolymphoid hyperplasia with eosinophilia with oral propranolol in two cases." 01/01/2018 - "Angiolymphoid Hyperplasia With Eosinophilia-Combination Treatment With Propranolol and Surgical Resection." 11/01/2016 - "Oral Propranolol as an Alternative Therapy for Orbital Angiolymphoid Hyperplasia With Eosinophilia."
4.	Imiquimod (Aldara)FDA LinkGeneric 01/01/2014 - "Angiolymphoid hyperplasia with eosinophilia treated successfully with imiquimod." 01/01/2007 - "Angiolymphoid hyperplasia with eosinophilia successfully treated with imiquimod. " 11/01/2004 - "Angiolymphoid hyperplasia with eosinophilia successfully treated with imiquimod."
5.	Isotretinoin (Accutane)FDA LinkGeneric 10/04/2006 - "Angiolymphoid hyperplasia with eosinophilia: efficacy of isotretinoin?" 11/01/2007 - "Angiolymphoid hyperplasia with eosinophilia treated with isotretinoin."
6.	Ethanol (Ethyl Alcohol)IBA 03/01/2022 - "Percutaneous ethanol sclerotherapy is a promising treatment for recalcitrant angiolymphoid hyperplasia with eosinophilia."
7.	Immunoglobulin E (IgE)IBA 05/01/1992 - "Our studies support previous observations of an unusual IgE-mediated immune reaction, and suggest an additional pathogenic role for adhesion events in the development of the pathognomonic cellular composition in angiolymphoid hyperplasia with eosinophilia." 05/01/1992 - "Distribution of adhesion molecules, IgE, and CD23 in a case of angiolymphoid hyperplasia with eosinophilia." 01/01/1984 - "This is a case report of angiolymphoid hyperplasia with eosinophilia occurring in a 12-year-old Caucasian boy with elevated levels of serum IgE. " 01/01/2012 - "The classical features of angiolymphoid hyperplasia with eosinophilia are characterized by a triad of painless subcutaneous masses in the head and neck region, blood and tissue eosinophilia, and markedly elevated immunoglobulin E (IgE) levels. " 09/01/1991 - "No staining pattern was diagnostic for any of these conditions and in particular, the reticular staining pattern of IgE in the germinal centres that is frequently reported in Kimura's disease and in angiolymphoid hyperplasia with eosinophilia was non-specific."
8.	Timolol (Blocadren)FDA LinkGeneric 07/01/2017 - "Angiolymphoid Hyperplasia with Eosinophilia and its Response to the Combination of Radiofrequency Ablation and Topical Timolol." 03/01/2021 - "Management of paronychia with pseudopyogenic granulomas secondary to epidermal growth factor receptor inhibitors: An assessment of topical timolol and the need for multiple medical and procedural therapies." 08/01/2016 - "Successful management of angiolymphoid hyperplasia with eosinophilia in a split-face trial of topical tacrolimus and timolol solution." 01/01/2018 - "Topical Timolol for Paronychia and Pseudopyogenic Granuloma in Patients Treated With Epidermal Growth Factor Receptor Inhibitors and Capecitabine."
9.	AntigensIBA 02/01/2007 - "Sixteen cases of KD showed positive staining, whereas all cases of hemangioma, angiolymphoid hyperplasia with eosinophilia and angiosarcoma were negative for this antigen Immunohistochemical detection of the human herpesvirus-8 latent nuclear antigen-1 is a useful for differentiating between KD and other vascular lesions." 08/01/1995 - "Kimura's disease and angiolymphoid hyperplasia with eosinophilia: new observations from immunohistochemical studies of lymphocyte markers, endothelial antigens, and granulocyte proteins."
10.	SolutionsIBA 08/01/2016 - "Successful management of angiolymphoid hyperplasia with eosinophilia in a split-face trial of topical tacrolimus and timolol solution."

Therapies and Procedures

1.	Dye Lasers 08/01/2009 - "Angiolymphoid hyperplasia with eosinophilia of the scalp: promising results of long-pulsed tunable dye laser treatment." 01/01/2021 - "Treatment of Angiolymphoid Hyperplasia With Eosinophilia With Pulsed Dye Laser." 11/01/2003 - "A 48-year-old Japanese woman with angiolymphoid hyperplasia with eosinophilia (ALHE) was successfully treated with a flashlamp pulsed dye laser (585 nm, 450 micros pulse duration). " 08/01/2003 - "Angiolymphoid hyperplasia with eosinophilia responsive to pulsed dye laser." 07/01/2000 - "Angiolymphoid hyperplasia with eosinophilia: successful treatment with pulsed dye laser using the double pulse technique."
2.	Therapeutics 11/01/2016 - "To our knowledge, our case is the second case report suggesting oral beta-blocker may be an alternative therapy for orbital angiolymphoid hyperplasia with eosinophilia." 08/01/2003 - "We report on a case of angiolymphoid hyperplasia with eosinophilia responding to pulsed dye laser therapy (585 nm) (SPTL-1a, Candela Corp, Wayland, Mass)." 11/01/2003 - "Rapid remission of severe pruritus from angiolymphoid hyperplasia with eosinophilia by pulsed dye laser therapy." 01/01/2022 - "Use of Dupilumab and Eosinophil Targeted Therapy in Treating Angiolymphoid Hyperplasia With Eosinophilia." 08/01/2021 - "Unusual presentation of angiolymphoid hyperplasia with eosinophilia treated with intralesional and topic corticosteroid combination therapy."
3.	Gas Lasers 01/01/2016 - "Facial angiolymphoid hyperplasia with eosinophilia: sustained remission following treatment with carbon dioxide laser." 09/01/2004 - "Treatment of angiolymphoid hyperplasia with eosinophilia with the carbon dioxide laser." 07/01/2001 - "Eradication of angiolymphoid hyperplasia with eosinophilia by copper vapor laser." 08/01/2016 - "Combined pulsed dye and CO2 lasers in the treatment of angiolymphoid hyperplasia with eosinophilia." 08/01/1989 - "Angiolymphoid hyperplasia with eosinophilia: removal with carbon dioxide laser in a patient on chronic oral anticoagulants."
4.	Cryotherapy (Therapy, Cold) 03/15/2019 - "Therefore, we recommend cryotherapy as effective and safe treatment modalities for angiolymphoid hyperplasia with eosinophilia. " 03/15/2019 - "Angiolymphoid Hyperplasia with Eosinophilia Successfully Treated with Cryotherapy." 01/01/2003 - "Cryotherapy in the treatment of angiolymphoid hyperplasia with eosinophilia." 03/01/2015 - "An Overlap of Angiolymphoid Hyperplasia with Eosinophilia and Kimura's Disease: Successful Treatment of Skin Lesions with Cryotherapy."
5.	Sclerotherapy 09/01/2014 - "Angiolymphoid hyperplasia with eosinophilia responsive to sclerotherapy." 03/01/2010 - "Angiolymphoid hyperplasia with eosinophilia treated with a novel combination technique of radiofrequency ablation and sclerotherapy." 03/01/2022 - "Percutaneous ethanol sclerotherapy is a promising treatment for recalcitrant angiolymphoid hyperplasia with eosinophilia."