|2.||Acute Coronary Syndrome
|3.||Coronary Artery Disease (Coronary Atherosclerosis)
|4.||Chest Pain (Chest Pains)
|1.||Cannon, Christopher P: 27 articles (09/2015 - 10/2002)|
|2.||Roe, Matthew T: 26 articles (06/2015 - 12/2002)|
|3.||Ohman, E Magnus: 24 articles (08/2013 - 08/2002)|
|4.||Peterson, Eric D: 20 articles (06/2015 - 06/2003)|
|5.||Harrington, Robert A: 19 articles (11/2014 - 01/2002)|
|6.||Murphy, Sabina A: 18 articles (09/2015 - 07/2002)|
|7.||Califf, R M: 18 articles (04/2015 - 01/2000)|
|8.||Crea, Filippo: 18 articles (09/2009 - 07/2002)|
|9.||Topol, E J: 18 articles (12/2001 - 01/2000)|
|10.||Braunwald, Eugene: 17 articles (10/2013 - 02/2002)|
|1.||Heparin (Liquaemin)FDA LinkGeneric
07/16/1992 - "Although heparin is beneficial in treating unstable angina, the disease process may be reactivated within hours of the discontinuation of this drug. "
05/13/1995 - "Subcutaneous heparin is effective in the control of myocardial ischaemia in patients with unstable angina."
05/01/1995 - "The combination of heparin and protracted administration of rt-PA at low doses is effective in stabilizing and reducing in-hospital adverse events in patients with unstable angina refractory to antianginal therapy."
01/01/1990 - "Heparin and antiaggregating therapy represent an effective treatment of unstable angina. "
12/01/1998 - "In unstable angina, the clinical efficacy of heparin is limited in time, and recurrence of adverse events has been reported after discontinuation of the anticoagulant. "
|2.||Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
11/01/1996 - "Although aspirin is beneficial in patients with unstable angina, it is a relatively weak inhibitor of platelet aggregation. "
09/01/2010 - "Aspirin use is associated with an improved long-term survival in an unselected population presenting with unstable angina."
01/01/2001 - "[Comparative efficacy of tiklid and aspirin in patients with unstable angina]."
01/01/2000 - "Clinical trials have shown that combined therapy with aspirin and LMWHs is significantly more effective than aspirin alone in reducing the risk of cardiac events in the acute treatment of patients affected by unstable angina. "
01/01/2000 - "An open randomized trial was performed of tiklid versus aspirin in patients with unstable angina pectoris (UAP). "
06/01/2013 - "In this study, the anti-platelet and antithrombotic actions of Z4A5, a new glycoprotein IIb/IIIa receptor inhibitor, were evaluated in a canine model of acute unstable angina. "
09/30/2001 - "In contrast, the large trials being performed in patients with unstable angina and following coronary interventions using oral glycoprotein IIb/IIIa antagonists have been very disappointing. "
01/01/2001 - "A number of studies have reported on the successful use of intravenous glycoprotein IIb/IIIa receptor antagonists in patients with unstable angina or undergoing percutaneous interventions. "
12/01/1999 - "Recent trials involving approximately 18,000 patients with unstable angina have investigated the efficacy and safety of glycoprotein IIb/IIIa receptor antagonists, which block the final common pathway of platelet aggregation. "
10/01/1998 - "Glycoprotein IIb/IIIa inhibition as an adjunct to medical therapy for unstable angina is also the subject of encouraging preliminary data, and 3 large-scale clinical trials have just been completed. "
|4.||Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA
08/01/1998 - "The ESSENCE study is the first double-blind trial to show that a LMWH is more effective than UFH in patients with unstable angina. "
11/01/1999 - "Other changes are awaited shortly with the arrival of low molecular weight heparin which some have shown to be effective in unstable angina. "
03/01/1997 - "Thus, this pilot study suggests that LMWH is equally effective in the treatment of unstable angina, the advantage of LMWH being the ease of administration and no need for monitoring aPTT levels during therapy."
01/01/1997 - "Ongoing studies (TIMI 11B) are evaluating the efficacy of a prolonged administration of low molecular weight heparin to alter the chronic process of unstable angina. "
08/01/1995 - "This study was designed to test the hypothesis that low molecular weight heparin may lessen the severity of ischemic events in patients with unstable angina. "
01/29/1988 - "Calcium antagonists have proved effective in stable angina, unstable angina and vasospastic angina. "
09/01/1990 - "Based on evidence from HINT and other trials, it is concluded that beta-blockers should be used as the first-line treatment in patients with unstable angina and that a calcium antagonist should be added when patients remain unstable despite beta-blockade.(ABSTRACT TRUNCATED AT 250 WORDS)"
02/01/1993 - "Spontaneous remission was defined as an absence of angina at rest for at least 3 months after withdrawal of treatment with calcium antagonists. "
05/01/2010 - "We selected 20 scans from a clinical study comparing CTCA to conventional coronary angiography (CCA) in stable and unstable angina patients based on a low number of motion artifacts and a positive calcium score. "
05/01/2010 - "Does slice thickness affect diagnostic performance of 64-slice CT coronary angiography in stable and unstable angina patients with a positive calcium score?"
|6.||Diltiazem (Cardizem)FDA LinkGeneric
09/01/1994 - "Since diltiazem was more effective than ISDN even though the coronary angiographic findings of the two groups were similar, it is possible that some action other than vasodilatation (such as a direct protective effect on the myocardium) may be responsible for the remission of unstable angina."
03/01/2005 - "Intravenous diltiazem therapy is effective and safe for patients with unstable angina pectoris. "
01/01/1987 - "Diltiazem was found to be a safe and effective drug for controlling anginal attacks in patients with unstable angina."
07/01/2005 - "The anti-ischemic benefits of diltiazem are well recognized; however, there are fewer studies of the use of intravenous diltiazem for early treatment of unstable angina pectoris (UAP). "
03/06/1992 - "Preliminary data in patients with unstable angina suggest that the drug is effective, although studies comparing intravenous diltiazem with other agents or with the oral preparation of diltiazem have not yet been reported. "
|7.||Enoxaparin (Lovenox)FDA LinkGeneric
01/01/2003 - "Enoxaparin in unstable angina patients who would have been excluded from randomized pivotal trials."
09/01/1999 - "Low molecular weight heparins (enoxaparin) in the management of unstable angina: the TIMI studies. "
06/01/1997 - "Dose-ranging trial of enoxaparin for unstable angina: results of TIMI 11A. "
07/23/2007 - "Using data from the CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the ACC/AHA Guidelines) National Quality Improvement Initiative, we determined the frequency of administration of excess (>10 mg above the recommended dose), lower-than-recommended (>10 mg below the recommended dose), and recommended doses of enoxaparin. "
04/01/2003 - "Rectus sheath haematoma with severe haemodynamic compromise after enoxaparin use for unstable angina."
|8.||tirofiban (Aggrastat)FDA Link
07/01/2008 - "Tirofiban is a potent and specific fib receptor antagonist, used in the treatment of unstable angina. "
02/15/2006 - "Downstream administration of a high-dose tirofiban bolus in high-risk patients with unstable angina undergoing early percutaneous coronary intervention."
04/01/2003 - "Suboptimal inhibition of platelet aggregation following tirofiban bolus in patients undergoing percutaneous coronary intervention for unstable angina pectoris."
09/01/1997 - "Three clinical trials, PRISM, PRISM PLUS, and RESTORE, have evaluated the safety and efficacy of tirofiban in unstable angina and in high-risk percutaneous transluminal coronary angioplasty (PTCA). "
01/01/2002 - "Tirofiban was compared to placebo after high-risk angioplasty for AMI or unstable angina. "
|9.||Nitroglycerin (Dynamite)FDA LinkGeneric
11/01/1985 - "The present study was designed to examine the safety and efficacy of titrating a nitroglycerin infusion to a fixed hemodynamic endpoint as initial therapy for patients admitted to a coronary care unit for medically refractory unstable angina, and to test the hypothesis that patients, responding to the addition of intravenous (i.v.) nitroglycerin to their previous antianginal regimen, could be crossed over to nitroglycerin administered by a new transdermal delivery system. "
01/01/1998 - "To study whether intravenous nitroglycerin (NTG) reduces the incidence of ischaemic events and leucocyte activation, as well as inhibiting platelet aggregation in patients with unstable angina pectoris. "
01/01/1998 - "Intravenous nitroglycerin reduces ischaemia in unstable angina pectoris: a double-blind placebo-controlled study."
10/01/1986 - "Eighteen patients, 13 male and five female, with unstable angina pectoris and who had greater than or equal to 3 anginal attacks/day despite treatment with beta- and/or Ca-blockers were treated for three days with transdermal nitroglycerin (Transiderm-Nitro 25 mg/24 hours) in a randomised, placebo-controlled trial. "
10/01/1998 - "Patients had either Canadian Heart Association class IV angina (n = 23) or unstable angina (n = 19) and were unable to be weaned from intravenous nitroglycerin. "
|10.||clopidogrel (Plavix)FDA Link
03/15/2005 - "The efficacy of platelet inhibition with clopidogrel for up to one year after ACS was demonstrated in the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) trial, a randomized trial of 12,562 patients in 28 countries that was conducted between 1998 and 2000. "
10/01/2013 - "This study aimed to evaluate the impact of PON1 Q192R in parallel to that of CYP2C19*2 (rs4244285) on clopidogrel responsiveness in a cohort of Chinese patients with unstable angina pectoris. "
10/30/2012 - "With the use of the Clopidogrel in Unstable Angina to Prevent Recurrent Events trial for Plavix as an example, this article proposes Multiple Comparisons with Control (Subgroup) and Multiple Comparisons with the Best (Subgroup) as methods to infer whether some subgroups of patients derive more or less benefit than wild-type patients and which subgroup or subgroups of patients derive maximum benefit or practically maximum benefit from the drug."
03/01/2012 - "Randomized studies were post hoc analyses of the Clopidogrel as Adjunctive Reperfusion Therapy (CLARITY), Clopidogrel for the Reduction of Events During Observation (CREDO), and Clopidogrel in Unstable Angina to Prevent Recurrent Ischemic Events trials. "
07/01/2008 - "Our objective was to conduct a comprehensive cost-effectiveness analysis of pre-treatment and long-term treatment with clopidogrel in percutaneous coronary intervention (PCI) in three European countries based on a meta-analysis of the PCI-Clopidogrel in Unstable angina to prevent Recurrent Events (CURE), Clopidogrel for the Reduction of Events During Observation (CREDO) and PCI-Clopidogrel as Adjunctive Therapy (CLARITY) trials. "
|1.||Angioplasty (Angioplasty, Transluminal)
08/01/1995 - "123I-BMIPP may be a clue to define the culprit lesion in unstable angina and be helpful to decide the best treatment and guide coronary angioplasty."
01/01/1984 - "Angioplasty can be used with good results and a low complication rate in unstable angina and following successful thrombolysis."
02/01/1992 - "Coronary angioplasty is an effective treatment for subgroups of patients with unstable angina. "
09/03/1991 - "Coronary angioplasty is an effective treatment for patients with angina at rest, either refractory or initially stabilized but returning despite pharmacologic treatment, and with early postinfarction angina. "
01/01/2001 - "Thus, the MIR data showed no protective effects of preinfarction angina in patients with AMI treated with primary angioplasty."
|2.||Coronary Balloon Angioplasty (Percutaneous Transluminal Coronary Angioplasty)
08/01/1990 - "Percutaneous transluminal coronary angioplasty (PTCA) has been used with good results in selected patients with unstable angina. "
07/01/1990 - "Percutaneous transluminal coronary angioplasty (PTCA) has been applied with good results to selected patients with unstable angina and to selected patients who have had prior bypass surgery. "
01/01/1987 - "These data indicate that percutaneous transluminal coronary angioplasty may be undertaken with relative safety in patients with unstable angina and leads to a substantial improvement in symptoms that is sustained during early follow up. "
08/08/1985 - "We conclude that emergency percutaneous transluminal coronary angioplasty may be useful for the treatment of selected patients with unstable angina pectoris who are unresponsive to intensive pharmacologic treatment."
07/01/1991 - "In conclusion, percutaneous transluminal coronary angioplasty may be undertaken relatively safely in unstable angina, it leads to substantial improvement in symptoms during the early follow-up period. "
12/01/1999 - "The drug has been shown to be cost effective in patients receiving the drug in conjunction with coronary stents, and subgroup analyses indicate additional cost effectiveness in certain groups of patients at high risk of ischaemic complications (notably those with acute MI and unstable angina)."
11/01/1998 - "Additional antiplatelet therapy may be beneficial in those patients in whom Multi-link stent diameter is less than 3.5 mm, particularly in those with unstable angina, but is not necessary for patients receiving Multi-link stents of 3.5 mm diameter or greater."
05/15/2005 - "To compare the efficacy of SES and PES with the efficacy of bare-metal stents for de novo coronary lesions in patients with stable or unstable angina. "
01/01/2010 - " spite of significant heterogeneity across the studies, our meta-analysis suggests that preprocedurally elevated levels of CRP are associated with greater in-stent restenosis after stenting and that this impact appears more prominent in unstable-angina patients."
01/01/2010 - "Our subgroup analysis that compared patients with stable and unstable angina showed a weighted mean difference in the CRP levels of 2.22 between the patients with and without in-stent restenosis, and the Z-score for overall effect was 2.23 (P=0.03) in 5 studies of unstable-angina patients. "
|4.||Coronary Artery Bypass (Coronary Artery Bypass Surgery)
12/01/1985 - "Thus, reversible ischemic myocardial dysfunction appears to be common in the general population of patients undergoing coronary artery bypass grafting; 40% of patients with unstable angina and 34% of those with stable angina can be expected to have improved regional wall motion after successful revascularization. "
07/01/2014 - "This study was conducted to evaluate the early post-operative morbidity and mortality of Coronary Artery Bypass Grafting (CABG) in patients with unstable angina. "
03/01/2003 - "studies published from 1990 onwards describing the outcome of percutaneous coronary intervention or coronary artery bypass surgery in patients 75 or 80 years, of whom 75% or more were classified as unstable angina. "
02/01/1997 - "The study group consisted of 30 patients with unstable angina who required coronary artery bypass grafting. "
04/01/2015 - "A 74-year-old male underwent elective coronary artery bypass grafting for unstable angina. "
11/06/2002 - "Percutaneous coronary intervention versus coronary bypass graft surgery for diabetic patients with unstable angina and risk factors for adverse outcomes with bypass: outcome of diabetic patients in the AWESOME randomized trial and registry."
07/01/1998 - "The results of our angioscopic study indicate that other than a high incidence of plaque friability in vein grafts, the surface morphology of culprit lesions in unstable angina patients is quite similar for saphenous vein grafts and native coronary arteries."
01/01/2012 - "We present a case of a patient with unstable angina pectoris two years after coronary artery by-pass graft surgery with the use of the right and left mammary artery. "
04/26/2008 - "Conversely, fewer patients with STEMI than those with non-STEMI or unstable angina were given beta blockers (57.5%vs 61.9%); lipid-lowering drugs (50.8%vs 53.9%); and coronary bypass graft surgery (1.9%vs 4.4%, p<0.0001 for all comparisons). "
03/01/2008 - "In patients with unstable angina and/or hemodynamic instability, in whom rapid and maximum restoration of myocardial perfusion is a priority, potentially lower graft flow in arterial grafts and off-pump surgery should be considered."