Aneuploidy (Aneuploid)

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5259 relevant articles (94 outcomes, 379 trials/studies) found for this Disease

Description: The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1).

Also Known As:

Aneuploid; Aneuploid Cell; Aneuploids; Aneuploid Cells; Aneuploidies; Cell, Aneuploid; Cells, Aneuploid

Relationship Network

Disease Context: Research Results

Signs and Symptoms Pathological Conditions

Pathologic Processes: 2210

Chromosome Aberrations: 6736

Chromosome Aberrations: 6736

Aneuploidy: 5259

Trisomy: 1332

Monosomy: 385

Related Diseases

1.	Neoplasms (Cancer)
2.	Aneuploidy (Aneuploid)
3.	Colorectal Neoplasms (Colorectal Cancer)
4.	Neoplasm Metastasis (Metastasis)
5.	Carcinoma (Carcinomatosis)

Experts

1.	Nicolaides, K H: 5 articles (02/2008 - 08/2000)
2.	Spencer, K: 4 articles (02/2008 - 08/2000)
3.	Lapègue, Sylvie: 4 articles (01/2007 - 01/2003)
4.	Bouilly, Karine: 4 articles (01/2007 - 01/2003)
5.	Ried, Thomas: 4 articles (01/2006 - 01/2003)
6.	Schmid, T E: 4 articles (09/2002 - 01/2000)
7.	Wyrobek, A J: 3 articles (05/2008 - 03/2001)
8.	Sun, Fengyun: 3 articles (03/2008 - 12/2004)
9.	Pacchierotti, Francesca: 3 articles (03/2008 - 05/2002)
10.	Eichenlaub-Ritter, Ursula: 3 articles (03/2008 - 12/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Aneuploidy:

1.	DNA (Deoxyribonucleic Acid)IBA 09/01/1994 - "The aims of the study were: 1) to compare the sensitivity of FISH and DNA flow cytometry in aneuploidy detection, 2) to determine which chromosome copy number changes are most common, and 3) which probe combinations would be most effective in aneuploidy diagnosis" 06/01/2002 - "When using tertiles as cutpoints for SPF classification, concordance rates ranged from 79.7% to 93.2% for DNA diploid samples and from 87.8% to 95.9% for DNA aneuploid samples, the best results being obtained with software working with a similar histogram resolution" 09/15/1996 - "The DNA analysis of the cirrhotic cells showed that polyploidy was dramatically reduced in patients with HCC, compared with normal hepatocytes, and aneuploid clones were present among diploid cells" 10/01/1987 - "Patients with rapidly proliferative diploid or DNA aneuploid tumours obtained complete remission more readily than patients with lowly proliferative diploid tumours" 01/01/1990 - "DNA aneuploidy was not related with other clinically defined risk factors such as age, white blood cell count, and rapid achievement of remission" Order ALL the reference details at left...
2.	Prostaglandins D (PGD)IBA 04/01/2004 - "This study evaluates whether IVF-intracytoplasmic sperm injection (ICSI) results could be improved by selecting embryos through PGD-AS (aneuploidy screening) in couples in whom the male partner presents meiotic abnormalities" 10/22/2001 - "The in vivo and in vitro efficiency and efficacy of PGD for aneuploidy." 08/01/2008 - "BACKGROUND: The objective of this study was to assess socio-emotional and language development in 2-year-old children born after preimplantation genetic diagnosis (PGD) and genetic aneuploidy screening (PGS), intracytoplasmic sperm injection (ICSI) and natural conception (NC) and to assess parental well-being" 01/01/2008 - "Despite the need for randomized controlled studies to quantify in more detail the clinical impact of the pre-selection of aneuploidy-free zygotes, the positive impact of PGD is particularly obvious from the comparison of reproductive outcome in the same patients with and without PGD, revealing the actual benefits of PGD." 06/01/2006 - "Six of the 16 embryos transferred in the PGD cycles were aneuploid for the AS study; four of them were also mosaics" Order ALL the reference details at left...
3.	Benzene (Benzole)IBA 03/01/2001 - "Study on frequencies of aneuploidy in mouse oocyte and female pronucleus of one cell zygote induced by benzene]" 01/01/1989 - "The genetic systems developed in the mould Aspergillus nidulans to study the chemical induction of mitotic genetic segregation were used to investigate the mechanism of aneuploidy induction by the main benzene hydroxy metabolites" 05/30/2005 - "Use of OctoChrome fluorescence in situ hybridization to detect specific aneuploidy among all 24 chromosomes in benzene-exposed workers." 03/01/2002 - "Results indicate that the benzene metabolites BT, HQ and t,t-MA induce chromosome-specific numerical and structural aberrations, and the fluorescence in situ hybridization (FISH) approach may be a useful and powerful technique for detection of aneuploidy." 06/01/2001 - "The aneuploidy resulting from benzene exposure in mice was a relatively infrequent event, with increases of both chromosome loss and hyperdiploidy being observed" Order ALL the reference details at left...
4.	alpha-Fetoproteins (AFP)IBA 06/01/2003 - "RESULTS: Among 686 patients, advanced maternal age was the most common indication for genetic testing (n = 469, 68.4%), followed by elevated aneuploidy risk on triple screen (n = 164, 23.9%), elevated maternal serum alpha-fetoprotein (n = 20, 2.9%), previous aneuploidy (n = 16, 2.3%) and family history of inheritable disease (n = 14, 2.1%)" 09/01/1998 - "The association of aneuploidy and unexplained elevated maternal serum alpha-fetoprotein." 08/01/1995 - "Elevated maternal serum alpha-fetoprotein levels: what is the risk of fetal aneuploidy?" 05/01/1994 - "In addition, not only the ratio of S-G2.M phase cells, but also the incidence of aneuploidy pattern of AFP positive stained cases was higher than the negative stained cases" 02/01/1993 - "In our consecutive series of 2,574 chorionic villus sampling (CVS) patients, 146 women (5.7%) underwent a subsequent amniocentesis in the same pregnancy for the indications of absent or insufficient villi (3.3%), elevated maternal serum alpha-fetoprotein (0.93%), CVS mosaicism (0.89%), culture failure (0.23%), specimen contamination (0.15%), and CVS aneuploidy (0.12%)" Order ALL the reference details at left...
5.	Colchicine FDA Link 02/01/1991 - "Brood analysis (five 2-day or five 3-day broods) showed that the largest increases in aneuploidy after cold treatment occurred in the first brood, which contains a high proportion of stage 14 oocytes, whereas colchicine induced the highest frequencies in the latter broods and DMN was effective in all but the last brood" 01/01/1987 - "The objective of the present study was to determine whether the time of administering colchicine influenced the incidence of aneuploidy in MII oocytes" 10/01/2008 - "Plants generally tolerate aneuploidy better than animals, and, through colchicine treatment and breeding strategies, it is possible to obtain inbred sibling plants with different numbers of chromosomes" 01/01/2004 - "Their chromosomes segregate with high fidelity during anaphase I. The model aneugen colchicine induced a meiotic arrest and aneuploidy in these in vitro grown, follicle-enclosed oocytes in a dose-dependent manner, comparable to in vivo tests" 10/01/2002 - "Although the main karyotype was 2n = 20, polyploidy (3n = 30 or 4n = 40) and aneuploidy were detected in each individual treated with colchicine, even those treated for only 1 h" Order ALL the reference details at left...
6.	Formaldehyde (Formol)IBA 02/01/1995 - "FISH on formalin-fixed tissues is especially beneficial in follow-up studies of cases involving termination after prenatal diagnosis or patients with a malignant disease where previous routine cytogenetics established the chromosomal aneuploidy" 02/01/1995 - "We have demonstrated that this application of interphase cytogenetics to the study of various formalin-fixed tissues is amenable to the detection of chromosomal aneuploidies and has specific advantages over cytogenetic analysis." 01/01/1995 - "Using this approach, 75 per cent of the karyotypes in 20 formalin-fixed placental samples (comprising aneuploids, triploids, and normals) were correctly identified" 01/01/1993 - "By contrast, no aneuploidy was detected in formalin fixed controls" 01/01/1993 - "It was then hypothesized that partial fixation of nodes in Carnoy's followed by formalin fixation might result in false aneuploid peaks" Order ALL the reference details at left...
7.	Proliferating Cell Nuclear Antigen (PCNA)IBA 06/01/1997 - "CONCLUSION: There have been no recurrence since transurethral resection in all IP in the study including the case recognized as aneuploid and positive for PCNA staining" 09/01/2003 - "Loss of oestrogen receptor beta, high PCNA and p53 expression and aneuploidy as markers of worse prognosis in ovarian granulosa cell tumours." 08/01/2000 - "Op18 levels were negatively correlated with oestrogen receptor (OR) expression and positively correlated with a high fraction of aneuploid cells, proliferation measured by proliferating cell nuclear antigen (PCNA) expression, tumour size and histopathologic grade" 11/01/1998 - "All of our cases of SCC showed the presence of aneuploid populations, which was not correlated with the clinicopathologic parameters or with the overexpression of bcl-1, bcl-2, bax, and PCNA" 02/01/1997 - "When patients are classified according to nuclear grading, is evident that all PCNA G4 are aneuploid and that 62.5% of PCNA G1 are diploid" Order ALL the reference details at left...
8.	Biological Markers (Surrogate Marker)IBA 11/01/2005 - "Between 2001 and 2003 we prospectively studied the acceptability and efficacy of screening for fetal aneuploidy in a large unselected population, using a risk calculation approach based on maternal age and serum markers, together with nuchal translucency at 11-14 weeks" 05/01/1999 - "These data may be helpful in understanding the pathophysiological basis of serum marker patterns in these aneuploidies." 02/01/1995 - "These procedures for detecting aneuploid male gametes are examples of "bridging biomarkers" between human and animal studies" 10/01/2008 - "Objective: To review the obstetrical outcomes associated with abnormally elevated or decreased level of one or more of the most frequently measured maternal serum marker analytes used in screening for aneuploidy" 02/01/2008 - "First-trimester ultrasound and biochemical markers of aneuploidy and the prediction of preterm or early preterm delivery." Order ALL the reference details at left...
9.	Vinblastine (Vinblastine Sulfate)FDA Link 05/01/2001 - "Mice (102/ElxC3H/El) F(1) were exposed in one laboratory (GSF) to vinblastine (VBL; single intraperitoneal injection of 0, 0.5, 1.0 or 2.0 mg/kg), one of the 10 priority compounds of the Commission of the European Communities (CEC) Aneuploidy Program" 05/01/1995 - "Synergism between gonadotrophins and vinblastine relative to the frequencies of metaphase I, diploid and aneuploid mouse oocytes." 04/01/1995 - "Vinblastine, the positive control for aneuploidy, produced predominantly centromere containing micronuclei and the addition of S9 was not required for its activity" 01/01/1995 - "Susceptibility to vinblastine-induced aneuploidy and preferential chromosome segregation during meiosis I in Robertsonian heterozygous mice." 11/01/1988 - "Meiotic arrest and aneuploidy induced by vinblastine in mouse oocytes." Order ALL the reference details at left...
10.	Propidium (Propidium Iodide)IBA 08/01/1989 - "Nuclei obtained by mechanical disaggregation of frozen tissue were stained with propidium iodide and analysed in a FACS IV. Aneuploidy was detected in 73% of cases" 07/01/2004 - "Reduction in promotion (6-10 weeks) was identified by depressed proliferation (cell cycle, bromodeoxyuridine incorporation (BrdU)) and aneuploidy (propidium iodide stain)" 06/01/1990 - "In two cases, the propidium iodide fluorescence histograms showed small (5 and 3% of the analyzed nuclei) but significant aneuploid subpopulations with DNA indices of approximately 1.5" 05/01/1989 - "In 41 of the 46 adequate samples (89%), an aneuploid peak in the alcohol preserved (propidium iodide stained) specimen correlated well with the fresh (acridine orange stained) specimen" 11/01/1976 - "By comparing euploid and aneuploid samples, we found that the fluorescence signals emitted from propidium iodide (PI) stained cells are linearly proportional to DNA content" Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 04/01/1997 - "The efficacy of chemotherapy was higher in aneuploid cases than in diploid cases" 02/01/1994 - "The efficacy of chemotherapy was higher in aneuploid than in diploid cases" 05/01/1998 - "In the present study, we analyze the relationship between aneuploidies of 15 different chromosomes assessed by FISH and prognosis in a series of 63 patients with MM treated with conventional chemotherapy" 02/01/2008 - "METHODS Aneuploidy was assessed before, and 6, 12 and/or 18-24 months after, the initiation of chemotherapy, and compared with age matched controls" 08/01/2006 - "2. Aneuploid tumours appear much often then diploid in group of patient who did not answer for first line chemotherapy 3. Patients with diploid tumours have better prognosis" Order ALL the reference details at left...
2.	Heterologous Transplantation (Xenotransplantation) 02/01/1993 - "The remaining one xenograft showed slower growth and aneuploidy, and had extensive numerical but less structural variability in its chromosomal constitution" 11/01/2006 - "184B5-MT1 cells exhibited aneuploidy, and they were efficient in generating tumors in the orthotopic xenograft model in immunodeficient mice" 08/15/1990 - "The in vitro culture of one such xenograft--derived from a human prostatic adenocarcinoma--resulted in the outgrowth of a transformed aneuploid mouse cell line" 05/01/2005 - "The adduced examples are taken from the following fields of investigation: (a) the physiology of reproduction, where pig oocytes are being used to study chromosomal abnormalities (aneuploidy) in the adult human oocyte; (b) the generation of suitable organs for xenotransplantation using transgene expression in pig tissues; (c) the skin physiology and the treatment of skin defects using cell therapy-based approaches that take advantage of similarities between pig and human epidermis; and (d) neurotransplantation using porcine neural stem cells grafted into inbred miniature pigs as an alternative model to non-human primates xenografted with human cells." 04/01/1993 - "Both the monolayer astrocytoma cells and the xenograft tumor cells from clone 2 were aneuploid, with a modal number of 84 chromosomes per metaphase; clones 1 and 3 were also aneuploid with modal numbers of 82 and 75/79, respectively" Order ALL the reference details at left...
3.	Transplantation (Transplant Recipients) 05/01/1967 - "Dependence of the efficacy of mouse leukosis transplantation upon the content of aneuploid cells in the transplanted material]" 08/01/2002 - "BACKGROUND: This study describes the technical approaches used in treatment of age-related oocyte aneuploidy, the efficiency of each step of nuclear transplantation into mouse and human oocytes, and the ability of germinal vesicle (GV) transplantation to restore artificially induced ooplasmic damage" 03/01/2005 - "Germinal vesicle transplantation (GVT) has been proposed as a possible treatment to correct age-related oocyte aneuploidy caused by dysfunctional ooplasm" 05/01/2004 - "For example, in addition to its proposed use as a way of generating stem cells, the basic technique of nuclear transplantation has proven useful in other ways, including its application to immature eggs as a new approach to the prevention of the aneuploidy common in older women, and for some recent advances in preimplantation genetic diagnosis" 01/01/2004 - "These observations are instructive for the future application of hES cells in transplantation therapies in which the use of aneuploid cells could be detrimental." Order ALL the reference details at left...
4.	Adjuvant Chemotherapy 11/01/1984 - "These results indicate that compared to aneuploid tumors either diploid tumors have a different natural history or they are more responsive to adjuvant chemotherapy, possibly due to a lower probability of their developing drug resistance." 01/01/1996 - "Our data point to a possible indication of a systemic adjuvant chemotherapy in Dukes' B2 colon cancer patients who have aneuploid tumors on image analysis" 08/01/1995 - "Our data may point out a possible indication for systemic adjuvant chemotherapy in Dukes' B2 colon cancer patients who have aneuploid tumors on image analysis" 09/01/1991 - "Similarities include the following: male sex predilection, large patient size, 75% or more affecting the appendicular site, metaphyseal location, generally unknown etiology, less than 10% of patients have documented metastasis at presentation, over 90% of tumors show high-grade histology, 75% of tumors show aneuploidy, the metastatic rate is 80% or more with amputation alone, the lung is the most common site of metastasis, and there is improved survival with adjuvant chemotherapy" 05/01/2008 - "The treatment consisted of primary staging surgery with addition of platinum-based adjuvant chemotherapy for the majority of aneuploid tumors" Order ALL the reference details at left...
5.	Immunotherapy 03/01/1995 - "Women experiencing recurrent aneuploidy in their abortus would not be expected to respond to immunotherapy" 10/15/1998 - "The presence of these aneuploidies might be responsible for treatment failures in the immunotherapy of gynecological cancer." 04/01/2001 - "In patients treated with chemotherapy or immunotherapy, the presence or the appearance of an aneuploid cell population is a good indication of tumor recurrence or progression" 05/01/1995 - "While the treatment of renal cancer patients with IL2-based immunotherapy regimens appears to be effective in advanced renal cell carcinoma the IL2-supplemented vaccines should be tested to assess their benefit in the situation of "minimal disease" after surgery especially in high-risk patients with aneuploid tumours." Order ALL the reference details at left...

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