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Dissociative Anesthetics

Intravenous anesthetics that induce a state of sedation, immobility, amnesia, and marked analgesia. Subjects may experience a strong feeling of dissociation from the environment. The condition produced is similar to NEUROLEPTANALGESIA, but is brought about by the administration of a single drug. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed)
Also Known As:
Anesthetics, Dissociative
Networked: 12 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Coyle, Joseph T: 4 articles (09/2012 - 04/2002)
2. Tsai, Guochuan: 2 articles (11/2003 - 04/2002)
3. Rolland, Benjamin: 1 article (01/2014)
4. Amad, Ali: 1 article (01/2014)
5. Jardri, Renaud: 1 article (01/2014)
6. Bordet, Régis: 1 article (01/2014)
7. Cottencin, Olivier: 1 article (01/2014)
8. Thomas, Pierre: 1 article (01/2014)
9. Konopaske, Glenn: 1 article (01/2012)
10. Basu, Alo: 1 article (01/2012)

Related Diseases

1. Schizophrenia (Dementia Praecox)
11/01/2003 - "Numerous clinical studies demonstrate that subanesthetic doses of dissociative anesthetics, which are noncompetitive antagonists at the NMDA receptor, replicate in normal subjects the cognitive impairments, negative symptoms, and brain functional abnormalities of schizophrenia. "
01/01/2014 - "Hallucinations are complex misperceptions, that principally occur in schizophrenia or after intoxication induced by three main classes of drugs: psychostimulants, psychedelics, and dissociative anesthetics. "
09/01/2012 - "Although glutamate was first hypothesized to be involved in the pathophysiology of schizophrenia in the 1980s, it was the demonstration that N-methyl-D-aspartate (NMDA) receptor antagonists, the dissociative anesthetics, could replicate the full range of psychotic, negative, cognitive, and physiologic features of schizophrenia in normal subjects that placed the "NMDA receptor hypofunction hypothesis" on firm footing. "
03/01/2010 - "Recognition that dissociative anesthetics block the N-methyl-D-aspartate (NMDA) receptor channel has inspired a search for glutamatergic therapeutic mechanisms because ketamine and phencyclidine are known to induce psychotic-like symptoms in healthy volunteers and exacerbate the symptoms of patients with schizophrenia. "
05/01/2007 - "Dissociative anesthetics such as phencyclidine (PCP) produce a syndrome in humans that is clinically indistinguishable from schizophrenia by blocking neurotransmission at N-methyl-D-aspartate (NMDA)-type glutamate receptors. "
2. Pain (Aches)
3. Unconsciousness (Loss of Consciousness)
4. Psychotic Disorders (Schizoaffective Disorder)
5. Hallucinations (Hallucination)

Related Drugs and Biologics

1. N-Methylaspartate (NMDA)
2. Ketamine
3. Glutamic Acid (Glutamate)
4. Glutamate Receptors (Glutamate Receptor)
5. Phencyclidine (Angel Dust)
6. Neurotransmitter Agents (Neurotransmitter)
7. Hallucinogens (Psychedelics)
8. Dopamine (Intropin)
9. Dexmedetomidine
10. Dopamine D2 Receptors (Dopamine D2 Receptor)

Related Therapies and Procedures

1. Eye Protective Devices (Goggles)
2. Analgesia