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Anencephaly (Aprosencephaly)

A malformation of the nervous system caused by failure of the anterior neuropore to close. Infants are born with intact spinal cords, cerebellums, and brainstems, but lack formation of neural structures above this level. The skull is only partially formed but the eyes are usually normal. This condition may be associated with folate deficiency. Affected infants are only capable of primitive (brain stem) reflexes and usually do not survive for more than two weeks. (From Menkes, Textbook of Child Neurology, 5th ed, p247)
Also Known As:
Aprosencephaly; Absence of Brain, Congenital; Anencephalia; Anencephalus; Congenital Absence of Brain; Hemicranial Anencephaly; Incomplete Anencephaly; Partial Anencephaly; Anencephalias; Anencephalies, Partial; Anencephaly, Hemicranial; Anencephaly, Incomplete; Anencephaly, Partial; Aprosencephalies; Brain Congenital Absence; Partial Anencephalies
Networked: 426 relevant articles (6 outcomes, 34 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Spinal Dysraphism (Spina Bifida)
2. Neural Tube Defects (Exencephaly)
3. Diaphragmatic Hernia
4. Hypercholesterolemia
5. Stillbirth

Experts

1. Oakley, Godfrey P: 21 articles (01/2022 - 01/2002)
2. Kancherla, Vijaya: 16 articles (01/2022 - 10/2013)
3. Shaw, Gary M: 11 articles (11/2014 - 07/2002)
4. National Birth Defects Prevention Study: 10 articles (11/2018 - 01/2009)
5. Canfield, Mark A: 8 articles (11/2016 - 01/2005)
6. Carmichael, Suzan L: 7 articles (11/2017 - 03/2005)
7. Ren, Aiguo: 6 articles (01/2019 - 04/2007)
8. Bell, Karen N: 6 articles (10/2013 - 11/2004)
9. Reefhuis, Jennita: 5 articles (12/2020 - 01/2009)
10. Romitti, Paul A: 5 articles (11/2018 - 11/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Anencephaly:
1. Folic Acid (Vitamin M)FDA LinkGeneric
2. Adrenocorticotropic Hormone (ACTH)FDA Link
3. Apolipoprotein A-I (Apolipoprotein A1)IBA
4. HDL LipoproteinsIBA
5. Lipoproteins (Lipoprotein)IBA
6. Dexamethasone (Maxidex)FDA LinkGeneric
7. ApoproteinsIBA
8. alpha-Fetoproteins (alpha-Fetoprotein)IBA
9. VitaminsIBA
10. Drinking WaterIBA

Therapies and Procedures

1. Induced Labor
2. Transplantation
3. Prenatal Care (Care, Prenatal)
4. Induced Abortion (Induced Abortions)
5. Organ Transplantation