Sideroblastic Anemia

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245 relevant articles (4 outcomes, 12 trials/studies) found for this Disease

Description: Anemia characterized by the presence of erythroblasts containing excessive deposits of iron in the marrow.

Also Known As:

Anemia, Sideroblastic; Anemias, Sideroblastic; Sideroblastic Anemias

Relationship Network

Disease Context: Research Results

Hemic and Lymphatic Diseases

Hematologic Diseases: 1480

Anemia: 16039

Sideroblastic Anemia: 245

Bone Marrow Diseases: 65

Myelodysplastic Syndromes: 3214

Sideroblastic Anemia: 245

Related Diseases

1.	Kidney Failure (Renal Failure)
2.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
3.	Iron Overload
4.	Hemochromatosis (Bronze Diabetes)
5.	Friedreich Ataxia (Friedreich's Ataxia)

Experts

1.	Fischel-Ghodsian, Nathan: 2 articles (05/2005 - 06/2004)
2.	Mengesha, Emebet: 2 articles (05/2005 - 06/2004)
3.	Bykhovskaya, Yelena: 2 articles (05/2005 - 06/2004)
4.	Rotta, Greice Adami: 1 article (08/2007)
5.	Bonatto, Diego: 1 article (08/2007)
6.	Miotto, Greice: 1 article (08/2007)
7.	Tessaro, Simone: 1 article (08/2007)
8.	Darbellay, Régis: 1 article (08/2006)
9.	Rideau, Alexandra: 1 article (08/2006)
10.	Costaridou, S: 1 article (08/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sideroblastic Anemia:

1.	Pyridoxine (Pyridoxin)FDA Link 10/10/1981 - "The findings show that the therapeutic efficacy of pyridoxin in primary sideroblastic anemia is due to its effect on defective ALAS. " 06/01/2003 - "The diagnosis of sideroblastic anemia was established by the presence of ringed sideroblasts in the bone marrow, and treatment with oral pyridoxine completely eliminated the ringed sideroblasts. " 10/01/2004 - "We report the case of a 40-year female who manifested late onset, pyridoxine-refractory X-linked sideroblastic anemia, heterozygous for the first described frameshift ALAS2 mutation, CD506-507 (-C). " 10/01/1999 - "A novel mutation of the erythroid-specific gamma-Aminolevulinate synthase gene in a patient with non-inherited pyridoxine-responsive sideroblastic anemia." 08/01/1999 - "[An infant case of sideroblastic anemia that responded to oral pyridoxine]" Order ALL the reference details at left...
2.	AntigensIBA 01/01/1984 - "A patient with well-differentiated lymphocytic lymphoma in remission presented with renal failure, sideroblastic anemia, and an acquired diminution in the expression of A antigen on his red cells. " 04/01/1989 - "A genetic association between human leucocytic antigen-linked hemochromatosis and idiopathic refractory sideroblastic anemia has been suggested that may predispose some patients with idiopathic refractory sideroblastic anemia to develop gross iron overload. " 04/01/1989 - "Study of the family of a patient with idiopathic refractory sideroblastic anemia and hemochromatosis revealed that 2 of 5 first-degree relatives had significant elevations of serum ferritin, and a shared human leucocytic antigen haplotype, supporting the concept that patients with idiopathic refractory sideroblastic anemia and significant iron overload have at least one allele for hemochromatosis." Order ALL the reference details at left...
3.	Hemoglobins (Hemoglobin)IBA 08/01/1999 - "The patient was given a diagnosis of sideroblastic anemia and responded to oral pyridoxine (50 mg/day) with an immediate increase of reticulocytes to 97/1000, resulting in an improved hemoglobin concentration. " 01/23/2004 - "Hemoglobin levels steadily increased, so the diagnosis of pyridoxine-responsive sideroblastic anemia was made. " 02/29/1984 - "Refractory and sideroblastic anemias are heterogenous syndromes which are characterized by a hyperblastic bone marrow with dyserythropoietic features and disturbances in iron- and hemoglobin metabolism. " 06/01/1968 - "Males affected with sideroblastic anemia had growth retardation, hypochromic microcytic anemia, elevated serum iron, decreased unsaturated iron-binding capacity, increased (59)Fe clearance, low (59)Fe incorporation into erythrocytes, normal erythrocyte survival ((51)Cr), normal hemoglobin electrophoretic pattern, erythroblastic hyperplasia of marrow with increased iron, and marked increase in marrow sideroblasts, particularly ringed sideroblasts. " 01/01/1976 - "Heme oxygenase (HO) and biliverdin reductase (BR), the two NADPH-dependent enzymes involved in the degradation of hemoglobin and its derivatives, were measured in bone marrow aspirates from 5 hematologically normal persons, 4 patients with chronic leucemia (CL), 11 patients with acute leucemia (AL), 8 patients with refractory sideroblastic anemia (RA), 7 patients with iron-deficiency anemia (IA), 5 patients with hemolytic anemia (HA), and 7 patients with secondary anemia (SA) to determine the enzymatic capacity of the bone marrow in different hematologic disorders for heme catabolism. " Order ALL the reference details at left...
4.	IronIBA 07/01/1990 - "Further study is necessary to confirm the staining mechanism, to elucidate the composition of iron deposits, and to explain the pathophysiology of sideroblastic anemia." 10/01/2009 - "As recently occurred with the discovery of the SLC25A38-related sideroblastic anemia, the identification of the genes responsible for as yet uncharacterized forms will provide further insights into mitochondrial iron metabolism of erythroid cells and the pathophysiology of sideroblastic anemia." 06/01/2009 - "The sideroblastic anemias are a heterogeneous group of congenital and acquired hematological disorders whose morphological hallmark is the presence of ringed sideroblasts-bone marrow erythroid precursors containing pathologic iron deposits within mitochondria. " 01/01/2009 - "Mitochondrial iron metabolism and sideroblastic anemia." 05/01/2007 - "BACKGROUND: For most cases of idiopathic acquired sideroblastic anemia (IASA), the molecular pathogenesis is unknown, despite the consistent morphological signature of abundant pathological ringed sideroblasts with their characteristic iron-engorged mitochondria. " Order ALL the reference details at left...
5.	Mitochondrial DNA (mtDNA)IBA 05/01/1991 - "Sporadic cases of sideroblastic anemia may represent mitochondrial mutations either at the germ cell or the somatic cell, and the most sensitive strategy of screening for both would be the study of mitochondrial DNA from circulating erythrocytes. " 03/15/2004 - "Functional relevant mutations of mitochondrial DNA (mtDNA) have been related to sideroblastic anemia and MDS. " 01/01/1999 - "The MERRF mutation of mitochondrial DNA in the bone marrow of a patient with acquired idiopathic sideroblastic anemia." 09/01/1997 - "Sideroblastic anemia associated with vacuolization of haemopoietic precursors can be observed in some constitutional diseases associated with mitochondrial DNA deletion. " 07/01/1997 - "A whole spectrum of disease forms, ranging from isolated sideroblastic anemia to combined Pearson and KSS, are associated with deletions of mtDNA. " Order ALL the reference details at left...
6.	Ferritins (Ferritin)IBA 03/01/2003 - "Mitochondrial ferritin expression in erythroid cells from patients with sideroblastic anemia." 11/01/1978 - "Because it is rapid and permits localization of ferritin-containing cytoplasmic inclusions, the reaction may be useful in the assessment of sideroblastic anemias." 01/01/2008 - "Acquired sideroblastic anemia with unilineage dysplasia (WHO RARS) is a clonal stem cell disorder characterized by erythroid dysplasia, mitochondrial accumulation of mitochondrial ferritin, defective erythroid maturation and anemia. " 05/01/2009 - "Ferritin is directly implicated in less common but potentially devastating human diseases including sideroblastic anemias, neurodegenerative disorders, and hemophagocytic syndrome. " 01/01/2007 - "The understanding of the role of mitochondrial ferritin in Fe oxidative metabolism may be useful in approaching clinical situations such as the treatment of Friedreich's ataxia, X-linked sideroblastic anemia, and in other neurodegenerative disorders." Order ALL the reference details at left...
7.	DNA (Deoxyribonucleic Acid)IBA 06/05/1986 - "Patients with sideroblastic anemia invariably had cells with a normal or high DNA content; none of these patients died during the study. " 09/01/1997 - "Haemopoiesis is polyclonal, without abnormality of nuclear DNA differing from the acquired idiopathic sideroblastic anemias which arise from a clonal transformed stem cell. " 01/22/2001 - "We report on a seven-year-old Japanese boy with Pearson syndrome, which is characterized by refractory sideroblastic anemia with vacuolization of marrow precursors and dysfunction of the exocrine pancreas, and caused by mitochondrial (mt) DNA deletions and duplications. " 08/07/2006 - "In addition, large deletions in mitochondrial DNA, whose integrity depends on a specific DNA polymerase, are the hallmark of Pearson's syndrome, a rare congenital disorder with sideroblastic anemia. " Order ALL the reference details at left...
8.	Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA 06/01/1968 - "Detailed clinical and genetic studies have been performed in a Negro family, which segregated for sex-linked sideroblastic anemia and glucose-6-phosphate dehydrogenase (G-6-DP) deficiency. " 04/01/1992 - "Sideroblastic anemia segregating with glucose-6-phosphate dehydrogenase deficiency." 06/01/1968 - "Hereditary sideroblastic anemia and glucose-6-phosphate dehydrogenase deficiency in a Negro family." Order ALL the reference details at left...
9.	Molecular Probes (Molecular Probe)IBA 01/17/1996 - "In this paper a review of the recent progress using molecular probes in the study of sideroblastic anemias and porphyrias is presented. " Order ALL the reference details at left...
10.	DeoxyuridineIBA 01/01/1978 - "Deoxyuridine suppression studies in bone marrow in primary refractory sideroblastic anemia." 01/01/1978 - "Because unexplained megaloblastic erythroid maturation occurs in patients with primary refractory sideroblastic anemia (PRSA), deoxyuridine (dU) suppression tests using 125I-UdR were performed on bone marrow from five patients with PRSA. " Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 05/01/1980 - "Sideroblastic anemia after treatment for Hogdkin's disease was seen in two patients 3 years after completion of radiation therapy and chemotherapy. " 01/15/1982 - "One patient, after a prodrome of macrocytic sideroblastic anemia, leukopenia, and thrombocytopenia, experienced erythroleukemia 34 months after starting chemotherapy, and cytogenetic studies revealed extensive chromosomal abnormalities. " Order ALL the reference details at left...
2.	Aftercare (After-Treatment) 05/01/1980 - "Sideroblastic anemia after treatment for Hogdkin's disease was seen in two patients 3 years after completion of radiation therapy and chemotherapy. " 07/01/1974 - "[Sideroblastic anemia after treatment with isoniazid (Nidrazid)]" 01/01/1987 - "We report two more cases, one with anemia of chronic disease and another with alcoholic sideroblastic anemia where the hemoglobin H was not detected at presentation and appeared after treatment of the underlying disorder. " Order ALL the reference details at left...
3.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 10/01/1992 - "Allogeneic bone marrow transplantation (BMT) was carried out on a 34-month-old boy with congenital sideroblastic anemia. " 10/01/1992 - "Congenital sideroblastic anemia successfully treated by allogeneic bone marrow transplantation." 01/01/2006 - "In this retrospective study, we report the results of the association of a combined phlebotomy program and chelation in hereditary sideroblastic anemia (HSA) to reduce iron overload after bone marrow transplantation (BMT). " Order ALL the reference details at left...
4.	Chelation Therapy (Therapy, Chelation) 04/28/1989 - "[A 2-year-old male patient with congenital sideroblastic anemia and long-term chelation therapy]" 01/01/2009 - "According to evidence-based guidelines, patients with sideroblastic anemia, 5q- syndrome, or other forms of refractory anemia, in whom long-term transfusion therapy is likely, are recognized as the best candidates to receive iron chelation therapy. " Order ALL the reference details at left...
5.	Renal Dialysis (Hemodialysis) 06/01/2003 - "We report here a patient who developed sideroblastic anemia at the age of 81 years while undergoing hemodialysis. " 06/01/2003 - "Late-onset X-linked sideroblastic anemia following hemodialysis." 01/01/1991 - "Vitamin B6 deficiency on hemodialysis causing sideroblastic anemia." Order ALL the reference details at left...

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