Autoimmune Hemolytic Anemia (Cold Agglutinin Disease)

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941 relevant articles (51 outcomes, 38 trials/studies) found for this Disease

Description: Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.

Also Known As:

Cold Agglutinin Disease; Anemia, Hemolytic, Autoimmune; Agglutinin Disease, Cold; Agglutinin Diseases, Cold; Anemia, Autoimmune Hemolytic; Anemias, Autoimmune Hemolytic; Autoimmune Hemolytic Anemias; Cold Agglutinin Diseases; Disease, Cold Agglutinin; Diseases, Cold Agglutinin; Hemolytic Anemias, Autoimmune; Anemia, Hemolytic, Idiopathic Acquired; Hemolytic Anemia, Autoimmune

Relationship Network

Disease Context: Research Results

Hemic and Lymphatic Diseases

Hematologic Diseases: 1420

Anemia: 15158

Hemolytic Anemia: 3205

Autoimmune Hemolytic Anemia: 941

Immune System Diseases: 1236

Autoimmune Diseases: 11575

Autoimmune Hemolytic Anemia: 941

Related Diseases

1.	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune)
2.	Syndrome
3.	Thrombocytopenia (Thrombopenia)
4.	Waldenstrom Macroglobulinemia (Macroglobulinemia)
5.	Multiple Myeloma

Experts

1.	D'Arena, Giovanni: 3 articles (03/2008 - 08/2006)
2.	Stahl, D: 3 articles (12/2005 - 01/2000)
3.	Cascavilla, Nicola: 2 articles (03/2008 - 07/2007)
4.	Izui, Shozo: 2 articles (02/2008 - 01/2003)
5.	Eastlund, Ted: 2 articles (08/2007 - 01/2006)
6.	Pinto, Antonio: 2 articles (07/2007 - 08/2006)
7.	D'Arco, Alfonso Maria: 2 articles (07/2007 - 08/2006)
8.	Califano, Catello: 2 articles (07/2007 - 08/2006)
9.	Amendola, Giovanni: 2 articles (07/2007 - 05/2003)
10.	Capalbo, Silvana: 2 articles (07/2007 - 08/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Autoimmune Hemolytic Anemia:

1.	rituximab (Mabthera)FDA Link 02/01/2008 - "Rituximab is the best treatment for cold agglutinin disease" 02/01/2005 - "We report herein the successful use of rituximab in the treatment of two patients with idiopathic refractory warm autoimmune hemolytic anemia, who are still in remission at 15 and 9 months following treatment." 10/01/2003 - "Successful induction and maintenance of long-term remission in a child with chronic relapsing autoimmune hemolytic anemia using rituximab." 04/01/2007 - "It is concluded that anti-CD20 monoclonal antibody (rituximab) is both effective and safe for the treatment of refractory autoimmune hemolytic anemia." 04/09/2005 - "Efficacy of therapy with anti-CD20 antibody (rituximab) in a patient with autoimmune hemolytic anemia associated]" Order ALL the reference details at left...
2.	Cyclophosphamide (Cytoxan)FDA Link 07/15/2002 - "To determine the safety and efficacy of high-dose cyclophosphamide among patients with severe refractory autoimmune hemolytic anemia, we treated 9 patients with cyclophosphamide (50 mg. kg(-1)" 09/01/2001 - "Intermittent high-dose cyclophosphamide therapy can be an effective treatment for refractory cold agglutinin disease." 07/15/2002 - "High-dose cyclophosphamide was well tolerated and induced durable remissions in patients with severe refractory autoimmune hemolytic anemia." 07/15/2002 - "High-dose cyclophosphamide for refractory autoimmune hemolytic anemia." 09/01/2001 - "Refractory idiopathic cold agglutinin disease successfully treated with intermittent high-dose cyclophosphamide]" Order ALL the reference details at left...
3.	Inosine Triphosphate (ITP)IBA 01/01/2001 - "A diagnosis of mixed-type autoimmune hemolytic anemia (AIHA) associated with ITP was made" 03/01/1990 - "A 25-years-old male, who had been diagnosed as ITP and treated at another hospital, was admitted in this hospital recently complaining of disseminated bullous-vesicular eruptions on the whole body and autoimmune hemolytic anemia" 09/01/1983 - "On the basis of tis observation, the present study was designed to investigate the prevalence of SLE in patients with the initial diagnosis of ITP, autoimmune hemolytic anemia (AIHA), Fisher-Evans' syndrome (F-E) and idiopathic aplastic bone marrow (IABM) and to investigate the salient clinical manifestations and prognosis of these patients" 09/01/2008 - "Idiopathic Thrombocytopenic Purpura (ITP) and Autoimmune Hemolytic Anemia (AIHA) are two autoimmune disorders which may be seen in association with CVID" 07/01/2007 - "Pathology included 19 cases of idiopathic thrombocytopenic purpura (ITP) and one case of autoimmune hemolytic anemia" Order ALL the reference details at left...
4.	Immunoglobulins (Immunoglobulin)IBA 12/01/1993 - "Efficacy of intravenous immunoglobulin in the treatment of autoimmune hemolytic anemia: results in 73 patients." 01/01/2000 - "Quantitative ELISA may be useful for determining the amount of red blood cell (RBC)-associated immunoglobulins (Igs) in patients with autoimmune hemolytic anemia (AIHA)" 09/01/1997 - "High-dose intravenous immunoglobulin as single therapy in a child with autoimmune hemolytic anemia." 12/01/1987 - "Clinical significance of the class of immunoglobulins on the erythrocytes in idiopathic autoimmune hemolytic anemia]" 01/01/1983 - "Autoimmune hemolytic anemia with immunoglobulin changes]" Order ALL the reference details at left...
5.	Danazol (Azol)FDA LinkGeneric 09/26/1992 - "We report the good results obtained with long-term danazol therapy (600 mg per day initially, than 400 mg per day) in 3 cases of chronic cold agglutinin disease and 1 case of idiopathic haemolytic anaemia with cold agglutinin in serum" 09/01/1993 - "Danazol may be an effective therapy in some cases of autoimmune hemolytic anemia with cold agglutinin." 09/01/1993 - "Severe autoimmune hemolytic anemia with cold agglutinin and sclerodermic features--favorable response to danazol." 02/01/1991 - "Thus, danazol may represent an important therapeutic option in the treatment of autoimmune hemolytic anemia." 02/01/1990 - "Idiopathic autoimmune hemolytic anemia successfully treated with danazol]" Order ALL the reference details at left...
6.	Prednisone (Sone)FDA LinkGeneric 01/31/1959 - "Prednisone in autoimmune hemolytic anemias: clinical and serological aspects.]" 05/01/1985 - "Splenectomy in 52 patients with autoimmune hemolytic anemia resulted in an excellent response in 64% (no further steroid therapy) and an improved status in another 21% (prednisone requirements, 15 mg/day or less)" 09/01/1980 - "Because of previous reports of benefit of plasma exchange in immunologic disorders, we plasmapheresed a 45-year-old woman with immune thrombocytopenia and autoimmune hemolytic anemia (Evans' syndrome) who appeared to be dying despite splenectomy, prednisone, immunosuppressives and transfusions" 01/11/1994 - "We report on a 59-year-old woman with severe cold agglutinin disease who was at first treated successfully with chlorambucil and prednisone" 10/01/2003 - "Successful management of severe chronic autoimmune hemolytic anemia with low dose cyclosporine and prednisone in an infant." Order ALL the reference details at left...
7.	AutoantibodiesIBA 01/01/2006 - "OBJECTIVE: To study the clinical characteristics of autoimmune hemolytic anemia (AIHA) with both warm and cold autoantibodies" 06/20/1981 - "The presentation of cold agglutinin disease is much more variable than has been seen in previous studies, haemolysis due to low titre autoantibodies being common" 01/01/2008 - "The diagnosis of autoimmune hemolytic anemia (AHA) requires evidence of shortened red blood cell (RBC) survival mediated by autoantibodies directed against autologous RBCs" 09/01/2007 - "This treatment inhibited the production of autoantibodies and the development of autoimmune hemolytic anemia" 01/01/2006 - "The clinical features of the autoimmune hemolytic anemia with both warm and cold autoantibodies]" Order ALL the reference details at left...
8.	Immunoglobulin M (IgM)IBA 12/01/2005 - "Investigation of autoimmune manifestations associated with WAS has shown that autoimmune hemolytic anemia and elevated serum IgM associate with a more severe clinical course" 05/01/2003 - "Autoimmune hemolytic anemia was significantly more observed in patients with high serum IgM level" 01/01/2003 - "Regulation of the immune response by natural IgM: lessons from warm autoimmune hemolytic anemia." 09/01/1998 - "Fatal autoimmune hemolytic anemia in a child due to warm-reactive immunoglobulin M antibody." 01/01/1998 - "Warm autoimmune hemolytic anemia associated with an IgM autoanti-Ge." Order ALL the reference details at left...
9.	Interferon-alpha (Interferon Alfa)FDA Link 04/01/2003 - "In our patient, clinical and laboratory findings suggested a correlation between autoimmune side effects of interferon-alpha and autoimmune hemolytic anemia." 04/01/1995 - "A case with autoimmune hemolytic anemia (AIHA) induced by interferon-alpha (IFN-alpha) is presented" 01/11/1994 - "Treatment of severe idiopathic cold-agglutinin diseases using interferon-alpha 2b]" 08/01/1989 - "Alpha-interferon for severe cold agglutinin disease." 06/01/2007 - "Complete remission of multiple myeloma after autoimmune hemolytic anemia: possible association with interferon-alpha." Order ALL the reference details at left...
10.	Immunoglobulin G (IgG)IBA 01/01/2007 - "Of the 49 patients carrying IgG on their RBCs, 21 (42.8%) were suffering from connective tissue disorders and another 16 patients (32.7%) had autoimmune hemolytic anemia" 02/01/2006 - "Here we identify C5a as a novel key mediator of autoimmune hemolytic anemia (AIHA) and show that mice lacking C5aR are partially resistant to this IgG autoantibody-induced disease model" 08/01/2003 - "These mice also exhibited reduced IgG-mediated phagocytosis of erythrocytes by Kupffer cells in a murine model of autoimmune hemolytic anemia" 02/01/2001 - "Detection of red blood cell-bound immunoglobulin G by flow cytometry and its application in the diagnosis of autoimmune hemolytic anemia." 04/17/2000 - "This demonstration of the respective roles in vivo of four different IgG isotypes, and of two phagocytic FcgammaRs, in autoimmune hemolytic anemia highlights the major importance of the regulation of IgG isotype responses in autoantibody-mediated pathology and humoral immunity." Order ALL the reference details at left...

Therapies and Procedures

1.	Splenectomy 03/01/2004 - "We conclude that laparoscopic splenectomy is a safe and effective treatment for autoimmune hemolytic anemia in patients with CLL who fail medical therapy." 05/12/1989 - "Remission of cold agglutinin disease following splenectomy]" 03/01/2008 - "32 years ago, the patient suffered the splenectomy, from a severe autoimmune hemolytic anemia" 06/30/2006 - "Thereafter, laparoscopic splenectomy was performed because her autoimmune hemolytic anemia was refractory and dependent on steroid therapy" 07/01/2004 - "Four patients underwent a splenectomy (2 complete responses, 2 failures); 2 additional splenectomies were performed for associated autoimmune hemolytic anemia" Order ALL the reference details at left...
2.	Transplants (Transplant) 07/01/2000 - "Furthermore, hemolytic anemia, autoimmune phenomena, and hyalinizing glomerular renal disease of New Zealand Black (NZB) mice were prevented or cured by stem cell transplants using purified stem cells from MHC-matched DBA/2 donors or NZB donors" 11/01/2001 - "We further hypothesize that the underlying mechanism of autoimmune hemolytic anemia is related to the passenger B lymphocytes in the graft." 11/01/2001 - "Severe Coombs'-negative autoimmune hemolytic anemia in a kidney transplant patient." 01/01/1998 - "Passenger lymphocytes in grafted kidney have been reported to result in autoimmune hemolytic anemia (AIHA) in minor ABO incompatible transplants" 05/01/2006 - "Autoimmune hemolytic anemia (AIHA) has been reported to occur after renal transplantation, and typically does so in the first few weeks post-transplant" Order ALL the reference details at left...
3.	Drug Therapy (Chemotherapy) 08/01/2007 - "Summarizing, PTLD may be accompanied by cold agglutinin disease, and both may be successfully treated by immuno-chemotherapy" 05/15/1982 - "One patient presented with an autoimmune hemolytic anemia, which remitted completely with chemotherapy" 10/01/1976 - "Drug therapy of autoimmune hemolytic anemia." 06/01/2003 - "Warm, active antibody adult autoimmune hemolytic anemia is the most common form of hemolytic anemia not related to drug therapy" 12/01/1986 - "Chemotherapy of balloon-occluded arterial infusion in a patient with unresectable hepatocellular carcinoma and autoimmune hemolytic anemia]" Order ALL the reference details at left...
4.	Plasmapheresis 08/01/2006 - "Plasmapheresis for fulminant autoimmune hemolytic anemia with rapidly progressing disturbance of consciousness]" 04/01/2002 - "Resolution of severe Donath-Landsteiner autoimmune hemolytic anemia temporally associated with institution of plasmapheresis." 01/01/1992 - "It is shown that low volumes of plasmapheresis can be used in combined treatment of patients with autoimmune hemolytic anemia who did not respond well to the routine therapy" 01/01/1992 - "Plasmapheresis in the comprehensive treatment of autoimmune hemolytic anemia]" 04/01/1985 - "Plasmapheresis as adjuvant therapy for autoimmune hemolytic anemia in two dogs." Order ALL the reference details at left...
5.	Aftercare (After-Treatment) 06/01/1998 - "Eight patients (22%) developed severe autoimmune hemolytic anemia (AIHA) during or after treatment, and one died" 01/01/2001 - "Systemic inflammatory response syndrome triggered by necrotizing cholecystitis after treatment of underlying low titer cold agglutinin disease]" 01/01/1998 - "After treatment of the lymphoma with irradiation to the brain and chemotherapy she developed Evans syndrome with autoimmune hemolytic anemia and thrombocytopenia" 04/15/2004 - "Conventional therapies for primary chronic cold agglutinin disease (CAD) are ineffective, but remissions after treatment with the anti-CD20 antibody rituximab have been described in a small, prospective trial and in some case reports" 07/01/1997 - "Although tests for autoimmune hemolytic anemia were negative the patient made a dramatic recovery after treatment with corticosteroids, suggesting an immune mediated mechanism nonetheless." Order ALL the reference details at left...

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