Aplastic Anemia (Anemia, Hypoplastic)

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3023 relevant articles (178 outcomes, 212 trials/studies) found for this Disease

Description: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.

Also Known As:

Anemia, Hypoplastic; Anemia, Aplastic; Anemias, Aplastic; Anemias, Hypoplastic; Aplastic Anemias; Hypoplastic Anemia; Hypoplastic Anemias

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Disease Context: Research Results

Hemic and Lymphatic Diseases

Hematologic Diseases: 1418

Anemia: 15125

Aplastic Anemia: 3023

Congenital Hypoplastic Anemia: 46

Bone Marrow Diseases: 60

Aplastic Anemia: 3023

Congenital Hypoplastic Anemia: 46

Related Diseases

1.	Leukemia
2.	Infection
3.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
4.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
5.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
354 Diseases and 1339 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	Young, Neal S: 13 articles (06/2007 - 05/2002)
2.	Bacigalupo, A: 8 articles (01/2008 - 01/2000)
3.	Kojima, Seiji: 7 articles (09/2008 - 08/2002)
4.	Locasciulli, A: 6 articles (01/2008 - 01/2000)
5.	Socié, G: 6 articles (01/2008 - 01/2000)
6.	Schrezenmeier, Hubert: 6 articles (08/2007 - 10/2002)
7.	Nakao, Shinji: 5 articles (05/2008 - 10/2004)
8.	Marsh, J: 5 articles (01/2008 - 01/2000)
9.	Locasciulli, Anna: 5 articles (08/2007 - 09/2004)
10.	Bacigalupo, Andrea: 5 articles (08/2007 - 09/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Aplastic Anemia:

1.	Antilymphocyte Serum (Anti-Thymocyte Globulin)IBA 08/01/1987 - "Antithymocyte globulin (ATG), a horse antihuman thymus antiserum highly effective in the majority of patients with aplastic anemia, was studied for its in vitro effects on hematopoietic progenitor cells" 12/01/1989 - "In contrast, two kinds of antilymphocyte globulin (ALG) were effective for 9.4% and 15.6% of the severe form of aplastic anemia, and two kinds of antithymocytoglobulin (ATG) were effective in 30.8% and 37.2% of the patients, although the difference between ALG and ATG was not statistically significant" 05/15/1991 - "Therapy with antilymphocyte globulin (ALG) has been shown to be effective in restoring hematopoiesis to some patients with aplastic anemia" 01/20/1983 - "These data indicate that antithymocyte globulin is effective in improving hematopoiesis in some patients with aplastic anemia." 11/01/1981 - "Anti-thymocyte globulin effective in the treatment of aplastic anemia does not stimulate granulocyte precursor cells." Get all the results and reference details, order at left...
2.	Cyclosporine (Ciclosporin)FDA LinkGeneric 07/01/1989 - "According to recent reports, cyclosporin (CsA) has been proven to be a cure for some patients with severe aplastic anemia (SAA)" 05/15/1992 - "Cyclosporine (CyA) therapy has been shown to be effective in some patients with aplastic anemia" 01/01/2001 - "AIM: To evaluate the efficacy of cyclosporin A (CyA) at different stages of immunosuppressive therapy (IST) in patients with aplastic anemia (AA)" 04/01/1998 - "Efficacy of cyclosporin A in the treatment of aplastic anemia and its mechanism]" 03/01/1995 - "The efficacy of cyclosporin for aplastic anemia was 13.8% after 8 weeks, and 28.0% after 16 weeks" Get all the results and reference details, order at left...
3.	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 12/01/1995 - "Combination therapy consisting of G-CSF and EPO may be beneficial for patients with aplastic anemia." 01/01/2000 - "Combination therapy with G-CSF and EPO may be safe and effective for elderly patients with aplastic anemia when the choice of therapy is limited." 09/15/2007 - "We report the results of a randomized study to elucidate whether addition of granulocyte colony-stimulating factor (G-CSF) to immunosuppressive therapy is valuable for the treatment of severe aplastic anemia (SAA) in adults" 05/15/2007 - "Granulocyte colony-stimulating factor and severe aplastic anemia." 04/01/2007 - "Relapse of aplastic anemia was not associated with a worse outcome in patients who did not receive G-CSF as first therapy, whereas relapse was associated with a significantly worse outcome in those patients who received G-CSF" Get all the results and reference details, order at left...
4.	Cyclophosphamide (Cytoxan)FDA Link 12/15/1998 - "BACKGROUND: Immunoablative high-dose cyclophosphamide without stem-cell rescue induces durable, complete remission in most patients with aplastic anemia" 07/15/2002 - "High-dose cyclophosphamide, without stem cell rescue, has been used successfully to treat aplastic anemia and other autoimmune disorders" 10/02/2001 - "OBJECTIVE: To confirm the safety and efficacy of high-dose cyclophosphamide therapy alone in patients with severe aplastic anemia" 10/02/2001 - "Durable treatment-free remission after high-dose cyclophosphamide therapy for previously untreated severe aplastic anemia." 12/01/2004 - "We conclude that the conditioning regimen containing cyclophosphamide and anti-CD52 MoAb is well tolerated and effective for acquired aplastic anemia with HLA-matched sibling donors" Get all the results and reference details, order at left...
5.	ErythropoietinIBA 12/01/1993 - "An immunologic crossreactant of erythropoietin seemed to develop and persist in serum samples from a patient during treatment and remission of idiopathic aplastic anemia" 07/01/1986 - "Clinico-hematological studies on the activity of serum erythropoietin and erythropoiesis in hypoplastic anemia]" 03/01/1998 - "Erythropoietin therapy for aplastic anemia." 02/01/1998 - "We examined the pharmacokinetics of recombinant human erythropoietin (rh-EPO) in genetically anemic mice (W/Wv genotype) to clarify its disposition mechanism in hematopoietic injury such as occurs in aplastic anemia" 01/01/1998 - "Hypoplastic anemias (AHC) on the other hand, are accompanied by significantly larger increases in the erythropoietin concentration" Get all the results and reference details, order at left...
6.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/01/1992 - "It is concluded that the combination of rHu GM-CSF and glucocorticosteroids can be used as a therapeutic option that may lead to beneficial results in drug-induced aplastic anemia." 12/22/1988 - "These results indicate that recombinant human GM-CSF is effective in stimulating myelopoiesis in patients with severe aplastic anemia and may benefit some patients in whom the disorder is refractory to standard forms of therapy." 07/01/1995 - "In the aplastic anemia trial, 9 out of 12 patients had some improvement when treated with GM-CSF" 01/01/1992 - "Clinical trials of granulocyte-macrophage colony-stimulating factor for the treatment of aplastic anemia." 09/15/1990 - "Nine pediatric patients (median age, 8 years; range, 0.7 to 19 years), eight with refractory aplastic anemia and one with newly diagnosed aplasia, were enrolled in a phase I/II trial of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) administered via continuous intravenous infusion" Get all the results and reference details, order at left...
7.	Methylprednisolone FDA LinkGeneric 04/01/1990 - "Therefore, a diagnosis of aplastic anemia was made, and bolus methylprednisolone therapy (1,000 mg/day x 3 days) was performed, which brought the patient to complete remission" 04/01/1990 - "Aplastic anemia associated with minimal serum M-protein treated successfully with repeated bolus methylprednisolone therapy]" 09/01/1995 - "A 19-year-old man was diagnosed as having severe aplastic anemia and received high-dose methylprednisolone treatment without hematological response" 01/01/1993 - "Between January 1986 and July 1990, 17 patients with acquired aplastic anemia were treated with ALG or ATG combined with high doses of methylprednisolone" 04/01/1991 - "Four males and two females, aged 13 to 57 years (median 22 years), with acquired severe aplastic anemia (AA) were treated with intravenous bolus of high doses of 6-methylprednisolone (MPL)" Get all the results and reference details, order at left...
8.	AndrogensIBA 09/29/1979 - "Immunosuppression, bone marrow infusion and low dose androgens, successful therapy of severe aplastic anemia]" 08/01/1984 - "Thus androgens may be particularly useful in the treatment of SLE-associated aplastic anemia." 05/01/1984 - "These results indicate that an in vitro CFU-E culture system to the presence of FMT may be helpful in predicting the response to androgens in vivo in patients with aplastic anemia." 01/01/1980 - "In a prospective group study, 254 cases of aplastic anemia treated with a high dose of androgens were followed a minimum of 4 months and up to 8 years" 03/01/1997 - "Androgens have been shown to be inferior in the treatment of aplastic anemia" Get all the results and reference details, order at left...
9.	Inosine Triphosphate (ITP)IBA 07/01/2005 - "The RP was highest in active phase of ITP, and relatively high in the partial remission phase of aplastic anemia" 07/01/2005 - "LP was significantly higher in patients with ITP, especially in active phase, while LP was markedly lower in patients with aplastic anemia (AA), ET, or CML" 01/01/1991 - "Children with a diagnosis of ITP who suffer a progressive fall in all hematologic cell lines should be examined for the possibility of EBV-associated aplastic anemia." 05/01/1988 - "The initial clinical and laboratory findings of 50 patients with aplastic anemia also were reviewed; all had features atypical of acute ITP" 05/01/1985 - "Effect of sera from patients with aplastic anemia and ITP on murine megakaryocytopoiesis]" Get all the results and reference details, order at left...
10.	GoldIBA 01/01/1995 - "A 65-year-old female with severe aplastic anemia induced by gold salt, whose hematopoietic recovery was initiated by rhGM-CSF therapy, was reported" 12/01/1987 - "Gold-induced aplastic anemia." 10/01/1987 - "Immunosuppression as initial treatment for gold induced aplastic anemia." 01/01/1986 - "Ultrastructural evidence for persistent gold in the bone marrow of a patient with aplastic anemia." 10/01/1985 - "Gold induced aplastic anemia." Get all the results and reference details, order at left...
632 Drugs and Important Bio-Agents and 2121 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 05/09/1991 - "Immunosuppression is the most effective treatment for patients with aplastic anemia, except for bone marrow transplantation" 01/01/1989 - "Although HLA-matched bone marrow transplantation leads to a faster and more complete recovery for children with aplastic anemia, immunosuppressive therapy can provide a good outcome for children with this disorder." 07/01/1980 - "Bone marrow transplantation has proved to be very helpful in the treatment of aplastic anemia and has provided impetus for increased knowledge concerning the pathogenesis of the aplasia" 01/01/2004 - "Given this, it has been suggested that allogenic bone marrow transplantation (BMT) possibly could be a cure for FOP, and drawn attention to a previously unappreciated case of an FOP patient who had successful BMT for aplastic anemia with apparent short- and medium-term arresting of the FOP disease process" 01/01/2000 - "Patients with severe aplastic anemia (SAA) can be successfully treated with bone marrow transplantation (BMT) or immunosuppressive therapy (IS)" Get all the results and reference details, order at left...
2.	Transplantation (Transplant Recipients) 06/01/1987 - "This preoperative regimen is extremely effective in decreasing rejection following transplantation for severe aplastic anemia" 09/01/1983 - "Twenty-nine of the 40 transplanted patients are surviving from 1.5 to 59 mo, with a median follow-up of 24 mo. The actuarial survival rate for these heavily transfused patients with aplastic anemia is 72% at 2 yr. This preparative regimen is extremely effective in decreasing rejection following transplantation for severe aplastic anemia" 08/01/1991 - "Allogeneic marrow transplantation from an HLA-identical sibling has proven to be an effective treatment for severe aplastic anemia with restoration of normal hematopoiesis and long-term survival in 70-80% of recipients" 02/01/2002 - "Survival of patients with aplastic anemia treated with transplantation of bone marrow has improved significantly over the past several decades" 08/01/1990 - "This study extends our previous observation that severe aplastic anemia acquired after exposure to drugs or toxins can be cured by marrow transplantation." Get all the results and reference details, order at left...
3.	Transplants (Transplant) 11/01/2004 - "We present a case of a 13-year-old boy who was diagnosed at age four with idopathic aplastic anemia, was treated successfully with an allogeneic bone marrow transplant, then subsequently developed skin, nail, and tongue lesions" 02/01/2004 - "In total, 64% were in remission or in chronic phase or had aplastic anemia (good risk), and 36% had active disease at the time of transplant (bad risk)" 08/01/2002 - "Matching of HLA class I alleles and improvement of preparative regimens should result in improved outcomes in patients with severe aplastic anemia who receive transplants from unrelated donors." 10/15/1998 - "Decreased rejection and improved survival of first and second marrow transplants for severe aplastic anemia (a 26-year retrospective analysis)." 10/01/1989 - "Eighty-five percent of untransfused and 70% of transfused patients with severe aplastic anemia (SAA) are cured with bone marrow transplants from histocompatible sibling donors" Get all the results and reference details, order at left...
4.	Stem Cell Transplantation 05/01/2007 - "Unrelated stem cell transplantation for severe acquired aplastic anemia: improved outcome in the era of high-resolution HLA matching between donor and recipient." 03/05/2003 - "Aplastic anemia can be effectively treated by stem cell transplantation or immunosuppression" 04/02/2002 - "Aplastic anemia can be effectively treated by stem-cell transplantation or immunosuppressive therapy" 02/01/2008 - "We conducted a prospective multicenter study to compare the efficacy of repeated immunosuppressive therapy (IST) with stem-cell transplantation (SCT) from an alternative donor in children with acquired aplastic anemia (AA) who failed to respond to an initial course of IST" 07/21/2008 - "A 30-year-old Japanese woman with acquired severe aplastic anemia (SAA), diagnosed 20 years ago, was referred to our institution for allogeneic stem cell transplantation (SCT)" Get all the results and reference details, order at left...
5.	Splenectomy 01/01/1990 - "Analysis of the clinical efficacy and long-term survival of patients with grave and not grave forms of aplastic anemia, subjected to splenectomy or treated with antilymphocytic globulin has shown that in grave aplastic anemia, the clinical efficacy of antilymphocytic globulin is higher than the efficacy of the operative treatment methods" 01/01/2006 - "AIM: To define efficacy of splenectomy (SE) in current programmed therapy of aplastic anemia (AA)" 11/01/1995 - "Efficacy of splenectomy at initial stage of multimodality treatment of severe aplastic anemia was assessed in 25 patients aged 15-42" 01/01/1992 - "She had a remission after delivery but two years later aplastic anemia refractory to steroid and splenectomy developed" 08/01/1975 - "Valve of the radioisotope method of study in the determination of indications for splenectomy in patients with hypo- and aplastic anemia]" Get all the results and reference details, order at left...
64 Therapies and Procedures and 1342 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

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