Androgen-Binding Protein

Carrier proteins produced in the Sertoli cells of the testis, secreted into the seminiferous tubules, and transported via the efferent ducts to the epididymis. They participate in the transport of androgens. Androgen-binding protein has the same amino acid sequence as SEX HORMONE-BINDING GLOBULIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.

Also Known As:

Networked: 34 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Du, Yeqing: 1 article (11/2021)
2.	Hu, Jianhong: 1 article (11/2021)
3.	Li, Yu: 1 article (11/2021)
4.	Ren, Fa: 1 article (11/2021)
5.	Wang, Liqiang: 1 article (11/2021)
6.	Xi, Huaming: 1 article (11/2021)
7.	Aydos, Kaan: 1 article (02/2019)
8.	Aydos, Oya Sena: 1 article (02/2019)
9.	Ozkavukcu, Sinan: 1 article (02/2019)
10.	Sunguroglu, Asuman: 1 article (02/2019)

Related Diseases

1.	Androgen-Insensitivity Syndrome (Testicular Feminization) 05/01/1976 - "The finding that dihydrotestosterone binding is abnormal in two forms of hereditary androgen resistance in addition to complete testicular feminization suggests either that these disorders are the result of allelic mutations affecting the function of the androgen-binding protein or that normal dihydrotestosterone binding requires the participation of more than one gene product." 11/01/1984 - "Using conditions for optimal recovery of androgen receptor from human testes established by previous studies, we detected the presence of a high-affinity (dissociation constant = 3.2 X 10(-10) mol/L), low-capacity (4.2 X 10(-12) mol/mg DNA), androgen-binding protein when tritium-labeled R1881 was incubated at 4 degrees C with nuclear extracts from the gonads of control patients or from a patient with testicular feminization syndrome but not when incubated at 37 degrees C. "
2.	Hypothyroidism 08/01/1999 - "Duration-dependent effect of transient neonatal hypothyroidism on sertoli and germ cell number, and plasma and testicular interstitial fluid androgen binding protein concentration." 08/01/1999 - "Impact of neonatal onset hypothyroidism on Sertoli cell number, plasma and testicular interstitial fluid androgen binding protein concentration." 02/01/2001 - "We have previously demonstrated that neonatal and transient neonatal hypothyroidism modulates Leydig, Sertoli, and germ cell numbers, sex steroids and androgen binding protein concentration. " 10/01/1989 - "Hypothyroidism, induced by oral administration of methimazole from the day of birth, was characterized by a severe retardation of body and testis growth and a net inhibition of the increase in Sertoli cell gamma-glutamyl transpeptidase (GGT) activity as well as in androgen-binding protein (ABP) and lactate production, which normally occur during postnatal development of Sertoli cells. "
3.	Hydatidiform Mole (Molar Pregnancy) 06/01/1983 - "We further studied the androgen-binding protein (ABP) that we recently evidenced in the serum from two patients with hydatidiform mole [Ref. " 10/01/1981 - "Extracts of hydatidiform mole vesicles and the fluid contained in these vesicles were shown to contain a trophoblastic androgen binding protein. " 10/01/1981 - "Evidence for the existence of an androgen binding protein in hydatidiform mole vesicles." 06/01/1983 - "Further evidence for distinction between sex hormone-binding globulin and an androgen-binding protein in hydatidiform mole serum." 12/01/1986 - "The trophoblastic androgen-binding protein (t-ABP) was purified 150-fold with a recovery of 51% from serum of patients with hydatidiform mole using various chromatographic techniques, successively affinity on concanavalin A, ion exchange on QAE-Sephadex A 50, gel filtration on Sephadex G 200 and chromatofocusing. "
4.	Cryptorchidism (Undescended Testes) 02/01/1982 - "The effects of experimental unilateral cryptorchidism on the scrotal testis regarding weight, morphology and secretion of tubular fluid and the sertoli-cell specific androgen binding protein (ABP) were studied. " 12/01/1975 - "The production of testicular androgen-binding protein (ABP), as a measure of Sertoli cell function, was studied after unilateral or bilateral experimental cryptorchidism in adult rats. " 10/01/1987 - "Androgen-binding protein (ABP) was measured in serum and testicular interstitial fluid (IF) from rats during sexual maturation or in adult rats in which impairment of spermatogenesis had been induced by (i) testosterone withdrawal following Leydig cell destruction, (ii) local heating (43 degrees C) of the testes for 30 min or (iii) induction of unilateral cryptorchidism (UCD). "
5.	Body Weight (Weight, Body) 04/01/1984 - "If related to constant body weight, the sum of testicular and epididymal androgen-binding protein was identical in both normo- and hyperglycaemic animals. " 07/01/1988 - "Body weight, testis, epididymis, prostate and seminal vesicle weights, the number of germ cells and Sertoli cells, tubular ultrastructure, epididymal and testicular levels of biologically active androgen-binding protein (ABP), and the plasma concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone were monitored. " 07/01/1993 - "The relationship of the testicular distribution and [3H]dihydrotestosterone-binding capacity of androgen-binding protein (ABP) to the completion of spermiogenesis was examined in mature rats given daily injections of 25 or 250 micrograms kg-1 body weight of GnRH antagonist (GnRH-A; Ac-D(2), Nal1, 4Cl-D, Phe2, D-Trp3, D-Arg6, D-Ala10) for two weeks with or without subcutaneous implantation of 10 cm testosterone capsules. "

Related Drugs and Biologics

1.	Metribolone
2.	Tritium
3.	Androgen Receptors (Androgen Receptor)
4.	DNA (Deoxyribonucleic Acid)
5.	Testosterone (Sustanon)
6.	Sex Hormone-Binding Globulin
7.	FSH Receptors (FSH Receptor)
8.	Steroids
9.	Dihydrotestosterone (Androstanolone)
10.	Follicle Stimulating Hormone (Follitropin)

Related Therapies and Procedures

1.	Injections
2.	Oral Administration