Anaplasia

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177 relevant articles (3 outcomes, 12 trials/studies) found for this Disease

Description: Loss of structural differentiation and useful function of neoplastic cells.

Also Known As:

Anaplasias

Relationship Network

Disease Context: Research Results

Neoplasms: 387730

Neoplastic Processes: 162

Anaplasia: 177

Signs and Symptoms Pathological Conditions

Pathologic Processes: 2211

Neoplastic Processes: 162

Anaplasia: 177

Related Diseases

1.	Neoplasms (Cancer)
2.	Wilms Tumor (Wilm's Tumor)
3.	Meningioma (Meningiomas)
4.	Rhabdoid Tumor (Rhabdoid Tumors)
5.	Clear Cell Sarcoma

Experts

1.	Bielinska, M: 1 article (07/2004)
2.	Kiupel, M: 1 article (07/2004)
3.	Capen, C C: 1 article (07/2004)
4.	Kiiveri, S: 1 article (07/2004)
5.	Peterson, R A: 1 article (07/2004)
6.	Heikinheimo, M: 1 article (07/2004)
7.	Wilson, D B: 1 article (07/2004)
8.	Paul, Dieter: 1 article (03/2004)
9.	Chávez-Dueñas, Lucía: 1 article (03/2004)
10.	Soto-Zárate, Carlos: 1 article (03/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Anaplasia:

1.	Keratins (Keratin)IBA 05/01/2008 - "Histologically, KCM is similar to KA, with a central keratin-filled crater, overhanging lips of epithelium, a sharp outline between the tumour nests and stroma, and lack of anaplasia and stroma desmoplasia" 11/01/2001 - "Ultrastructual features included cytokeratin filaments and desmosomes, as well as features of anaplasia (irregular cytoplasmic and nuclear margins, surface filopodia, and abnormal intermediate filament production)" 03/01/2006 - "The following features of the resected tumor were helpful for concluding that these acini were benign: lack of cytological anaplasia in spite of structural atypia, presence of scattered basal cells confirmed by immunohistochemistry (high-molecular-weight cytokeratin), and histological transition from these acini to apparently benign slit-like glands" 08/01/1990 - "The changes of keratin fibers appeared to be parallel to the grade of histological anaplasia of the tumor formed by implantation of bladder carcinoma cell line cells to nude mice" 03/01/1988 - "Six cases are reported (four gliosarcomas and two glioblastomas) in which the epithelial-like areas of glial anaplasia showed focal squamous cell differentiation, characterized by the development of epithelial whorls, keratin pearls and immunopositivity for cytokeratin" Order ALL the reference details at left...
2.	Tamoxifen FDA LinkGeneric 01/01/1983 - "No correlation was found between response to treatment with tamoxifen and disease free interval but a favourable connection was observed between good response and low grade of anaplasia of the tumor" Order ALL the reference details at left...
3.	Cyclophosphamide (Cytoxan)FDA Link 10/01/1994 - "The addition of cyclophosphamide to the three-drug treatment regimen improved the 4-year relapse-free survival rate of children with stage II to IV diffuse anaplasia" 10/01/1994 - "PURPOSE: To evaluate the effect of the combination of vincristine, dactinomycin, and doxorubicin with (regimen J) or without (regimen DD-RT) cyclophosphamide on the relapse-free survival of children with stages II to IV Wilms' tumor and focal or diffuse anaplasia" Order ALL the reference details at left...
4.	DNA (Deoxyribonucleic Acid)IBA 01/01/1993 - "This study aims to address the possibility that expression of the HPA binding ligand may be of prognostic significance through an association with increased cellular proliferation (as measured by S-phase fraction and histological grade), anaplasia (reflected in histological grade), or ploidy (DNA index)" 12/01/1996 - "The aim of the present work is therefore to investigate whether the quantitative description of morphonuclear features (including cell anaplasia) and the DNA ploidy level can contribute significant information to the Gleason grading, thus partly at least reducing its subjective nature" 01/01/1983 - "It was found that the growth of anaplasia of the tumour tissue to be characterized by increased "DNA Accumulation Index" and increased polyploidy" 06/22/1979 - "The results demonstrate a correlation between the degree of cellular anaplasia and the occurrence of cell populations with increased DNA content in the tumours" 01/01/1978 - "There was a correlation between cell anaplasia and the DNA distribution: grade III bladder tumours had larger 4c and 8c fractions than grade II tumours." Order ALL the reference details at left...
5.	Estrogens (Estrogen)FDA Link 06/01/1980 - "Low SPF's were associated with older age, minimal nuclear anaplasia, and estrogen receptor positivity, but SPF was the only variable that could be shown to have independent prognostic significance" 01/01/1988 - "Retrospectively, an increased recurrence-free survival in TAM treated patients was significant in the following subgroups: tumor less than 5 cm, positive lymph nodes, anaplasia grade II and estrogen receptor level greater than 100 fmol/mg cytosol protein" 06/01/1994 - "Sixty-six cases were investigated for the prognostic influence of estrogen (ER) and progesterone (PgR) status, mitotic activity, degree of nuclear anaplasia, and inflammatory reaction" 08/12/1991 - "However, the prolongation is only significant in patients with four or more positive nodes, with tumours of less than 5 centimeters or with tumours of anaplasia grade II. Estrogen (ER) and progesterone receptor (PgR) concentrations were measured in tumours from 309 and 219 patients, respectively" 03/01/1985 - "A statistical association with estrogen receptor content and grade of anaplasia was found for two of the antigens, Mam 3a and Mam 3b" Order ALL the reference details at left...
6.	CollagenIBA 12/01/2002 - "Histologically, the lesion was composed of astrocytes and collagen-producing fibroblasts with no anaplasia" 06/15/2007 - "METHODS: The study included 74 adult patients with histologically confirmed medulloblastomas and retrospectively reassessed 67 cases with available slides for the presence of nodularity, collagen deposition (desmoplasia without nodules), and degree and extent of anaplasia" 01/01/2003 - "In some areas, an abundance of keloidal collagen imparted a close resemblance to a solitary fibrous tumor, making it difficult to establish the diagnosis on the initial needle biopsy, although the malignant nature of the tumor was suggested because of nuclear anaplasia" 07/01/1990 - "We have studied the ultrastructural distribution of GFAP, vimentin, FVIII/RAg and collagen IV in biopsies of human gliomas with various degree of anaplasia" 12/01/1983 - "The initial biochemical data (serum[S]-carcinoembryonic antigen, S-lactate dehydrogenase, S-gammaglutamyl transferase, S-alkaline phosphatase urine[U]-creatinine, and three urinary quantities related to collagen metabolism) and surgical pathology data (tumor size, grade of tumor anaplasia, number of positive lymph nodes, number of negative lymph nodes) were examined in 52 consecutive postmenopausal risk group II patients operated for primary breast cancer without metastatic disease (mastectomy + partial axillary resection) who participated in the Danish Breast Cancer Group's controlled clinical trial of radiation (RT) alone, and RT + levamisol" Order ALL the reference details at left...
7.	Proliferating Cell Nuclear Antigen (PCNA)IBA 02/01/1995 - "PCNA L.I. was found to correlate significantly with grading and more specifically with mitotic activity and degree of nuclear anaplasia" 01/01/1994 - "The PCNA index correlated closely with either the nuclear anaplasia or T stage, and increased in conjunction with the increased nuclear anaplasia (rs = 0.641; p < 0.001) or T stage (rs = 0.435; p < 0.01)" 01/01/1994 - "There was a significant difference in the PCNA index according to the growth pattern (p < 0.001), nuclear anaplasia (p < 0.001) and T stage (p < 0.01)" 11/01/1993 - "PCNA LI was found to correlate significantly with grading and more specifically with mitotic activity and degree of nuclear anaplasia" 02/01/1995 - "Our results indicate that mitotic activity and degree of nuclear anaplasia might be the most important parameters to take into consideration, when studying the role of PCNA in exocrine pancreatic carcinomas." Order ALL the reference details at left...
8.	EnzymesIBA 02/01/1990 - "With the increasing anaplasia, there was a corresponding rise in the activity of the two enzymes" 07/01/1973 - "Oxidative-reductive enzymes and the phenomenon of anaplasia in neuroectodermal tumors (a histochemical study)]" 09/01/1997 - "No correlations, however, were observed between mRNA levels of TIMPs and prognostic factors such as patient age, tumor size, grade of anaplasia, or steroid receptor status; neither were any correlations found between these clinicopathological characteristics and the mRNA expression of the collagenolytic enzymes matrix metalloproteinase-2 and matrix metalloproteinase-9" Order ALL the reference details at left...
9.	tranilast (N 5')IBA 01/15/2001 - "After surgery, patients were assigned according to tumor stage and histology to four different treatment groups: stage I and favorable histology (n = 5) were to have no further treatment (NFT); stage I and standard histology or anaplasia (n = 244), VCR and AMD for 17 weeks (AV); stages II and III and favorable or standard histology, VCR, AMD, and an anthracycline for 27 weeks (AVE) with no abdominal radiotherapy for stage II N0 disease (n = 75) or with a 15-Gy dose of abdominal irradiation (RTH) in case of stages IIN1 and III (n = 56)" 05/01/1983 - "These included congenital mesoblastic nephroma (n = 5), fetal rhabdomyomatous nephroblastoma (n = 2), cystic partially differentiated nephroblastoma (n = 3), nephroblastoma with focal or diffuse anaplasia (n = 2), clear cell sarcoma or bone metastasizing renal tumor of childhood (n = 4), rhabdoid tumor (n = 2) and rhabdomyosarcomatous nephroblastoma (n = 3)" 02/01/1994 - "The PCNA scores for each tumor were as follows; the renal specimens for the control study (n = 10, a mean +/- SD of 8.04 +/- 3.59%); the nephroblastomas without anaplasia (n = 15, 27.70 +/- 7.59%); the nephroblastomas with anaplasia (n = 3, 36.89 +/- 1.17%); the sarcomatous renal tumors (n = 5, 27.75 +/- 5.02); the renal cell carcinomas (n = 2, 28.31 +/- 0.86%), a congenital mesoblastic nephroma and a juxtaglomerular cell tumor (10.05 and 10.80%, respectively)" Order ALL the reference details at left...
10.	Vincristine (Oncovin)FDA LinkGeneric 09/01/1991 - "According to the National Wilms' Tumor Studies (NWTS), a group of patients with histologic features of anaplasia or sarcomatous Wilms' tumors (malignant rhabdoid tumors and clear cell sarcomas) were less responsive to vincristine and actinomycin" 10/01/1994 - "CONCLUSION: We conclude that children with focal anaplasia have an excellent prognosis when treated with vincristine, doxorubicin, and dactinomycin" 10/01/1994 - "PURPOSE: To evaluate the effect of the combination of vincristine, dactinomycin, and doxorubicin with (regimen J) or without (regimen DD-RT) cyclophosphamide on the relapse-free survival of children with stages II to IV Wilms' tumor and focal or diffuse anaplasia" Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 05/01/2004 - "The main objective of the trial was the randomized question, if the postoperative two drug chemotherapy for stage I in intermediate risk or anaplasia can be reduced from conventional 3 courses to an experimental 1 course without loss of efficacy" 10/01/2006 - "The mean duration of first chemotherapy regimen (DD or EE) was 20, 39, and 36 weeks, respectively, before anaplasia was identified at second surgery" 05/01/1999 - "CONCLUSIONS: Preoperative chemotherapy did not obliterate or produce anaplasia" 01/01/1996 - "Chemotherapy would be useful for LGIO cases containing limited arcas of anaplasia" 01/01/1996 - "The histological examination of two of those resections revealed limited areas of anaplasia; complementary chemotherapy was then conducted" Order ALL the reference details at left...
2.	Castration 03/01/1990 - "Twelve factors were considered in the study; "age", "stage", "histological findings (structural atypism = SAT, nuclear anaplasia = NAN, Gleason's primary and secondary pattern)", "pretreatment level of total acid (ACP) and of alkaline phosphatase (ALP)", "castration performed or not performed", "doses of estrogen", "type of response of local prostatic tumor and of ACP to endocrine therapy"" Order ALL the reference details at left...
3.	Nephrectomy 10/01/2006 - "Open biopsy or partial/complete nephrectomy identified anaplasia at initial diagnostic procedure in 10 of 18 children" 10/01/2006 - "RESULTS: Anaplasia was identified in 0 of 7 tumors by core needle biopsy, 3 of 9 tumors by open wedge biopsy, and in 7 of 9 cases by partial or complete nephrectomy" 01/01/1998 - "Based on a retrospective analysis of 60 cases of nephroblastoma, the author reaches the following conclusions: 1) correct diagnosis and treatment of the nephroblastoma depend on the team-work involving the surgeon, the chemotherapist and the pathologist; 2) during the macroscopic analysis the pathologist is asked to: establish/determine if the tumor penetrates the renal capsule, establish the tumor invasion into the renal sinus vessels, establish if the medial limit of the renal sinus is occupied or not by the tumor and, include the nephrectomy specimens in the category over or below 550 g; 3) during the microscopical analysis the pathologist is asked to: actually make the positive diagnosis of nephroblastoma, identify the presence or the absence of the diffuse or focal anaplasia; and 4) based on this data the surgeon will complete the staging while the chemotherapist will choose a certain protocol depending on the stage and on the presence or absence of the anaplasia." 01/01/1987 - "The renal tumor present in 7 was nephroblastoma (NB) of the classical type without anaplasia or nephroblastomatosis, bilateral in 1, and unilateral but multinodular in 2. Five underwent nephrectomy for a renal mass, and in 2 NB was found at open biopsy or at autopsy" 04/01/1999 - "RESULTS: At review of the nephrectomy slides, the diagnoses were: Wilms tumor (16 patients), with anaplasia in one case, rhabdoid tumor (2 patients), neuroblastoma (2 patients), mesoblastic nephroma (2 patients), clear cell sarcoma (1 patient), malignant teratoma (1 patient), and renal cell carcinoma (1 patient)" Order ALL the reference details at left...
4.	Transplants (Transplant) 03/01/1977 - "In the course of serial passages of adenocarcinoma (AKTOL), arising from fetal colonic tissues which underwent spontaneous malignization after being grafted to syngeneic adult mice, there was an increase in the rate of growth of the subcutaneous transplants, and multiple intrapulmonary tumour nodes formed after its intravenous inoculation (the first transplant generations had no such capacity); the morphological anaplasia of the tumour increased" Order ALL the reference details at left...
5.	Adjuvant Chemotherapy 10/01/1992 - "Histologic grade of primary tumors and number of cycles of adjuvant chemotherapy administered had a significant correlation to patients' survival: patients with grade 2 anaplasia had a better 3- and 5-year survival rates than those with grade 3 anaplasia, and patients receiving 3 or more cycles of chemotherapy had a better 3-year survival rate than those with 2 or less cycles" Order ALL the reference details at left...

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