Loss of structural differentiation and useful function of neoplastic cells.
Also Known As:
Networked: 196 relevant articles (3 outcomes, 11 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Wilms Tumor (Wilm's Tumor)
3. Meningioma (Meningiomas)
4. Medulloblastoma
5. Rhabdoid Tumor (Rhabdoid Tumors)


1. Willingham, Mark C: 5 articles (01/2016 - 09/2003)
2. Cheng, Sheue-Yann: 4 articles (01/2016 - 09/2003)
3. Burger, Peter C: 3 articles (01/2009 - 05/2004)
4. Ying, Hao: 3 articles (10/2004 - 09/2003)
5. Zhao, Li: 2 articles (01/2016 - 09/2003)
6. Grundy, Paul: 2 articles (01/2014 - 10/2006)
7. Anderson, James R: 2 articles (01/2014 - 05/2011)
8. Hamilton, Thomas E: 2 articles (05/2011 - 10/2006)
9. Argani, Pedram: 2 articles (05/2011 - 10/2006)
10. Ritchey, Michael L: 2 articles (05/2011 - 10/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Anaplasia:
1. Keratins (Keratin)IBA
2. TamoxifenFDA LinkGeneric
3. Cyclophosphamide (Cytoxan)FDA LinkGeneric
4. DNA (Deoxyribonucleic Acid)IBA
5. Estrogens (Estrogen)FDA Link
6. CollagenIBA
12/01/2002 - "Histologically, the lesion was composed of astrocytes and collagen-producing fibroblasts with no anaplasia. "
06/15/2007 - "The study included 74 adult patients with histologically confirmed medulloblastomas and retrospectively reassessed 67 cases with available slides for the presence of nodularity, collagen deposition (desmoplasia without nodules), and degree and extent of anaplasia. "
01/01/2003 - "In some areas, an abundance of keloidal collagen imparted a close resemblance to a solitary fibrous tumor, making it difficult to establish the diagnosis on the initial needle biopsy, although the malignant nature of the tumor was suggested because of nuclear anaplasia. "
07/01/1990 - "We have studied the ultrastructural distribution of GFAP, vimentin, FVIII/RAg and collagen IV in biopsies of human gliomas with various degree of anaplasia. "
12/01/1983 - "The initial biochemical data (serum[S]-carcinoembryonic antigen, S-lactate dehydrogenase, S-gammaglutamyl transferase, S-alkaline phosphatase urine[U]-creatinine, and three urinary quantities related to collagen metabolism) and surgical pathology data (tumor size, grade of tumor anaplasia, number of positive lymph nodes, number of negative lymph nodes) were examined in 52 consecutive postmenopausal risk group II patients operated for primary breast cancer without metastatic disease (mastectomy + partial axillary resection) who participated in the Danish Breast Cancer Group's controlled clinical trial of radiation (RT) alone, and RT + levamisol. "
7. Proliferating Cell Nuclear Antigen (PCNA)IBA
8. tranilast (N 5')IBA
9. Vincristine (Oncovin)FDA LinkGeneric
10. EnzymesIBA

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Castration
3. Radiotherapy
4. Nephrectomy
06/01/2015 - "Pathologic results revealed positive surgical margins in 2 lesions with enucleation and in 2 with partial nephrectomies and anaplasia in 4 patients. "
10/01/2006 - "Open biopsy or partial/complete nephrectomy identified anaplasia at initial diagnostic procedure in 10 of 18 children. "
05/01/2011 - "Anaplasia was diagnosed after completion of the initial course of chemotherapy in 14 patients (initial surgical procedure: 9 open biopsies, 4 needle biopsies, 1 partial nephrectomy). "
10/01/2006 - "Anaplasia was identified in 0 of 7 tumors by core needle biopsy, 3 of 9 tumors by open wedge biopsy, and in 7 of 9 cases by partial or complete nephrectomy. "
01/01/1998 - "Based on a retrospective analysis of 60 cases of nephroblastoma, the author reaches the following conclusions: 1) correct diagnosis and treatment of the nephroblastoma depend on the team-work involving the surgeon, the chemotherapist and the pathologist; 2) during the macroscopic analysis the pathologist is asked to: establish/determine if the tumor penetrates the renal capsule, establish the tumor invasion into the renal sinus vessels, establish if the medial limit of the renal sinus is occupied or not by the tumor and, include the nephrectomy specimens in the category over or below 550 g; 3) during the microscopical analysis the pathologist is asked to: actually make the positive diagnosis of nephroblastoma, identify the presence or the absence of the diffuse or focal anaplasia; and 4) based on this data the surgeon will complete the staging while the chemotherapist will choose a certain protocol depending on the stage and on the presence or absence of the anaplasia."
5. Transplantation (Transplant Recipients)