Opioid Analgesics (Opioids)

Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.

Also Known As:

Opioids; Analgesics, Opioid; Full Opioid Agonists; Opioid Full Agonists; Opioid Mixed Agonist-Antagonists; Opioid Partial Agonists; Partial Opioid Agonists; Agonist-Antagonists, Opioid Mixed; Agonists, Full Opioid; Agonists, Opioid Full; Agonists, Opioid Partial; Agonists, Partial Opioid; Analgesic, Opioid; Full Agonists, Opioid; Mixed Agonist-Antagonists, Opioid; Opioid Agonists, Full; Opioid Agonists, Partial; Opioid Mixed Agonist Antagonists; Partial Agonists, Opioid; Opioid; Opioid Analgesic

Networked: 43863 relevant articles (3756 outcomes, 6973 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Therapeutic Uses: 47080
    - Central Nervous System Agents: 51
      - Analgesics: 40553
        Narcotics: 5541
        Opioid Analgesics: 43863
      - Central Nervous System Depressants: 117
        Narcotics: 5541
        Opioid Analgesics: 43863
  - Physiological Effects of Drugs: 1
    - Central Nervous System Depressants: 117
      - Narcotics: 5541
        Opioid Analgesics: 43863
    - Peripheral Nervous System Agents: 5
      - Sensory System Agents
        Analgesics: 40553
        Narcotics: 5541
        Opioid Analgesics: 43863

Experts

1.	Mercadante, Sebastiano: 142 articles (05/2022 - 05/2002)
2.	Bruera, Eduardo: 129 articles (01/2022 - 02/2002)
3.	Degenhardt, Louisa: 96 articles (01/2022 - 03/2003)
4.	Kaye, Alan D: 81 articles (05/2022 - 01/2005)
5.	Sullivan, Mark D: 77 articles (05/2022 - 12/2005)
6.	Brummett, Chad M: 75 articles (12/2022 - 05/2009)
7.	Pergolizzi, Joseph V: 73 articles (12/2021 - 09/2009)
8.	Dahan, Albert: 68 articles (11/2022 - 03/2005)
9.	Becker, William C: 66 articles (01/2022 - 12/2004)
10.	Manchikanti, Laxmaiah: 64 articles (01/2022 - 04/2004)

Related Diseases

1.	Pain (Aches) 08/18/2015 - "However, close reading of the primary literature supports a different conclusion: opioids have been shown in randomized controlled trials (RCTs) to be highly effective in the treatment of chronic nonmalignant pain; long-term follow-up studies have shown that this effectiveness can be maintained; and effectiveness has been limited in many clinical trials by failure to take into account high variability in dose requirements, failure to adequately treat depression, and use of suboptimal outcome measures. " 10/01/1999 - "Alternative approaches to reducing visceral sensation include the use of the opioid kappa agonists, which have no central opioid effects although clinical trials have suggested that these agents are not highly effective in relieving IBS pain. " 12/01/2022 - "Delivery pain is the most unbearable pain and can be relieved with intrathecal opioids. " 03/01/2022 - "In this small sample of patients undergoing highly individualized and variable opioid taper, the opioid taper was significantly associated with improved pain responses to the cold-pressor test, with the pain threshold on average increasing by 1.14 s every 6 weeks (p = 0.0084, 95% confidence interval [CI] for 6-week change 0.3039-2.0178) and pain tolerance on average increasing by 2.87 s every 6 weeks (p = 0.0026, 95% CI for 6-week change 1.02-4.7277). " 01/01/2022 - "Although surgical revascularization is extremely effective in alleviating ischemic pain related to PAD, it is unclear whether this practice results in the discontinuation of opioids after surgery. "
2.	Postoperative Pain 06/01/2023 - "Intrathecal opioids are highly effective in the management of post-operative pain. " 11/01/2021 - "We sought to determine which modalities are most effective in managing postoperative pain and reducing postoperative opioid use. " 02/01/1988 - "Several investigations have shown that constant rate infusions of opioids are highly effective in the provision of postoperative pain relief. " 11/01/2016 - "This study demonstrates that STR-324 is effective in postoperative pain management due to its strong antihyperalgesic effects mediated via opioid-dependent antinociceptive pathways. " 04/01/2014 - "Six trials demonstrated a small and short-lasting, but statistically significant reduction of post-operative pain scores, and four trials observed a statistically significant reduction in post-operative, supplemental opioid consumption that was, however, of limited clinical relevance. "
3.	Cancer Pain 01/01/2018 - "Opioids are highly effective for cancer pain but are associated with multiple adverse effects and risk of addiction. " 01/01/2017 - "Perceptions about the efficacy and appropriateness of opioids for the management of chronic non-cancer pain (CNCP) have dramatically transformed in recent decades. " 06/01/2011 - "In general, opioids are highly effective against cancer-related pain. " 03/01/2002 - "Students agreed most strongly (mean +/- standard deviation [SD]) that the educational material on the CD-ROM was presented clearly (3.9 +/- 1.1), the CD-ROM format was easy to use (4.0 +/- 0.8), the CD-ROM course improved knowledge of opioid use for cancer pain (4.0 +/- 0.7), and the course improved understanding of opioid-related side effects (4.0 +/- 0.7). " 09/01/2001 - "Most students agreed strongly that the home hospice visit was a positive experience (mean +/- SD 4.8 +/- 0.44) that helped them to understand the management of cancer pain (mean 4.7 +/- 0.46) and opioid-related side effects (mean 4.5 +/- 0.57). "
4.	Chronic Pain 10/17/2020 - "All users would recommend it to others with chronic pain; nearly all trusted the information and said it helped them think about my treatment goals (94%), understand my chronic pain (82%), make the most of my next doctor's visit (82%), and not want to use opioids (73%). " 09/30/2014 - "The objectives of the article are to review the following: (1) the key initiating causes of the epidemic; (2) the evidence for safety and effectiveness of opioids for chronic pain; (3) federal and state policy responses; and (4) recommendations for neurologists in practice to increase use of best practices/universal precautions most likely to improve effective and safe use of opioids and to reduce the likelihood of severe adverse and overdose events. " 11/01/2012 - "Opioids are an extremely important part of medical practice, and for thousands of years, continued to provide relief from severe acute and chronic pain. " 01/01/2004 - "Opioid analgesics are highly effective for treating many forms of acute and chronic pain. " 02/15/2023 - "The MORE program has been proven effective in reducing opioids and increasing well-being in patients suffering from chronic pain and thus constitutes a promising therapeutic approach. "
5.	Opioid-Related Disorders (Opiate Addiction) 01/01/2023 - "Opioid dependence is associated with substantial health and social burdens, and opioid agonist treatment (OAT) is highly effective in improving multiple outcomes for people who receive this treatment. " 11/01/2019 - "Medication assisted treatment (MAT) is highly effective in reducing illicit opioid use and preventing overdose in individuals with opioid use disorder (OUD); however, treatment retention of patients engaged in MAT is a significant clinical concern. " 03/01/2019 - "Research is continuing on opioid use disorder, effects of opioid use on the fetus, and best treatment approaches. " 01/01/2019 - "These findings illustrate that medication for opioid use disorders, as delivered in the H & S system in Vermont, is highly effective for reducing opioid use and overdose and improving functioning in many life domains." 01/01/2019 - "Opioid agonist treatment (OAT) is currently the most effective treatment for people with opioid dependence. "

Related Drugs and Biologics

1.	Opioid Analgesics (Opioids)
2.	Analgesics (Analgesic Drugs)
3.	Morphine (MS Contin)
4.	Buprenorphine (Subutex)
5.	Methadone (Dolophine)
6.	Fentanyl (Sublimaze)
7.	Acetaminophen (Paracetamol)
8.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
9.	Ketamine
10.	Bupivacaine (Bupivacaine Hydrochloride)

Related Therapies and Procedures

1.	Therapeutics
2.	Analgesia
3.	Pain Management
4.	Length of Stay
5.	Drug Therapy (Chemotherapy)