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Congenital Pain Insensitivity

A syndrome characterized by indifference to PAIN despite the ability to distinguish noxious from nonnoxious stimuli. Absent corneal reflexes and MENTAL RETARDATION may be associated. Familial forms with autosomal recessive and autosomal dominant patterns of inheritance have been described. (Adams et al., Principles of Neurology, 6th ed, p1343)
Also Known As:
Pain Insensitivity, Congenital; Congenital Analgesia; Congenital Indifference to Pain; Insensitivity, Congenital Pain; Congenital Pain Indifference; Congenital Pain Indifferences; Analgesia, Congenital; Pain Indifference, Congenital
Networked: 20 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1. Pain (Aches)
2. Hereditary Sensory and Autonomic Neuropathies (HSAN)
3. Neurogenic Inflammation
4. Paresthesia (Dysesthesia)
5. Mental Retardation (Idiocy)

Experts

1. King, Glenn F: 2 articles (10/2013 - 03/2012)
2. Lakhotia, Disha: 1 article (01/2015)
3. Kandregula, Chaitanya Ram: 1 article (01/2015)
4. Koya, Srikanth: 1 article (01/2015)
5. Ravichandra, K S: 1 article (01/2015)
6. Undheim, Eivind A B: 1 article (10/2013)
7. Klint, Julie K: 1 article (10/2013)
8. Yang, Shilong: 1 article (10/2013)
9. Lai, Ren: 1 article (10/2013)
10. Li, Yuan: 1 article (10/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Congenital Pain Insensitivity:
1. Sodium Channels (Sodium Channel)IBA
2. Naloxone (Narcan)FDA LinkGeneric
3. 3-(2-carboxyindol-3-yl)propionic acidIBA
4. Sodium Channel Blockers (Potassium Sparing Diuretics)IBA
5. Nerve Growth Factor (NGF)IBA
6. Vanilmandelic Acid (Vanillylmandelic Acid)IBA
7. Norepinephrine (Noradrenaline)FDA LinkGeneric
8. Melanins (Melanin)IBA
9. Hydrocortisone (Cortisol)FDA LinkGeneric
10. Homovanillic AcidIBA

Therapies and Procedures

1. Rhizotomy
2. Analgesia
3. Amputation
4. Ganglionectomy
5. Injections