Amprolium

A veterinary coccidiostat that interferes with THIAMINE metabolism.

Also Known As:

Amprol; Amprolium Chloride; Amprolium Hydrochloride; Anticoccid; Noé-Socopharm Hydrochloride; Némaprol; Pyridinium, 1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-methyl-, Chloride (1:1); Chloride, Amprolium; Hydrochloride, Amprolium; Hydrochloride, Noé-Socopharm; Noé Socopharm Hydrochloride

Networked: 107 relevant articles (20 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Picolines: 14
      - Amprolium: 107
        pancoxin plus: 1
        duocoxin

Experts

1.	Ahad, Shazia: 5 articles (03/2018 - 04/2014)
2.	Malik, Tauseef Ahmad: 5 articles (03/2018 - 04/2014)
3.	Tanveer, Syed: 5 articles (03/2018 - 04/2014)
4.	Chand, Naila: 3 articles (04/2022 - 07/2016)
5.	Alhidary, Ibrahim A: 2 articles (02/2021 - 07/2016)
6.	Khan, Rifat Ullah: 2 articles (02/2021 - 07/2016)
7.	Nawchoo, Irshad Ahmad: 2 articles (03/2018 - 03/2017)
8.	Chishti, M Z: 2 articles (04/2016 - 04/2014)
9.	Johri, R K: 2 articles (04/2016 - 04/2014)
10.	Kamili, Azra N: 2 articles (04/2016 - 04/2014)

Related Diseases

1.	Coccidiosis 07/01/2021 - "This study was carried out to compare the efficacy of immunization, by a low-dose of live sporulated oocysts of different Eimeria species separately, with the efficacy of amprolium plus sulphaquinoxaline in the management of challenged coccidiosis in Japanese quail. " 01/01/2011 - "had similar efficacy with amprolium in the treatment of chicken coccidiosis." 06/01/1989 - "The efficacy of preventive in-feed medication with amprolium (2000 ppm) was studied on a farm where clinical coccidiosis in unweaned lambs at pasture has been a problem for the past seven years. " 07/04/2023 - "In this study, Eimeria papillate was used to infect the mouse jejunum, and the response of the liver to induced coccidiosis on treatment with nanosilver synthesized from Zingiber officinale (NS) and the reference anticoccidial drug amprolium was compared. " 03/01/2021 - "Considering the results of three floor pen trials and two ASTs described and assessed in a previous EFSA opinion and taking into account the newly submitted AST, the FEEDAP Panel concludes that COXAM ® is efficacious in controlling coccidiosis in chickens for fattening at a dose of 125 mg amprolium HCl/kg complete feed. "
2.	Weight Gain 03/01/2023 - "The results revealed that supplementation of 1% TTEO and treatment of amprolium improved feed intake, weight gain and feed conversion ratio in infected quails compared to the positive control. " 07/01/1984 - "The manufacturer's proposed level (0.0175%) and twice the proposed level (0.0350%) of amprolium had no significant effect on weight gains or mortality in the safety trial. " 03/01/2018 - "Activity was measured in comparison to the reference drug amprolium on the basis of oocyst output reduction, mean weight gain of birds and feed conversion ratio. " 03/01/2017 - "Activity was measured in comparison to the reference drug amprolium on the basis of oocyst output reduction, mean weight gain of birds and feed conversion ratio. " 06/01/2016 - "applanatum was measured in comparison to the reference drug amprolium on the basis of oocysts per gram of faeces, weight gain and feed conversion ratio. "
3.	Body Weight (Weight, Body) 11/01/2023 - "Animals were supplemented with amprolium @ 62.50 mg/kg body weight (bw) (GI), turmeric @ 200 and 300 mg/kg bw (GII and GIII) and ginger @ 200 and 300 mg/kg bw (GIV and GV), orally for 7 days and GVI animals were kept as untreated infected control. " 02/14/2021 - "Conversely, higher (p < 0.05) body weight, dressing percentage, and feed conversion ratio were observed in infected + Amprolium, GSP2.5 + OZ50, and GSP5 + OZ50 treatments in comparison to the positive control. " 06/01/1994 - "Polioencephalomalacia was induced in eight buffalo calves, 6-12 months old, by drenching amprolium (300 mg/kg body weight per day) for 29-55 days. " 02/01/1993 - "Eight apparently healthy male buffalo calves of 6 to 12 months of age were drenched with amprolium (300 mg/kg body weight) till the development of clinical signs. " 10/01/1975 - "In each of 2 experiments, 2 calves received an oral dose of amprolium at 100 mg/kg of body weight for 30 days, 2 calves were similarly inoculated but received no medication, and 2 calves served as uninoculated, unmedicated controls. "
4.	Sarcocystosis 02/01/1980 - "The efficacy of amprolium against clinical sarcocystosis resulting from Sarcocystis ovicanis was determined in two experiments involving 40 lambs. " 10/01/1975 - "Effect of amprolium on acute sarcocystosis in experimentally infected calves." 10/01/1975 - "Data from overall weight gains, packed cell volume, body temperature, postmortem and histological examinations, and serum enzyme levels indicate that amprolium reduced the severity of experimental sarcocystosis." 02/01/1980 - "Data from deaths, body temperatures, weight gains, serum protein levels, hematocrits, hemoglobin values, LDH and SGOT values, postmortem examinations, and histological examinations indicated that amprolium at both levels tested reduced the number of deaths and severity of clinical signs of sarcocystosis in experimentally infected lambs as compared with unmedicated controls."
5.	Infections 12/10/2005 - "These data suggest that salilomycin with amprolium may be a promising treatment for myxosporean infections in intensively cultured warm-water fish, exhibiting action partially via the enhancement of host, innate immune functions and leading to parasite elimination." 11/28/2023 - "After 60 min of infection, groups (4 and 5) were treated for 5 consecutive days with the recommended doses of PAE and amprolium. " 01/01/2023 - "meleagrimitis, with or without amprolium intervention, caused a very mild infection that induced protective immunity and challenge markedly affected both the ileal and cecal microbiome." 08/01/2017 - "Effect of Calotropis procera (madar) and amprolium supplementation on parasitological parameters of broilers during mixed Eimeria species infection." 01/01/2011 - "Also at day 7 post-infection, each chicken in four infected groups was given graded doses (250, 500 and 1,000 mg/kg b.w.) of the extract or amprolium (conventional drug). "

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Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Oral Administration