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Ammonia-Lyases

Enzymes that catalyze the formation of a carbon-carbon double bond by the elimination of AMMONIA. EC 4.3.1.

Also Known As:

Ammonia Lyases; Lyase, Ammonia; Ammonia Lyase; Ammonia-Lyase

Networked: 9 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ahmed, Bilal: 1 article (04/2020)
2.	Amo, Aduragbemi: 1 article (04/2020)
3.	Wang, Zhongyuan: 1 article (04/2020)
4.	Wei, Chunhua: 1 article (04/2020)
5.	Yadav, Vivek: 1 article (04/2020)
6.	Yang, Xiaozhen: 1 article (04/2020)
7.	Zhang, Xian: 1 article (04/2020)
8.	Hendrikse, Natalie M: 1 article (01/2020)
9.	Holmberg Larsson, Albin: 1 article (01/2020)
10.	Kuprin, Sergei: 1 article (01/2020)

Related Diseases

1.	Phenylketonurias (Phenylketonuria) 04/01/2013 - "Ammonia lyases (AL) and aminomutases (AM) are emerging in green synthetic routes to chiral amines and an AL is being explored as an enzyme therapeutic for treating phenylketonuria and cancer. " 11/01/2018 - "This study assessed the immunogenicity of pegvaliase (recombinant Anabaena variabilis phenylalanine [Phe] ammonia lyase [PAL] conjugated with polyethylene glycol [PEG]) treatment in adults with phenylketonuria (PKU) and its impact on safety and efficacy. " 01/28/2020 - "Phenylalanine/tyrosine ammonia-lyases (PAL/TALs) have been approved by the FDA for treatment of phenylketonuria and may harbour potential for complementary treatment of hereditary tyrosinemia Type I. Herein, we explore ancestral sequence reconstruction as an enzyme engineering tool to enhance the therapeutic potential of PAL/TALs. "
2.	Neoplasms (Cancer) 04/01/2013 - "Ammonia lyases (AL) and aminomutases (AM) are emerging in green synthetic routes to chiral amines and an AL is being explored as an enzyme therapeutic for treating phenylketonuria and cancer. "
3.	Virus Diseases (Viral Diseases) 10/01/2019 - "In this study, we characterized the role of maize phenylalanine ammonia-lyases (ZmPALs) in accumulation of the defence signal salicylic acid (SA) and in resistance to virus infection. "
4.	Foodborne Diseases 12/01/2009 - "We used computational analysis of sequences, structures, genome contexts, and phylogenies of ethanolamine-ammonia lyases to address these questions and to evaluate recent data-mining studies that have suggested an association between bacterial food poisoning and the diol utilization pathways. "
5.	Disease Resistance 04/23/2020 - "In recent years, some key players like phenylalanine ammonia lyases (PALs) from the phenylpropanoid pathway are proposed to have broad spectrum disease resistance (BSR) without yield penalties. " 08/01/2015 - "Mutations in PHE ammonia lyase 1 (PAL1) and putative kinase At1g76360 rendered Arabidopsis hypersensitive to UV stress, while loss of function from putative methyltransferase At4g22530, novel plant snare 12 (NPSN12) and defense gene activated disease resistance 2 (ADR2) conferred higher UV stress resistance. " 01/01/2016 - "SCLEO treatment did not, however, stimulate phenylalanin ammonia-lyase, polyphenol oxidase, or chitinase, enzymes related to disease resistance. "

Related Drugs and Biologics

1.	Enzymes
2.	Amines
3.	Phenylalanine (L-Phenylalanine)
4.	Salicylic Acid (2 Hydroxybenzoic Acid)
5.	Ethanolamine (Colamine)
6.	Polyethylene Glycols (Polyethylene Glycol)
7.	pegvaliase
8.	Tyrosine (L-Tyrosine)
9.	Phosphotransferases (Kinase)
10.	Methyltransferases