Aminopterin

01/01/1986 - "Further studies are needed to define the precise efficacy of deaza-aminopterin in patients with urothelial tract cancers."
04/01/1998 - "Phase I and pharmacokinetic trial of aminopterin in patients with refractory malignancies."
05/01/2010 - "Renewed interest in antifols for the treatment of childhood cancers has resulted from identification of novel antifols with broad spectrums of anti-cancer activity and from re-evaluation of the original clinical antifol, aminopterin. "
08/01/1990 - "The value for Km derived with aminopterin was similar to that derived for either tumor cell FPGS. "
08/01/1990 - "For FPGS derived from proliferative intestinal epithelium, aminopterin was also the preferred substrate, but the value for Vmax (derived with crude cell-free extract) was 6-fold lower than for tumor cell FPGS. "

11/15/2005 - "Phase II trial of oral aminopterin for adults and children with refractory acute leukemia."
01/01/1996 - "A case for the use of aminopterin in treatment of patients with leukemia based on metabolic studies of blasts in vitro."
01/01/1984 - "In 1948, Farber and colleagues at the Boston Children's Hospital reported that aminopterin produced complete remissions in about one-third of children with acute leukemia. "
02/01/1962 - "Treatment of meningeal leukemia with intrathecal aminopterin."
04/01/1952 - "Treatment of acute lymphatic leukemia with aminopterin."

05/01/2000 - "Therapeutic suppression of tissue reactivity: II. Effect of aminopterin in rheumatoid arthritis and psoriasis. "
02/01/1951 - "II. Effect of aminopterin in rheumatoid arthritis and psoriasis."
12/01/1985 - "Aminopterin, a folic acid analogue was first reported in 1948 to produce temporary remission of acute leukemia of children, was also reported in 1951 to produce an important and rapid improvement in patients with rheumatoid arthritis (RA) and psoriasis. "
01/01/2020 - "Auxiliary in vitro and in vivo biological evaluation of hydrogen peroxide sensitive prodrugs of methotrexate and aminopterin for the treatment of rheumatoid arthritis."
01/01/2018 - "Synthesis and Evaluation of Hydrogen Peroxide Sensitive Prodrugs of Methotrexate and Aminopterin for the Treatment of Rheumatoid Arthritis."

03/01/1964 - "[UNSUCCESSFUL TRIALS WITH AMINOPTERIN IN VARIOUS FORMS OF PSORIASIS]."
07/01/1972 - "[Aminopterin treatment in psoriasis]."
01/01/1968 - "An unusual side effect of aminopterin in the treatment of psoriasis vulgaris."
04/01/1965 - "CURIOSITIES IN DERMATOLOGY; A CASE OF PSORIASIS IN AN AFRICAN TREATED WITH AMINOPTERIN."
12/01/1964 - "AMINOPTERIN FOR PSORIASIS. "

11/01/2007 - "A pilot open trial evaluating the efficacy of low-dose aminopterin in the canine homologue of human atopic dermatitis."
01/01/2014 - "LD-aminopterin in the canine homologue of human atopic dermatitis: a randomized, controlled trial reveals dosing factors affecting optimal therapy."