|1.||Mokry, J: 5 articles (12/2013 - 11/2007)|
|2.||Calkovska, A: 5 articles (12/2013 - 11/2007)|
|3.||Mokra, D: 5 articles (12/2013 - 11/2007)|
|4.||Doukky, Rami: 4 articles (10/2015 - 06/2012)|
|5.||Petraskova, M: 4 articles (01/2013 - 11/2007)|
|6.||Czuczwar, Stanisław J: 4 articles (07/2005 - 04/2002)|
|7.||Rangel, Maria Octavia: 3 articles (10/2015 - 04/2013)|
|8.||Dick, Rizcallah: 3 articles (10/2015 - 04/2013)|
|9.||Wassouf, Marwan: 3 articles (10/2015 - 04/2013)|
|10.||Morales Demori, Raysa: 3 articles (10/2015 - 06/2012)|
|1.||Asthma (Bronchial Asthma)
01/01/2001 - "Patients in these trials were predominantly school-aged children hospitalised for acute severe asthma with a baseline FEV1 at 35-40% of predicted and/or a baseline Pulmonary Index of 6-7. Aminophylline significantly improved percentage predicted FEV1 by 6 - 8 hours (WMD 8.4%; 95% CI: 0.82, 15.92%). "
01/01/2012 - "The use of intravenous aminophylline did not result in significant additional bronchodilation compared to standard care with inhaled beta(2)-agonists in patients experiencing an asthma exacerbation in the ED setting, or in a significant reduction in the risk of hospital admission. "
08/01/2003 - "Intravenous aminophylline is effective in children with acute asthma and was the bronchodilator of choice for many years. "
11/01/2000 - "Intravenous aminophylline is widely used for the treatment of acute asthma and anecdotes about its apparent effectiveness abound. "
09/01/1992 - "In our retrospective study of 68 episodes of acute severe asthma in the last 5 years at our institute, however, the additional administration of aminophylline with beta 2-agonists was clearly shown to be effective with infrequent minor side effects."
|2.||Chronic Obstructive Pulmonary Disease (COPD)
01/01/2014 - "The levels of IL-1β, TNF-α, p-NF-κB, p-IκBα, TGF-β1 and Smad2 were significantly higher in COPD rats than in controls, while they were dramatically reduced in the three TCM- and aminophylline-treated groups. "
12/01/1990 - "Aminophylline does not appear to be beneficial for outpatients with decompensated COPD and may be harmful."
06/01/1987 - "Thus, aminophylline, as customarily used in subjects with COPD, is associated with a significant reduction in rCBF."
01/01/1987 - "In order to evaluate the separate effects of aminophylline on the neural and muscular components of the respiratory control system, assessed by electromyographic activity of the diaphragm (EMGd) and mouth occlusion pressure (P0.1), respectively, 6 normal subjects and 14 patients with mild or moderate chronic airflow obstruction (8 asthmatics and 6 COPD) were studied during CO2 rebreathing, before and after administration of a therapeutic dose of aminophylline 5.6 mg/kg. Compared to normal subjects, before aminophylline administration both asthmatic and COPD patients exhibited a significantly greater value in EMGd response slope to CO2. "
10/01/2005 - "Younger patients have more improvement in PEFR than older patients; however, older COPD patients have more symptoms relief in chest tightness after aminophylline therapy."
05/01/1989 - "Aminophylline will be continued to be used acutely even though it appears there is no improvement in bronchospasm in the first few hours of treatment when aminophylline is added to therapy. "
01/01/1984 - "This study was undertaken to evaluate a method of prospectively estimating appropriate aminophylline infusion rates in acutely ill, hospitalized patients with bronchospasm. "
06/01/2008 - "Aminophylline is usually used during anaesthesia to treat bronchospasm but recent findings suggest that it can also be used to shorten recovery time after general anaesthesia. "
08/01/2007 - "It is suggested that continuous infusion of aminophylline is well tolerated and may prove useful in improving the gas exchange in long-term mechanically ventilated neonates with refractory bronchospasm."
08/01/2007 - "The aim was to determine the effectiveness of continuous aminophylline infusion on refractory bronchospasm in long-term mechanically ventilated neonates. "
10/01/2014 - "On the basis of the results Aminophylline, a dose (300 mg/kg) producing tonic-clonic seizures and mortality in 100% animals was selected as control in the study. "
10/01/2005 - "Pharmacological studies on mechanisms of aminophylline-induced seizures in rats."
12/01/1999 - "The objective of this study was to test the effects of aminophylline on seizure length. "
06/01/1986 - "Previous studies have shown that methylxanthines such as aminophylline increase the clinical severity and length of electrically elicited limbic afterdischarges in naive and kindled rats without lowering seizure threshold. "
01/01/2015 - "However, RAF offered 66.67-33.33% protections against aminophylline-induced seizures at doses of 150 and 600 mg/kg, but RAF, S1, and S2 had no effect on MES-induced seizures. "
06/01/2003 - "Aminophylline produced significant improvement in periodic breathing but exerted no significant effect on the other types of apnea. "
11/01/1978 - "The effectiveness of aminophylline in treating apnea in premature infants must be related to its central stimulating effect and not to an improvement in lung function and oxygenation."
08/01/2014 - "This study supports the preventative effects of aminophylline on apnea in extreme premature infants. "
08/01/2014 - "This study aimed to assess the safety and prophylactic effects of aminophylline on the incidence of apnea in premature neonates. "
03/01/2013 - "This study investigated 104 very low birth weight infants using aminophylline 5 mg/kg treating apnea who were hospitalized in our department during 2011-2012. "
|6.||Doxapram (Doxapram Hydrochloride)
|7.||Caffeine (No Doz)
|9.||Purinergic P1 Receptors (Adenosine Receptor)
|4.||Artificial Respiration (Mechanical Ventilation)