|1.||Branco, Luiz G S: 3 articles (09/2014 - 02/2013)|
|2.||Soriano, Renato N: 3 articles (09/2014 - 02/2013)|
|3.||Sabino, João P: 2 articles (09/2014 - 08/2014)|
|4.||Donatti, Alberto F: 2 articles (09/2014 - 08/2014)|
|5.||Jiang, Xinghong: 2 articles (05/2013 - 01/2013)|
|6.||Xu, Guang-Yin: 2 articles (05/2013 - 01/2013)|
|7.||Xiao, Ying: 2 articles (05/2013 - 01/2013)|
|8.||Wielosz, Marian: 2 articles (05/2007 - 07/2002)|
|9.||Urbańska, Ewa M: 2 articles (05/2007 - 07/2002)|
|10.||Schwarcz, R: 2 articles (01/2007 - 06/2000)|
11/01/1996 - "1. Injection of aminooxyacetic acid (AOAA) into the entorhinal cortex in vivo produces acute seizures and cell loss in medial entorhinal cortex. "
06/19/1992 - "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats. "
06/19/1992 - "Age dependency of the susceptibility of rats to aminooxyacetic acid seizures."
09/01/1991 - "Aminooxyacetic acid (AOAA), a potent yet nonspecific transaminase inhibitor, is known to cause convulsions when administered at high doses to experimental animals. "
03/01/1991 - "Systemic (s.c.) administration of aminooxyacetic acid (AOAA) in mice triggered clonic convulsions with a CD50 (convulsive dose) of 68 mg/kg (range 54-86). "
|2.||Wounds and Injuries (Trauma)
08/01/1984 - "Aminooxyacetic acid (AOAA) has been shown to confer protection against noise-induced cochlear trauma . "
09/01/2011 - "Aminooxyacetic acid hemihydrochloride (AOAA), an inhibitor of C-S lyase, reduced renal injuries due to cisplatin in rats, suggesting involvement of C-S lyase. "
01/01/1994 - "Aminooxyacetic acid, an inhibitor of ACC-synthase activity, and 2,5-norbornadiene, an inhibitor of ethylene action, suppressed the wound-induced accumulation of ACC-oxidase mRNA, while an addition of ethylene in these tissues restored the accumulation of ACC-oxidase mRNA.(ABSTRACT TRUNCATED AT 250 WORDS)"
01/01/1980 - "The anticonvulsant effect of aminooxyacetic acid (AOAA) was examined on a model of experimental epilepsy (kindling) induced by daily appropriate amygdaloid stimulation in the rat. "
06/01/2000 - "This lesion is duplicated in rats by a focal, intra-entorhinal injection of the "indirect" excitotoxin aminooxyacetic acid (AOAA), providing a model that can be used to study the mechanisms underlying seizure-induced cell death and epilepsy. "
05/01/1988 - "The antiepileptic activity of GABA-mimetics (phenibut, sodium valproate and aminooxyacetic acid/AOAA/) was studied in experiments on the model of hippocampal penicillin-induced epilepsy in rats. "
04/01/1986 - "Three drugs which increase GABA-mediated inhibitory neurotransmission in the brain, namely the GABA degradation inhibitors aminooxyacetic acid (AOAA) and gamma-acetylenic GABA (GAG), and the GABA receptor agonist THIP (gaboxadol), were administered to epilepsy-prone gerbils via subcutaneously implanted osmotic minipumps for 2 weeks. "
04/01/2014 - "To test this hypothesis, we measured pulmonary ventilation (V˙E) and deep body temperature of rats before and after intracerebroventricular (icv) or intra-AVPO microinjection of aminooxyacetate (AOA; CBS inhibitor) or Na2 S (H2 S donor) followed by 60 min of hypoxia exposure (7% O2 ). "
09/01/2014 - "Tb was measured before and after bilateral microinjection of aminooxyacetate (AOA, 0.2, 1 and 2 pmol/100 nl, a cystathionine β-synthase, CBS, inhibitor) or vehicle into the RVLM followed by a 60-min normoxia (21% inspired O2) or hypoxia (7% inspired O2) exposure. "
08/15/2014 - "Ventilation (VE) was measured before and after bilateral microinjection of Na2S (H2S donor, 0.04, 1 and 2 pmol/100 nl) or aminooxyacetate (AOA, 0.2, 1 and 2 pmol/100 nl, a cystathionine β-synthase, CBS, inhibitor) into the RVLM/Bötzinger complex followed by a 60-min period of hypoxia (7% inspired O2) or normoxia exposure. "
05/01/1996 - "The competitive inhibitor of transaminases, aminooxyacetate, prevents both the observed intracellular decrease in glutamate during anoxia and the increase in intracellular glutamate after reoxygenation of cardiomyocytes. "
08/15/2015 - "Like hypoxia, NaHS (a H2S donor) inhibited TASK activity and elevated [Ca(2+)]i. To inhibit the production of H2S, glomus cells were incubated (3h) with inhibitors of cystathionine-β-synthase and cystathionine-γ-lyase (DL-propargylglycine, aminooxyacetic acid, β-cyano-L-alanine; 0.3 mM). "
07/23/2013 - "Treatment of nude mice with aminooxyacetic acid attenuated the growth of patient-derived colon cancer xenografts and reduced tumor blood flow. "
07/23/2013 - "ShRNA-mediated silencing of CBS or its pharmacological inhibition with aminooxyacetic acid reduced HCT116 cell proliferation, migration, and invasion; reduced endothelial cell migration in tumor/endothelial cell cocultures; and suppressed mitochondrial function (oxygen consumption, ATP turnover, and respiratory reserve capacity), as well as glycolysis. "
02/01/1992 - "4. When the tumor cells were cultured in Eagle's medium with aminooxyacetate or in the absence of glutamine, a marked reduction in the cellular NAD/NADH ratio was observed. "
11/12/1981 - "Moreover, to quantitate such an activity, the effects of these two inhibitors have been compared with those induced under the same experimental conditions by aminooxyacetate, an inhibitor of the malate-aspartate shuttle which is known to operate in this strain of ascites tumor. "
09/01/1986 - "Oxypolarographic tests showed the following: glutamine oxidation was prominent in the tumor mitochondria and was mediated through an NAD-linked reaction, while mitochondria from the liver showed a feeble glutamine oxidation; glutamine oxidation by tumor mitochondria was inhibited either by aminooxyacetate, inhibitor of transaminases, or prior incubation of mitochondria with DON (6-diazo-5-oxonorleucine), which inhibited mitochondrial glutaminases. "
|4.||Valproic Acid (Valproate, Semisodium)
|7.||gamma-Aminobutyric Acid (GABA)
|9.||4-Aminobutyrate Transaminase (4 Aminobutyrate Transaminase)
|10.||Glutamic Acid (Glutamate)
|2.||Heterologous Transplantation (Xenotransplantation)