Aminolevulinic Acid (Levulan)

A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.

Also Known As:

Levulan; 5 Aminolevulinate; 5-Aminolaevulinate; 5-Aminolevulinate; Aminolevulinic Acid Hydrochloride; Delta-Aminolevulinic Acid; 5 Amino Levulinic Acid; 5 Aminolaevulinate; Acid Hydrochloride, Aminolevulinic; Acid, 5-Amino Levulinic; Acid, Aminolevulinic; Acid, Delta-Aminolevulinic; Delta Aminolevulinic Acid; Hydrochloride, Aminolevulinic Acid; Levulinic Acid, 5-Amino; 5-Amino Levulinic Acid; Pentanoic acid, 5-amino-4-oxo-

Networked: 819 relevant articles (77 outcomes, 87 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Maytin, Edward V: 14 articles (01/2020 - 05/2009)
2.	Hasan, Tayyaba: 13 articles (01/2020 - 03/2006)
3.	Stummer, Walter: 13 articles (12/2019 - 03/2007)
4.	Pogue, Brian W: 11 articles (06/2020 - 05/2002)
5.	Wilson, Brian C: 10 articles (12/2020 - 11/2003)
6.	Chen, Bin: 8 articles (01/2022 - 09/2006)
7.	Kawczyk-Krupka, Aleksandra: 8 articles (09/2018 - 07/2003)
8.	Gouya, Laurent: 6 articles (01/2022 - 08/2015)
9.	Ogura, Shun-Ichiro: 6 articles (05/2021 - 02/2014)
10.	Anand, Sanjay: 6 articles (02/2019 - 05/2009)

Related Diseases

1.	Actinic Keratosis 11/08/2020 - "Currently, aminolevulinic acid-mediated dPDT has been approved to treat actinic keratosis patients in Europe. " 11/01/2020 - "5-Aminolevulinate (ALA) patches with red light (630-nm light source and a total light dose of 37 J/cm2 ) is an effective treatment indicated by food and drug administration (FDA) and european medicines agency (EMA) only for grade I to II actinic keratosis located on the scalp and face. " 03/30/2018 - "Topical formulations of delta-aminolevulinic acid for the treatment of actinic keratosis: Characterization and efficacy evaluation." 09/01/2014 - "The effect of multiple sequential light sources to activate aminolevulinic Acid in the treatment of actinic keratoses: a retrospective study." 09/01/2010 - "Eighteen patients with actinic keratoses of the face or upper limbs received an application of a 20% delta-aminolevulinic acid cream and were submitted to diode light irradiation at a wavelength of 630 nm. A total of 328 actinic keratoses were treated, obtaining complete cure in 210 (64.0%) after 24 weeks. "
2.	Acne Vulgaris 08/01/2000 - "Topical aminolevulinic acid plus red light is an effective treatment of acne vulgaris, associated with significant side-effects. " 08/01/2000 - "There was clinical and statistically significant clearance of inflammatory acne by aminolevulinic acid plus red light, for at least 20 wk after multiple treatments and 10 wk after a single treatment. " 08/01/2000 - "Potentially, aminolevulinic acid plus red light may be useful for some patients with acne." 08/01/2000 - "Each of 22 subjects with acne on the back was treated in four sites with aminolevulinic acid plus red light, aminolevulinic acid alone, light alone, and untreated control. " 07/01/2009 - "In this African-American patient, 20% aminolevulinic acid/blue-light photodynamic therapy was effective in treating facial acne vulgaris."
3.	Neoplasms (Cancer) 06/01/2023 - "Aminolevulinic acid-photodynamic diagnosis (ALA-PDD) is a promising alternative method to detect cancer cells because of its high specificity and low rate of side effects. " 01/01/2022 - "In Reply to the Letter to the Editor Regarding "5-Aminolevulinic Acid False Positives in Cerebral Neuro-Oncology: Not All That Is Fluorescent Is Tumor. " 01/01/2022 - "Letter to the Editor Regarding "5-Aminolevulinic Acid False Positives in Cerebral Neuro-Oncology: Not All That Is Fluorescent Is Tumor. " 01/01/2020 - "A new, high-definition (4 K) and 3-dimensional exoscope (ORBEYE; Sony Olympus Medical Solutions Inc, Tokyo, Japan) was used during the surgical approach and throughout tumor removal, which was aided by five-aminolevulinic acid (5-ALA) derived fluorescence. " 12/01/2019 - "Photoirradiation after aminolevulinic acid treatment suppresses cancer cell proliferation through the HO-1/p21 pathway."
4.	Basal Cell Carcinoma (Rodent Ulcer) 06/01/2020 - "This study with 5- aminolevulinic acid drug Levulon was conducted in patients with superficial skin basal cell carcinoma. " 06/01/2000 - "Delta-aminolevulinic acid in superficial basal cell carcinomas and normal skin-a microdialysis and perfusion study." 09/01/2007 - "Aminolevulinic acid (ALA) and light irradiation is a treatment option in basal cell carcinomas (BCC). " 07/01/2004 - "Photodynamic therapy with delta-aminolevulinic acid using red light (approximately 630 nm) sources has been reported as effective in treatment of superficial and small nodular basal cell carcinomas. " 01/01/2000 - "This study was conducted to assess the efficacy of aminolevulinic acid-based photodynamic treatment for residual or recurrent basal cell carcinomas after radiotherapy. "
5.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 04/14/2009 - "To investigate effect of temperature on delta-aminolevulinic acid (ALA) induced photodynamic reaction in laryngeal squamous carcinoma cells. " 04/14/2009 - "[Effects of elevating temperature on photodynamic reaction in laryngeal squamous carcinoma cells induced by delta-aminolevulinic acid]." 01/01/2016 - "In this manuscript, we compare the efficacy of aminolevulinic acid (ALA) mediated PDT and SDT in a squamous cell carcinoma (A431) cell line as well as the ability of these treatments to reduce the size of A431 ectopic tumours in mice. " 05/01/1993 - "To study porphyrin biosynthesis in normal human keratinocytes and A431 cells derived from human epidermoid carcinoma, cultured cells were incubated with delta-aminolevulinic acid (ALA), the precursor of porphyrin synthesis, and accumulation of porphyrins was measured spectrofluorometrically. " 12/01/2001 - "Delta aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) is a fluorescent sensitizer that permits detection and treatment of squamous cell carcinoma of the oral cavity. "

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Related Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy)
2.	Therapeutics
3.	Dye Lasers
4.	Gas Lasers
5.	Radiotherapy