Amino Sugars

03/08/2022 - "Therefore, we discuss an approach where in-house-developed peptidic amino sugar molecules have been used to target pre-miR-21 to inhibit miR-21 biogenesis, and hence antagonize its tumor-causing effect and inhibit EMT. "
01/01/2022 - "Due to lack of amino sugar with aging, people will suffer from various epidemic bone diseases called "undead cancer" by the World Health Organization. "
02/05/2020 - "Glucosamine (GlcN), a natural amino sugar in human body, was reported to exhibit anticancer activity against some tumors. "
07/15/1993 - "However, conjugates of two derivatives, alpha 3I and N-acetyl-gamma 1I, in which the rhamnose residue is present but the amino sugar residue of the parent drug is either missing or modified, significantly inhibited tumor growth over a 4-fold dose range and produced long-term tumor-free survivors. "
12/01/1980 - "The antitumor activity of doxorubicin and three new derivatives modified on the position 4' of the amino sugar was tested against five human colon tumors and two human rectal tumors (originating from different patients) and xenografted into nude mice. "

01/01/1985 - "The chemotherapeutic action of 5-fluorouridine in rats and mice, carrying the AS-30D and the TA3 ascites tumor, respectively, is significantly improved by pretreatment with an amino sugar together with 6-azauridine."

02/21/2003 - "Since the mucosal membrane, the site of infection is rich in amino sugars, this specific adaptation is important for the establishment of infection. "
01/01/2022 - "N-acetylglucosamine (GlcNAc), an important amino sugar at the infection sites of the fungal pathogen Candida albicans, triggers multiple cellular processes. "
01/01/2021 - "Other sugars, amino acids, and organic acids were also enriched upon infection. "
01/01/2015 - "N-acetylquinovosamine (2-acetamido-2,6-di-deoxy-D-glucose, QuiNAc) is a relatively rare amino sugar residue found in glycans of few pathogenic gram-negative bacteria where it can play a role in infection. "
05/01/2012 - "The mucosal membranes of the host, which are the primary sites of its infection, are rich in amino sugars like N-acetylglucosamine (GlcNAc). "

12/17/2020 - "In conclusion, amino sugars profoundly alter the interactions between pathogenic and commensal streptococci by reprogramming central metabolism.IMPORTANCE Carbohydrate metabolism is central to the development of dental caries. "
01/01/2019 - "Collectively, these findings demonstrate that amino sugars can enhance the beneficial properties of low-passage-number commensal oral streptococci and highlight their potential for moderating the cariogenicity of oral biofilms.IMPORTANCE Dental caries is driven by dysbiosis of oral biofilms in which dominance by acid-producing and acid-tolerant bacteria results in loss of tooth mineral. "
01/01/2016 - "gordonii Notably, NagRSg binding was inhibited by GlcN-6-P, but G-6-P had no effect, unlike for NagRSm This study expands the understanding of amino sugar metabolism and NagR-dependent gene regulation in streptococci and highlights the potential for therapeutic applications of amino sugars to prevent dental caries. "
01/01/2016 - "Biochemical and genetic aspects of the metabolism of the amino sugars N-acetylglucosamine (GlcNAc) and glucosamine (GlcN) by commensal oral streptococci and the effects of these sugars on interspecies competition with the dental caries pathogen Streptococcus mutans were explored. "

02/01/1987 - "Amino-sugars inhibit the in vitro cytoadherence of Plasmodium falciparum-infected erythrocytes to melanoma cells."
01/01/1977 - "A study of glycoprotein components in trypsin-digested material from the surface of isolated melanotic melanoma cells showed presence of amino sugars, protein-bound hexoses, fucose and sialic acids. "