Amelogenesis Imperfecta

Subscribe to Selected New Research on Amelogenesis Imperfecta

113 relevant articles (0 outcomes, 9 trials/studies) found for this Disease

Description: An autosomal dominant or X-linked disorder in which there is faulty development of the dental enamel owing to agenesis, hypoplasia, or hypocalcification of the enamel. It is marked by enamel that is very thin and friable and frequently stained in various shades of brown. (Dorland, 27th ed)

Disease Context: Research Results

Stomatognathic Diseases: 250

Tooth Diseases: 12

Tooth Abnormalities: 16

Amelogenesis Imperfecta: 113

Dental Enamel Hypoplasia: 16

Stomatognathic System Abnormalities

Tooth Abnormalities: 16

Amelogenesis Imperfecta: 113

Dental Enamel Hypoplasia: 16

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 422

Congenital Abnormalities: 9333

Stomatognathic System Abnormalities

Tooth Abnormalities: 16

Amelogenesis Imperfecta: 113

Dental Enamel Hypoplasia: 16

Related Diseases

1.	Syndrome
2.	Stomatognathic Diseases (Dental Disease)
3.	Mandibulofacial Dysostosis (Treacher Collins Syndrome)
4.	Craniosynostoses
5.	Inborn Genetic Diseases (Disease, Hereditary)

Experts

1.	Wright, J T: 6 articles (07/2004 - 08/2001)
2.	Hu, J C-C: 3 articles (01/2008 - 01/2003)
3.	Gibson, C W: 3 articles (03/2002 - 01/2001)
4.	Simmer, J P: 2 articles (01/2008 - 05/2004)
5.	Ariga, T: 2 articles (01/2007 - 11/2002)
6.	Sakiyama, Y: 2 articles (01/2007 - 11/2002)
7.	Kida, M: 2 articles (01/2007 - 11/2002)
8.	Hart, P S: 2 articles (07/2004 - 04/2002)
9.	Simmons, D: 2 articles (07/2004 - 10/2000)
10.	Hart, T C: 2 articles (07/2004 - 04/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Amelogenesis Imperfecta:

1.	AmelogeninIBA 03/01/2002 - "Amelogenins, the major protein component of the mineralizing enamel extracellular matrix, are critical for normal enamel formation as documented in the linkage studies of a group of inherited disorders, with defective enamel formation, called Amelogenesis imperfecta" 11/01/1998 - "In this study, we have determined the nucleotide sequences of regions of the intron 1 and intron 2 of the X and Y human amelogenin genes (AMGX, AMGY) for the first time, and established a polymerase chain reaction (PCR) protocol to amplify six exons of AMGX and AMGY for the diagnosis of amelogenesis imperfecta, because previous studies have shown that some of the AI patients have such mutations" 03/01/1995 - "In this study we describe a 9-bp deletion in exon 2 of the amelogenin gene (AMGX) causing X-linked hypoplastic amelogenesis imperfecta, a disease characterized by defective enamel" 05/30/2008 - "Both transgenic strains that express the most abundant amelogenin (TgM180) have relatively normal enamel, but strains of mice that express a mutated amelogenin (TgP70T), which leads to amelogenesis imperfecta in humans, have heterogeneous enamel structures" 05/30/2008 - "Enamel from amelogenin (Amelx) null mice is hypoplastic and disorganized, similar to that observed in X-linked forms of the human enamel defect amelogenesis imperfecta resulting from amelogenin gene mutations" Order ALL the reference details at left...
2.	tuftelin (enamelin)IBA 10/01/2000 - "The purpose of this study was to determine the human chromosomal localization of enamelin to establish an association with various forms of amelogenesis imperfecta" 10/01/2008 - "Identifying polymorphism in enamelin gene in amelogenesis imperfecta (AI)." 04/18/2008 - "Enamelin is critical for proper dental enamel formation, and defects in the human enamelin gene cause autosomal dominant amelogenesis imperfecta" 08/01/2007 - "These results define the ATE1 mice as a model for local hypoplastic autosomal-dominant amelogenesis imperfecta (AIH2), which is caused by enamelin truncation mutations in humans." 08/01/2007 - "Analysis of our data shows that the amelogenesis imperfecta phenotype is linked to a C > T transition in exon 8 of the enamelin gene" Order ALL the reference details at left...
3.	Proteins (Proteins, Gene)IBA 12/01/2005 - "This paper focuses mainly on the candidate genes involved in amelogenesis imperfecta and the proteins derived from them, and reviews current knowledge on their structure, localization within the tissue, and correlation with the various types of this disorder." 12/01/2005 - "Some of the genes encoding specific enamel proteins have been indicated as candidate genes for amelogenesis imperfecta" 12/01/2005 - "Genes and related proteins involved in amelogenesis imperfecta." 05/01/2002 - "Diverse forms of pathologies can be derived from the lack of flexibility in tissues and the absence of required concentrations of certain types of proteins (e.g., amelogenesis imperfecta)" 09/01/2001 - "Mutations in the genes encoding enamel proteins lead to amelogenesis imperfecta, a collection of inherited diseases having enamel malformations as the predominant phenotype" Order ALL the reference details at left...
4.	Calcium Carbonate (Limestone)FDA Link 09/01/2007 - "A recent study provided genetic and morphological evidence that rat autosomal-recessive mutation, whitish chalk-like teeth (wct), induced tooth enamel defects resembling those of human amelogenesis imperfecta (AI)" 10/01/2007 - "Our previous findings have demonstrated that the rat autosomal-recessive mutation, whitish chalk-like teeth (wct), induces enamel defects resembling those of human amelogenesis imperfecta (AI) in continuously growing incisor teeth" 12/01/2005 - "A novel autosomal-recessive mutation, whitish chalk-like teeth, resembling amelogenesis imperfecta, maps to rat chromosome 14 corresponding to human 4q21." Order ALL the reference details at left...
5.	Sodium Hypochlorite (Clorox)IBA 05/01/2006 - "OBJECTIVE: The aim of this study was to evaluate the effect of the treatment of sodium hypochlorite (NaOCl) after acid conditioning of the enamel and dentin of the primary teeth affected with hypocalcified amelogenesis imperfecta (HCAI) on the shear bond strength of the composite material" 11/01/1994 - "Enamel pretreatment with sodium hypochlorite to enhance bonding in hypocalcified amelogenesis imperfecta: case report and SEM analysis." Order ALL the reference details at left...
6.	RNA (Ribonucleic Acid)IBA 01/01/1995 - "This minireview highlights selected examples of scientific progress derived from the following experimental strategies: (i) molecular approaches to the organization of the mouse and human chromosomes, with the mapping of specific gene sequences linked to human diseases (e.g., amelogenesis imperfecta, Boston type craniosynostosis, Rieger's syndrome, Treacher Collins syndrome); (ii) reverse genetic approaches for studies of gene function; (iii) homologous recombinations and the advances from "knock-out" transgenic mouse models for human craniofacial-oral-dental diseases; (iv) mutational analyses of congenital craniofacial-oral-dental dysmorphogenesis; (v) structural biology studies using computer-assisted molecular modeling for protein-protein, protein-nucleic acid and protein-inorganic interactions; (vi) computer modeling of genetic paradigms; and (vii) a cluster of newer methodologies including computer-assisted morphometry, new microinjection techniques, new cell membrane and intracellular dyes, and a number of new RNA and DNA viral constructs for the delivery of genes to enhance the resolution of cell fate maps, cell lineage studies and gene therapy approaches to human diseases." Order ALL the reference details at left...
7.	Ethylnitrosourea (N-Ethyl-N-nitrosourea)IBA 08/01/2007 - "We previously isolated a mouse strain with an amelogenesis imperfecta phenotype (ATE1 mice) from a dominant ethylnitrosourea screen and mapped the disease-causing defect to a 9-cM region of mouse chromosome 5. In the current study, we tested the hypothesis that there is a mutation in enamelin (ENAM) or ameloblastin (AMBN), both of which are located within the linkage region, by sequencing these two candidate genes" Order ALL the reference details at left...
8.	Coloring Agents (Dyes)IBA 01/01/1995 - "This minireview highlights selected examples of scientific progress derived from the following experimental strategies: (i) molecular approaches to the organization of the mouse and human chromosomes, with the mapping of specific gene sequences linked to human diseases (e.g., amelogenesis imperfecta, Boston type craniosynostosis, Rieger's syndrome, Treacher Collins syndrome); (ii) reverse genetic approaches for studies of gene function; (iii) homologous recombinations and the advances from "knock-out" transgenic mouse models for human craniofacial-oral-dental diseases; (iv) mutational analyses of congenital craniofacial-oral-dental dysmorphogenesis; (v) structural biology studies using computer-assisted molecular modeling for protein-protein, protein-nucleic acid and protein-inorganic interactions; (vi) computer modeling of genetic paradigms; and (vii) a cluster of newer methodologies including computer-assisted morphometry, new microinjection techniques, new cell membrane and intracellular dyes, and a number of new RNA and DNA viral constructs for the delivery of genes to enhance the resolution of cell fate maps, cell lineage studies and gene therapy approaches to human diseases." Order ALL the reference details at left...
9.	Viral DNAIBA 01/01/1995 - "This minireview highlights selected examples of scientific progress derived from the following experimental strategies: (i) molecular approaches to the organization of the mouse and human chromosomes, with the mapping of specific gene sequences linked to human diseases (e.g., amelogenesis imperfecta, Boston type craniosynostosis, Rieger's syndrome, Treacher Collins syndrome); (ii) reverse genetic approaches for studies of gene function; (iii) homologous recombinations and the advances from "knock-out" transgenic mouse models for human craniofacial-oral-dental diseases; (iv) mutational analyses of congenital craniofacial-oral-dental dysmorphogenesis; (v) structural biology studies using computer-assisted molecular modeling for protein-protein, protein-nucleic acid and protein-inorganic interactions; (vi) computer modeling of genetic paradigms; and (vii) a cluster of newer methodologies including computer-assisted morphometry, new microinjection techniques, new cell membrane and intracellular dyes, and a number of new RNA and DNA viral constructs for the delivery of genes to enhance the resolution of cell fate maps, cell lineage studies and gene therapy approaches to human diseases." Order ALL the reference details at left...
10.	Proline (L-Proline)FDA Link 02/01/1997 - "All three cases of hypomaturation amelogenesis imperfecta enamel showed an increased proline content compared with normal enamel or other amelogenesis imperfecta types" 04/01/2007 - "To better understand the function of the 180-amino-acid amelogenin (M180), and to test the hypothesis that a single proline-to-threonine (P70T) change would lead to an enamel defect similar to amelogenesis imperfecta (AI) in humans, we generated transgenic mice with expression of M180, or M180 with the proline-to-threonine (P70T) mutation, under control of the Amelx gene regulatory regions" 05/01/2008 - "Amelogenin with a proline 41 to threonine mutation (P41T) is hydrolyzed at a lower rate by matrix metalloproteinase 20 (MMP20), resulting in an inherited tooth enamel defect, amelogenesis imperfecta (AI)" 05/30/2003 - "K5 failed to bind to ATMP when the third proline was substituted with threonine, as in some cases of human X-linked amelogenesis imperfecta or when tyrosyl residues were substituted with phenylalanine" 09/28/2001 - "CK14 failed to bind to ATMP when the third proline was substituted with threonine, as in some cases of human X-linked amelogenesis imperfecta or when tyrosyl residues were substituted with phenylalanine" Order ALL the reference details at left...

Therapies and Procedures

1.	Prosthodontics 01/01/2007 - "This case report describes the prosthodontic treatment for a 28-year-old man and a 16-year-old boy diagnosed with amelogenesis imperfecta" 05/01/2005 - "CONCLUSION: Patients with severe clinical manifestations of amelogenesis imperfecta obtained extensive prosthodontic treatment at an early age" 05/01/2005 - "PURPOSE: This article reports on a retrospective study on patients with a diagnosis of amelogenesis imperfecta and on their prosthodontic management, oral health status, and attitudes toward their condition" 05/01/2005 - "A retrospective study of the prosthodontic management of patients with amelogenesis imperfecta." 12/01/2003 - "This clinical report describes the prosthodontic treatment for an 18-year-old man diagnosed with amelogenesis imperfecta" Order ALL the reference details at left...
2.	Crowns (Crown, Dental) 08/01/2007 - "This article presents a patient with amelogenesis imperfecta rehabilitated with all-ceramic crowns following surgical and orthodontic intervention" 08/01/2007 - "Rehabilitation of a patient with amelogenesis imperfecta using all-ceramic crowns: a clinical report." 01/01/1995 - "The ITN care of amelogenesis imperfecta (first dentition) with composite polymeric materials as well as steel crowns--a case report]" 01/01/1985 - "Amelogenesis imperfecta--orthodontic problems and their solution using multiband appliances and temporary steel crowns]" 04/01/1975 - "The oral findings, consisting of disturbances in the structure of the enamel in both deciduous and permanent teeth, resemble those of amelogenesis imperfecta, Type 1. Preformed crowns are recommended as the initial treatment, in order to avoid loss of vertical height" Order ALL the reference details at left...
3.	Overlay Denture 01/01/1985 - "The provision of overdentures for a patient with amelogenesis imperfecta." 10/01/1983 - "Overdenture management of amelogenesis imperfecta." Order ALL the reference details at left...
4.	Tooth Movement 01/01/1974 - "Minor tooth movement in amelogenesis imperfecta: a case report." Order ALL the reference details at left...
5.	Osteotomy 10/01/1998 - "Functional conditions, skeletal and dento-alveolar stability and condylar changes in 15 patients with mandibular hypoplasia, anterior open bite (AOB) and amelogenesis imperfecta (AI), who had undergone a Le Fort I osteotomy, were analysed after a mean follow-up of 5 years" Order ALL the reference details at left...

Best Treatments:
Research Summary Report
on Amelogenesis Imperfecta

*WARNING* This specific disease subtype has a relatively small number of significant evidence outcomes. You may proceed to order anyway, or go back to the search field and enter a more general type of the target illness. Once your report has been ordered, however, we can't refund the purchase.

CureHunter Patient-Physician Summary Reports collect in one document all the medications ever reported in the US National Library of Medicine—1949 to the present—to be effective against your target disease. CureHunter research summary reports will vary in length from 25 to 250 pages. Analytic charts allow you and your physicians to see at a glance your medication options—including new, promising, off-label and experimental all rated for clinical efficacy.

Free Updates for 1 Year
All 0 Outcomes
Top 200 Key Drugs and Biologics
Top 50 Key Therapies and Procedures
Detailed History Charts
Full Research Reference Details
Sample PDF Report on Psoriasis >>

Price:

$24.00 & Delivery via PDF download
updates for 1 year

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License Details >>

Price:

$490.00 access via web interface
1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m"
1 year subscription

Proceed to Checkout >>