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Amelogenesis Imperfecta

A clinically and genetically heterogeneous group of hereditary conditions characterized by malformed DENTAL ENAMEL, usually involving DENTAL ENAMEL HYPOPLASIA and/or TOOTH HYPOMINERALIZATION.
Networked: 215 relevant articles (0 outcomes, 17 trials/studies)

Disease Context: Research Results

Related Diseases

1. Mandibulofacial Dysostosis (Treacher Collins Syndrome)
2. Tooth Diseases
3. Stomatognathic Diseases (Dental Disease)
4. Craniosynostoses (Craniosynostosis)
5. Retinitis Pigmentosa (Pigmentary Retinopathy)

Experts

1. Wright, J T: 12 articles (04/2007 - 01/2000)
2. Simmer, James P: 8 articles (02/2015 - 05/2002)
3. Simmer, J P: 8 articles (07/2010 - 04/2000)
4. Hu, Jan C-C: 7 articles (02/2015 - 05/2002)
5. Gibson, Carolyn W: 7 articles (09/2014 - 01/2005)
6. Bartlett, John D: 7 articles (09/2014 - 12/2002)
7. Wright, J Timothy: 6 articles (09/2014 - 01/2005)
8. Hart, T C: 6 articles (07/2004 - 04/2000)
9. Mighell, Alan J: 5 articles (10/2015 - 02/2009)
10. Kirkham, Jennifer: 5 articles (05/2014 - 02/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Amelogenesis Imperfecta:
1. AmelogeninIBA
09/01/2014 - "The purposes of this study were to: (1) investigate adhesion through shear bond strength (SBS) testing of a resin composite bonded with a self-etching bonding system (SEB) to amelogenesis imperfecta (AI)-affected deproteinized mouse enamel or dentin; and (2) compare wild-type (WT), amelogenin null (AmelxKO), and matrix metalloproteinase-20 null (Mmp20KO) enamel and dentin phenotypes using micro-CT and nanoindentation. "
01/01/2014 - "The aim of this study was to report the clinical findings and the screening of mutations of amelogenin gene of a 7-year-old boy with amelogenesis imperfecta (AI). "
03/01/2002 - "Amelogenins, the major protein component of the mineralizing enamel extracellular matrix, are critical for normal enamel formation as documented in the linkage studies of a group of inherited disorders, with defective enamel formation, called Amelogenesis imperfecta. "
11/01/1998 - "In this study, we have determined the nucleotide sequences of regions of the intron 1 and intron 2 of the X and Y human amelogenin genes (AMGX, AMGY) for the first time, and established a polymerase chain reaction (PCR) protocol to amplify six exons of AMGX and AMGY for the diagnosis of amelogenesis imperfecta, because previous studies have shown that some of the AI patients have such mutations. "
03/01/1995 - "In this study we describe a 9-bp deletion in exon 2 of the amelogenin gene (AMGX) causing X-linked hypoplastic amelogenesis imperfecta, a disease characterized by defective enamel. "
2. tuftelin (enamelin)IBA
3. Proteins (Proteins, Gene)IBA
4. Sodium Hypochlorite (Clorox)IBA
5. Calcium Carbonate (Limestone)FDA Link
6. Codon (Codons)IBA
7. Transcription Factors (Transcription Factor)IBA
8. RNA (Ribonucleic Acid)IBA
9. Ethylnitrosourea (N-Ethyl-N-nitrosourea)IBA
10. Coloring Agents (Dyes)IBA

Therapies and Procedures

1. Crowns (Crown, Dental)
2. Overlay Denture
3. Prosthodontics
4. Mouth Rehabilitation
5. Orthodontics