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Ameloblastoma

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An immature epithelial tumor of the JAW originating from the epithelial rests of Malassez or from other epithelial remnants of the ENAMEL from the developmental period. It is a slowly growing tumor, usually benign, but displays a marked propensity for invasive growth.

Also Known As:

Ameloblastomas

Networked: 371 relevant articles (3 outcomes, 82 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Neoplasms: 420531
- Neoplasms by Histologic Type: 1
  - Odontogenic Tumors: 129
    - Ameloblastoma: 371

Related Diseases

1.	Ameloblastoma
2.	Odontogenic Cysts (Keratocyst)
3.	Neoplasms (Cancer)
4.	Odontogenic Tumors (Dental Tissue Neoplasm)
5.	Dentigerous Cyst

Experts

1.	Kumamoto, Hiroyuki: 16 articles (04/2008 - 01/2002)
2.	Ooya, Kiyoshi: 15 articles (09/2007 - 01/2002)
3.	Zhong, Ming: 13 articles (12/2007 - 04/2003)
4.	Wang, Jie: 13 articles (12/2007 - 04/2003)
5.	Ooya, K: 12 articles (09/2008 - 04/2001)
6.	Kumamoto, H: 12 articles (09/2008 - 04/2001)
7.	Zhang, Bo: 9 articles (12/2007 - 04/2003)
8.	Hou, Lin: 8 articles (12/2007 - 04/2003)
9.	Nagatsuka, Hitoshi: 6 articles (10/2009 - 09/2002)
10.	Tao, Qian: 5 articles (12/2009 - 02/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ameloblastoma:

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/01/2006 - "In the present study, from the flow cytometry results, we found that the prolonged-treatment of TNFalpha until 24 h, resulted apoptosis in AM-1 cells (ameloblastoma cell line). " 07/01/2005 - "In the present study, we found that RANKL and TNFalpha were expressed and secreted by ameloblastoma cells, and was proven to induce osteoclastogenesis. " 04/01/2009 - "BACKGROUND: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a recently identified death factor that acts as a potent apoptosis inducer in ameloblastomas. " 01/01/2006 - "Inhibition of Akt and MAPK pathways elevated potential of TNFalpha in inducing apoptosis in ameloblastoma." 07/01/2005 - "These results suggested that ameloblastoma by secreting RANKL and TNFalpha could induce osteoclastogenesis." Order ALL the reference details at left...
2.	AntibodiesIBA 04/01/1985 - "Collectively, these studies indicate that the use of specific antibodies to basement membrane components may help to differentiate ameloblastomas from malignant lesions." 06/01/2009 - "Fifty seven ameloblastomas were analyzed immunohistochemically with antibodies against the isoform alpha of the smooth muscle actin (alpha-SMA), a specific marker of myofibroblasts, MMP-2 and uPA. " 03/01/2006 - "METHODS: Tissue specimens of 10 tooth germs, 40 benign ameloblastomas, and five malignant ameloblastomas were examined immunohistochemically with the use of antibodies against RB, E2F-1, and phosphorylated RB. " 02/01/2003 - "METHODS: Frozen tissue sections of seven tooth germs and 22 ameloblastomas were immunohistochemically examined using anti-MMP-1, -2 and -9 and anti-TIMP-1 and -2 antibodies. " 11/01/2002 - "METHODS: Specimens of seven tooth germs, 36 benign ameloblastomas and five malignant ameloblastomas were examined by immunohistochemistry using antibodies against iNOS and 27-, 60- and 70-kDa HSPs (HSP27, HSP60 and HSP70). " Order ALL the reference details at left...
3.	Protein Kinases (Protein Kinase)IBA 07/01/2004 - "K-Ras gene status and expression of Ras/mitogen-activated protein kinase (MAPK) signaling molecules in ameloblastomas." 01/01/2006 - "These results suggested that TNFalpha induced both cell survival and apoptosis pathways in ameloblastoma and potential of TNFalpha in inducing apoptosis can be improved by inhibiting TNFalpha-induced Akt and p44/42 mitogen-activated protein kinase (MAPK) cell survival pathways." 07/01/2004 - "BACKGROUND: To clarify the roles of rat sarcoma (Ras)/mitogen-activated protein kinase (MAPK) signaling pathway in oncogenesis and cytodifferentiation of odontogenic tumors, K-Ras gene status and expression of Ras, Raf1, MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK)1, and ERK1/2 proteins were analyzed in ameloblastomas as well as in tooth germs. " Order ALL the reference details at left...
4.	Messenger RNA (mRNA)IBA 01/01/2007 - "OBJECTIVE: To study the expression of HOXC13 mRNA in ameloblastoma (AB), and to investigate its biological significance. " 12/01/2003 - "OBJECTIVE: The purpose of this study was to characterise the mRNA expression of genes in the mouse tumours that are either expressed in human ameloblastomas or essential for normal odontogenesis and to correlate the expression to the histological phenotype. " 07/01/1992 - "In these studies, the gene expression parameters for human ameloblastomas have been characterized with the techniques of messenger RNA phenotyping in combination with Northern and in situ hybridization analysis of messenger RNA. " 01/01/2009 - "MMP-2 mRNA expression was significantly higher in ameloblastoma compared with KCOT (P < 0.01), but was no different in recurrent ameloblastoma versus primary ameloblastoma. " 10/01/2006 - "PURPOSE: To investigate the expression of c-fos, c-jun and hTERT mRNA in human ameloblastoma (AB) and to determine their clinicobiological significance. " Order ALL the reference details at left...
5.	Proliferating Cell Nuclear Antigen (PCNA)IBA 02/01/2003 - "OBJECTIVE: This study used proliferating cell nuclear antigen (PCNA) and Ki67 to evaluate and compare the in situ proliferative activity of (1) solid and multicystic and (2) unicystic ameloblastomas in an attempt to provide a scientific basis for any differences in biologic behavior that exists between these 2 groups of lesions. " 09/01/1996 - "In the present study, we examined the immunohistochemical detection of proliferating cell nuclear antigen (PCNA) in 23 cases of ameloblastoma and evaluated the correlation between the positive index of PCNA and the clinical and histological character. " 01/01/1994 - "Immunohistochemical study on proliferating cell nuclear antigen expression in ameloblastomas." 05/01/2008 - "Ameloblastoma showed MK localization in the peripheral columnar cells in budding processes from the parenchyma, which frequently expressed proliferating cell nuclear antigen. " 01/01/2005 - "PCNA immunohistochemical expression revealed stronger quantitative labeling index for the follicular ameloblastoma, while for p53 protein the strongest quantitative labeling index was detected in the plexiform type. " Order ALL the reference details at left...
6.	ParaffinIBA 11/01/2007 - "MATERIALS AND METHODS: Four samples of paraffin-embedded ameloblastoma with granular cells were studied. " 06/01/2007 - "Paraffin-embedded specimens from 30 ameloblastomas (20 solid and 10 unicystic tumors) and 12 AOTs were submitted to immunohistochemistry using the catalyzed signal amplification system. " 02/01/2003 - "STUDY DESIGN: This descriptive cross-sectional study was done on archival paraffin blocks (n = 37), consisting of 10 conventional ameloblastomas, 7 cases of unicystic ameloblastoma, 10 odontogenic keratocysts, and 10 dentigerous cysts, all accessioned between 1994 and 2000. " 02/01/2003 - "The study consisted of 58 formalin-fixed, paraffin-embedded specimens of ameloblastoma that were immunohistochemically stained with a monoclonal anti-EGFR antibody (clone 31G7). " 10/01/1999 - "The proliferative potential of two common histologic variants of ameloblastoma was investigated immunohistochemically using Ki-67 antibody on routinely processed, formalin-fixed, paraffin-embedded sections. " Order ALL the reference details at left...
7.	Keratins (Keratin)IBA 04/01/1999 - "The aim of this study was to assess keratin expression in African ameloblastomas and to correlate this with their clinical and histological features. " 04/01/1999 - "An immunohistochemical study of keratin expression in ameloblastoma from a Kenyan population." 12/01/1988 - "Immunohistochemical studies of ameloblastoma with special emphasis on keratin." 09/01/2007 - "The term keratoameloblastoma has been used to describe a histologically heterogeneous group of ameloblastoma variants which have in common the formation of keratin by the ameloblastomatous epithelium. " 10/01/2001 - "An additional prominent feature of the present ameloblastoma was formation of hard tissue in continuation, in part, of the accumulated keratin in the fibrous tissue. " Order ALL the reference details at left...
8.	DNA (Deoxyribonucleic Acid)IBA 10/01/2002 - "The purpose of the study was to examine the TP53 status of ameloblastomas using newly developed yeast functional assay whose accuracy and sensitivity has been proven to be higher than those of the previous DNA structure-based methods such as single strand conformation polymorphism (SSCP) analysis. " 06/01/2002 - "OBJECTIVE: The purpose of this study was to investigate the role of nuclear morphometric parameters, DNA content and Ag-NOR count in the differentiating malignant and benign ameloblastomas. " 06/01/2002 - "AgNOR count and DNA index in malignant ameloblastoma were significantly higher than those in benign ameloblastoma (P < 0.01). " 06/01/2002 - "METHODS: Totally 17 cases of malignant ameloblastomas were examined by using HE, AgNOR and DNA stain methods. " 03/01/1993 - "HPV type 18 DNA was identified in an intrabony ameloblastoma using radiolabelled in situ hybridization. " Order ALL the reference details at left...
9.	AmelogeninIBA 01/01/2009 - "In line with previous studies, the molecular determinants of tooth development-amelogenin, Msx1, Msx2, Dlx2, Dlx3, Bmp2, and Bmp4-were analyzed by RT-PCR, ISH, and immunolabeling in 12 recurrent ameloblastomas and in one case of CCOC. " 07/01/1992 - "The results of these studies confirm that amelogenin, a gene transcribed solely by differentiated ameloblasts, was expressed by epithelial cells from human ameloblastomas. " 09/01/2005 - "Analysis of amelogenin gene (AMGX, AMGY) expression in ameloblastoma." 05/01/2001 - "Malignant ameloblastomas exhibited various degrees of amelogenin expression with constant CK19 expression in neoplastic cells. " 05/01/2001 - "RESULTS: Immunohistochemical reactivity for amelogenin was detected in many peripheral columnar or cuboidal cells and some central polyhedral cells in ameloblastomas, and histological variants showed various degrees of amelogenin expression. " Order ALL the reference details at left...
10.	Proteins (Proteins, Gene)IBA 09/01/1999 - "To study the possible roles of bcl-2 family proteins in oncogenesis and cytodifferentiation of odontogenic epithelium, the expression of bcl-2, bcl-x and bax proteins was examined immunohistochemically in tooth germs and various types of ameloblastoma. " 02/01/2010 - "The patterns of expression of the proteins studied agree with the locally more invasive behavior of ameloblastomas in comparison to AOTs. " 09/01/2008 - "Acanthomatous ameloblastomas showed no reactivity for Bid, Bim, Bad, Noxa, or Puma in keratinizing cells, whereas granular cells in granular cell ameloblastomas reacted with these BH3-only proteins. " 08/01/2006 - "Differential expression of apoptosis-related proteins in various cellular components of ameloblastomas." 05/01/2004 - "p53 gene status and expression of p53, MDM2, and p14 proteins in ameloblastomas." Order ALL the reference details at left...

Therapies and Procedures

1.	Aftercare (After-Treatment) 03/01/2009 - "Four years after treatment, the patient continued to show good results, with no recurrence of the ameloblastoma." 06/01/2005 - "A minimum of 5 years of follow-up reviews are necessary after treatment of ameloblastoma." 07/01/2008 - "The treatment for ameloblastoma varies from curettage to en bloc resection, and the reported recurrence rates after treatment are high; the safety margin of resection is important to avoid recurrence. " 01/01/2010 - "Occurrence of ameloblastoma in a patient with nasopharyngeal carcinoma after treatment by irradiation." 02/01/1989 - "However, as the case presented here demonstrates, even in a patient without the characteristic history of multiple recurrences and operations, ameloblastoma may appear as a metastatic lesion, usually to the lung, many years after treatment of the primary tumor. " Order ALL the reference details at left...
2.	Oral Surgery (Maxillofacial Surgery) 01/01/2006 - "OBJECTIVE: The aim of the study was to review all the cases of ameloblastoma seen at the Oral and Maxillofacial Surgery Clinic of the Lagos University Teaching Hospital, Nigeria, between 1980 and 2003. " 10/01/2009 - "During a 13-year period (from 1994 to 2007), in the Oral and Maxillofacial Surgery Department of the Pitié-Salpêtrière Hospital, 116 new cases of adult ameloblastomas, were analyzed for treatment composed against radiographic presentation, size, histological type. " 12/01/2006 - "SUBJECTS AND METHODS: The series comprised all the 18 cases of ameloblastoma of the jaw seen in patients under the age of 20 years in the two major hospitals in Jamaica with an oral and maxillofacial surgery department from 1980 to 1995. " 10/01/2002 - "INTRODUCTION: Cases of maxillary ameloblastomas from 15-year database (1986-2000) collected in the Department of Cranio-Maxillofacial Surgery of the University Hospital of Zurich were evaluated. " 07/01/2002 - "PURPOSE: The purpose of this report was 1) to report the experience of the University of Maryland, Department of Oral and Maxillofacial Surgery (OMS Department) in the treatment of ameloblastoma in children and 2) to review the world literature on the treatment of ameloblastoma in children from 1970 to 2001. " Order ALL the reference details at left...
3.	Curettage 12/01/2003 - "Primary treatment comprised enucleation and bone curettage in 10 cases and radical surgery in 7. Forty percent of the unicystic lesions and 53.3% of the non-unicystic ameloblastomas of our study presented at least 1 recurrence. " 12/01/2007 - "In contrast, conservative procedures such as enucleation and/or curettage result in local control rates of approximately 80% and 50% for unicystic and multicystic ameloblastomas, respectively. " 07/01/2006 - "The recurrence rate following local enucleation and curettage was unacceptably high, and this included the cases of unicystic ameloblastoma, which should be treated more aggressively than has been recommended in the past." 02/01/2004 - "A case of desmoplastic ameloblastoma recurring within 2 months of curettage is presented. " 01/01/2004 - "In this report, we presented a case of maxillary ameloblastoma, which had been surgically treated in another health care unit by Caldwell-Luc and local curettage operations and recurred early in a wide anatomic area. " Order ALL the reference details at left...
4.	Oral Pathology 11/01/2009 - "STUDY DESIGN: Resection specimens of 24 ameloblastomas were retrieved from the files of the Department of Oral Pathology at the University of Limpopo. " 01/01/2007 - "Oral pathology quiz #3. Case number 3. Ameloblastoma." 04/01/2006 - "These results seem to confirm that acanthomatous ameloblastoma is a malignant or potentially malignant lesion and emphasizes that nuclear morphometry analysis can be an useful diagnostic and prognostic method in canine oral pathology." 01/01/2005 - "Oral pathology quiz # 47: case number 1. Ameloblastoma." 01/01/1999 - "To enhance knowledge of DA, 7 cases of DA (7.9%) were retrieved from 89 ameloblastomas field in the Department of Oral Pathology, Hiroshima University School of Dentistry and analyzed clinicopathologically and histopathologically. " Order ALL the reference details at left...
5.	Oral Medicine 11/01/1993 - "Four hundred and one cases of ameloblastoma of the jaw diagnosed in the Division of Stomatology, Institute for Medical Research, Kuala Lumpur, between 1967 and 1991 have been analysed. " 08/01/2000 - "Study Design: A retrospective analysis of every patient with an ameloblastoma of the mandible treated in the Department of Oral Medicine and Oral Surgery at the Jordan University of Science and Technology between 1989 and 1999 was conducted. " 02/01/2006 - "Three cases of ameloblastoma recurrence in the grafted iliac bone were treated at the Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Wuhan University from 1989 to 2005. " 07/01/1999 - "Comparing our results with the literature demonstrated to us that this tumor may be considered to be a worldwide problem due to the similarity in clinical findings among different ethnic groups CASE SERIES: The purpose of this study of 20 patients with ameloblastoma of the mandible and maxilla diagnosed at the Stomatology and Head and Neck Services of Heliópolis Hospital, São Paulo, Brazil, from 1980 to 1997, was to establish the histopathologic pattern of classification of those tumors through optical microscopy and the relation of this histopathology to therapeutic management. " Order ALL the reference details at left...

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