|1.||Centers for Disease Control and Prevention (CDC): 39 articles (11/2014 - 02/2000)|
|2.||Fan, Jia: 36 articles (05/2015 - 06/2002)|
|3.||Zhou, Jian: 29 articles (05/2015 - 04/2005)|
|4.||Tang, Zhao-You: 26 articles (09/2014 - 06/2002)|
|5.||Carr, Brian I: 25 articles (11/2015 - 11/2004)|
|6.||Li, Yan: 22 articles (03/2014 - 05/2002)|
|7.||Lin, Han-Chieh: 21 articles (11/2015 - 01/2010)|
|8.||Huang, Yi-Hsiang: 21 articles (11/2015 - 02/2004)|
|9.||Huo, Teh-Ia: 21 articles (11/2015 - 02/2004)|
|10.||Satomura, Shinji: 21 articles (05/2015 - 07/2002)|
04/01/2014 - "In addition, prime-boost immunization with the optimized AFP significantly increased the frequency of AFP-specific memory CD8 T cells in the liver that were highly effective against emerging HCC tumor cells, further enhancing the tumor prevention of carcinogen-induced autochthonous HCC. "
07/01/2008 - "AFP-L3 is the most reliable tumor marker for estimating overall survival and disease-free survival in patients with HCC effectively treated by RFA in contrast to AFP and DCP."
06/21/2000 - "The most striking finding was that women with high levels of serum alpha-fetoprotein, compared with women with low levels of serum alpha-fetoprotein, showed a particularly reduced incidence of large tumors (>2 cm; RR = 0.24 [95% CI = 0.11-0.50]). "
12/01/1999 - "For most tumors, T/Th for AFP and DIII was significantly greater than T/Th for Tc-99m sestamibi and Tl-201. "
12/01/1987 - "This striking molecular variation of the alpha-fetoprotein produced by these different tumors is helpful in the clinical distinction of these tumors."
|2.||Hepatocellular Carcinoma (Hepatoma)
08/01/2012 - "In a real-world setting, the combination of US and AFP would be the most effective for hepatocellular carcinoma surveillance."
01/01/1983 - "Serial measurement of AFP appears to be the most helpful for detection of hepatocellular carcinoma at the early stage, particularly in cirrhotic patients. "
07/01/2003 - "The paucity of high-quality data calls for more rigorous study of AFP and other diagnostic tests for detecting hepatocellular carcinoma in HCV-infected patients with an accepted gold standard applied to the entire cohort. "
01/01/2009 - "It is concluded that AFP is a significant markers for Hepatocellular carcinoma, helpful in assessing problems in management of HCC and monitoring treatment regiments. "
02/01/2006 - "A significantly greater proportion of respondents screened for hepatocellular carcinoma using either alpha-fetoprotein or ultrasound every 6 months (P < 0.05). "
|3.||Neoplasm Metastasis (Metastasis)
01/01/1987 - "For an early detection of metastases the best results (efficiency 0.92) were achieved with the combination of beta-HCG with AFP and X-ray examination of the chest."
05/01/2001 - "After these treatments, the multiple liver metastases were reduced remarkably, with a marked decrease of serum AFP levels. "
01/01/2002 - "The aim of this study is to evaluate usefulness of plasma CT, CEA and AFP assay in the early detection of relapse or metastasis of MTC. "
10/01/2001 - "We analyzed a concentration of AFP in preliminary study and in monitoring depending on clinical advances of tumour, mass of primary tumour and metastases to lymph nodes. "
08/01/1989 - "After this combined therapy, AFP levels decreased and recurrent lesions in the liver as well as pulmonary metastases disappeared on image studies. "
|4.||Down Syndrome (Down's Syndrome)
08/01/2002 - "Integration of NT and second trimester serum AFP and hCG assay yielded the best screening efficacy for Down syndrome."
03/01/1999 - "A policy of first trimester scanning followed by serum alpha-fetoprotein screening and additional scanning as clinically indicated is effective in detecting major structural abnormalities, but scanning at 18-22 weeks and serum biochemical screening for trisomy 21 improved the detection rates. "
08/01/1994 - "These results support the mathematical model that hCG is the major contributor to the increased sensitivity of multi-analyte screening and demonstrate that screening programs can attain substantial improvement in detection of second-trimester Down syndrome by adding hCG to AFP and age."
12/01/1995 - "AFP, hCG, uE3] has been found effective in identifying the majority of pregnancies with Down syndrome in the second trimester. "
09/01/2011 - "Decreased AFP concentrations increase the calculated risk of Down's syndrome; therefore falsely low AFP, due to assay interference, may artificially increase a patient's risk, and have the potential to cause false screen positive results. "
07/01/1990 - "In conclusion, AFP is and remains the best marker for HCC and the only one effective in discriminating of HCC from cirrhosis. "
06/01/1999 - "The mean serum AFP value was significantly greater in patients with more fibrosis. "
06/01/2015 - "The complementary use of AFP and US improved the effectiveness of HCC surveillance in patients with cirrhosis."
07/01/2010 - "The diagnostic efficacy of the log ratio [log(p9/4)] was similar to that of AFP in differentiating HCC from fibrosis. "
11/01/2007 - "The combination with AFP measurements led to improved discrimination between HCC and cirrhosis. "
|2.||Chorionic Gonadotropin (Human Chorionic Gonadotropin)
|3.||Biological Tumor Markers (Tumor Markers)
|4.||Biological Markers (Surrogate Marker)
|9.||Pregnancy-Associated Plasma Protein-A (PAPP-A)
|1.||Drug Therapy (Chemotherapy)
|4.||Combination Drug Therapy (Combination Chemotherapy)