Follicular Mucinosis

A disease of the pilosebaceous unit, presenting clinically as grouped follicular papules or plaques with associated hair loss. It is caused by mucinous infiltration of tissues, and usually involving the scalp, face, and neck. It may be primary (idiopathic) or secondary to mycosis fungoides or reticulosis.

Also Known As:

Networked: 85 relevant articles (6 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Mycosis Fungoides
2.	Follicular Mucinosis
3.	Alopecia (Baldness)
4.	Mucinoses
5.	Lymphomatoid Papulosis

Experts

1.	Geller, Shamir: 2 articles (11/2019 - 06/2019)
2.	Myskowski, Patricia L: 2 articles (11/2019 - 06/2019)
3.	Pulitzer, Melissa P: 2 articles (11/2019 - 09/2012)
4.	Borgia, Francesco: 2 articles (09/2019 - 04/2016)
5.	Giuffrida, Roberta: 2 articles (09/2019 - 04/2016)
6.	Duvic, Madeleine: 2 articles (05/2018 - 01/2003)
7.	Cañueto, Javier: 2 articles (09/2014 - 11/2013)
8.	Santos-Briz, Angel: 2 articles (09/2014 - 11/2013)
9.	Chong, Alvin H: 1 article (05/2022)
10.	Lasocki, Anita: 1 article (05/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Follicular Mucinosis:

1.	Minocycline (Cyclops)FDA LinkGeneric 03/01/2003 - "We report a case of idiopathic alopecia mucinosa that responded to minocycline with a complete remission and we review the literature on alopecia mucinosa." 04/01/2000 - "A case of follicular mucinosis treated successfully with minocycline." 01/01/2010 - "Follicular mucinosis: clinical, histologic, and molecular remission with minocycline." 01/01/2010 - "In this report, we describe a patient with clonal idiopathic primary follicular mucinosis who had complete clinical, histologic, and molecular remission with minocycline therapy."
2.	pimecrolimus (Elidel)FDA Link 01/01/2009 - "A case of follicular mucinosis treated successfully with pimecrolimus." 01/01/2022 - "Localized Follicular Mucinosis in a Child Treated Successfully with Pimecrolimus and Targeted Phototherapy."
3.	Imiquimod (Aldara)FDA LinkGeneric 05/01/2014 - "Treatment of primary follicular mucinosis with imiquimod 5% cream." 05/01/2014 - "We present a case of primary follicular mucinosis in which complete clinical remission was achieved after treatment with topical imiquimod 5%. "
4.	MucinsIBA 09/01/2022 - "Follicular mucinosis is an epithelial reaction pattern characterized by follicular mucin accumulation. " 02/01/2021 - "Follicular mucinosis (FM) is an epithelial reaction pattern characterized by follicular mucin accumulation. " 09/01/2019 - "Follicular mucinosis (FM) is a rare inflammatory disorder histologically characterized by mucin deposition in the follicular epithelium. " 05/24/2019 - "Follicular mucinosis (FM) is a rare disorder of the skin characterized by follicular degeneration due to the accumulation of mucin within the pilosebaceous unit, with associated inflammatory changes. " 11/01/2013 - "Follicular mucinosis (FM) is an uncommon reaction pattern in which the accumulation of mucin in the follicular epithelium is the main pathologic finding. "
5.	Isotretinoin (Accutane)FDA LinkGeneric 12/01/2004 - "He was diagnosed as primary benign generalized follicular mucinosis, and treated with isotretinoin. " 12/01/2004 - "Follicular mucinosis responding to isotretinoin treatment." 01/01/1999 - "To the best of our knowledge, the benefits of isotretinoin in the treatment of follicular mucinosis have never been reported previously. " 01/01/1999 - "We describe the case of a 33-year-old Caucasian male with follicular mucinosis successfully treated with isotretinoin. " 01/01/1999 - "Follicular mucinosis successfully treated with isotretinoin."
6.	T-Cell Antigen Receptors (T-Cell Receptor)IBA 11/01/1997 - "Follicular mucinosis, Staphylococcus aureus, and oligoclonal expansion of the T-cell receptor V beta chain genes 6 and 7 were present in the skin. " 05/01/1988 - "Clonal rearrangement of the T cell receptor beta gene in the circulating lymphocytes of erythrodermic follicular mucinosis." 01/01/2004 - "To investigate T-cell clonality in a series of eosinophilic pustular folliculitis with follicular mucinosis, we performed heteroduplex analysis of re-arranged T-cell receptor gamma gene in seven cases of eosinophilic pustular folliculitis with follicular mucinosis. " 11/01/1997 - "Follicular mucinosis associated with scarring alopecia, oligoclonal T-cell receptor V beta expansion, and Staphylococcus aureus: when does follicular mucinosis become mycosis fungoides?" 11/01/1993 - "Southern blot analysis of immunoglobulin and T-cell antigen receptor gene rearrangements may fail to aid the clinician in establishing a diagnosis of a cutaneous malignancy due to the limits of detection sensitivity in minimally infiltrated lesions (eg, parapsoriasis and patch-stage mycosis fungoides) or the still uncertain prognostic significance of clonality in benign cutaneous diseases (eg, follicular mucinosis, pityriasis lichenoides et varioliformis acuta, lymphomatoid papulosis, and cutaneous lymphoid hyperplasia). "
7.	DapsoneFDA Link 08/01/1974 - "Follicular mucinosis responding to dapsone." 01/01/2003 - "Urticaria-like follicular mucinosis responding to dapsone." 09/01/1989 - "Follicular mucinosis presenting as acute dermatitis and response to dapsone." 01/01/2021 - "Acneiform follicular mucinosis successfully treated with lesional narrowband UVB, oral dapsone, and topical retinoid therapy."
8.	Ointments (Pastes)IBA 09/01/2023 - "Papulonodular nonalopecic primary follicular mucinosis successfully treated with tacrolimus ointment." 03/01/2014 - "Follicular mucinosis treated with topical 0.1% tacrolimus ointment." 09/01/2019 - "Combination of tacalcitol ointment and photodynamic therapy for the treatment of follicular mucinosis of the scalp."
9.	InterferonsIBA 05/01/1991 - "Successful treatment of primary progressive follicular mucinosis with interferons." 06/01/2001 - "Follicular mucinosis associated with early stage cutaneous T-cell lymphoma: successful treatment with interferon alpha-2b and acitretin." 01/01/2003 - "We present a case of mycosis fungoides with follicular mucinosis that was treated with incomplete courses of interferon, isotretinoin, and polychemotherapy with subsequent rapid progression to tumor-stage mycosis fungoides with large cell transformation and nodal and bone marrow involvement. "
10.	Indomethacin (Indometacin)FDA LinkGeneric 02/01/1988 - "Follicular mucinosis: response to indomethacin." 04/01/2023 - "An atypical case of eosinophilic pustular folliculitis with associated secondary follicular mucinosis treated with indomethacin." 08/01/2009 - "Successful Treatment of Recalcitrant Primary Follicular Mucinosis with Indomethacin and Low-dose Intralesional Interferon Alpha."

Therapies and Procedures

1.	Therapeutics 07/01/2014 - "No uniformly effective therapy exists for follicular mucinosis, although several treatments are routinely used. " 12/01/2004 - "No effective standard therapy for follicular mucinosis is available. " 03/01/2003 - "Therapy for alopecia mucinosa remains problematic. " 01/01/2003 - "When associated with follicular mucinosis, mycosis fungoides commonly pursues an aggressive course, often undergoing large-cell transformation, which is associated with resistance to therapy and poor prognosis. " 03/01/1994 - "Our results suggest that antecedent follicular mucinosis and lymphomatoid papulosis may be associated with short relapse-free survival in T1 and T2 patients treated with total skin electron beam therapy. "
2.	Phototherapy (Light Therapy) 10/01/2022 - "Successful treatment of follicular mucinosis with low-dose UVA1 phototherapy." 04/01/2016 - "Follicular mucinosis with diffuse scalp alopecia treated with narrow-band UVB phototherapy: the role of trichoscopy in monitoring therapeutic outcomes." 01/01/2022 - "Localized Follicular Mucinosis in a Child Treated Successfully with Pimecrolimus and Targeted Phototherapy."
3.	Aftercare (After-Treatment) 05/01/2014 - "We present a case of primary follicular mucinosis in which complete clinical remission was achieved after treatment with topical imiquimod 5%. "
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 06/01/2012 - "Mycosis fungoides-associated follicular mucinosis after bone-marrow transplantation." 01/01/2004 - "Follicular mucinosis occurring after bone marrow transplantation in a patient with acute lymphoblastic leukemia." 01/01/2016 - "We present the first reported case of follicular mucinosis arising in an adolescent with acute myelogenous leukemia and acute graft-versus-host disease after an allogeneic bone marrow transplantation. "
5.	Photochemotherapy (Photodynamic Therapy) 09/01/2022 - "This report describes two patients with these two forms of follicular mucinosis, who both had an excellent response to photodynamic therapy. " 09/01/2022 - "Follicular mucinosis successfully treated by photodynamic therapy: Two case reports." 03/01/2008 - "Primary follicular mucinosis: excellent response to treatment with photodynamic therapy." 09/01/2019 - "Combination of tacalcitol ointment and photodynamic therapy for the treatment of follicular mucinosis of the scalp."