|1.||Sasano, Hironobu: 53 articles (10/2015 - 03/2002)|
|2.||Pitt, Bertram: 46 articles (11/2015 - 04/2002)|
|3.||Rossi, Gian Paolo: 44 articles (12/2015 - 07/2002)|
|4.||Mulatero, Paolo: 42 articles (01/2016 - 07/2002)|
|5.||Satoh, Fumitoshi: 41 articles (01/2016 - 09/2003)|
|6.||Calhoun, David A: 38 articles (01/2014 - 12/2002)|
|7.||Reincke, Martin: 37 articles (01/2016 - 12/2003)|
|8.||Stowasser, Michael: 36 articles (01/2016 - 02/2002)|
|9.||Wu, Kwan-Dun: 36 articles (11/2015 - 07/2002)|
|10.||Veglio, Franco: 35 articles (12/2015 - 07/2002)|
|1.||Hypertension (High Blood Pressure)
07/01/2010 - "At the end of the follow-up, 16 patients (59.3%) were considered to experience "complete resolution" without postoperative medications, whereas 7 patients (25.9%) "improved" with medications and 4 patients (14.8%) were "uncontrolled." Three factors (< or =2 antihypertensive medications [P=0.007], duration of hypertension <6 yr [P=0.002], and serum aldosterone <350 pg/mL [P<0.001]) were the predictive for complete resolution in univariate analysis. "
06/01/2007 - "Similarly, although aldosterone blockade is apparently beneficial in individuals with refractory hypertension, this evidence is not currently based on robust randomized, double-blind trial."
11/01/2002 - "In essential hypertension, a low dose of aldosterone antagonist added to antihypertensive treatment significantly improved left ventricular diastolic function. "
04/01/2012 - "Hypertension was less likely to be cured in patients with a longer history of hypertension, higher preoperative BP levels, larger number of drug classes, or lower urinary aldosterone levels. "
03/01/2013 - "Aldosterone inhibition with mineralcorticoid receptor antagonists (MRAs) is an effective treatment for resistant hypertension. "
11/28/2012 - "Aldosterone antagonist therapy for heart failure and reduced ejection fraction has been highly efficacious in randomized trials. "
01/01/2007 - "Anti-aldosterone treatment has proven effective in patients with heart failure. "
07/01/2003 - "In particular, ACE inhibition, beta-blockade and aldosterone antagonism have proven to be effective in modulating the process of remodeling and in reducing the occurrence of adverse events in heart failure. "
06/01/2003 - "The mechanisms of action of aldosterone inhibition are still poorly understood, despite its proven efficacy in heart failure. "
02/25/2010 - "Reducing aldosterone action is beneficial in various major diseases such as heart failure. "
09/01/1975 - "The concentration of aldosterone in the venous effluent from the adrenal glands containing adenomas was significantly greater than in the venous effluent from contralateral glands. "
12/01/1994 - "In patients with adenomas who were cured or improved, aldosterone secretion was more likely to lateralize. "
06/01/1989 - "Of 34 quantitative measures, only lesion-liver and lesion-kidney intensity ratios at 2,000/150 showed statistically significant differences among nonhyperfunctioning adenomas, aldosterone-producing lesions, and corticosteroid-producing lesions; however, the authors question the significance of these differences because of the abundant noise associated with the 2,000/150 sequence. "
07/01/1986 - "The established surgical cure for aldosterone-producing adenoma justifies a thorough preoperative evaluation. "
10/01/2015 - "Aldosterone-producing adenomas (APAs) are found in 1.5-3.0% of hypertensive patients in primary care and can be cured by surgery. "
|4.||Hyperaldosteronism (Conn Syndrome)
09/01/2012 - "The obligatory use of tests confirming autonomy of aldosterone secretion in patients screened for primary aldosteronism seems cost-effective in limiting the number of patients for further diagnosis."
07/01/2001 - "If all hypertensive patients are screened for primary aldosteronism and the workup is continued methodically in those with a positive screening test, patients with unilateral overproduction of aldosterone who potentially can be cured surgically are not denied the possibility of cure."
08/01/2010 - "Adrenal venous sampling (AVS) is generally considered to be the gold standard in distinguishing unilateral and bilateral aldosterone hypersecretion in primary hyperaldosteronism. "
01/01/2008 - "Adrenal vein sampling (AVS) is considered the gold-standard test to demonstrate unilateral aldosterone excess in primary aldosteronism, yet no single approach to interpretation of AVS has been externally validated. "
08/01/2014 - "The aim of the study was to assess the repeatability and interpretation of urinary aldosterone in patients examined for suspected primary aldosteronism. "
04/01/1998 - "Basic hormonal studies and CT can be used effectively to differentiate aldosterone-producing neoplasia from hyperplasia in most cases."
01/01/1980 - "Adrenal vein catheterization with aldosterone determinations was helpful in establishing the presence of hyperplasia in approximately 70% of these cases. "
01/01/2011 - "This study was performed to further investigate if P-450(c11beta) contributes to the overproduction of aldosterone in APA and nodular hyperplasia tissues. "
01/01/2016 - "Conversely, nodular hyperplasia on final pathology may be a risk factor for ongoing aldosterone hypersecretion. "
01/26/2015 - "[High doses of aldosterone antagonist is a condition of sufficient blood pressure control in bilateral adrenal hyperplasia]."
|9.||Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
|10.||Mineralocorticoid Receptors (Mineralocorticoid Receptor)
|2.||Cardiac Resynchronization Therapy
|3.||Drug Therapy (Chemotherapy)
|5.||Implantable Defibrillators (Implantable Cardioverter-Defibrillator)