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Alanine Racemase

A pyridoxal-phosphate protein that reversibly catalyzes the conversion of L-alanine to D-alanine. EC 5.1.1.1.

Also Known As:

Racemase, Alanine; Alanine racemase

Networked: 12 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Isomerases: 463
    - Racemases and Epimerases: 412
      - Amino Acid Isomerases
        Alanine Racemase: 12

Experts

1.	Prosser, Gareth A: 2 articles (10/2016 - 12/2013)
2.	Fan, Xiaolong: 1 article (09/2021)
3.	Li, Fengsai: 1 article (09/2021)
4.	Li, Yijing: 1 article (09/2021)
5.	Li, Yue: 1 article (09/2021)
6.	Qiao, Xinyuan: 1 article (09/2021)
7.	Sui, Ling: 1 article (09/2021)
8.	Tang, Lijie: 1 article (09/2021)
9.	Wang, Li: 1 article (09/2021)
10.	Wang, Xiaona: 1 article (09/2021)

Related Diseases

1.	Anthrax 05/01/2008 - "These structures confirm the binding mode of L-Ala-P but suggest an unexpected mechanism of inhibition of alanine racemase by this compound and could provide a basis for the design of improved alanine racemase inhibitors with potential as anti-anthrax therapies." 05/01/2008 - "Alanine racemase has attracted much interest as a possible target for anti-anthrax drugs: not only is D-alanine a vital component of the bacterial cell wall, but recent studies also indicate that alanine racemase, which is accessible in the exosporium, plays a key role in inhibition of germination in B. " 08/01/2004 - "Three proteins (immune inhibitor A, GPR-like spore protease, and alanine racemase) initially identified by proteomics in our laboratory were found to have differential expressions during anthrax spore germination and early outgrowth. "
2.	Tuberculosis (Tuberculoses) 01/01/2011 - "In an effort to discover new drugs to treat tuberculosis (TB) we chose alanine racemase as the target of our drug discovery efforts. " 12/12/2013 - "tuberculosis challenged with DCS and reveal that d-alanine:d-alanine ligase is more strongly inhibited than alanine racemase at equivalent DCS concentrations. " 10/01/2016 - "tuberculosis During our studies on alternative inhibitors of the d-alanine pathway, we discovered that the canonical alanine racemase (Alr) inhibitor β-chloro-d-alanine (BCDA) is a very poor inhibitor of recombinant M. " 09/01/2021 - "d-cycloserine (DCS), a second line drug used in the treatment of Mycobacterium tuberculosis infection, can inhibit two key enzymes in D-Ala metabolism: alanine racemase and d-alanine-d-alanine ligase. "
3.	Infections 09/26/2021 - "In this study, to explore whether the alanine racemase gene (Alr) could be used as a screening marker and develop an efficient oral vaccine against PEDV infection, a recombinant strain was constructed using Lactobacillus casei with Alr deletion (L. "
4.	African Trypanosomiasis (Nagana) 01/01/2007 - "PLP-dependent enzymes for which there are already commercially available drugs are DOPA decarboxylase (involved in the Parkinson disease), GABA aminotransferase (epilepsy), serine hydroxymethyltransferase (tumors and malaria), ornithine decarboxylase (African sleeping sickness and, potentially, tumors), alanine racemase (antibacterial agents), and human cytosolic branched-chain aminotransferase (pathological states associated to the GABA/glutamate equilibrium concentrations). "
5.	Starvation 01/01/1988 - "Extractable alanine racemase was low following such starvation. "

Related Drugs and Biologics

1.	Alanine (L-Alanine)
2.	Vaccines
3.	5-bromo-4-chloroindoxyl acetate
4.	Enzymes
5.	D-alanylalanine synthetase
6.	Glutamic Acid (Glutamate)
7.	DNA Primers
8.	Glycine Hydroxymethyltransferase (Serine Hydroxymethyltransferase)
9.	Proteins (Proteins, Gene)
10.	Peptide Hydrolases (Proteases)

Related Therapies and Procedures

1.	Therapeutics