Akinetic Mutism (Coma Vigil)

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53 relevant articles (10 outcomes, 3 trials/studies) found for this Disease

Description: A syndrome characterized by a silent and inert state without voluntary motor activity despite preserved sensorimotor pathways and vigilance. Bilateral FRONTAL LOBE dysfunction involving the anterior cingulate gyrus and related brain injuries are associated with this condition. This may result in impaired abilities to communicate and initiate motor activities. (From Adams et al., Principles of Neurology, 6th ed, p348; Fortschr Neurol Psychiatr 1995 Feb;63(2):59-67)

Also Known As:

Coma Vigil; Akinetic Autism; Coma Vigilans; Akinetic Mutisms; Autism, Akinetic; Vigil, Coma; Vigils, Coma; Mutism, Akinetic

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3405

Central Nervous System Diseases: 929

Brain Diseases: 1117

Akinetic Mutism: 53

Related Diseases

1.	Syndrome
2.	Stroke (Strokes)
3.	Movement Disorders (Movement Disorder)
4.	Poisoning
5.	Hydrocephalus (Hydrocephaly)
33 Diseases and 26 more articles analyzed in the Research Interface, order at left...

Experts

1.	Borasio, G D: 1 article (03/2008)
2.	Jox, R: 1 article (03/2008)
3.	Schöch, H: 1 article (03/2008)
4.	Kutzer, K: 1 article (03/2008)
5.	Callender, David M: 1 article (01/2008)
6.	Spiegel, David R: 1 article (01/2008)
7.	Casella, Daniel P: 1 article (01/2008)
8.	Dhadwal, Neetu: 1 article (01/2008)
9.	Rhee, Jong Joo: 1 article (09/2007)
10.	Kwon, Seon-Joo: 1 article (09/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Akinetic Mutism:

1.	Bromocriptine (Parlodel)FDA LinkGeneric 09/01/2007 - "Postoperatively, the patient developed akinetic mutism, but her condition improved after administration of bromocriptine" 12/01/2003 - "This patient developed akinetic mutism postoperatively, which improved with bromocriptine" 02/01/1997 - "The akinetic mutism of the boy was resistant to antiparkinsonian therapy before megadosage of bromocriptine (120 mg/day)" 04/17/1993 - "Treatment of akinetic mutism with bromocriptine]" 08/01/1991 - "Four case studies are presented describing the successful treatment of abulia at a lesser severity than akinetic mutism with bromocriptine" Get all the results and reference details, order at left...
2.	Dopamine Agonists (Dopamine Agonist)IBA 11/01/1981 - "Akinetic mutism from hypothalamic damage: successful treatment with dopamine agonists." 05/01/2007 - "We describe a 72-year-old man who developed akinetic mutism following a cerebrovascular accident involving his right internal watershed area and responded well to dopaminergic agonists" 02/01/1999 - "Akinetic mutism after fourth ventricle choroid plexus papilloma: treatment with a dopamine agonist." 04/01/1987 - "We conclude that whole-brain or total-body irradiation may increase blood-brain barrier permeability to polyene antibiotics, and that high-dose therapy with dopamine agonists is unlikely to benefit patients with akinetic mutism due to diffuse white-matter lesions." 08/01/2003 - "Postoperatively, the patient developed the clinical syndrome of akinetic mutism, but her condition improved after the administration of the dopaminergic agonist bromocriptine" Get all the results and reference details, order at left...
3.	zolpidem (Ambien)FDA LinkGeneric 07/01/2007 - "We conducted a randomized, double-blind, placebo-controlled, single-patient (N = 1) trial to evaluate the efficacy of zolpidem in a 48-year-old woman with an akinetic mutism" Get all the results and reference details, order at left...
4.	Trihexyphenidyl (Artane)FDA LinkGeneric 05/01/1989 - "Cases involving two patients who presented post-traumatic prolonged disturbance of consciousness (PTPDC), namely akinetic mutism, and recovered from it after treatment with trihexyphenidyl were reported" 10/01/1987 - "Shortly after administration of levodopa and trihexyphenidyl, akinetic mutism began to improve, but upward gaze palsy was not affected" 10/01/1987 - "A case of akinetic mutism was reported with reference to a marked improvement by levodopa, bromocriptine and trihexyphenidyl" 10/01/1987 - "Akinetic mutism from recurrent hydrocephalus: successful treatment with levodopa, bromocriptine and trihexyphenidyl]" Get all the results and reference details, order at left...
5.	Levodopa (L Dopa)FDA LinkGeneric 07/01/2000 - "Akinetic mutism from frontal lobe damage responding to levodopa." 10/01/1987 - "Shortly after administration of levodopa and trihexyphenidyl, akinetic mutism began to improve, but upward gaze palsy was not affected" 10/01/1987 - "A case of akinetic mutism was reported with reference to a marked improvement by levodopa, bromocriptine and trihexyphenidyl" 10/01/1987 - "Akinetic mutism from recurrent hydrocephalus: successful treatment with levodopa, bromocriptine and trihexyphenidyl]" Get all the results and reference details, order at left...
6.	Cyclosporine (Ciclosporin)FDA LinkGeneric 12/01/1990 - "Three patients developed akinetic mutism on the third day after the introduction of intravenous cyclosporin A, given for immunosuppression after liver transplantation" 12/01/1990 - "One patient in addition developed a florid orofacial dyskinesia, which resolved completely, as did the akinetic mutism, after withdrawal of cyclosporin" 12/01/1990 - "In these patients the time course of the akinetic mutism and extrapyramidal syndrome, which developed in the absence of any other identifiable cause, suggests cyclosporin A was the precipitating factor" 12/01/1990 - "Cyclosporin-associated akinetic mutism and extrapyramidal syndrome after liver transplantation." Get all the results and reference details, order at left...
7.	Metoprolol (Lopressor)FDA LinkGeneric 06/01/1995 - "The patient developed a syndrome of akinetic mutism that improved after administration of bromocriptine and metoprolol." Get all the results and reference details, order at left...
8.	SteroidsIBA 01/01/1995 - "After 6 weeks of severe akinetic mutism refractory to one ECT treatment and trials of steroids and stimulants, the patient recovered spontaneously over a 2-month period" Get all the results and reference details, order at left...
9.	Carbon MonoxideIBA 01/01/1991 - "This study was performed 187 days after acute CO poisoning, in a state of chronic akinetic mutism that followed a lucid interval" Get all the results and reference details, order at left...
10.	Ephedrine FDA LinkGeneric 04/01/2005 - "Akinetic mutism related to hydrocephalus and cerebellar surgery treated with bromocriptine and ephedrine" 01/01/1992 - "Relief of akinetic mutism from obstructive hydrocephalus using bromocriptine and ephedrine" Get all the results and reference details, order at left...
37 Drugs and Important Bio-Agents and 45 more articles analyzed in the Research Interface, order at left...

Therapies and Procedures

1.	Ventriculoperitoneal Shunt 03/01/1976 - "After suboccipital exploratory craniotomy and ventriculo-peritoneal shunt akinetic mutism improved gradually, and he was discharged on foot after 7 months" Get all the results and reference details, order at left...
2.	Craniotomy 03/01/1976 - "After suboccipital exploratory craniotomy and ventriculo-peritoneal shunt akinetic mutism improved gradually, and he was discharged on foot after 7 months" Get all the results and reference details, order at left...
3.	Aftercare (After-Treatment) 09/01/2007 - "An 11-year-old girl with obstructive hydrocephalus developed akinetic mutism after treatment for hydrocephalus due to aqueductal stenosis by ventriculoperitoneal (VP) shunting" 05/01/1989 - "Cases involving two patients who presented post-traumatic prolonged disturbance of consciousness (PTPDC), namely akinetic mutism, and recovered from it after treatment with trihexyphenidyl were reported" 11/01/1994 - "2. Reports of single cases and case series claim improvement of akinetic mutism, non-fluent aphasia, apathy, attentional and other neuropsychiatric disturbances after treatment with bromocriptine, a D2 dopamine receptor agonist" Get all the results and reference details, order at left...
4.	Active Euthanasia 03/01/2008 - "Active euthanasia for patients in coma vigilans?]" 07/01/2007 - "This single investigation which was restricted to patients suffering from coma vigil and to employees of the public health service, does not prove that the total population has generally changed its attitude toward active euthanasia" 07/01/2007 - "An examination was made concerning doctors' and nursing staff's attitudes towards active euthanasia of patients suffering from coma vigil (2652 doctors and 5785 nursing staff were interviewed)" Get all the results and reference details, order at left...
5.	Transplants (Transplant) 04/15/2003 - "METHODS: The authors describe a dramatic neurologic syndrome after orthotopic heart transplant characterized by akinetic mutism, blepharospasm, anomic aphasia, and delirium" Get all the results and reference details, order at left...
16 Therapies and Procedures and 15 more articles analyzed in the Research Interface, order at left...

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