Agranulocytosis (Granulocytopenia)

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2740 relevant articles (99 outcomes, 153 trials/studies) found for this Disease

Description: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).

Also Known As:

Granulocytopenia; Agranulocytoses; Granulocytopenias

Relationship Network

Disease Context: Research Results

Hemic and Lymphatic Diseases

Hematologic Diseases: 1421

Leukocyte Disorders: 5

Leukopenia: 3021

Agranulocytosis: 2740

Neutropenia: 8252

Related Diseases

1.	Infection
2.	Schizophrenia (Dementia Praecox)
3.	Neoplasms (Cancer)
4.	Fever (Fevers)
5.	Neutropenia

Experts

1.	Dettling, M: 4 articles (10/2007 - 11/2000)
2.	Cascorbi, I: 4 articles (10/2007 - 11/2000)
3.	Andrès, Emmanuel: 4 articles (06/2005 - 04/2002)
4.	Maloisel, F: 4 articles (01/2003 - 01/2000)
5.	Andrès, E: 4 articles (01/2003 - 01/2000)
6.	Vidal, X: 3 articles (03/2008 - 01/2000)
7.	Ballarín, E: 3 articles (03/2008 - 01/2000)
8.	Ibáñez, L: 3 articles (03/2008 - 01/2000)
9.	Maloisel, Frédéric: 3 articles (06/2005 - 09/2003)
10.	Uetrecht, J P: 3 articles (11/2002 - 03/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Agranulocytosis:

1.	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 05/01/1994 - "G-CSF is effective for patients with granulocytopenia after AC bypass surgery, but we need more experiences to know the best way of administration." 03/01/2005 - "This study examined whether granulocyte colony-stimulating factor (G-CSF) is beneficial for the treatment of antithyroid drug-induced agranulocytosis" 04/15/2002 - "CONCLUSION: Our findings suggest that G-CSF therapy may be beneficial in the management of drug-induced agranulocytosis in elderly patients." 07/01/1997 - "Because the recovery time for thionamide-induced agranulocytosis typically ranges from 1 to 2 weeks and sometimes is even longer, G-CSF may have been beneficial in accelerating the return of the granulocytes" 11/08/1993 - "Despite the high cost of the drug, treatment with granulocyte-colony stimulating factor was found to be cost-effective for patients with uncomplicated drug-induced agranulocytosis." Order ALL the reference details at left...
2.	Clozapine (Clozaril)FDA LinkGeneric 03/01/1995 - "Presented here is a case of clozapine overdose treated successfully with supportive care in which agranulocytosis did not develop." 09/01/1999 - "The atypical antipsychotic agent clozapine is known to be effective in schizophrenic patients refractory to other medications; however, it induces agranulocytosis in approximately 1-2%" 09/14/2006 - "Thus functional data derived from the in vitro stromal system defined in these studies may enable further investigation of the mechanisms subserving stromal impairment in clozapine-induced agranulocytosis and direct attention to improved methods for its prevention." 09/01/1994 - "Due to the risk of agranulocytosis, clozapine cannot yet be considered a first-choice treatment for psychotic symptoms, but many studies indicate it to be helpful with a wide variety of treatment-resistant ones." 12/01/1996 - "Clozapine does not constitute a first-line treatment due to the occurrence of agranulocytosis" Order ALL the reference details at left...
3.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 05/01/1995 - "Further studies are warranted to delineate the role of GM-CSF in the treatment of drug-induced agranulocytosis." 03/28/2005 - "Subcutaneous GM-CSF, 400 mug once daily, days 12-19, was added if dose-limiting granulocytopenia was encountered" 09/01/2001 - "It was concluded that, dose intensification with GM-CSF prophylaxis is benefical in increasing the treatment tolerability by decreasing the intensity of granulocytopenia as well as providing rapid recovery." 02/15/1999 - "The main toxicity was myelosuppression, although the administration of GM-CSF significantly reduced the percentage of patients with Grade 4 granulocytopenia (53% vs. 78%)" 01/01/1999 - "Duration of granulocytopenia (median: 33 days with GM-CSF) versus 35 days with placebo) and frequency of infectious episodes were not significantly influenced by GM-CSF" Order ALL the reference details at left...
4.	Filgrastim (Neupogen)FDA Link 01/01/2006 - "The authors present their own observation of a patient suffering from drug-induced agranulocytosis, cured with filgastrim-neupogen, a recombinant colony-stimulating human granulocyte factor." 09/01/1994 - "RESULTS: Time from onset until resolution of agranulocytosis was 8.2 +/- 2.1 days compared with a historical study of seven cases where filgrastim was not used and 15.7 +/- 3.7 days were required for resolution" 04/01/2004 - "Despite filgrastim, the major toxicities were hematologic with 15 of 30 patients developing grade 3/4 granulocytopenia" 11/01/1998 - "Both were treated with filgrastim in an attempt to decrease the duration of agranulocytosis" 11/01/1998 - "Administration of filgrastim in two patients with drug-induced agranulocytosis." Order ALL the reference details at left...
5.	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/01/1994 - "Our results, with others, clearly show that hematopoietic growth factors are effective in severe antithyroid drug-induced agranulocytosis." 03/01/1999 - "Case reports provide promising results with a shortening in the duration of agranulocytosis, a possible reduction in the duration of hospitalisation and the fatality rate in patients treated with haematopoietic growth factors (HGF) compared with historical controls" 12/01/1994 - "The results demonstrate that patients with a severe granulocytopenia (< 0.1 x 10(9)/l) treated with hematopoietic growth factors had a significantly faster recovery of the peripheral blood granulocytes compared to previous published studies" 01/01/2006 - "Haptenic agranulocytosis: treatment with hemopoietic growth factors]" 03/01/2004 - "Long-term outcome of patients treated with hematopoietic growth factors for idiosyncratic drug-induced agranulocytosis." Order ALL the reference details at left...
6.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)FDA LinkGeneric 09/08/2003 - "Trimethoprim-sulfamethoxazole-induced life-threatening agranulocytosis." 05/07/1988 - "Cotrimoxazole-induced agranulocytosis]" 10/24/1987 - "Cotrimoxazole-induced agranulocytosis]" 10/01/1984 - "Twenty patients were randomly assigned to treatment with trimethoprim/sulfamethoxazole during 20 episodes of profound granulocytopenia; 23 patients in the control group were followed through 25 granulocytopenic episodes" 04/10/1984 - "Fatal agranulocytosis and toxic liver damage after use of trimethoprim-sulfamethoxazole]" Order ALL the reference details at left...
7.	Interleukin-1 (Interleukin 1)IBA 08/01/1989 - "These results show that a single low dose of IL-1 may be used to accelerate the reconstitution of granulocytes following granulocytopenia induced with chemotherapy." 09/29/1998 - "Interleukin-1 has been effective in various animal models of potentially lethal bacterial infection, even during severe granulocytopenia" 01/01/1994 - "Interleukin-1 has been shown effective in an animal model of disseminated candidiasis, even during severe granulocytopenia" 01/01/1994 - "Interleukin-1 has been shown effective in various animal models of potentially lethal bacterial infection, even during severe granulocytopenia" 11/01/1987 - "We conclude that a monokine preparation containing IL-1 activity can induce profound granulocytopenia, pulmonary leukostasis, and acute pulmonary vascular endothelial injury." Order ALL the reference details at left...
8.	Anti-Bacterial Agents (Antibiotics)IBA 02/01/1995 - "Agranulocytosis induced by macrolide antibiotics." 04/01/1994 - "Agranulocytosis has been reported in 5-15% of patients treated with high-dose betalactam antibiotics (BLA)" 01/01/1993 - "Time required to develop agranulocytosis with antibiotics was < 19 days in comparison to > 40 days required with nonantibiotic drugs" 12/01/1991 - "When Aspergillus is isolated in the setting of corticosteroid therapy, antibiotics, or granulocytopenia, one must suspect invasive disease." 04/01/1990 - "The patient with agranulocytosis was given corticosteroid, granulocyte concentrate, gammaglobulin, and antibiotics, too" Order ALL the reference details at left...
9.	Methimazole (Thiamazole)FDA LinkGeneric 11/01/1993 - "The present study was undertaken to determine the efficacy of rhG-CSF administration in patients with methimazole-induced (MMI) agranulocytosis" 06/01/2006 - "After initiation of treatment with 30 mg of thiamazole daily, the patient's thyroid function improved but 4 weeks later, thiamazole induced agranulocytosis occurred and the drug was discontinued" 05/01/1991 - "Methimazole and agranulocytosis--clinical study." 09/01/2008 - "Agranulocytosis patients more often took medications already associated with agranulocytosis than controls (p = 0.01), mainly methimazole (OR 44.2, 95% CI 6.8 to infinity)" 01/01/2006 - "The best-known adverse hematologic reaction of methimazole is agranulocytosis" Order ALL the reference details at left...
10.	Levamisole (Decaris)FDA Link 12/01/1977 - "Because of the known tendency of levamisole to produce agranulocytosis, we believe it should not be used in man unless proven effective in a carefully controlled double-blind study." 09/01/1984 - "Transient granulocytopenia was observed in 3. It is concluded that levamisole may be effective in frequently relapsing INS with minimal side effects." 09/01/1980 - "Studies on levamisole--induced agranulocytosis." 11/01/2000 - "A significantly higher incidence of leuco-granulocytopenia was observed in the arm A (5 FU alone) inducing more frequent dose delays and adaptations as well as levamisole's withdrawal" 02/01/1991 - "The most serious adverse effect associated with levamisole is granulocytopenia" Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 02/01/1988 - "The 24 patients who achieved a complete remission received one to nine (median, four) additional courses of intensive chemotherapy for remission consolidation and/or relapse, and experienced 132 episodes of severe granulocytopenia" 09/01/1990 - "A total of 8 courses of anticancer chemotherapy with 25-30 mg/m2 of CDDP performed biweekly resulted in a partial remission (56%) but no side effects, including gastrointestinal damage and agranulocytosis" 09/01/2005 - "During induction chemotherapy, grade 3/4 granulocytopenia occurred in 32% and 38% of patients on study arms 1 and 2, respectively" 01/01/1993 - "Twenty-six patients who received two cycles of the identical chemotherapy regimen and had granulocytopenia less than 1 x 10(9) cells/l after the first cycle of chemotherapy were eligible for this study" 05/01/2007 - "Non-chemotherapy drug-induced agranulocytosis." Order ALL the reference details at left...
2.	Leukocyte Transfusion 01/01/1982 - "This study suggests that leukocyte transfusions from unstimulated normal donors are effective in the management of patients with potentially reversible granulocytopenia." 08/20/1977 - "Leukocyte transfusions thus have an important adjuvant role in the management of patients with severe granulocytopenia." 01/01/1971 - "Histocompatible leukocyte transfusion during granulocytopenia." 04/23/1966 - "The symptomatic treatment of agranulocytosis by leukocyte transfusion]" 08/20/1977 - "The role of leukocyte transfusions in the prevention and treatment of infections in adults with granulocytopenia was investigated" Order ALL the reference details at left...
3.	Splenectomy 03/01/1949 - "A case of cyclical agranulocytosis with marked improvement following splenectomy." 05/01/1982 - "Granulocytopenia and monocytopenia were present; the latter was not often corrected by splenectomy" 12/01/1951 - "Cyclic acute agranulocytosis: report of a case, with improvement after splenectomy." 01/01/1997 - "Effective splenectomy in agranulocytosis associated with systemic lupus erythematosus." 01/01/1996 - "Hence, the prognosis is unfavorable for patients with septic shock in a state of agranulocytosis, if their SAPS score on admission is higher than 21, if they develop polyorgan failure with involvement of more than three organ systems, have a history of splenectomy, their hemoblastosis is resistant to chemotherapy, and there are no prospects for granulocytopoiesis recovery." Order ALL the reference details at left...
4.	Plasmapheresis 10/01/1982 - "However, the agranulocytosis improved with repeated plasmapheresis and the patient achieved a clinical remission." 07/01/1996 - "Intensive care of myelotoxic agranulocytosis using nonselective plasmapheresis]" 07/01/1995 - "Plasmapheresis was applied in 10 patients given chemotherapy and radiation treatment for myelotoxic agranulocytosis" 01/01/2004 - "Plasmapheresis in the treatment of hyperthyroidism associated with agranulocytosis: A case report." 01/01/1997 - "A case of the successful use of plasmapheresis in the combined treatment of a female patient with autoimmune agranulocytosis against a background of Schmidt's syndrome]" Order ALL the reference details at left...
5.	Remission Induction 08/20/1977 - "Seven patients with acute myelogenous leukemia received HLA-matched leukocytes during the period of maximal granulocytopenia associated with initial remission induction therapy; 20 concurrently treated patients who did not receive leukocyte transfusions were the control group" 02/15/1992 - "In summary, the addition of GM-CSF to intensive chemotherapy in refractory adult ALL was associated with a reduction in the remission induction mortality, probably secondary to a shorter duration of granulocytopenia, but not with an improvement in complete response rates." 10/01/2002 - "In acute lymphoblastic leukemia (ALL), treatment with granulocyte colony stimulating factor (G-CSF) during remission induction shortens granulocytopenia and may decrease morbidity due to infections" 04/01/1983 - "Patients given trimethoprim-sulfamethoxazole plus nystatin during initial remission induction experienced an increased duration (22.6 vs. 13.6 days) of profound granulocytopenia (less than 100 granulocytes/mm3; P = 0.007)" 08/01/1983 - "Sixty-five previously untreated patients (34 women, 31 men) with acute myelocytic leukemia, ranging in age from 15 to 71 (median 43) years, were treated for remission induction with 7-day courses of cytarabine (100 mg/m2/day continuous i.v. infusion) together with daunorubicin (45 mg/m2/day rapid i.v. injection) on days 1, 2 and 3. Supportive care consisted of broad spectrum antibiotics for fever in the presence of granulocytopenia and substitution of erythrocytes and platelets" Order ALL the reference details at left...

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